Selective microRNA expression of exosomes from retinal pigment epithelial cells by oxidative stress
Vision Res. 2024 Apr 8;220:108388. doi: 10.1016/j.visres.2024.108388. Online ahead of print.ABSTRACTThe function of exosomal miRNAs (miRs) in retinal degeneration is largely unclear. We were aimed to investigate the functions of exosomes as well as their miRs derived from retinal pigment epithelial (RPE) cells following exposure to oxidative stress (OS). After the OS by lipopolysaccharide and rotenone on RPE cells, interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-α) were upregulated, along with the decreased mitochondrial membrane potential and upregulated oxidative damage marker 8-OH-dG...
Source: Vision Research - April 9, 2024 Category: Opthalmology Authors: Zhengyu Zhang Qinyuan Gu Lu Chen Dongqing Yuan Xunyi Gu Huiming Qian Ping Xie Qinghuai Liu Zizhong Hu Source Type: research
Systemic and Bilateral Severe Ocular Toxoplasmosis Resembling Autoimmune Phenomena: A Case Report
CONCLUSION AND IMPORTANCE: This case underscores the importance of ruling out an infectious etiology in all cases of uveitis. Additionally, it alerts clinicians to the possibility that elevated positive autoantibodies may result from a severe inflammatory reaction caused by pathogens rather than an autoimmune or autoinflammatory disease, particularly in instances of poor treatment response or atypical clinical presentation.PMID:38592492 | DOI:10.1080/09273948.2024.2336605 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 9, 2024 Category: Allergy & Immunology Authors: Sofia Romero-Santos Daniela Parra-Tanoux Carlos Cifuentes-Gonz ález Juliana Mu ñoz-Ortiz Germ án Mejía-Salgado Alejandra de-la-Torre Source Type: research
Reduced light exposure mitigates streptozotocin-induced vascular changes and gliosis in diabetic retina by an anti-inflammatory effect and increased retinal cholesterol turnover
Chem Biol Interact. 2024 Apr 7:110996. doi: 10.1016/j.cbi.2024.110996. Online ahead of print.ABSTRACTDiabetic retinopathy is not cured efficiently and changes of lifestyle measures may delay early retinal injury in diabetes. The aim of our study was to investigate the effects of reduced daily light exposure on retinal vascular changes in streptozotocin (STZ)-induced model of DM with emphasis on inflammation, Aqp4 expression, visual cycle and cholesterol metabolism-related gene expression in rat retina and RPE. Male Wistar rats were divided into the following groups: 1. control; 2. diabetic group (DM) treated with streptozo...
Source: Chemico-Biological Interactions - April 9, 2024 Category: Molecular Biology Authors: Dolika D Vasovi ć Sanja Ivkovi ć Ana Živanović Tamara Major Jelena M Mila šin Na đa S Nikolić Jelena M Simonovi ć Nikola Šutulović Dragan Hrn čić Olivera Stanojlovi ć Milena Veskovi ć Dejan M Ra šić Du šan Mladenović Source Type: research
An Update on Dragged-Fovea Diplopia Syndrome
Semin Ophthalmol. 2024 Apr 9:1-5. doi: 10.1080/08820538.2024.2323121. Online ahead of print.ABSTRACTDragged-fovea diplopia syndrome (DFDS) is a type of binocular double vision caused by a displacement of the fovea in one or both eyes due to retinal disorders including epiretinal membranes or other maculopathies. DFDS induces diplopia through a mismatch between peripheral motor fusion and central (foveal) fusion. It can be diagnosed by utilizing the Lights on - Lights off test. While there is no cure, there are treatments for DFDS including monocular occlusion or blurring (tape, lenses, IOL), Bangerter filter, and Fresnel p...
Source: Seminars in Ophthalmology - April 9, 2024 Category: Opthalmology Authors: Whitney Stuard Sambhariya Melanie Truong-Le Source Type: research
Vitamin A-treated natural killer cells reduce interferon-gamma production and support regulatory T-cell differentiation
Eur J Immunol. 2024 Apr 9:e2250342. doi: 10.1002/eji.202250342. Online ahead of print.ABSTRACTNatural killer (NK) cells are innate cytotoxic lymphocytes that contribute to immune responses against stressed, transformed, or infected cells. NK cell effector functions are regulated by microenvironmental factors, including cytokines, metabolites, and nutrients. Vitamin A is an essential micronutrient that plays an indispensable role in embryogenesis and development, but was also reported to regulate immune responses. However, the role of vitamin A in regulating NK cell functions remains poorly understood. Here, we show that th...
Source: European Journal of Immunology - April 9, 2024 Category: Allergy & Immunology Authors: Mingeum Jeong Francesco Cortopassi Jia-Xiang See Carolina De La Torre Adelheid Cerwenka Ana Stojanovic Source Type: research
Selective microRNA expression of exosomes from retinal pigment epithelial cells by oxidative stress
Vision Res. 2024 Apr 8;220:108388. doi: 10.1016/j.visres.2024.108388. Online ahead of print.ABSTRACTThe function of exosomal miRNAs (miRs) in retinal degeneration is largely unclear. We were aimed to investigate the functions of exosomes as well as their miRs derived from retinal pigment epithelial (RPE) cells following exposure to oxidative stress (OS). After the OS by lipopolysaccharide and rotenone on RPE cells, interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-α) were upregulated, along with the decreased mitochondrial membrane potential and upregulated oxidative damage marker 8-OH-dG...
Source: Vision Research - April 9, 2024 Category: Opthalmology Authors: Zhengyu Zhang Qinyuan Gu Lu Chen Dongqing Yuan Xunyi Gu Huiming Qian Ping Xie Qinghuai Liu Zizhong Hu Source Type: research
Autophagy in dry AMD: a promising therapeutic strategy for retinal pigment epithelial cell damage
Exp Eye Res. 2024 Apr 7:109889. doi: 10.1016/j.exer.2024.109889. Online ahead of print.ABSTRACTDry age-related macular degeneration (AMD) is a prevalent clinical condition that leads to permanent damage to central vision and poses a significant threat to patients' visual health. Although the pathogenesis of dry AMD remains unclear, there is consensus on the role of retinal pigment epithelium (RPE) damage. Oxidative stress and chronic inflammation are major contributors to RPE cell damage, and the NOD-like receptor thermoprotein structural domain-associated protein 3 (NLRP3) inflammasome mediates the inflammatory response l...
Source: Experimental Eye Research - April 9, 2024 Category: Opthalmology Authors: Zhao Zhang Fengming Liang Jun Chang Xiaoqian Shan Zhixian Yin Li Wang Shujiao Li Source Type: research
The Recent Advances in the Function and Mechanism of Caveolin-1 in Retinal Neovascularization
Curr Drug Targets. 2024 Apr 5. doi: 10.2174/0113894501310201240403065930. Online ahead of print.ABSTRACTRetinal neovascularization diseases have relatively high rates of evitable blindness. Abnormal retinal neovascularization is their main hallmark, which can damage the structure and function of the eye and lead to impaired vision. Caveolin-1 is a membrane protein that is expressed in many types of retinal cells and is involved in retinal neovascularization. This review presents a comprehensive analysis of global research on specific functions of caveolin-1 in retinal neovascularization. We believe that the mechanism of ac...
Source: Current Drug Targets - April 9, 2024 Category: Drugs & Pharmacology Authors: Rui Zhang Yalong Dang Source Type: research
An Update on Dragged-Fovea Diplopia Syndrome
Semin Ophthalmol. 2024 Apr 9:1-5. doi: 10.1080/08820538.2024.2323121. Online ahead of print.ABSTRACTDragged-fovea diplopia syndrome (DFDS) is a type of binocular double vision caused by a displacement of the fovea in one or both eyes due to retinal disorders including epiretinal membranes or other maculopathies. DFDS induces diplopia through a mismatch between peripheral motor fusion and central (foveal) fusion. It can be diagnosed by utilizing the Lights on - Lights off test. While there is no cure, there are treatments for DFDS including monocular occlusion or blurring (tape, lenses, IOL), Bangerter filter, and Fresnel p...
Source: Seminars in Ophthalmology - April 9, 2024 Category: Opthalmology Authors: Whitney Stuard Sambhariya Melanie Truong-Le Source Type: research
Vitamin A-treated natural killer cells reduce interferon-gamma production and support regulatory T-cell differentiation
Eur J Immunol. 2024 Apr 9:e2250342. doi: 10.1002/eji.202250342. Online ahead of print.ABSTRACTNatural killer (NK) cells are innate cytotoxic lymphocytes that contribute to immune responses against stressed, transformed, or infected cells. NK cell effector functions are regulated by microenvironmental factors, including cytokines, metabolites, and nutrients. Vitamin A is an essential micronutrient that plays an indispensable role in embryogenesis and development, but was also reported to regulate immune responses. However, the role of vitamin A in regulating NK cell functions remains poorly understood. Here, we show that th...
Source: European Journal of Immunology - April 9, 2024 Category: Allergy & Immunology Authors: Mingeum Jeong Francesco Cortopassi Jia-Xiang See Carolina De La Torre Adelheid Cerwenka Ana Stojanovic Source Type: research
The Recent Advances in the Function and Mechanism of Caveolin-1 in Retinal Neovascularization
Curr Drug Targets. 2024 Apr 5. doi: 10.2174/0113894501310201240403065930. Online ahead of print.ABSTRACTRetinal neovascularization diseases have relatively high rates of evitable blindness. Abnormal retinal neovascularization is their main hallmark, which can damage the structure and function of the eye and lead to impaired vision. Caveolin-1 is a membrane protein that is expressed in many types of retinal cells and is involved in retinal neovascularization. This review presents a comprehensive analysis of global research on specific functions of caveolin-1 in retinal neovascularization. We believe that the mechanism of ac...
Source: Current Drug Targets - April 9, 2024 Category: Drugs & Pharmacology Authors: Rui Zhang Yalong Dang Source Type: research
Autophagy in dry AMD: A promising therapeutic strategy for retinal pigment epithelial cell damage
Exp Eye Res. 2024 Apr 7;242:109889. doi: 10.1016/j.exer.2024.109889. Online ahead of print.ABSTRACTDry age-related macular degeneration (AMD) is a prevalent clinical condition that leads to permanent damage to central vision and poses a significant threat to patients' visual health. Although the pathogenesis of dry AMD remains unclear, there is consensus on the role of retinal pigment epithelium (RPE) damage. Oxidative stress and chronic inflammation are major contributors to RPE cell damage, and the NOD-like receptor thermoprotein structural domain-associated protein 3 (NLRP3) inflammasome mediates the inflammatory respon...
Source: Experimental Eye Research - April 9, 2024 Category: Opthalmology Authors: Zhao Zhang Fengming Liang Jun Chang Xiaoqian Shan Zhixian Yin Li Wang Shujiao Li Source Type: research
The Recent Advances in the Function and Mechanism of Caveolin-1 in Retinal Neovascularization
Curr Drug Targets. 2024 Apr 5. doi: 10.2174/0113894501310201240403065930. Online ahead of print.ABSTRACTRetinal neovascularization diseases have relatively high rates of evitable blindness. Abnormal retinal neovascularization is their main hallmark, which can damage the structure and function of the eye and lead to impaired vision. Caveolin-1 is a membrane protein that is expressed in many types of retinal cells and is involved in retinal neovascularization. This review presents a comprehensive analysis of global research on specific functions of caveolin-1 in retinal neovascularization. We believe that the mechanism of ac...
Source: Current Drug Targets - April 9, 2024 Category: Drugs & Pharmacology Authors: Rui Zhang Yalong Dang Source Type: research
An Update on Dragged-Fovea Diplopia Syndrome
Semin Ophthalmol. 2024 Apr 9:1-5. doi: 10.1080/08820538.2024.2323121. Online ahead of print.ABSTRACTDragged-fovea diplopia syndrome (DFDS) is a type of binocular double vision caused by a displacement of the fovea in one or both eyes due to retinal disorders including epiretinal membranes or other maculopathies. DFDS induces diplopia through a mismatch between peripheral motor fusion and central (foveal) fusion. It can be diagnosed by utilizing the Lights on - Lights off test. While there is no cure, there are treatments for DFDS including monocular occlusion or blurring (tape, lenses, IOL), Bangerter filter, and Fresnel p...
Source: Seminars in Ophthalmology - April 9, 2024 Category: Opthalmology Authors: Whitney Stuard Sambhariya Melanie Truong-Le Source Type: research
The Recent Advances in the Function and Mechanism of Caveolin-1 in Retinal Neovascularization
Curr Drug Targets. 2024 Apr 5. doi: 10.2174/0113894501310201240403065930. Online ahead of print.ABSTRACTRetinal neovascularization diseases have relatively high rates of evitable blindness. Abnormal retinal neovascularization is their main hallmark, which can damage the structure and function of the eye and lead to impaired vision. Caveolin-1 is a membrane protein that is expressed in many types of retinal cells and is involved in retinal neovascularization. This review presents a comprehensive analysis of global research on specific functions of caveolin-1 in retinal neovascularization. We believe that the mechanism of ac...
Source: Current Drug Targets - April 9, 2024 Category: Drugs & Pharmacology Authors: Rui Zhang Yalong Dang Source Type: research
