Glycolytic enzymes as vaccines against schistosomiasis: testing schistosoma mansoni phosphoglycerate mutase in mice
J Parasitol. 2024 Mar 1;110(2):96-105. doi: 10.1645/23-7.ABSTRACTSchistosomiasis is a globally burdensome parasitic disease caused by flatworms (blood flukes) in the genus Schistosoma. The current standard treatment for schistosomiasis is the drug praziquantel, but there is an urgent need to advance novel interventions such as vaccines. Several glycolytic enzymes have been evaluated as vaccine targets for schistosomiasis, and data from these studies are reviewed here. Although these parasites are canonically considered to be intracellular, proteomic analysis has revealed that many schistosome glycolytic enzymes are additio...
Source: The Journal of Parasitology - March 11, 2024 Category: Parasitology Authors: David B Pirovich Akram A Da'dara Patrick J Skelly Source Type: research
Molecular characterization of the < em > meq < /em > oncogene of Marek's disease virus in vaccinated Brazilian poultry farms reveals selective pressure on prevalent strains
This study sheds light on the circulation of MDV strains capable of infecting vaccinated birds. We emphasize the urgency of adopting preventive measures to manage MDV outbreaks threatening the poultry farming industry.PMID:38465827 | PMC:PMC10930104 | DOI:10.1080/01652176.2024.2318198 (Source: Veterinary Quarterly)
Source: Veterinary Quarterly - March 11, 2024 Category: Veterinary Research Authors: Ruy D Chac ón Christian J S ánchez-Llatas Sarah L Pajuelo Andrea J Diaz Forero Victor Jimenez-Vasquez Jack A M édico Luis F Soto-Ugaldi Claudete S Astolfi-Ferreira Antonio J Piantino Ferreira Source Type: research
Glycolytic enzymes as vaccines against schistosomiasis: testing schistosoma mansoni phosphoglycerate mutase in mice
J Parasitol. 2024 Mar 1;110(2):96-105. doi: 10.1645/23-7.ABSTRACTSchistosomiasis is a globally burdensome parasitic disease caused by flatworms (blood flukes) in the genus Schistosoma. The current standard treatment for schistosomiasis is the drug praziquantel, but there is an urgent need to advance novel interventions such as vaccines. Several glycolytic enzymes have been evaluated as vaccine targets for schistosomiasis, and data from these studies are reviewed here. Although these parasites are canonically considered to be intracellular, proteomic analysis has revealed that many schistosome glycolytic enzymes are additio...
Source: The Journal of Parasitology - March 11, 2024 Category: Parasitology Authors: David B Pirovich Akram A Da'dara Patrick J Skelly Source Type: research
Glycolytic enzymes as vaccines against schistosomiasis: testing schistosoma mansoni phosphoglycerate mutase in mice
J Parasitol. 2024 Mar 1;110(2):96-105. doi: 10.1645/23-7.ABSTRACTSchistosomiasis is a globally burdensome parasitic disease caused by flatworms (blood flukes) in the genus Schistosoma. The current standard treatment for schistosomiasis is the drug praziquantel, but there is an urgent need to advance novel interventions such as vaccines. Several glycolytic enzymes have been evaluated as vaccine targets for schistosomiasis, and data from these studies are reviewed here. Although these parasites are canonically considered to be intracellular, proteomic analysis has revealed that many schistosome glycolytic enzymes are additio...
Source: The Journal of Parasitology - March 11, 2024 Category: Parasitology Authors: David B Pirovich Akram A Da'dara Patrick J Skelly Source Type: research
Glycolytic enzymes as vaccines against schistosomiasis: testing schistosoma mansoni phosphoglycerate mutase in mice
J Parasitol. 2024 Mar 1;110(2):96-105. doi: 10.1645/23-7.ABSTRACTSchistosomiasis is a globally burdensome parasitic disease caused by flatworms (blood flukes) in the genus Schistosoma. The current standard treatment for schistosomiasis is the drug praziquantel, but there is an urgent need to advance novel interventions such as vaccines. Several glycolytic enzymes have been evaluated as vaccine targets for schistosomiasis, and data from these studies are reviewed here. Although these parasites are canonically considered to be intracellular, proteomic analysis has revealed that many schistosome glycolytic enzymes are additio...
Source: The Journal of Parasitology - March 11, 2024 Category: Parasitology Authors: David B Pirovich Akram A Da'dara Patrick J Skelly Source Type: research
Antibody-mediated depletion of select leukocyte subsets in blood and tissue of nonhuman primates
We report quantitative measurements of in vivo depletion at multiple tissue sites providing insight into the range of cell types depleted by a given mAb. While we found substantial depletion of target cell types in blood and tissue of many animals, residual cells remained, often residing within tissue. Notably, we find that animal-to-animal variation is substantial and consequently studies that use these reagents should be powered accordingly. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 11, 2024 Category: Allergy & Immunology Source Type: research
CheV enhances the virulence of Salmonella Enteritidis, and the Chev-deleted Salmonella vaccine provides immunity in mice
Salmonella enteritidis (SE) is a major zoonotic pathogen and causes infections in a variety of hosts. The development of novel vaccines for SE is necessary to eradicate this pathogen. Genetically engineered atten... (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - March 11, 2024 Category: Veterinary Research Authors: Lu Zhang, Tonglei Wu, Fengjie Wang, Wan Liu, Guixin Zhao, Yanying Zhang, Zhiqiang Zhang and Qiumei Shi Tags: Research Source Type: research
Attenuated vaccine PmCQ2 Δ4555–4580 effectively protects mice against Pasteurella multocida infection
Pasteurella multocida type A (PmA) mainly causes respiratory diseases such as pneumonia in bovines, leading to great economic losses to the breeding industry. At present, there is still no effective commercial va... (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - March 9, 2024 Category: Veterinary Research Authors: Fang He, Pan Xiong, Huihui Zhang, Liu Yang, Yangyang Qiu, Pan Li, Guangfu Zhao, Nengzhang Li and Yuanyi Peng Tags: Research Source Type: research
No vaccine interference between bovine coronavirus and bovine herpesvirus-1 in a randomized trial when coadministrating two intranasal modified-live viral vaccines to neonatal calves
This study provides evidence an MLV vaccine containing BHV-1 and an MLV BC vaccine can be coadministered to neonatal calves without significantly altering immune responses to the 2 viruses or compromising the prevention of BHV-1 respiratory disease. Calves receiving the BC + N3 vaccine had a significant reduction in lung pathology after BHV-1 aerosol challenge.PMID:38457927 | DOI:10.2460/ajvr.23.12.0281 (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - March 8, 2024 Category: Veterinary Research Authors: Michael W Bolton Scott Nordstrom Kevin Hill Lowell Midla Karthic Rajamanikam Philip J Griebel Source Type: research
Virus-like particles of louping ill virus elicit potent neutralizing antibodies targeting multimers of viral envelope protein
This study aimed to develop high-efficacy non-infectious protein-based vaccine candidates. Specifically, soluble envelope protein (sE), and virus-like particles (VLPs), comprised of the precursor of membrane and envelope proteins, were generated, characterized, and studied for their immunogenicity in mice. Results showed that the VLPs induced more potent virus neutralizing response compared to sE, even though the total anti-envelope IgG content induced by the two antigens was similar. Depletion of anti-monomeric E protein antibodies from mouse immune sera suggested that the neutralizing antibodies elicited by the VLPs targ...
Source: Vaccine - March 8, 2024 Category: Allergy & Immunology Authors: Rapeepat Tandavanitj Chayanee Setthapramote Giuditta De Lorenzo Ricardo Sanchez-Velazquez Jordan J Clark Mara Rocchi Colin McInnes Alain Kohl Arvind H Patel Source Type: research
No vaccine interference between bovine coronavirus and bovine herpesvirus-1 in a randomized trial when coadministrating two intranasal modified-live viral vaccines to neonatal calves
This study provides evidence an MLV vaccine containing BHV-1 and an MLV BC vaccine can be coadministered to neonatal calves without significantly altering immune responses to the 2 viruses or compromising the prevention of BHV-1 respiratory disease. Calves receiving the BC + N3 vaccine had a significant reduction in lung pathology after BHV-1 aerosol challenge.PMID:38457927 | DOI:10.2460/ajvr.23.12.0281 (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - March 8, 2024 Category: Veterinary Research Authors: Michael W Bolton Scott Nordstrom Kevin Hill Lowell Midla Karthic Rajamanikam Philip J Griebel Source Type: research
No vaccine interference between bovine coronavirus and bovine herpesvirus-1 in a randomized trial when coadministrating two intranasal modified-live viral vaccines to neonatal calves
This study provides evidence an MLV vaccine containing BHV-1 and an MLV BC vaccine can be coadministered to neonatal calves without significantly altering immune responses to the 2 viruses or compromising the prevention of BHV-1 respiratory disease. Calves receiving the BC + N3 vaccine had a significant reduction in lung pathology after BHV-1 aerosol challenge.PMID:38457927 | DOI:10.2460/ajvr.23.12.0281 (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - March 8, 2024 Category: Veterinary Research Authors: Michael W Bolton Scott Nordstrom Kevin Hill Lowell Midla Karthic Rajamanikam Philip J Griebel Source Type: research
The Use of Rabbits Used to Propagate Human Lice for Research
Comp Med. 2024 Mar 7. doi: 10.30802/AALAS-CM-23-000073. Online ahead of print.ABSTRACTThe globally important human diseases of trench fever, epidemic typhus, and relapsing fever are vectored by the human louse Pediculus humanus humanus. Although these conditions are epidemically quiescent at present, they persist in socially dysfunctional situations of war, deprivation, and crowding. The taxonomically closely related head louse, Pediculus humanus capitis, does not respect economic or social status and is quite common in most countries. The 2 types of lice are now recognized as conspecific ecotypes of a single species. Whil...
Source: Comparative Medicine - March 7, 2024 Category: Zoology Authors: Steven H Weisbroth Source Type: research
The Use of Rabbits Used to Propagate Human Lice for Research
Comp Med. 2024 Mar 7. doi: 10.30802/AALAS-CM-23-000073. Online ahead of print.ABSTRACTThe globally important human diseases of trench fever, epidemic typhus, and relapsing fever are vectored by the human louse Pediculus humanus humanus. Although these conditions are epidemically quiescent at present, they persist in socially dysfunctional situations of war, deprivation, and crowding. The taxonomically closely related head louse, Pediculus humanus capitis, does not respect economic or social status and is quite common in most countries. The 2 types of lice are now recognized as conspecific ecotypes of a single species. Whil...
Source: Comparative Medicine - March 7, 2024 Category: Zoology Authors: Steven H Weisbroth Source Type: research
The Use of Rabbits Used to Propagate Human Lice for Research
Comp Med. 2024 Mar 7. doi: 10.30802/AALAS-CM-23-000073. Online ahead of print.ABSTRACTThe globally important human diseases of trench fever, epidemic typhus, and relapsing fever are vectored by the human louse Pediculus humanus humanus. Although these conditions are epidemically quiescent at present, they persist in socially dysfunctional situations of war, deprivation, and crowding. The taxonomically closely related head louse, Pediculus humanus capitis, does not respect economic or social status and is quite common in most countries. The 2 types of lice are now recognized as conspecific ecotypes of a single species. Whil...
Source: Comparative Medicine - March 7, 2024 Category: Zoology Authors: Steven H Weisbroth Source Type: research
