Antibody-mediated depletion of select leukocyte subsets in blood and tissue of nonhuman primates

We report quantitative measurements of in vivo depletion at multiple tissue sites providing insight into the range of cell types depleted by a given mAb. While we found substantial depletion of target cell types in blood and tissue of many animals, residual cells remained, often residing within tissue. Notably, we find that animal-to-animal variation is substantial and consequently studies that use these reagents should be powered accordingly.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research