GSE236747 Subolesin knockdown in tick cells provides insights into vaccine protective mechanisms
In this study, RNAseq and proteomic analyses were carried out in wild type and Subolesin knockdown tick ISE6 cells in order to identify and characterize the functional implications of Subolesin in tick cells, demonstrating once again the importance of this antigen in vaccine development against tick and TBDs. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 20, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Ixodes scapularis Source Type: research
Animal vaccine strain Brucella abortus infection in a plateletpheresis donor: A case report
Transfusion. 2024 Mar 19. doi: 10.1111/trf.17799. Online ahead of print.NO ABSTRACTPMID:38501889 | DOI:10.1111/trf.17799 (Source: Transfusion)
Source: Transfusion - March 19, 2024 Category: Hematology Authors: Meredith G Parsons Daniela Hermelin Andrew Hennenfent Rebekah V Tiller Pallavi Annambhotla Mar ía E Negrón Sridhar V Basavaraju Louis M Katz Source Type: research
Vaccine development: obligate intracellular bacteria new tools, old pathogens: the current state of vaccines against obligate intracellular bacteria
Obligate intracellular bacteria have remained those for which effective vaccines are unavailable, mostly because protection does not solely rely on an antibody response. Effective antibody-based vaccines, however, have been developed against extracellular bacteria pathogens or toxins. Additionally, obligate intracellular bacteria have evolved many mechanisms to subvert the immune response, making vaccine development complex. Much of what we know about protective immunity for these pathogens has been determined using infection-resolved cases and animal models that mimic disease. These studies have laid the groundwork for an...
Source: Frontiers in cellular and infection microbiology - March 19, 2024 Category: Microbiology Source Type: research
Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)
Bioinformation. 2024 Feb 29;20(2):91-102. doi: 10.6026/973206300200091. eCollection 2024.ABSTRACTRift Valley Fever (RVF) is a mosquito-borne viral zoonosis caused by RVFV in humans and livestock. Currently, there are no approved vaccines or antiviral therapies available. Additionally, in Saudi Arabia, there is a lack of a routine screening system to monitor RVFV in humans and animals which hinders to design and develop the preventive measures as well as the prediction of future outbreaks and the potential re-emergence of RVFV. Hence, we have performed the cloning, sequencing, and phylogenetic analysis, of nucleocapsid (N) ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Ahmed Mohamed Hassan Arwa Ahmed Zehairy Al-Judaibi Awatif Abid Sayed Sartaj Sohrab Ibraheem Azhar Esam Source Type: research
Survivin in lung cancer: a potential target for therapy and prevention-a narrative review
CONCLUSIONS: Nuclear survivin is a potential biomarker for advanced non-small cell lung cancer. It plays a role in determining drug responsiveness and is found to be significantly elevated in cases of resistance to chemotherapy. Multiple compounds and immunization strategies have been identified to impact lung cancer cells; however, they are currently in the early stages of phase I or phase II clinical trials. The substantial promise of survivin-based immunogenicity-focused treatments warrants in-depth investigation and exploration.PMID:38496694 | PMC:PMC10938099 | DOI:10.21037/tlcr-23-621 (Source: Cell Research)
Source: Cell Research - March 18, 2024 Category: Cytology Authors: Akhil Goud Pachimatla Robert Fenstermaker Michael Ciesielski Sai Yendamuri Source Type: research
Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)
Bioinformation. 2024 Feb 29;20(2):91-102. doi: 10.6026/973206300200091. eCollection 2024.ABSTRACTRift Valley Fever (RVF) is a mosquito-borne viral zoonosis caused by RVFV in humans and livestock. Currently, there are no approved vaccines or antiviral therapies available. Additionally, in Saudi Arabia, there is a lack of a routine screening system to monitor RVFV in humans and animals which hinders to design and develop the preventive measures as well as the prediction of future outbreaks and the potential re-emergence of RVFV. Hence, we have performed the cloning, sequencing, and phylogenetic analysis, of nucleocapsid (N) ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Ahmed Mohamed Hassan Arwa Ahmed Zehairy Al-Judaibi Awatif Abid Sayed Sartaj Sohrab Ibraheem Azhar Esam Source Type: research
Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)
Bioinformation. 2024 Feb 29;20(2):91-102. doi: 10.6026/973206300200091. eCollection 2024.ABSTRACTRift Valley Fever (RVF) is a mosquito-borne viral zoonosis caused by RVFV in humans and livestock. Currently, there are no approved vaccines or antiviral therapies available. Additionally, in Saudi Arabia, there is a lack of a routine screening system to monitor RVFV in humans and animals which hinders to design and develop the preventive measures as well as the prediction of future outbreaks and the potential re-emergence of RVFV. Hence, we have performed the cloning, sequencing, and phylogenetic analysis, of nucleocapsid (N) ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Ahmed Mohamed Hassan Arwa Ahmed Zehairy Al-Judaibi Awatif Abid Sayed Sartaj Sohrab Ibraheem Azhar Esam Source Type: research
Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)
Bioinformation. 2024 Feb 29;20(2):91-102. doi: 10.6026/973206300200091. eCollection 2024.ABSTRACTRift Valley Fever (RVF) is a mosquito-borne viral zoonosis caused by RVFV in humans and livestock. Currently, there are no approved vaccines or antiviral therapies available. Additionally, in Saudi Arabia, there is a lack of a routine screening system to monitor RVFV in humans and animals which hinders to design and develop the preventive measures as well as the prediction of future outbreaks and the potential re-emergence of RVFV. Hence, we have performed the cloning, sequencing, and phylogenetic analysis, of nucleocapsid (N) ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Ahmed Mohamed Hassan Arwa Ahmed Zehairy Al-Judaibi Awatif Abid Sayed Sartaj Sohrab Ibraheem Azhar Esam Source Type: research
Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)
Bioinformation. 2024 Feb 29;20(2):91-102. doi: 10.6026/973206300200091. eCollection 2024.ABSTRACTRift Valley Fever (RVF) is a mosquito-borne viral zoonosis caused by RVFV in humans and livestock. Currently, there are no approved vaccines or antiviral therapies available. Additionally, in Saudi Arabia, there is a lack of a routine screening system to monitor RVFV in humans and animals which hinders to design and develop the preventive measures as well as the prediction of future outbreaks and the potential re-emergence of RVFV. Hence, we have performed the cloning, sequencing, and phylogenetic analysis, of nucleocapsid (N) ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Ahmed Mohamed Hassan Arwa Ahmed Zehairy Al-Judaibi Awatif Abid Sayed Sartaj Sohrab Ibraheem Azhar Esam Source Type: research
Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)
Bioinformation. 2024 Feb 29;20(2):91-102. doi: 10.6026/973206300200091. eCollection 2024.ABSTRACTRift Valley Fever (RVF) is a mosquito-borne viral zoonosis caused by RVFV in humans and livestock. Currently, there are no approved vaccines or antiviral therapies available. Additionally, in Saudi Arabia, there is a lack of a routine screening system to monitor RVFV in humans and animals which hinders to design and develop the preventive measures as well as the prediction of future outbreaks and the potential re-emergence of RVFV. Hence, we have performed the cloning, sequencing, and phylogenetic analysis, of nucleocapsid (N) ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Ahmed Mohamed Hassan Arwa Ahmed Zehairy Al-Judaibi Awatif Abid Sayed Sartaj Sohrab Ibraheem Azhar Esam Source Type: research
Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)
Bioinformation. 2024 Feb 29;20(2):91-102. doi: 10.6026/973206300200091. eCollection 2024.ABSTRACTRift Valley Fever (RVF) is a mosquito-borne viral zoonosis caused by RVFV in humans and livestock. Currently, there are no approved vaccines or antiviral therapies available. Additionally, in Saudi Arabia, there is a lack of a routine screening system to monitor RVFV in humans and animals which hinders to design and develop the preventive measures as well as the prediction of future outbreaks and the potential re-emergence of RVFV. Hence, we have performed the cloning, sequencing, and phylogenetic analysis, of nucleocapsid (N) ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Ahmed Mohamed Hassan Arwa Ahmed Zehairy Al-Judaibi Awatif Abid Sayed Sartaj Sohrab Ibraheem Azhar Esam Source Type: research
