Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)
Bioinformation. 2024 Feb 29;20(2):91-102. doi: 10.6026/973206300200091. eCollection 2024.ABSTRACTRift Valley Fever (RVF) is a mosquito-borne viral zoonosis caused by RVFV in humans and livestock. Currently, there are no approved vaccines or antiviral therapies available. Additionally, in Saudi Arabia, there is a lack of a routine screening system to monitor RVFV in humans and animals which hinders to design and develop the preventive measures as well as the prediction of future outbreaks and the potential re-emergence of RVFV. Hence, we have performed the cloning, sequencing, and phylogenetic analysis, of nucleocapsid (N) ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Ahmed Mohamed Hassan Arwa Ahmed Zehairy Al-Judaibi Awatif Abid Sayed Sartaj Sohrab Ibraheem Azhar Esam Source Type: research
Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)
Bioinformation. 2024 Feb 29;20(2):91-102. doi: 10.6026/973206300200091. eCollection 2024.ABSTRACTRift Valley Fever (RVF) is a mosquito-borne viral zoonosis caused by RVFV in humans and livestock. Currently, there are no approved vaccines or antiviral therapies available. Additionally, in Saudi Arabia, there is a lack of a routine screening system to monitor RVFV in humans and animals which hinders to design and develop the preventive measures as well as the prediction of future outbreaks and the potential re-emergence of RVFV. Hence, we have performed the cloning, sequencing, and phylogenetic analysis, of nucleocapsid (N) ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Ahmed Mohamed Hassan Arwa Ahmed Zehairy Al-Judaibi Awatif Abid Sayed Sartaj Sohrab Ibraheem Azhar Esam Source Type: research
Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)
Bioinformation. 2024 Feb 29;20(2):91-102. doi: 10.6026/973206300200091. eCollection 2024.ABSTRACTRift Valley Fever (RVF) is a mosquito-borne viral zoonosis caused by RVFV in humans and livestock. Currently, there are no approved vaccines or antiviral therapies available. Additionally, in Saudi Arabia, there is a lack of a routine screening system to monitor RVFV in humans and animals which hinders to design and develop the preventive measures as well as the prediction of future outbreaks and the potential re-emergence of RVFV. Hence, we have performed the cloning, sequencing, and phylogenetic analysis, of nucleocapsid (N) ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Ahmed Mohamed Hassan Arwa Ahmed Zehairy Al-Judaibi Awatif Abid Sayed Sartaj Sohrab Ibraheem Azhar Esam Source Type: research
Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)
Bioinformation. 2024 Feb 29;20(2):91-102. doi: 10.6026/973206300200091. eCollection 2024.ABSTRACTRift Valley Fever (RVF) is a mosquito-borne viral zoonosis caused by RVFV in humans and livestock. Currently, there are no approved vaccines or antiviral therapies available. Additionally, in Saudi Arabia, there is a lack of a routine screening system to monitor RVFV in humans and animals which hinders to design and develop the preventive measures as well as the prediction of future outbreaks and the potential re-emergence of RVFV. Hence, we have performed the cloning, sequencing, and phylogenetic analysis, of nucleocapsid (N) ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Ahmed Mohamed Hassan Arwa Ahmed Zehairy Al-Judaibi Awatif Abid Sayed Sartaj Sohrab Ibraheem Azhar Esam Source Type: research
Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)
Bioinformation. 2024 Feb 29;20(2):91-102. doi: 10.6026/973206300200091. eCollection 2024.ABSTRACTRift Valley Fever (RVF) is a mosquito-borne viral zoonosis caused by RVFV in humans and livestock. Currently, there are no approved vaccines or antiviral therapies available. Additionally, in Saudi Arabia, there is a lack of a routine screening system to monitor RVFV in humans and animals which hinders to design and develop the preventive measures as well as the prediction of future outbreaks and the potential re-emergence of RVFV. Hence, we have performed the cloning, sequencing, and phylogenetic analysis, of nucleocapsid (N) ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Ahmed Mohamed Hassan Arwa Ahmed Zehairy Al-Judaibi Awatif Abid Sayed Sartaj Sohrab Ibraheem Azhar Esam Source Type: research
Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)
Bioinformation. 2024 Feb 29;20(2):91-102. doi: 10.6026/973206300200091. eCollection 2024.ABSTRACTRift Valley Fever (RVF) is a mosquito-borne viral zoonosis caused by RVFV in humans and livestock. Currently, there are no approved vaccines or antiviral therapies available. Additionally, in Saudi Arabia, there is a lack of a routine screening system to monitor RVFV in humans and animals which hinders to design and develop the preventive measures as well as the prediction of future outbreaks and the potential re-emergence of RVFV. Hence, we have performed the cloning, sequencing, and phylogenetic analysis, of nucleocapsid (N) ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Ahmed Mohamed Hassan Arwa Ahmed Zehairy Al-Judaibi Awatif Abid Sayed Sartaj Sohrab Ibraheem Azhar Esam Source Type: research
Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)
Bioinformation. 2024 Feb 29;20(2):91-102. doi: 10.6026/973206300200091. eCollection 2024.ABSTRACTRift Valley Fever (RVF) is a mosquito-borne viral zoonosis caused by RVFV in humans and livestock. Currently, there are no approved vaccines or antiviral therapies available. Additionally, in Saudi Arabia, there is a lack of a routine screening system to monitor RVFV in humans and animals which hinders to design and develop the preventive measures as well as the prediction of future outbreaks and the potential re-emergence of RVFV. Hence, we have performed the cloning, sequencing, and phylogenetic analysis, of nucleocapsid (N) ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Ahmed Mohamed Hassan Arwa Ahmed Zehairy Al-Judaibi Awatif Abid Sayed Sartaj Sohrab Ibraheem Azhar Esam Source Type: research
Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)
Bioinformation. 2024 Feb 29;20(2):91-102. doi: 10.6026/973206300200091. eCollection 2024.ABSTRACTRift Valley Fever (RVF) is a mosquito-borne viral zoonosis caused by RVFV in humans and livestock. Currently, there are no approved vaccines or antiviral therapies available. Additionally, in Saudi Arabia, there is a lack of a routine screening system to monitor RVFV in humans and animals which hinders to design and develop the preventive measures as well as the prediction of future outbreaks and the potential re-emergence of RVFV. Hence, we have performed the cloning, sequencing, and phylogenetic analysis, of nucleocapsid (N) ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Ahmed Mohamed Hassan Arwa Ahmed Zehairy Al-Judaibi Awatif Abid Sayed Sartaj Sohrab Ibraheem Azhar Esam Source Type: research
Safety and immunogenicity of a novel trivalent recombinant MVA-based equine encephalitis virus vaccine: A Phase 1 clinical trial
CONCLUSION: The study demonstrated that MVA-BN-WEV is well tolerated, induces immune responses, and is suitable for further development.CLINICAL TRIAL REGISTRY NUMBER: NCT04131595.PMID:38494412 | DOI:10.1016/j.vaccine.2024.03.011 (Source: Vaccine)
Source: Vaccine - March 17, 2024 Category: Allergy & Immunology Authors: Carlos Fierro Heinz Weidenthaler Sanja Vidojkovic Darja Schmidt Zarina Gafoor Daria Stroukova Susan Zwiers Jutta M üller Ariane Volkmann Source Type: research
An equine iPSC-based phenotypic screening platform identifies pro- and anti-viral molecules against West Nile virus
AbstractOutbreaks of West Nile virus (WNV) occur periodically, affecting both human and equine populations. There are no vaccines for humans, and those commercialised for horses do not have sufficient coverage. Specific antiviral treatments do not exist. Many drug discovery studies have been conducted, but since rodent or primate cell lines are normally used, results cannot always be transposed to horses. There is thus a need to develop relevant equine cellular models. Here, we used induced pluripotent stem cells to develop a new in vitro model of WNV-infected equine brain cells suitable for microplate assay, and assessed ...
Source: Veterinary Research - March 16, 2024 Category: Veterinary Research Source Type: research
Caffeic acid phenethyl ester: An effective antiviral agent against porcine reproductive and Respiratory Syndrome Virus
Antiviral Res. 2024 Mar 13:105868. doi: 10.1016/j.antiviral.2024.105868. Online ahead of print.ABSTRACTPorcine Reproductive and Respiratory Syndrome (PRRS) presents a formidable viral challenge in swine husbandry. Confronting the constraints of existing veterinary pharmaceuticals and vaccines, this investigation centers on Caffeic Acid Phenethyl Ester (CAPE) as a prospective clinical suppressant for the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The study adopts an integrated methodology to evaluate CAPE's antiviral attributes. This encompasses a dual-phase analysis of CAPE's interaction with PRRSV, both ...
Source: Antiviral Research - March 15, 2024 Category: Virology Authors: Zhanding Cui Jing Zhang Jinlong Wang Jinlong Liu Pu Sun Jiaoyang Li Guoxiu Li Ying Sun Juanbin Ying Kun Li Zhixun Zhao Hong Yuan Xingwen Bai Xueqing Ma Pinghua Li Yuanfang Fu Huifang Bao Dong Li Qiang Zhang Zaixin Liu Yimei Cao Zengjun Lu Source Type: research
Evaluation of protective efficacy, serological responses, and cytokine modulation induced by polyvalent Leptospira vaccines in hamsters
Comp Immunol Microbiol Infect Dis. 2024 Mar 12;108:102159. doi: 10.1016/j.cimid.2024.102159. Online ahead of print.ABSTRACTWhole-cell inactivated vaccines (bacterins) are the only licensed vaccines available for leptospirosis prevention and control, especially in domestic and farm animals. However, despite their widespread use, inconsistencies in their efficacy have been reported. Because immunity induced by bacterins is mainly mediated by antibodies against leptospiral lipopolysaccharides, the involvement of cellular responses is not well-known. The aim of this study was to investigate the efficacy and characterize the hu...
Source: Comparative immunology, microbiology and infectious diseases. - March 15, 2024 Category: Allergy & Immunology Authors: Natasha Rodrigues de Oliveira Mara Andrade Colares Maia Francisco Denis Souza Santos Amilton Clair Pinto Seixas Neto Tha ís Larré Oliveira Bohn Odir Ant ônio Dellagostin Source Type: research
Evaluation of protective efficacy, serological responses, and cytokine modulation induced by polyvalent Leptospira vaccines in hamsters
Comp Immunol Microbiol Infect Dis. 2024 Mar 12;108:102159. doi: 10.1016/j.cimid.2024.102159. Online ahead of print.ABSTRACTWhole-cell inactivated vaccines (bacterins) are the only licensed vaccines available for leptospirosis prevention and control, especially in domestic and farm animals. However, despite their widespread use, inconsistencies in their efficacy have been reported. Because immunity induced by bacterins is mainly mediated by antibodies against leptospiral lipopolysaccharides, the involvement of cellular responses is not well-known. The aim of this study was to investigate the efficacy and characterize the hu...
Source: Comparative immunology, microbiology and infectious diseases. - March 15, 2024 Category: Allergy & Immunology Authors: Natasha Rodrigues de Oliveira Mara Andrade Colares Maia Francisco Denis Souza Santos Amilton Clair Pinto Seixas Neto Tha ís Larré Oliveira Bohn Odir Ant ônio Dellagostin Source Type: research
Evaluation of protective efficacy, serological responses, and cytokine modulation induced by polyvalent Leptospira vaccines in hamsters
Comp Immunol Microbiol Infect Dis. 2024 Mar 12;108:102159. doi: 10.1016/j.cimid.2024.102159. Online ahead of print.ABSTRACTWhole-cell inactivated vaccines (bacterins) are the only licensed vaccines available for leptospirosis prevention and control, especially in domestic and farm animals. However, despite their widespread use, inconsistencies in their efficacy have been reported. Because immunity induced by bacterins is mainly mediated by antibodies against leptospiral lipopolysaccharides, the involvement of cellular responses is not well-known. The aim of this study was to investigate the efficacy and characterize the hu...
Source: Comparative immunology, microbiology and infectious diseases. - March 15, 2024 Category: Allergy & Immunology Authors: Natasha Rodrigues de Oliveira Mara Andrade Colares Maia Francisco Denis Souza Santos Amilton Clair Pinto Seixas Neto Tha ís Larré Oliveira Bohn Odir Ant ônio Dellagostin Source Type: research
Evaluation of protective efficacy, serological responses, and cytokine modulation induced by polyvalent Leptospira vaccines in hamsters
Comp Immunol Microbiol Infect Dis. 2024 Mar 12;108:102159. doi: 10.1016/j.cimid.2024.102159. Online ahead of print.ABSTRACTWhole-cell inactivated vaccines (bacterins) are the only licensed vaccines available for leptospirosis prevention and control, especially in domestic and farm animals. However, despite their widespread use, inconsistencies in their efficacy have been reported. Because immunity induced by bacterins is mainly mediated by antibodies against leptospiral lipopolysaccharides, the involvement of cellular responses is not well-known. The aim of this study was to investigate the efficacy and characterize the hu...
Source: Comparative immunology, microbiology and infectious diseases. - March 15, 2024 Category: Allergy & Immunology Authors: Natasha Rodrigues de Oliveira Mara Andrade Colares Maia Francisco Denis Souza Santos Amilton Clair Pinto Seixas Neto Tha ís Larré Oliveira Bohn Odir Ant ônio Dellagostin Source Type: research
