Caffeic acid phenethyl ester: An effective antiviral agent against porcine reproductive and Respiratory Syndrome Virus
Antiviral Res. 2024 Mar 13:105868. doi: 10.1016/j.antiviral.2024.105868. Online ahead of print.ABSTRACTPorcine Reproductive and Respiratory Syndrome (PRRS) presents a formidable viral challenge in swine husbandry. Confronting the constraints of existing veterinary pharmaceuticals and vaccines, this investigation centers on Caffeic Acid Phenethyl Ester (CAPE) as a prospective clinical suppressant for the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The study adopts an integrated methodology to evaluate CAPE's antiviral attributes. This encompasses a dual-phase analysis of CAPE's interaction with PRRSV, both in vitro and in vivo, and an examination of its influence on viral replication. Varied dosages of CAPE were subjected to empirical testing in animal models to quantify its efficacy in combating PRRSV infections. The findings reveal a pronounced antiviral potency, notably in prophylactic scenarios. As a predominant component of propolis, CAPE stands out as a promising candidate for clinical suppression, showing exceptional effectiveness in pre-exposure prophylaxis regimes. This highlights the potential of CAPE in spearheading cutting-edge strategies for the management of future PRRSV outbreaks.PMID:38490343 | DOI:10.1016/j.antiviral.2024.105868
Source: Antiviral Research - Category: Virology Authors: Zhanding Cui Jing Zhang Jinlong Wang Jinlong Liu Pu Sun Jiaoyang Li Guoxiu Li Ying Sun Juanbin Ying Kun Li Zhixun Zhao Hong Yuan Xingwen Bai Xueqing Ma Pinghua Li Yuanfang Fu Huifang Bao Dong Li Qiang Zhang Zaixin Liu Yimei Cao Zengjun Lu Source Type: research
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