The addition of curcumin to the diet of post-weaning dairy calves: effects on ruminal fermentation, immunological, and oxidative responses
AbstractIncorporating Curcumin into animal diets holds significant promise for enhancing both animal health and productivity, with demonstrated positive impacts on antioxidant activity, anti-microbial responses. Therefore, this study aimed to determine whether adding Curcumin to the diet of dairy calves would influence ruminal fermentation, hematologic, immunological, oxidative, and metabolism variables. Fourteen Jersey calves were divided into a control group (GCON) and a treatment group (GTRA). The animals in the GTRA received a diet containing 65.1 mg/kg of dry matter (DM) Curcumin (74% purity) for an experimental per...
Source: Tropical Animal Health and Production - April 25, 2024 Category: Veterinary Research Source Type: research
Curcumin-loaded liposomes modulating the synergistic role of EpCAM and estrogen receptor alpha in lung cancer management
This study delves into the in vitro potential of liposomal therapeutics utilizing Curcumin-loaded PlexoZome® (CUR-PLXZ) in targeting EpCAM/TROP1 and Estrogen Receptor Alpha (ERα) signalling pathways for LC management. The prevalence of LC, particularly non-small cell lung cancer (NSCLC), underscores the urgent need for effective treatments. Biomarkers like EpCAM/TROP1 and ERα/NR3A1 play crucial roles in guiding targeted therapies and influencing prognosis. EpCAM plays a key role in cell-cell adhesion and signalling along with ERα which is a nuclear receptor that binds estrogen and regulates gene expression in response ...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Manisha Singh Gabriele De Rubis Sofia Kokkinis Keshav Raj Paudel Stewart Yeung Philip Michael Hansbro Brian Gregory George Oliver Kamal Dua Source Type: research
Evaluation of drug release efficiency and antibacterial property of a pH-responsive dextran-based silver nanocomposite hydrogel
This study aims to develop dextran-graft-poly(4-acryloylmorpholine) silver nanocomposite using a microwave-assisted method to evaluate its drug-release efficiency and antimicrobial activity. The materials were characterized by FT-IR, FE-SEM, EDS, XRD, HR-TEM, TGA, and BET techniques. Drug loading and release efficiency were evaluated using CUR as the model drug. The swelling and drug release studies were conducted in buffer solutions of pH 1.2 and 7.4. Staphylococcus aureus and Escherichia coli were employed to evaluate the antibacterial activity. The cytotoxicity was assessed by MTT assay against the breast MCF-10. Higher...
Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: Amos Luanda M Manohar Rompicherla Narayana Charyulu Vishalakshi Badalamoole Source Type: research
Curcumin-loaded liposomes modulating the synergistic role of EpCAM and estrogen receptor alpha in lung cancer management
This study delves into the in vitro potential of liposomal therapeutics utilizing Curcumin-loaded PlexoZome® (CUR-PLXZ) in targeting EpCAM/TROP1 and Estrogen Receptor Alpha (ERα) signalling pathways for LC management. The prevalence of LC, particularly non-small cell lung cancer (NSCLC), underscores the urgent need for effective treatments. Biomarkers like EpCAM/TROP1 and ERα/NR3A1 play crucial roles in guiding targeted therapies and influencing prognosis. EpCAM plays a key role in cell-cell adhesion and signalling along with ERα which is a nuclear receptor that binds estrogen and regulates gene expression in response ...
Source: Pathology, Research and Practice - April 24, 2024 Category: Pathology Authors: Manisha Singh Gabriele De Rubis Sofia Kokkinis Keshav Raj Paudel Stewart Yeung Philip Michael Hansbro Brian Gregory George Oliver Kamal Dua Source Type: research
Curcumin alleviates zearalenone-induced liver injury in mice by scavenging reactive oxygen species and inhibiting mitochondrial apoptosis pathway
In conclusion, CUR alleviated ZEN-induced liver injury in mice by scavenging ROS and inhibiting the mitochondrial apoptotic pathway.PMID:38657456 | DOI:10.1016/j.ecoenv.2024.116343 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - April 24, 2024 Category: Environmental Health Authors: Xiaopeng Yang Hao Zheng Junlong Niu Xiaoshuang Chen Hongfei Li Zhiyong Rao Yongpeng Guo Wei Zhang Zhixiang Wang Source Type: research
Evaluation of drug release efficiency and antibacterial property of a pH-responsive dextran-based silver nanocomposite hydrogel
This study aims to develop dextran-graft-poly(4-acryloylmorpholine) silver nanocomposite using a microwave-assisted method to evaluate its drug-release efficiency and antimicrobial activity. The materials were characterized by FT-IR, FE-SEM, EDS, XRD, HR-TEM, TGA, and BET techniques. Drug loading and release efficiency were evaluated using CUR as the model drug. The swelling and drug release studies were conducted in buffer solutions of pH 1.2 and 7.4. Staphylococcus aureus and Escherichia coli were employed to evaluate the antibacterial activity. The cytotoxicity was assessed by MTT assay against the breast MCF-10. Higher...
Source: International Journal of Biological Macromolecules - April 24, 2024 Category: Biochemistry Authors: Amos Luanda M Manohar Rompicherla Narayana Charyulu Vishalakshi Badalamoole Source Type: research
Curcumin-loaded liposomes modulating the synergistic role of EpCAM and estrogen receptor alpha in lung cancer management
This study delves into the in vitro potential of liposomal therapeutics utilizing Curcumin-loaded PlexoZome® (CUR-PLXZ) in targeting EpCAM/TROP1 and Estrogen Receptor Alpha (ERα) signalling pathways for LC management. The prevalence of LC, particularly non-small cell lung cancer (NSCLC), underscores the urgent need for effective treatments. Biomarkers like EpCAM/TROP1 and ERα/NR3A1 play crucial roles in guiding targeted therapies and influencing prognosis. EpCAM plays a key role in cell-cell adhesion and signalling along with ERα which is a nuclear receptor that binds estrogen and regulates gene expression in response ...
Source: Pathology, Research and Practice - April 24, 2024 Category: Pathology Authors: Manisha Singh Gabriele De Rubis Sofia Kokkinis Keshav Raj Paudel Stewart Yeung Philip Michael Hansbro Brian Gregory George Oliver Kamal Dua Source Type: research
Curcumin alleviates zearalenone-induced liver injury in mice by scavenging reactive oxygen species and inhibiting mitochondrial apoptosis pathway
In conclusion, CUR alleviated ZEN-induced liver injury in mice by scavenging ROS and inhibiting the mitochondrial apoptotic pathway.PMID:38657456 | DOI:10.1016/j.ecoenv.2024.116343 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - April 24, 2024 Category: Environmental Health Authors: Xiaopeng Yang Hao Zheng Junlong Niu Xiaoshuang Chen Hongfei Li Zhiyong Rao Yongpeng Guo Wei Zhang Zhixiang Wang Source Type: research
Cancers, Vol. 16, Pages 1642: Assessing the Effects of Curcumin and 450 nm Photodynamic Therapy on Oxidative Metabolism and Cell Cycle in Head and Neck Squamous Cell Carcinoma: An In Vitro Study
Andrea Amaroli
Oral cancer is the 16th most common malignant tumor worldwide. The risk of recurrence and mortality is high, and the survival rate is low over the following five years. Recent studies have shown that curcumin causes apoptosis in tumor cells by affecting FoF1-ATP synthase (ATP synthase) activity, which, in turn, hinders cell energy production, leading to a loss of cell viability. Additionally, irradiation of curcumin within cells can intensify its detrimental effects on cancer cell viability and proliferation (photodynamic therapy). We treated the OHSU-974 cell line, a model for human head and neck squam...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Silvia Ravera Claudio Pasquale Isabella Panfoli Matteo Bozzo Dimitrios Agas Silvia Bruno Michael R. Hamblin Andrea Amaroli Tags: Article Source Type: research
Anti-inflammatory effect of curcuminoids and their analogs in hyperosmotic human corneal limbus epithelial cells
To assess the efficacy of curcuminoids (curcumin, demethoxycurcumin, bisdemethoxycurcumin [BDC]) and their analogs (tetrahydrocurcumin [THC], tetrahydrodemethoxycurcumin [THDC], tetrahydrobisdemethoxycurcumin)... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - April 23, 2024 Category: Complementary Medicine Authors: Ngamjit Kasetsuwan, Usanee Reinprayoon, Lita Uthaithammarat, Amornpun Sereemaspun, Nutchanart Sae-liang, Waraluck Chaichompoo and Apichart Suksamrarn Tags: Research Source Type: research
Development of natural dye photosensitizers for dye-sensitized solar cells: a review
Environ Sci Pollut Res Int. 2024 Apr 22. doi: 10.1007/s11356-024-33360-4. Online ahead of print.ABSTRACTDye-sensitized solar cell (DSSC) is a photovoltaic device that can be produced from natural source pigments or natural dyes. The selection of natural dyes for DSSC application is currently under research. The utilization of natural dye materials that are easy to obtain, cost-effective, and non-toxic can reduce waste during DSSC fabrication. Natural dyes can be extracted from plants through extraction and chromatography methods. The suitability and viability of utilizing natural dyes as photosensitizers in DSSCs can be pr...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Aripin Triyanto Nora'aini Ali Hasiah Salleh Jan Setiawan Norhafiza I Yatim Source Type: research
Development of natural dye photosensitizers for dye-sensitized solar cells: a review
Environ Sci Pollut Res Int. 2024 Apr 22. doi: 10.1007/s11356-024-33360-4. Online ahead of print.ABSTRACTDye-sensitized solar cell (DSSC) is a photovoltaic device that can be produced from natural source pigments or natural dyes. The selection of natural dyes for DSSC application is currently under research. The utilization of natural dye materials that are easy to obtain, cost-effective, and non-toxic can reduce waste during DSSC fabrication. Natural dyes can be extracted from plants through extraction and chromatography methods. The suitability and viability of utilizing natural dyes as photosensitizers in DSSCs can be pr...
Source: Environmental Science and Pollution Research International - April 22, 2024 Category: Environmental Health Authors: Aripin Triyanto Nora'aini Ali Hasiah Salleh Jan Setiawan Norhafiza I Yatim Source Type: research
Cancers, Vol. 16, Pages 1611: An Overview of the Spices Used for the Prevention and Potential Treatment of Gastric Cancer
We present the potential molecular mechanisms responsible for the effectivity of a given seasoning substance and their impact on GC cells. We discuss their potential effects on proliferation, apoptosis, and migration. For most of the spices discussed, we also outline the unavailability and side effects of their use. (Source: Cancers)
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Katarzyna Kostelecka Łukasz Bryliński Olga Komar Justyna Michalczyk Agata Mi łosz Jan Bi łogras Filip Woli ński Alicja Forma Jacek Baj Tags: Review Source Type: research
Evaluating the dose ‐dependent effects of curcumin nano‐micelles on rumen fermentation, nitrogen metabolism, and nutrient digestibility in heat‐stressed fattening lambs: Implications for climate change and sustainable animal production
This study evaluated the dose-dependent impacts of dietary curcumin nano-micelles (CNM) on rumen fermentation, nitrogen metabolism, and nutrient digestibility in heat-stressed fattening lambs. Thirty-two crossbred male lambs [ ˆIle-de-France × (Dalagh × Romanov)] were utilized within the current study. The initial weight of lambs was documented as averaged by 31.2 ± 1.55 kg, while they were in their 4th to 5th months of age. Animals were fed increasing doses of dietary CNM (0, 20, 40, and 80 mg/day) ov er 97 days, under severe heat stress conditions with average temperature-humidity index (THI) of 24.5....
Source: Journal of Animal Physiology and Animal Nutrition - April 21, 2024 Category: Zoology Authors: Mostafa Bokharaeian,
Abdolhakim Toghdory,
Taghi Ghoorchi Tags: ORIGINAL ARTICLE Source Type: research
Curcumin reduces myocardial ischemia-reperfusion injury, by increasing endogenous H < sub > 2 < /sub > S levels and further modulating m < sup > 6 < /sup > A
CONCLUSION: CUR attenuates MIRI by regulating the expression of H2S level-regulating enzymes and increasing the endogenous H2S levels. Increased H2S levels could regulate the m6A-related proteins expression and intracellular total RNA m6A levels.PMID:38643323 | DOI:10.1007/s11033-024-09478-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 20, 2024 Category: Molecular Biology Authors: Jiankun Cui Xin Wang Lingling Dong Qinwen Wang Source Type: research
