Molecules, Vol. 29, Pages 1757: Wondrous Yellow Molecule: Are Hydrogels a Successful Strategy to Overcome the Limitations of Curcumin?
ewska
Curcumin is a natural compound with a great pharmaceutical potential that involves anticancer, anti-inflammatory, antioxidant, and neuroprotective activity. Unfortunately, its low bioavailability, instability, and poor water solubility significantly deteriorate its clinical use. Many attempts have been made to overcome this issue, and encapsulating curcumin in a hydrogel matrix may improve those properties. Hydrogel formulation is used in many drug delivery forms, including classic types and novel forms such as self-assembly systems or responsive to external factors. Reviewed studies confirmed better properties o...
Source: Molecules - April 12, 2024 Category: Chemistry Authors: Magdalena Stachowiak Dariusz T. Mlynarczyk Jolanta Dlugaszewska Tags: Review Source Type: research
Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review
Z Gastroenterol. 2024 Apr 11. doi: 10.1055/a-2279-5045. Online ahead of print.ABSTRACTPhytotherapeutics are gaining influence in the treatment of gastroenterological diseases. Their popularity and growing evidence of efficacy contribute to their integration into medical guidelines. A systematic screening identified recommended phytotherapeutic approaches. Based on current scientific data, some recommendations for the use of phytotherapeutic agents are given. For irritable bowel syndrome the use of peppermint oil is "strongly recommended", especially for pain and flatulence. Other phytotherapeutics such as STW-5, Tibetan Pa...
Source: Zeitschrift fur Gastroenterologie - April 11, 2024 Category: Gastroenterology Authors: Sandra Utz Miriam Bittel Jost Langhorst Source Type: research
Rapid identifying of COX-2 inhibitors from turmeric (Curcuma longa) by bioaffinity ultrafiltration coupled with UPLC-Q Exactive-Orbitrap-MS and zebrafish-based in vivo validation
This study screened out and verified unreported COX-2 ligands, potentially accelerating the discovery of new bioactive compounds in other functional foods.PMID:38604020 | DOI:10.1016/j.bioorg.2024.107357 (Source: Bioorganic Chemistry)
Source: Bioorganic Chemistry - April 11, 2024 Category: Chemistry Authors: Zhenwei Lan Rui Yang Hu Wang Xingyang Xue Yue Sun Shumei Wang Ying Zhang Jiang Meng Source Type: research
Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review
Z Gastroenterol. 2024 Apr 11. doi: 10.1055/a-2279-5045. Online ahead of print.ABSTRACTPhytotherapeutics are gaining influence in the treatment of gastroenterological diseases. Their popularity and growing evidence of efficacy contribute to their integration into medical guidelines. A systematic screening identified recommended phytotherapeutic approaches. Based on current scientific data, some recommendations for the use of phytotherapeutic agents are given. For irritable bowel syndrome the use of peppermint oil is "strongly recommended", especially for pain and flatulence. Other phytotherapeutics such as STW-5, Tibetan Pa...
Source: Zeitschrift fur Gastroenterologie - April 11, 2024 Category: Gastroenterology Authors: Sandra Utz Miriam Bittel Jost Langhorst Source Type: research
Rapid identifying of COX-2 inhibitors from turmeric (Curcuma longa) by bioaffinity ultrafiltration coupled with UPLC-Q Exactive-Orbitrap-MS and zebrafish-based in vivo validation
This study screened out and verified unreported COX-2 ligands, potentially accelerating the discovery of new bioactive compounds in other functional foods.PMID:38604020 | DOI:10.1016/j.bioorg.2024.107357 (Source: Bioorganic Chemistry)
Source: Bioorganic Chemistry - April 11, 2024 Category: Chemistry Authors: Zhenwei Lan Rui Yang Hu Wang Xingyang Xue Yue Sun Shumei Wang Ying Zhang Jiang Meng Source Type: research
Phytotherapeutic recommendations in medical guidelines for the treatment of gastroenterological diseases - a systematic review
Z Gastroenterol. 2024 Apr 11. doi: 10.1055/a-2279-5045. Online ahead of print.ABSTRACTPhytotherapeutics are gaining influence in the treatment of gastroenterological diseases. Their popularity and growing evidence of efficacy contribute to their integration into medical guidelines. A systematic screening identified recommended phytotherapeutic approaches. Based on current scientific data, some recommendations for the use of phytotherapeutic agents are given. For irritable bowel syndrome the use of peppermint oil is "strongly recommended", especially for pain and flatulence. Other phytotherapeutics such as STW-5, Tibetan Pa...
Source: Zeitschrift fur Gastroenterologie - April 11, 2024 Category: Gastroenterology Authors: Sandra Utz Miriam Bittel Jost Langhorst Source Type: research
Revolutionizing Knee Osteoarthritis Treatment: Innovative Self-Nano-Emulsifying Polyethylene Glycol Organogel of Curcumin for Effective Topical Delivery
AAPS PharmSciTech. 2024 Apr 10;25(4):80. doi: 10.1208/s12249-024-02789-8.ABSTRACTIn the current study, self-nano-emulsifying (SNE) physically cross-linked polyethylene glycol (PEG) organogel (SNE-POG) as an innovative hybrid system was fabricated for topical delivery of water-insoluble and unstable bioactive compound curcumin (CUR). Response surface methodology (RSM) based on Optimal Design was utilized to evaluate the formulation factors. Solid fiber mechanism with homogenization was used to prepare formulations. Pharmaceutical evaluation including rheological and texture analysis, their mathematical correlations besides ...
Source: AAPS PharmSciTech - April 10, 2024 Category: Drugs & Pharmacology Authors: Mahtab Baharizade Seyed Iman Ghetmiri Mohsen Mohammady Soliman Mohammadi-Samani Gholamhossein Yousefi Source Type: research
Combined supplementation with hesperidin, phytosterols and curcumin decreases adiposity and improves metabolic health in ovariectomized rats
Food Funct. 2024 Apr 10. doi: 10.1039/d3fo05122f. Online ahead of print.ABSTRACTIn recent years many women have looked for alternative therapies to address menopause. Hesperidin, phytosterols and curcumin are bioactive compounds that can ameliorate some cardiovascular risk factors associated with menopause, although there are no data concerning the effects of their combined supplementation. We used ovariectomized (OVX) rats, a postmenopausal model with oestrogen deficiency, to evaluate whether supplementation with a multi-ingredient (MI) including hesperidin, phytosterols and curcumin for 57 days would display beneficial e...
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Julio Baudin Julia Hernandez-Baixauli Sergio Quesada-V ázquez Francisca Mulero Francesc Puiggr òs Llu ís Arola Antoni Caimari Source Type: research
A TNF- α inhibitor abolishes sepsis-induced cognitive impairment in mice by modulating acetylcholine and nitric oxide homeostasis, BDNF release, and neuroinflammation
In this study, we used lipopolysaccharide (LPS) to create a model of cognitive impairment by inducing systemic and neuroinflammation in experimental animals. LPS was injected intraperitoneally at a dose of 0.5mg/kg during the last seven days of the study. Adalimumab (ADA), a TNF-α inhibitor, was injected at a dose of 10mg/kg a total of 3 times throughout the study. On the last two days of the experiment, 50mg/kg of curcumin was administered orally as a positive control group. Open field (OF) and elevated plus maze tests (EPM) were used to measure anxiety-like behaviors. The tail suspension test (TST) was used to measure d...
Source: Brain Research - April 10, 2024 Category: Neurology Authors: Mehmet Öz H üseyin Erdal Source Type: research
A TNF- α inhibitor abolishes sepsis-induced cognitive impairment in mice by modulating acetylcholine and nitric oxide homeostasis, BDNF release, and neuroinflammation
In this study, we used lipopolysaccharide (LPS) to create a model of cognitive impairment by inducing systemic and neuroinflammation in experimental animals. LPS was injected intraperitoneally at a dose of 0.5mg/kg during the last seven days of the study. Adalimumab (ADA), a TNF-α inhibitor, was injected at a dose of 10mg/kg a total of 3 times throughout the study. On the last two days of the experiment, 50mg/kg of curcumin was administered orally as a positive control group. Open field (OF) and elevated plus maze tests (EPM) were used to measure anxiety-like behaviors. The tail suspension test (TST) was used to measure d...
Source: Behavioural Brain Research - April 10, 2024 Category: Neurology Authors: Mehmet Öz H üseyin Erdal Source Type: research
Revolutionizing Knee Osteoarthritis Treatment: Innovative Self-Nano-Emulsifying Polyethylene Glycol Organogel of Curcumin for Effective Topical Delivery
AAPS PharmSciTech. 2024 Apr 10;25(4):80. doi: 10.1208/s12249-024-02789-8.ABSTRACTIn the current study, self-nano-emulsifying (SNE) physically cross-linked polyethylene glycol (PEG) organogel (SNE-POG) as an innovative hybrid system was fabricated for topical delivery of water-insoluble and unstable bioactive compound curcumin (CUR). Response surface methodology (RSM) based on Optimal Design was utilized to evaluate the formulation factors. Solid fiber mechanism with homogenization was used to prepare formulations. Pharmaceutical evaluation including rheological and texture analysis, their mathematical correlations besides ...
Source: AAPS PharmSciTech - April 10, 2024 Category: Drugs & Pharmacology Authors: Mahtab Baharizade Seyed Iman Ghetmiri Mohsen Mohammady Soliman Mohammadi-Samani Gholamhossein Yousefi Source Type: research
A TNF- α inhibitor abolishes sepsis-induced cognitive impairment in mice by modulating acetylcholine and nitric oxide homeostasis, BDNF release, and neuroinflammation
In this study, we used lipopolysaccharide (LPS) to create a model of cognitive impairment by inducing systemic and neuroinflammation in experimental animals. LPS was injected intraperitoneally at a dose of 0.5mg/kg during the last seven days of the study. Adalimumab (ADA), a TNF-α inhibitor, was injected at a dose of 10mg/kg a total of 3 times throughout the study. On the last two days of the experiment, 50mg/kg of curcumin was administered orally as a positive control group. Open field (OF) and elevated plus maze tests (EPM) were used to measure anxiety-like behaviors. The tail suspension test (TST) was used to measure d...
Source: Brain Research - April 10, 2024 Category: Neurology Authors: Mehmet Öz H üseyin Erdal Source Type: research
A TNF- α inhibitor abolishes sepsis-induced cognitive impairment in mice by modulating acetylcholine and nitric oxide homeostasis, BDNF release, and neuroinflammation
In this study, we used lipopolysaccharide (LPS) to create a model of cognitive impairment by inducing systemic and neuroinflammation in experimental animals. LPS was injected intraperitoneally at a dose of 0.5mg/kg during the last seven days of the study. Adalimumab (ADA), a TNF-α inhibitor, was injected at a dose of 10mg/kg a total of 3 times throughout the study. On the last two days of the experiment, 50mg/kg of curcumin was administered orally as a positive control group. Open field (OF) and elevated plus maze tests (EPM) were used to measure anxiety-like behaviors. The tail suspension test (TST) was used to measure d...
Source: Behavioural Brain Research - April 10, 2024 Category: Neurology Authors: Mehmet Öz H üseyin Erdal Source Type: research
A TNF- α inhibitor abolishes sepsis-induced cognitive impairment in mice by modulating acetylcholine and nitric oxide homeostasis, BDNF release, and neuroinflammation
In this study, we used lipopolysaccharide (LPS) to create a model of cognitive impairment by inducing systemic and neuroinflammation in experimental animals. LPS was injected intraperitoneally at a dose of 0.5mg/kg during the last seven days of the study. Adalimumab (ADA), a TNF-α inhibitor, was injected at a dose of 10mg/kg a total of 3 times throughout the study. On the last two days of the experiment, 50mg/kg of curcumin was administered orally as a positive control group. Open field (OF) and elevated plus maze tests (EPM) were used to measure anxiety-like behaviors. The tail suspension test (TST) was used to measure d...
Source: Behavioural Brain Research - April 10, 2024 Category: Neurology Authors: Mehmet Öz H üseyin Erdal Source Type: research
GSE256152 Transcriptomics and metabonomics study on the effect of combined exercise with curcumin supplementation on breast cancer in mice
This study constructed an anti breast tumor mouse model under the combined effects of curcumin treatment and swimming exercise. Transcriptomics and metabolomics techniques were used to screen differentially expressed genes and metabolites, evaluate the anti-cancer effect, and analyze the molecular regulatory mechanisms related to metabolism. Through the mouse phenotype observation, including the detection of tumor appearance, tumor imaging in vivo, and HE staining results of pathological sections, curcumin administration and exercise intervention combined treatment has more obvious inhibitory effect on breast cancer than a...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
