Phytochemicals, Herbal Extracts, and Dietary Supplements for Metabolic Disease Management
Endocr Metab Immune Disord Drug Targets. 2024 Apr 26. doi: 10.2174/0118715303287911240409055710. Online ahead of print.ABSTRACTComprehensive and effective care techniques have become essential due to the global epidemic dimensions of metabolic disorders, including diabetes, obesity, and cardiovascular ailments. Recent research highlights the potential of dietary supplements, herbal extracts, and phytochemicals in treating metabolic diseases. This abstract conveys the current state of the science in this field by highlighting these findings' underlying mechanisms and potential therapeutic applications. Plant-based diets con...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Endocrinology Authors: Praveen Halagali Aparna Inamdar Jagroop Singh Amit Anand Poulami Sadhu Rashmi Pathak Himanshu Sharma Deepak Biswas Source Type: research
Investigation of Cytotoxic and Antileishmanial Activity of Hybrid Silver Nanoparticle Complexes: Potential Drug Candidates against Leishmania Species
In this study, it was aimed to investigate the cytotoxic and in vitro antileishmanial activity of hybrid silver nanoparticle (AgNP) complexes. In this study, three types of nanoparticles (NPs), oxidized amylose-silver (OA-Ag) NPs, oxidized amylose-curcumin (OA-Cur) NPs and oxidized amylose-curcumin-silver (OA-CurAgNP) nanoparticles were synthesized. The cytotoxic activity of the synthesized nanoparticles was determined against L929 mouse fibroblasts and the in vitro antileishmanial activity was determined against Leishmania tropica, Leishmania infantum and Leishmania donovani isolates by the broth microdilution method. It ...
Source: Mikrobiyoloji Bulteni - April 27, 2024 Category: Microbiology Authors: Yener Özel İbrahim Çavuş Umut Yilmaz Feyzullah Tokay Sema Ba ğdat Ahmet Özbilgin Mehmet Ünlü G ülhan Vardar Ünlü Source Type: research
Curcumin-derivatives as fluorescence-electrochemical dual probe for ultrasensitive detections of picric acid in aqueous media
Talanta. 2024 Apr 22;275:126113. doi: 10.1016/j.talanta.2024.126113. Online ahead of print.ABSTRACTWe are reporting the two curcumin derivatives, ferrocenyl curcumin (Fc-cur) and 4-nitro-benzylidene curcumin (NBC), as a probe through dual modalities, i.e., fluorescence and electrochemical methods, for the detection of nitro-analytes, such as picric acid (PA). The probes exhibited aggregation-induced enhanced emission (AIEE), and the addition of picric acid (PA) demonstrated good and specific fluorimetric identification of PA in the aggregated state. By using density functional theory (DFT), the mechanism of picric acid's (...
Source: Talanta - April 26, 2024 Category: Chemistry Authors: Anupama Rai Niki Sweta Jha Padma Sharma Suresh Tiwari Ranga Subramanian Source Type: research
The synergistic effect of curcumin and mitoquinol mesylate on cognitive impairment and the neuropathology of Alzheimer's disease
Brain Res. 2024 Apr 24:148959. doi: 10.1016/j.brainres.2024.148959. Online ahead of print.ABSTRACTGiven the complexity and heterogeneity of Alzheimer's disease (AD) pathology, targeted monotherapies drug may not be effective. Therefore, a synergistic combination therapy of curcumin and Mito Q was proposed and evaluated in a triple-transgenic AD model mice (3 × Tg-AD mice). The cognitive ability was assessed using behavioral tests and typical pathological changes were observed through Western blotting and histological analysis. The results demonstrated a significant enhancement in cognitive ability along with the mitigatio...
Source: Brain Research - April 26, 2024 Category: Neurology Authors: Yongli Xie Xuexia Li Qingqing Shi Linfeng Le Chao Wang Hao Xu Guoli Wu Xiubo Du Zetao Chen Source Type: research
Curcumin-derivatives as fluorescence-electrochemical dual probe for ultrasensitive detections of picric acid in aqueous media
Talanta. 2024 Apr 22;275:126113. doi: 10.1016/j.talanta.2024.126113. Online ahead of print.ABSTRACTWe are reporting the two curcumin derivatives, ferrocenyl curcumin (Fc-cur) and 4-nitro-benzylidene curcumin (NBC), as a probe through dual modalities, i.e., fluorescence and electrochemical methods, for the detection of nitro-analytes, such as picric acid (PA). The probes exhibited aggregation-induced enhanced emission (AIEE), and the addition of picric acid (PA) demonstrated good and specific fluorimetric identification of PA in the aggregated state. By using density functional theory (DFT), the mechanism of picric acid's (...
Source: Talanta - April 26, 2024 Category: Chemistry Authors: Anupama Rai Niki Sweta Jha Padma Sharma Suresh Tiwari Ranga Subramanian Source Type: research
Molecules, Vol. 29, Pages 1985: Design and Synthesis of Dimethylaminomethyl-Substituted Curcumin Derivatives: Potent Anti-Inflammatory, Anti-Oxidant, and Radioprotection Activity, Improved Aqueous Solubility Compared with Curcumin
Shuchen Liu
Although the wide variety of bioactivities of curcumin has been reported by researchers, the clinical application of curcumin is still limited due to its poor aqueous solubility. In view of this, a series of dimethylaminomethyl-substituted curcumin derivatives were designed and synthesized (compounds 1–15). Acetate of these derivatives were prepared (compounds 1a–15a). The Mannich reaction and aldol condensation reaction are the main reactions involved in this study. Compounds 6, 10, 12, 3a, 5a, 6a, 7a, 8a, 10a, 11a, 12a, 13a, 14a, and 15a exhibited better in vitro anti-inflamm...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Huiling Gu Sifan Liu Kai Liang Ziming Xia Guangjie Zhang Bin Li Shuchen Liu Tags: Article Source Type: research
Molecules, Vol. 29, Pages 2010: Systematic Review of Chemical Compounds with Immunomodulatory Action Isolated from African Medicinal Plants
asmané Semde
A robust, well-functioning immune system is the cornerstone of good health. Various factors may influence the immune system’s effectiveness, potentially leading to immune system failure. This review aims to provide an overview of the structure and action of immunomodulators isolated from African medicinal plants. The research was conducted according to PRISMA guidelines. Full-text access research articles published in English up to December 2023, including plant characteristics, isolated phytochemicals, and immuno-modulatory activities, were screened. The chemical structures of the isolated ...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Wendwaoga Ars ène Nikiema Moussa Ou édraogo Windbedma Prisca Ou édraogo Souleymane Fofana Boris Honor é Amadou Ouédraogo Talwendpanga Edwige Delma Belem Amad é Gambo Moustapha Abdoulaye Aim é Serge Sawadogo Raogo Ou édraogo Rasman é Semde Tags: Systematic Review Source Type: research
The Potential Mechanism of the Anti-Liver Fibrotic Effect of Curcumin in the Gut-Liver Axis
Journal of Medicinal Food, Ahead of Print. (Source: Journal of Medicinal Food)
Source: Journal of Medicinal Food - April 26, 2024 Category: Nutrition Authors: Qiao Geng Yanyan Xu Weifang Huang Yang Hu Heiying Jin Haibing Hua Desong Kong Source Type: research
New Solid Forms of Tetrahydrocurcumin with Improved Solubility
CrystEngComm, 2024, Accepted Manuscript DOI: 10.1039/D4CE00259H, PaperFanyu Tian, Mengyuan Xia, Hao Wang, Bingrui Zhang, Zhenfeng Ding, Xiaoyi Rong, Bingqing Zhu, Xuefeng Mei Tetrahydrocurcumin (THC), one of the active metabolites of curcumin, possesses pharmacological activities similar to those of curcumin, such as hypoglycemic, hypolipidemic and antioxidant effects. However, poor water solubility of THC... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - April 25, 2024 Category: Chemistry Authors: Fanyu Tian Source Type: research
Curcumin nanogel and its efficacy against oxidative stress and inflammation in rat models of ischemic stroke
Nanomedicine, Ahead of Print. (Source: Future Medicine: Nanomedicine)
Source: Future Medicine: Nanomedicine - April 25, 2024 Category: Nanotechnology Authors: Gulrana Khuwaja Sivakumar S Moni Mohammad Firoz Alam Hafiz A Makeen Sarvat Zafar Mohammad Ashafaq Hasan Alhazmi Asim Najmi Shabihul Fatma Sayed Syed Mohammad Shakeel Iqubal Source Type: research
Curcumin nanogel and its efficacy against oxidative stress and inflammation in rat models of ischemic stroke
Nanomedicine, Ahead of Print. (Source: Nanomedicine)
Source: Nanomedicine - April 25, 2024 Category: Nanotechnology Authors: Gulrana Khuwaja Sivakumar S Moni Mohammad Firoz Alam Hafiz A Makeen Sarvat Zafar Mohammad Ashafaq Hasan Alhazmi Asim Najmi Shabihul Fatma Sayed Syed Mohammad Shakeel Iqubal Source Type: research
The addition of curcumin to the diet of post-weaning dairy calves: effects on ruminal fermentation, immunological, and oxidative responses
AbstractIncorporating Curcumin into animal diets holds significant promise for enhancing both animal health and productivity, with demonstrated positive impacts on antioxidant activity, anti-microbial responses. Therefore, this study aimed to determine whether adding Curcumin to the diet of dairy calves would influence ruminal fermentation, hematologic, immunological, oxidative, and metabolism variables. Fourteen Jersey calves were divided into a control group (GCON) and a treatment group (GTRA). The animals in the GTRA received a diet containing 65.1 mg/kg of dry matter (DM) Curcumin (74% purity) for an experimental per...
Source: Tropical Animal Health and Production - April 25, 2024 Category: Veterinary Research Source Type: research
Curcumin-loaded liposomes modulating the synergistic role of EpCAM and estrogen receptor alpha in lung cancer management
This study delves into the in vitro potential of liposomal therapeutics utilizing Curcumin-loaded PlexoZome® (CUR-PLXZ) in targeting EpCAM/TROP1 and Estrogen Receptor Alpha (ERα) signalling pathways for LC management. The prevalence of LC, particularly non-small cell lung cancer (NSCLC), underscores the urgent need for effective treatments. Biomarkers like EpCAM/TROP1 and ERα/NR3A1 play crucial roles in guiding targeted therapies and influencing prognosis. EpCAM plays a key role in cell-cell adhesion and signalling along with ERα which is a nuclear receptor that binds estrogen and regulates gene expression in response ...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Manisha Singh Gabriele De Rubis Sofia Kokkinis Keshav Raj Paudel Stewart Yeung Philip Michael Hansbro Brian Gregory George Oliver Kamal Dua Source Type: research
Evaluation of drug release efficiency and antibacterial property of a pH-responsive dextran-based silver nanocomposite hydrogel
This study aims to develop dextran-graft-poly(4-acryloylmorpholine) silver nanocomposite using a microwave-assisted method to evaluate its drug-release efficiency and antimicrobial activity. The materials were characterized by FT-IR, FE-SEM, EDS, XRD, HR-TEM, TGA, and BET techniques. Drug loading and release efficiency were evaluated using CUR as the model drug. The swelling and drug release studies were conducted in buffer solutions of pH 1.2 and 7.4. Staphylococcus aureus and Escherichia coli were employed to evaluate the antibacterial activity. The cytotoxicity was assessed by MTT assay against the breast MCF-10. Higher...
Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: Amos Luanda M Manohar Rompicherla Narayana Charyulu Vishalakshi Badalamoole Source Type: research
Curcumin-loaded liposomes modulating the synergistic role of EpCAM and estrogen receptor alpha in lung cancer management
This study delves into the in vitro potential of liposomal therapeutics utilizing Curcumin-loaded PlexoZome® (CUR-PLXZ) in targeting EpCAM/TROP1 and Estrogen Receptor Alpha (ERα) signalling pathways for LC management. The prevalence of LC, particularly non-small cell lung cancer (NSCLC), underscores the urgent need for effective treatments. Biomarkers like EpCAM/TROP1 and ERα/NR3A1 play crucial roles in guiding targeted therapies and influencing prognosis. EpCAM plays a key role in cell-cell adhesion and signalling along with ERα which is a nuclear receptor that binds estrogen and regulates gene expression in response ...
Source: Pathology, Research and Practice - April 24, 2024 Category: Pathology Authors: Manisha Singh Gabriele De Rubis Sofia Kokkinis Keshav Raj Paudel Stewart Yeung Philip Michael Hansbro Brian Gregory George Oliver Kamal Dua Source Type: research
