A TNF- α inhibitor abolishes sepsis-induced cognitive impairment in mice by modulating acetylcholine and nitric oxide homeostasis, BDNF release, and neuroinflammation
In this study, we used lipopolysaccharide (LPS) to create a model of cognitive impairment by inducing systemic and neuroinflammation in experimental animals. LPS was injected intraperitoneally at a dose of 0.5mg/kg during the last seven days of the study. Adalimumab (ADA), a TNF-α inhibitor, was injected at a dose of 10mg/kg a total of 3 times throughout the study. On the last two days of the experiment, 50mg/kg of curcumin was administered orally as a positive control group. Open field (OF) and elevated plus maze tests (EPM) were used to measure anxiety-like behaviors. The tail suspension test (TST) was used to measure d...
Source: Brain Research - April 10, 2024 Category: Neurology Authors: Mehmet Öz H üseyin Erdal Source Type: research
A TNF- α inhibitor abolishes sepsis-induced cognitive impairment in mice by modulating acetylcholine and nitric oxide homeostasis, BDNF release, and neuroinflammation
In this study, we used lipopolysaccharide (LPS) to create a model of cognitive impairment by inducing systemic and neuroinflammation in experimental animals. LPS was injected intraperitoneally at a dose of 0.5mg/kg during the last seven days of the study. Adalimumab (ADA), a TNF-α inhibitor, was injected at a dose of 10mg/kg a total of 3 times throughout the study. On the last two days of the experiment, 50mg/kg of curcumin was administered orally as a positive control group. Open field (OF) and elevated plus maze tests (EPM) were used to measure anxiety-like behaviors. The tail suspension test (TST) was used to measure d...
Source: Behavioural Brain Research - April 10, 2024 Category: Neurology Authors: Mehmet Öz H üseyin Erdal Source Type: research
A TNF- α inhibitor abolishes sepsis-induced cognitive impairment in mice by modulating acetylcholine and nitric oxide homeostasis, BDNF release, and neuroinflammation
In this study, we used lipopolysaccharide (LPS) to create a model of cognitive impairment by inducing systemic and neuroinflammation in experimental animals. LPS was injected intraperitoneally at a dose of 0.5mg/kg during the last seven days of the study. Adalimumab (ADA), a TNF-α inhibitor, was injected at a dose of 10mg/kg a total of 3 times throughout the study. On the last two days of the experiment, 50mg/kg of curcumin was administered orally as a positive control group. Open field (OF) and elevated plus maze tests (EPM) were used to measure anxiety-like behaviors. The tail suspension test (TST) was used to measure d...
Source: Behavioural Brain Research - April 10, 2024 Category: Neurology Authors: Mehmet Öz H üseyin Erdal Source Type: research
GSE256152 Transcriptomics and metabonomics study on the effect of combined exercise with curcumin supplementation on breast cancer in mice
This study constructed an anti breast tumor mouse model under the combined effects of curcumin treatment and swimming exercise. Transcriptomics and metabolomics techniques were used to screen differentially expressed genes and metabolites, evaluate the anti-cancer effect, and analyze the molecular regulatory mechanisms related to metabolism. Through the mouse phenotype observation, including the detection of tumor appearance, tumor imaging in vivo, and HE staining results of pathological sections, curcumin administration and exercise intervention combined treatment has more obvious inhibitory effect on breast cancer than a...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Molecules, Vol. 29, Pages 1718: Inhibition of MMP-2 and MMP-9 by Dietary Antioxidants in THP-1 Macrophages and Sera from Patients with Breast Cancer
aria Liuzzi
Polyphenols, the main antioxidants of diet, have shown anti-inflammatory, antioxidant and anticarcinogenic activities. Here, we compared the effects of four polyphenolic compounds on ROS production and on the levels of matrix metalloproteinase (MMP)-2 and -9, which represent important pathogenetic factors of breast cancer. THP-1 differentiated macrophages were activated by LPS and simultaneously treated with different doses of a green tea extract (GTE), resveratrol (RSV), curcumin (CRC) and an olive fruit extract (oliplus). By using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, we found...
Source: Molecules - April 10, 2024 Category: Chemistry Authors: Tiziana Latronico Tania Petraglia Carmela Sileo Domenico Bilancia Rocco Rossano Grazia Maria Liuzzi Tags: Article Source Type: research
Synthesis, theoretical analysis, and biological properties of a novel tridentate Schiff base palladium (II) complex
Biometals. 2024 Apr 9. doi: 10.1007/s10534-024-00598-x. Online ahead of print.ABSTRACTSchiff base complexes play a crucial role in bioinorganic chemistry. A novel curcumin/phenylalanine tridentate Schiff base ligand and its palladium (II) complex were synthesized so that they were stable in aqueous buffer. The structure of the complex was investigated using a variety of methods, including DFT, NBO analysis, FMOs, and MESP. The interaction of the complex with a plasmid (pUC19) and CT-DNA was studied. The anticancer, antibacterial, and antioxidant activities of the complex were examined. The statistical analysis of the MTT a...
Source: Biometals - April 9, 2024 Category: Biochemistry Authors: Samira Jahangiry Maryam Lashanizadegan Pouneh Sadat Pourhosseini Mansoureh Zahedi-Tabrizi Source Type: research
Quinolone Derivatives as Anticancer Agents: Importance in Medicinal Chemistry
Curr Top Med Chem. 2024 Apr 8. doi: 10.2174/0115680266300736240403075307. Online ahead of print.ABSTRACTQuinolone is a heterocyclic compound containing carbonyl at the C-2 or C-4 positions with nitrogen at the C-1 position. The scaffold was first identified for its antibacterial properties, and the derivatives were known to possess many pharmacological activities, including anticancer. In this review, the quinolin-2(H)-one and quinolin-4(H)-one derivatives were identified to inhibit several various proteins and enzymes involved in cancer cell growth, such as topoisomerase, mi-crotubules, protein kinases, phosphoinositide 3...
Source: Current Topics in Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Nursyuhada Azzman Sirajudheen Anwar Wan Ahmad Syazani Mohamed Nafees Ahemad Source Type: research
Synthesis, theoretical analysis, and biological properties of a novel tridentate Schiff base palladium (II) complex
Biometals. 2024 Apr 9. doi: 10.1007/s10534-024-00598-x. Online ahead of print.ABSTRACTSchiff base complexes play a crucial role in bioinorganic chemistry. A novel curcumin/phenylalanine tridentate Schiff base ligand and its palladium (II) complex were synthesized so that they were stable in aqueous buffer. The structure of the complex was investigated using a variety of methods, including DFT, NBO analysis, FMOs, and MESP. The interaction of the complex with a plasmid (pUC19) and CT-DNA was studied. The anticancer, antibacterial, and antioxidant activities of the complex were examined. The statistical analysis of the MTT a...
Source: Biometals - April 9, 2024 Category: Biochemistry Authors: Samira Jahangiry Maryam Lashanizadegan Pouneh Sadat Pourhosseini Mansoureh Zahedi-Tabrizi Source Type: research
Quinolone Derivatives as Anticancer Agents: Importance in Medicinal Chemistry
Curr Top Med Chem. 2024 Apr 8. doi: 10.2174/0115680266300736240403075307. Online ahead of print.ABSTRACTQuinolone is a heterocyclic compound containing carbonyl at the C-2 or C-4 positions with nitrogen at the C-1 position. The scaffold was first identified for its antibacterial properties, and the derivatives were known to possess many pharmacological activities, including anticancer. In this review, the quinolin-2(H)-one and quinolin-4(H)-one derivatives were identified to inhibit several various proteins and enzymes involved in cancer cell growth, such as topoisomerase, mi-crotubules, protein kinases, phosphoinositide 3...
Source: Current Topics in Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Nursyuhada Azzman Sirajudheen Anwar Wan Ahmad Syazani Mohamed Nafees Ahemad Source Type: research
Synthesis, theoretical analysis, and biological properties of a novel tridentate Schiff base palladium (II) complex
Biometals. 2024 Apr 9. doi: 10.1007/s10534-024-00598-x. Online ahead of print.ABSTRACTSchiff base complexes play a crucial role in bioinorganic chemistry. A novel curcumin/phenylalanine tridentate Schiff base ligand and its palladium (II) complex were synthesized so that they were stable in aqueous buffer. The structure of the complex was investigated using a variety of methods, including DFT, NBO analysis, FMOs, and MESP. The interaction of the complex with a plasmid (pUC19) and CT-DNA was studied. The anticancer, antibacterial, and antioxidant activities of the complex were examined. The statistical analysis of the MTT a...
Source: Biometals - April 9, 2024 Category: Biochemistry Authors: Samira Jahangiry Maryam Lashanizadegan Pouneh Sadat Pourhosseini Mansoureh Zahedi-Tabrizi Source Type: research
Quinolone Derivatives as Anticancer Agents: Importance in Medicinal Chemistry
Curr Top Med Chem. 2024 Apr 8. doi: 10.2174/0115680266300736240403075307. Online ahead of print.ABSTRACTQuinolone is a heterocyclic compound containing carbonyl at the C-2 or C-4 positions with nitrogen at the C-1 position. The scaffold was first identified for its antibacterial properties, and the derivatives were known to possess many pharmacological activities, including anticancer. In this review, the quinolin-2(H)-one and quinolin-4(H)-one derivatives were identified to inhibit several various proteins and enzymes involved in cancer cell growth, such as topoisomerase, mi-crotubules, protein kinases, phosphoinositide 3...
Source: Current Topics in Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Nursyuhada Azzman Sirajudheen Anwar Wan Ahmad Syazani Mohamed Nafees Ahemad Source Type: research
Synthesis, theoretical analysis, and biological properties of a novel tridentate Schiff base palladium (II) complex
Biometals. 2024 Apr 9. doi: 10.1007/s10534-024-00598-x. Online ahead of print.ABSTRACTSchiff base complexes play a crucial role in bioinorganic chemistry. A novel curcumin/phenylalanine tridentate Schiff base ligand and its palladium (II) complex were synthesized so that they were stable in aqueous buffer. The structure of the complex was investigated using a variety of methods, including DFT, NBO analysis, FMOs, and MESP. The interaction of the complex with a plasmid (pUC19) and CT-DNA was studied. The anticancer, antibacterial, and antioxidant activities of the complex were examined. The statistical analysis of the MTT a...
Source: Biometals - April 9, 2024 Category: Biochemistry Authors: Samira Jahangiry Maryam Lashanizadegan Pouneh Sadat Pourhosseini Mansoureh Zahedi-Tabrizi Source Type: research
Quinolone Derivatives as Anticancer Agents: Importance in Medicinal Chemistry
Curr Top Med Chem. 2024 Apr 8. doi: 10.2174/0115680266300736240403075307. Online ahead of print.ABSTRACTQuinolone is a heterocyclic compound containing carbonyl at the C-2 or C-4 positions with nitrogen at the C-1 position. The scaffold was first identified for its antibacterial properties, and the derivatives were known to possess many pharmacological activities, including anticancer. In this review, the quinolin-2(H)-one and quinolin-4(H)-one derivatives were identified to inhibit several various proteins and enzymes involved in cancer cell growth, such as topoisomerase, mi-crotubules, protein kinases, phosphoinositide 3...
Source: Current Topics in Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Nursyuhada Azzman Sirajudheen Anwar Wan Ahmad Syazani Mohamed Nafees Ahemad Source Type: research
Epigenetic Impact of Curcumin and Thymoquinone on Cancer Therapeutics
Curr Med Chem. 2024 Apr 4. doi: 10.2174/0109298673288542240327112351. Online ahead of print.ABSTRACTToday, one of the most prevalent reasons for death among people is carcinoma. Because it is still on the increase throughout the world, there is a critical need for in- -depth research on the pathogenic mechanisms behind the disease as well as for efficient treatment. In the field of epigenetics, gene expression alterations that are inherited but not DNA sequence changes are investigated. Three key epigenetic changes, histone modifications, DNA methylation and non-coding RNA (ncRNA) expression, are principally responsible fo...
Source: Current Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Vikas Kumar Roohi Kesharwani Dilip K Patel Amita Verma Mohamed Gamil Mehanna Ayman Mohammad Azizah Salim Bawadood Fahad A Alabassi Firoz Anwar Source Type: research
Response of Male Reproductive System Against Ionizing Radiation and Available Radio-protective Agents: Cellular and Molecular Insight
CONCLUSION: Further study is needed to optimize these tactics and fill knowledge gaps. Also, the effective components of herbal, synthetic drugs, etc., should be isolated and tested up to clinical levels, paving the way for successful radioprotection and radiomitigation strategies in the male reproductive system.PMID:38584548 | DOI:10.2174/0118744710285874240326041025 (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 8, 2024 Category: Radiology Authors: Ronit Parashar Sanwar Mal Yadav Priyadarshi Meena Raj Kumar Kuldeep S Jheeta Priya Saini Dev Dutt Patel Source Type: research
