Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration
In conclusion, a comprehensive understanding of the complex pathophysiology of AD and the exploration of herbal interventions offer a holistic approach to managing this devastating disease. Future research should address the limitations associated with herbal drugs and further evaluate the efficacy of promising natural products in clinical settings.PMID:38623983 | DOI:10.2174/0115672050309057240404075003 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 16, 2024 Category: Neurology Authors: Debasis Sen Sunny Rathee Vishal Pandey Sanjay K Jain Umesh K Patil Source Type: research
Preparation of pH-sensitive porous polylactic acid-based medical dressing with self-pumping function
In this study, we fabricated a pH-sensitive colorimetric chronic wound dressing with self-pumping function using electrostatic spinning technology. It consisted of three layers: a polylactic acid-curcumin (PCPLLA) hydrophobic layer, a hydrolyzed polyacrylonitrile (HPAN) transfer layer, and a polyacrylonitrile-purple kale anthocyanin (PAN-PCA) hydrophilic layer. The results showed that the preparation of porous PLLA fiber membrane loaded with 0.2 % Cur was achieved by adjusting the spinning-related parameters, which could ensure that the composite dressing had sufficient anti-inflammatory, antibacterial and antioxidant prop...
Source: International Journal of Biological Macromolecules - April 16, 2024 Category: Biochemistry Authors: Zijian Zhang Jianyong Li Yi Wang Xiaojie Wang Liming Wang Yinghua Qiu Fangyi Li Jianfeng Li Maocheng Ji Jia Man Source Type: research
Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration
In conclusion, a comprehensive understanding of the complex pathophysiology of AD and the exploration of herbal interventions offer a holistic approach to managing this devastating disease. Future research should address the limitations associated with herbal drugs and further evaluate the efficacy of promising natural products in clinical settings.PMID:38623983 | DOI:10.2174/0115672050309057240404075003 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 16, 2024 Category: Neurology Authors: Debasis Sen Sunny Rathee Vishal Pandey Sanjay K Jain Umesh K Patil Source Type: research
Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration
In conclusion, a comprehensive understanding of the complex pathophysiology of AD and the exploration of herbal interventions offer a holistic approach to managing this devastating disease. Future research should address the limitations associated with herbal drugs and further evaluate the efficacy of promising natural products in clinical settings.PMID:38623983 | DOI:10.2174/0115672050309057240404075003 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 16, 2024 Category: Neurology Authors: Debasis Sen Sunny Rathee Vishal Pandey Sanjay K Jain Umesh K Patil Source Type: research
Retraction Note: Curcumin inhibits proliferation, migration, invasion and promotes apoptosis of retinoblastoma cell lines through modulation of miR-99a and JAK/STAT pathway
(Source: BMC Cancer)
Source: BMC Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Yaping Li, Weixuan Sun, Ning Han, Ying Zou and Dexin Yin Tags: Retraction Note Source Type: research
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease
In this study, we found that TXNIP knockout suppressed renal fibrosis and activation of mammalian target of rapamycin complex 1 (mTORC1) and restored transcription factor EB (TFEB) and autophagy activation in diabetic kidneys. Simultaneously, TXNIP interference inhibited epithelial-to-mesenchymal transformation (EMT), collagen I and fibronectin expression, and mTORC1 activation, increased TFEB nuclear translocation, and promoted autophagy restoration in HK-2 cells exposed to high glucose (HG). Rapamycin, an inhibitor of mTORC1, increased TFEB nuclear translocation and autophagy in HK-2 cells under HG conditions. Moreover, ...
Source: Renal Failure - April 14, 2024 Category: Urology & Nephrology Authors: Yunxia Du Ming Wu Shan Song Yawei Bian Yonghong Shi Source Type: research
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease
In this study, we found that TXNIP knockout suppressed renal fibrosis and activation of mammalian target of rapamycin complex 1 (mTORC1) and restored transcription factor EB (TFEB) and autophagy activation in diabetic kidneys. Simultaneously, TXNIP interference inhibited epithelial-to-mesenchymal transformation (EMT), collagen I and fibronectin expression, and mTORC1 activation, increased TFEB nuclear translocation, and promoted autophagy restoration in HK-2 cells exposed to high glucose (HG). Rapamycin, an inhibitor of mTORC1, increased TFEB nuclear translocation and autophagy in HK-2 cells under HG conditions. Moreover, ...
Source: Renal Failure - April 14, 2024 Category: Urology & Nephrology Authors: Yunxia Du Ming Wu Shan Song Yawei Bian Yonghong Shi Source Type: research
Curcumin and quercetin co-encapsulated in nanoemulsions for nasal administration: a promising therapeutic and prophylactic treatment for viral respiratory infections
Eur J Pharm Sci. 2024 Apr 12:106766. doi: 10.1016/j.ejps.2024.106766. Online ahead of print.ABSTRACTOne of the most frequent causes of respiratory infections are viruses. Viruses reaching the airways can be absorbed by the human body through the respiratory mucosa and mainly infect lung cells. Several viral infections are not yet curable, such as coronavirus-2 (SARS-CoV-2). Furthermore, the side effect of synthetic antiviral drugs and reduced efficacy against resistant variants have reinforced the search for alternative and effective treatment options, such as plant-derived antiviral molecules. Curcumin (CUR) and quercetin...
Source: European Journal of Pharmaceutical Sciences - April 14, 2024 Category: Drugs & Pharmacology Authors: Daniela Pastorim Vaiss Jamile Lima Rodrigues Virginia Campello Yurgel Frank do Carmo Guedes Lauanda Larissa Mendon ça da Matta Paula Alice Bezerra Barros Gustavo Richter Vaz Ra íssa Nunes Dos Santos Bibiana Franzen Matte Larine Kupski Jaqueline Garda-Bu Source Type: research
Curcumin and quercetin co-encapsulated in nanoemulsions for nasal administration: a promising therapeutic and prophylactic treatment for viral respiratory infections
Eur J Pharm Sci. 2024 Apr 12:106766. doi: 10.1016/j.ejps.2024.106766. Online ahead of print.ABSTRACTOne of the most frequent causes of respiratory infections are viruses. Viruses reaching the airways can be absorbed by the human body through the respiratory mucosa and mainly infect lung cells. Several viral infections are not yet curable, such as coronavirus-2 (SARS-CoV-2). Furthermore, the side effect of synthetic antiviral drugs and reduced efficacy against resistant variants have reinforced the search for alternative and effective treatment options, such as plant-derived antiviral molecules. Curcumin (CUR) and quercetin...
Source: European Journal of Pharmaceutical Sciences - April 14, 2024 Category: Drugs & Pharmacology Authors: Daniela Pastorim Vaiss Jamile Lima Rodrigues Virginia Campello Yurgel Frank do Carmo Guedes Lauanda Larissa Mendon ça da Matta Paula Alice Bezerra Barros Gustavo Richter Vaz Ra íssa Nunes Dos Santos Bibiana Franzen Matte Larine Kupski Jaqueline Garda-Bu Source Type: research
Effect of Curcuma longa extract on reproduction function in mice and testosterone production in Leydig cells
This study aimed to investigate the efficacy of Curcuma longa extract (CLE) on Kidney-Yang deficiency mice induced by hydrocortisone and the possible roles in testosterone secretion in Leydig cells. We evaluated male sexual behaviour, reproductive organ weight, testosterone levels, and histological tissue changes in hydrocortisone-induced mice. CLE effectively reversed hydrocortisone-induced Kidney-Yang deficiency syndrome by improving sexual behaviour, testis and epididymis weight, testosterone levels and reducing pathological damage. Our in vitro study further indicated that CLE stimulated testosterone production via upr...
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Yisheng Zhang Liu Yang Shan Xue Yichang Zhang Zihan Li Min Zhang Guoyin Kai Juan Li Source Type: research
Fabrication, structure, characterization and emulsion application of citrate agar
Int J Biol Macromol. 2024 Apr 11:131451. doi: 10.1016/j.ijbiomac.2024.131451. Online ahead of print.ABSTRACTCitric acid esterified agar (CA) with different degrees of substitution (DS) was prepared, and CA gel was used to stabilize O/W emulsions. Compared with native agar (NA), CA had lower gel strength, higher transparency, and higher water contact angle. Further analysis of DS, group content ratio, Fourier transform infrared, and nuclear magnetic resonance data showed that the CA underwent cross-linking reaction. Emulsion properties revealed that CA gel emulsion (CAGE) had smaller particle size and lower ζ-potential tha...
Source: International Journal of Biological Macromolecules - April 13, 2024 Category: Biochemistry Authors: Feng Jiang Xinwei Xu Qiong Xiao Zhenyi Li Huifen Weng Fuquan Chen Anfeng Xiao Source Type: research
Effect of Curcuma longa extract on reproduction function in mice and testosterone production in Leydig cells
This study aimed to investigate the efficacy of Curcuma longa extract (CLE) on Kidney-Yang deficiency mice induced by hydrocortisone and the possible roles in testosterone secretion in Leydig cells. We evaluated male sexual behaviour, reproductive organ weight, testosterone levels, and histological tissue changes in hydrocortisone-induced mice. CLE effectively reversed hydrocortisone-induced Kidney-Yang deficiency syndrome by improving sexual behaviour, testis and epididymis weight, testosterone levels and reducing pathological damage. Our in vitro study further indicated that CLE stimulated testosterone production via upr...
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Yisheng Zhang Liu Yang Shan Xue Yichang Zhang Zihan Li Min Zhang Guoyin Kai Juan Li Source Type: research
Effect of Curcuma longa extract on reproduction function in mice and testosterone production in Leydig cells
This study aimed to investigate the efficacy of Curcuma longa extract (CLE) on Kidney-Yang deficiency mice induced by hydrocortisone and the possible roles in testosterone secretion in Leydig cells. We evaluated male sexual behaviour, reproductive organ weight, testosterone levels, and histological tissue changes in hydrocortisone-induced mice. CLE effectively reversed hydrocortisone-induced Kidney-Yang deficiency syndrome by improving sexual behaviour, testis and epididymis weight, testosterone levels and reducing pathological damage. Our in vitro study further indicated that CLE stimulated testosterone production via upr...
Source: J Cell Mol Med - April 13, 2024 Category: Molecular Biology Authors: Yisheng Zhang Liu Yang Shan Xue Yichang Zhang Zihan Li Min Zhang Guoyin Kai Juan Li Source Type: research
Effect of Curcuma longa extract on reproduction function in mice and testosterone production in Leydig cells
This study aimed to investigate the efficacy of Curcuma longa extract (CLE) on Kidney-Yang deficiency mice induced by hydrocortisone and the possible roles in testosterone secretion in Leydig cells. We evaluated male sexual behaviour, reproductive organ weight, testosterone levels, and histological tissue changes in hydrocortisone-induced mice. CLE effectively reversed hydrocortisone-induced Kidney-Yang deficiency syndrome by improving sexual behaviour, testis and epididymis weight, testosterone levels and reducing pathological damage. Our in vitro study further indicated that CLE stimulated testosterone production via upr...
Source: J Cell Mol Med - April 13, 2024 Category: Molecular Biology Authors: Yisheng Zhang Liu Yang Shan Xue Yichang Zhang Zihan Li Min Zhang Guoyin Kai Juan Li Source Type: research
Smartphone-based imaging colorimetric assay for monitoring the quality of curcumin in turmeric powder
Anal Sci. 2024 Apr 12. doi: 10.1007/s44211-024-00562-2. Online ahead of print.ABSTRACTThis research developed a colorimetric assay for semi-quantitative curcumin detection. The screening test was performed using a ferric chloride to form a brownish color which was further used to evaluate the amount of curcumin in the turmeric powder samples. The quantitative assay was performed based on the color intensity of the curcumin target using a smartphone digital image colorimetry with a developed lightbox constructed with a white light-emitting diodes (LED) light source as the measurement device. Images in red, green, and blue (...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - April 12, 2024 Category: Chemistry Authors: Jongjit Jantra Siriwan Teepoo Suchera Thananimit Source Type: research
