Curcumin Effects on Age-Related Changes in Oral Immunity: An < em > In Vivo < /em > Study
Br J Nutr. 2024 Apr 18:1-21. doi: 10.1017/S0007114524000801. Online ahead of print.ABSTRACTThe current study aimed to investigate the effects of ageing on oral immunity using β-defensin (DEFB) 1/2 as a marker and evaluate the effects of curcumin (CUR) on these processes. The study sample included 30 male C57BL/6J mice divided into three groups based on the treatment method used. The young control (YC) and old control (OC) groups received 0.5% methylcellulose-400 (curcumin vehicle) orally for five days, whereas the CUR group of older mice received a curcumin solution suspended in 0.5% methylcellulose-400 (dose: 3.0 mg/kg b...
Source: The British Journal of Nutrition - April 18, 2024 Category: Nutrition Authors: Ippei Uemura Natsuko Takahashi-Suzuki Akari Sano Shogo Yamada Akifumi Nakata Takashi Satoh Source Type: research
The Combined Impact of Curcumin: Piperine and Sorafenib on microRNAs and Different Pathways in Breast Cancer Cells
This study suggests that the combination of sorafenib and curcumin: piperine can combat breast cancer by modulating several microRNAs and signaling pathways involved in the development and progression of breast cancer. (Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - April 18, 2024 Category: Biochemistry Source Type: research
Cancers, Vol. 16, Pages 1554: The Role of Curcumin in Cancer: A Focus on the PI3K/Akt Pathway
os A. Alexiou
Cancer is a life-threatening disease and one of the leading causes of death worldwide. Despite significant advancements in therapeutic options, most available anti-cancer agents have limited efficacy. In this context, natural compounds with diverse chemical structures have been investigated for their multimodal anti-cancer properties. Curcumin is a polyphenol isolated from the rhizomes of Curcuma longa and has been widely studied for its anti-inflammatory, anti-oxidant, and anti-cancer effects. Curcumin acts on the regulation of different aspects of cancer development, including initiation, metastasis, an...
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Vasiliki Zoi Athanassios P. Kyritsis Vasiliki Galani Diamanto Lazari Chrissa Sioka Spyridon Voulgaris Georgios A. Alexiou Tags: Review Source Type: research
Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration
In conclusion, a comprehensive understanding of the complex pathophysiology of AD and the exploration of herbal interventions offer a holistic approach to managing this devastating disease. Future research should address the limitations associated with herbal drugs and further evaluate the efficacy of promising natural products in clinical settings.PMID:38623983 | DOI:10.2174/0115672050309057240404075003 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 16, 2024 Category: Neurology Authors: Debasis Sen Sunny Rathee Vishal Pandey Sanjay K Jain Umesh K Patil Source Type: research
Preparation of pH-sensitive porous polylactic acid-based medical dressing with self-pumping function
In this study, we fabricated a pH-sensitive colorimetric chronic wound dressing with self-pumping function using electrostatic spinning technology. It consisted of three layers: a polylactic acid-curcumin (PCPLLA) hydrophobic layer, a hydrolyzed polyacrylonitrile (HPAN) transfer layer, and a polyacrylonitrile-purple kale anthocyanin (PAN-PCA) hydrophilic layer. The results showed that the preparation of porous PLLA fiber membrane loaded with 0.2 % Cur was achieved by adjusting the spinning-related parameters, which could ensure that the composite dressing had sufficient anti-inflammatory, antibacterial and antioxidant prop...
Source: International Journal of Biological Macromolecules - April 16, 2024 Category: Biochemistry Authors: Zijian Zhang Jianyong Li Yi Wang Xiaojie Wang Liming Wang Yinghua Qiu Fangyi Li Jianfeng Li Maocheng Ji Jia Man Source Type: research
Curcumin regulates pulmonary extracellular matrix remodeling and mitochondrial function to attenuate pulmonary fibrosis by regulating the miR-29a-3p/DNMT3A axis
Biomed Pharmacother. 2024 Apr 15;174:116572. doi: 10.1016/j.biopha.2024.116572. Online ahead of print.ABSTRACTEpigenetic regulation and mitochondrial dysfunction are essential to the progression of idiopathic pulmonary fibrosis (IPF). Curcumin (CCM) in inhibits the progression of pulmonary fibrosis by regulating the expression of specific miRNAs and pulmonary fibroblast mitochondrial function; however, the underlying mechanism is unclear. C57BL/6 mice were intratracheally injected with bleomycin (5 mg/kg) and treated with CCM (25 mg/kg body weight/3 times per week, intraperitoneal injection) for 28 days. Verhoeff-Van Gieso...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 16, 2024 Category: Drugs & Pharmacology Authors: Meng-Hsuan Cheng Hsuan-Fu Kuo Chia-Yuan Chang Jui-Chi Chang I-Fan Liu Chong-Chao Hsieh Chih-Hsin Hsu Chia-Yang Li Shu-Chi Wang Yung-Hsiang Chen Chuang-Rung Chang Tsung-Ying Lee Yu-Ru Liu Chi-Yuan Huang Szu-Hui Wu Wei-Lun Liu Po-Len Liu Source Type: research
Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration
In conclusion, a comprehensive understanding of the complex pathophysiology of AD and the exploration of herbal interventions offer a holistic approach to managing this devastating disease. Future research should address the limitations associated with herbal drugs and further evaluate the efficacy of promising natural products in clinical settings.PMID:38623983 | DOI:10.2174/0115672050309057240404075003 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 16, 2024 Category: Neurology Authors: Debasis Sen Sunny Rathee Vishal Pandey Sanjay K Jain Umesh K Patil Source Type: research
Retraction Note: Curcumin inhibits proliferation, migration, invasion and promotes apoptosis of retinoblastoma cell lines through modulation of miR-99a and JAK/STAT pathway
(Source: BMC Cancer)
Source: BMC Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Yaping Li, Weixuan Sun, Ning Han, Ying Zou and Dexin Yin Tags: Retraction Note Source Type: research
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease
In this study, we found that TXNIP knockout suppressed renal fibrosis and activation of mammalian target of rapamycin complex 1 (mTORC1) and restored transcription factor EB (TFEB) and autophagy activation in diabetic kidneys. Simultaneously, TXNIP interference inhibited epithelial-to-mesenchymal transformation (EMT), collagen I and fibronectin expression, and mTORC1 activation, increased TFEB nuclear translocation, and promoted autophagy restoration in HK-2 cells exposed to high glucose (HG). Rapamycin, an inhibitor of mTORC1, increased TFEB nuclear translocation and autophagy in HK-2 cells under HG conditions. Moreover, ...
Source: Renal Failure - April 14, 2024 Category: Urology & Nephrology Authors: Yunxia Du Ming Wu Shan Song Yawei Bian Yonghong Shi Source Type: research
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease
In this study, we found that TXNIP knockout suppressed renal fibrosis and activation of mammalian target of rapamycin complex 1 (mTORC1) and restored transcription factor EB (TFEB) and autophagy activation in diabetic kidneys. Simultaneously, TXNIP interference inhibited epithelial-to-mesenchymal transformation (EMT), collagen I and fibronectin expression, and mTORC1 activation, increased TFEB nuclear translocation, and promoted autophagy restoration in HK-2 cells exposed to high glucose (HG). Rapamycin, an inhibitor of mTORC1, increased TFEB nuclear translocation and autophagy in HK-2 cells under HG conditions. Moreover, ...
Source: Renal Failure - April 14, 2024 Category: Urology & Nephrology Authors: Yunxia Du Ming Wu Shan Song Yawei Bian Yonghong Shi Source Type: research
Curcumin and quercetin co-encapsulated in nanoemulsions for nasal administration: a promising therapeutic and prophylactic treatment for viral respiratory infections
Eur J Pharm Sci. 2024 Apr 12:106766. doi: 10.1016/j.ejps.2024.106766. Online ahead of print.ABSTRACTOne of the most frequent causes of respiratory infections are viruses. Viruses reaching the airways can be absorbed by the human body through the respiratory mucosa and mainly infect lung cells. Several viral infections are not yet curable, such as coronavirus-2 (SARS-CoV-2). Furthermore, the side effect of synthetic antiviral drugs and reduced efficacy against resistant variants have reinforced the search for alternative and effective treatment options, such as plant-derived antiviral molecules. Curcumin (CUR) and quercetin...
Source: European Journal of Pharmaceutical Sciences - April 14, 2024 Category: Drugs & Pharmacology Authors: Daniela Pastorim Vaiss Jamile Lima Rodrigues Virginia Campello Yurgel Frank do Carmo Guedes Lauanda Larissa Mendon ça da Matta Paula Alice Bezerra Barros Gustavo Richter Vaz Ra íssa Nunes Dos Santos Bibiana Franzen Matte Larine Kupski Jaqueline Garda-Bu Source Type: research
Curcumin and quercetin co-encapsulated in nanoemulsions for nasal administration: a promising therapeutic and prophylactic treatment for viral respiratory infections
Eur J Pharm Sci. 2024 Apr 12:106766. doi: 10.1016/j.ejps.2024.106766. Online ahead of print.ABSTRACTOne of the most frequent causes of respiratory infections are viruses. Viruses reaching the airways can be absorbed by the human body through the respiratory mucosa and mainly infect lung cells. Several viral infections are not yet curable, such as coronavirus-2 (SARS-CoV-2). Furthermore, the side effect of synthetic antiviral drugs and reduced efficacy against resistant variants have reinforced the search for alternative and effective treatment options, such as plant-derived antiviral molecules. Curcumin (CUR) and quercetin...
Source: European Journal of Pharmaceutical Sciences - April 14, 2024 Category: Drugs & Pharmacology Authors: Daniela Pastorim Vaiss Jamile Lima Rodrigues Virginia Campello Yurgel Frank do Carmo Guedes Lauanda Larissa Mendon ça da Matta Paula Alice Bezerra Barros Gustavo Richter Vaz Ra íssa Nunes Dos Santos Bibiana Franzen Matte Larine Kupski Jaqueline Garda-Bu Source Type: research
Effect of Curcuma longa extract on reproduction function in mice and testosterone production in Leydig cells
This study aimed to investigate the efficacy of Curcuma longa extract (CLE) on Kidney-Yang deficiency mice induced by hydrocortisone and the possible roles in testosterone secretion in Leydig cells. We evaluated male sexual behaviour, reproductive organ weight, testosterone levels, and histological tissue changes in hydrocortisone-induced mice. CLE effectively reversed hydrocortisone-induced Kidney-Yang deficiency syndrome by improving sexual behaviour, testis and epididymis weight, testosterone levels and reducing pathological damage. Our in vitro study further indicated that CLE stimulated testosterone production via upr...
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Yisheng Zhang Liu Yang Shan Xue Yichang Zhang Zihan Li Min Zhang Guoyin Kai Juan Li Source Type: research
Fabrication, structure, characterization and emulsion application of citrate agar
Int J Biol Macromol. 2024 Apr 11:131451. doi: 10.1016/j.ijbiomac.2024.131451. Online ahead of print.ABSTRACTCitric acid esterified agar (CA) with different degrees of substitution (DS) was prepared, and CA gel was used to stabilize O/W emulsions. Compared with native agar (NA), CA had lower gel strength, higher transparency, and higher water contact angle. Further analysis of DS, group content ratio, Fourier transform infrared, and nuclear magnetic resonance data showed that the CA underwent cross-linking reaction. Emulsion properties revealed that CA gel emulsion (CAGE) had smaller particle size and lower ζ-potential tha...
Source: International Journal of Biological Macromolecules - April 13, 2024 Category: Biochemistry Authors: Feng Jiang Xinwei Xu Qiong Xiao Zhenyi Li Huifen Weng Fuquan Chen Anfeng Xiao Source Type: research
Effect of Curcuma longa extract on reproduction function in mice and testosterone production in Leydig cells
This study aimed to investigate the efficacy of Curcuma longa extract (CLE) on Kidney-Yang deficiency mice induced by hydrocortisone and the possible roles in testosterone secretion in Leydig cells. We evaluated male sexual behaviour, reproductive organ weight, testosterone levels, and histological tissue changes in hydrocortisone-induced mice. CLE effectively reversed hydrocortisone-induced Kidney-Yang deficiency syndrome by improving sexual behaviour, testis and epididymis weight, testosterone levels and reducing pathological damage. Our in vitro study further indicated that CLE stimulated testosterone production via upr...
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Yisheng Zhang Liu Yang Shan Xue Yichang Zhang Zihan Li Min Zhang Guoyin Kai Juan Li Source Type: research
