Enhancing the efficacy of nano-curcumin on cancer cells through mixture design optimization of three emulsifiers
Curcumin, a vital bioactive compound found naturally, has diverse biological applications. However, a major limitation of curcumin is its low bioavailability caused by its limited solubility in water. Hence, i... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 30, 2024 Category: Chemistry Authors: Zahra Sayyar and Hoda Jafarizadeh-Malmiri Tags: Research Source Type: research
Prepuberty is a window period for curcumin to prevent obesity in postnatal overfed rats
CONCLUSION: Prepuberty is a window period for CUR intervention to improve programmed outcomes in postnatal overfed rats.IMPACT: Overnutrition during the first 1000 days of life has persistent negative effects on metabolism. Strategies should be taken to prevent overnutrition in early life to reduce the risk of obesity and metabolic disease in later life. A small-litter rat model was utilized to simulate early-life overnutrition in humans. We investigated the different effects and critical period for curcumin intervention on postnatal overfed rats. Dietary curcumin intervention before puberty could effectively transform nut...
Source: Pediatric Research - March 29, 2024 Category: Pediatrics Authors: Susu Du Nan Zhou Wen Zheng Xiaolei Zhu Ru Ling Wei Zhou Xiaonan Li Source Type: research
The Protective Effects of Curcumin against Renal Toxicity
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673271161231121061148. Online ahead of print.ABSTRACTCurcumin is a naturally polyphenolic compound used for hepatoprotective, thrombosuppressive, neuroprotective, cardioprotective, antineoplastic, antiproliferative, hypoglycemic, and antiarthritic effects. Kidney disease is a major public health problem associated with severe clinical complications worldwide. The protective effects of curcumin against nephrotoxicity have been evaluated in several experimental models. In this review, we discussed how curcumin exerts its protective effect against renal toxicity and also illustr...
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Jianan Zhai Zhengguo Chen Qi Zhu Zhifang Guo Ningning Wang Cong Zhang Haoyuan Deng Shaopeng Wang Guang Yang Source Type: research
Polycystic Ovary Syndrome and Oxidative Stress. Natural Treatments
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673270372231130071320. Online ahead of print.ABSTRACTPolycystic ovary syndrome (PCOS) is one of the most frequent endocrinopathology affecting women in their reproductive ages. However, PCOS is also related to metabolic abnormalities such as metabolic syndrome (MS), insulin resistance (IR), and type 2 diabetes, among others. Consequently, an inflammatory and pro-oxidative status is also present in these patients, aggravating the syndrome's symptoms. This work aims to discuss some late treatments that focus on oxidative stress (OS) as a central feature related to primary PCOS ...
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Alicia Beatriz Motta Source Type: research
Prepuberty is a window period for curcumin to prevent obesity in postnatal overfed rats
CONCLUSION: Prepuberty is a window period for CUR intervention to improve programmed outcomes in postnatal overfed rats.IMPACT: Overnutrition during the first 1000 days of life has persistent negative effects on metabolism. Strategies should be taken to prevent overnutrition in early life to reduce the risk of obesity and metabolic disease in later life. A small-litter rat model was utilized to simulate early-life overnutrition in humans. We investigated the different effects and critical period for curcumin intervention on postnatal overfed rats. Dietary curcumin intervention before puberty could effectively transform nut...
Source: Pediatric Research - March 29, 2024 Category: Pediatrics Authors: Susu Du Nan Zhou Wen Zheng Xiaolei Zhu Ru Ling Wei Zhou Xiaonan Li Source Type: research
Polycystic Ovary Syndrome and Oxidative Stress. Natural Treatments
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673270372231130071320. Online ahead of print.ABSTRACTPolycystic ovary syndrome (PCOS) is one of the most frequent endocrinopathology affecting women in their reproductive ages. However, PCOS is also related to metabolic abnormalities such as metabolic syndrome (MS), insulin resistance (IR), and type 2 diabetes, among others. Consequently, an inflammatory and pro-oxidative status is also present in these patients, aggravating the syndrome's symptoms. This work aims to discuss some late treatments that focus on oxidative stress (OS) as a central feature related to primary PCOS ...
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Alicia Beatriz Motta Source Type: research
The Protective Effects of Curcumin against Renal Toxicity
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673271161231121061148. Online ahead of print.ABSTRACTCurcumin is a naturally polyphenolic compound used for hepatoprotective, thrombosuppressive, neuroprotective, cardioprotective, antineoplastic, antiproliferative, hypoglycemic, and antiarthritic effects. Kidney disease is a major public health problem associated with severe clinical complications worldwide. The protective effects of curcumin against nephrotoxicity have been evaluated in several experimental models. In this review, we discussed how curcumin exerts its protective effect against renal toxicity and also illustr...
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Jianan Zhai Zhengguo Chen Qi Zhu Zhifang Guo Ningning Wang Cong Zhang Haoyuan Deng Shaopeng Wang Guang Yang Source Type: research
Curcumin/TGF- β1 siRNA loaded solid lipid nanoparticles alleviate cerebral injury after intracerebral hemorrhage by transnasal brain targeting
In conclusion, our designed siRNA/CUR@SLN showed good brain targeting and anti-inflammatory effect ability after nasal administration, which lays the foundation for the treatment of inflammation caused by ICH and offers a novel approach for brain-targeted drug delivery and brings new hope.PMID:38552289 | DOI:10.1016/j.colsurfb.2024.113857 (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - March 29, 2024 Category: Biotechnology Authors: Munire Abudurexiti Jun Xue Xianzhe Li Xiaofeng Zhang Yongyi Qiu Senjie Xiong Guojing Liu Sangui Yuan Rongrui Tang Source Type: research
Prepuberty is a window period for curcumin to prevent obesity in postnatal overfed rats
CONCLUSION: Prepuberty is a window period for CUR intervention to improve programmed outcomes in postnatal overfed rats.IMPACT: Overnutrition during the first 1000 days of life has persistent negative effects on metabolism. Strategies should be taken to prevent overnutrition in early life to reduce the risk of obesity and metabolic disease in later life. A small-litter rat model was utilized to simulate early-life overnutrition in humans. We investigated the different effects and critical period for curcumin intervention on postnatal overfed rats. Dietary curcumin intervention before puberty could effectively transform nut...
Source: Pediatric Research - March 29, 2024 Category: Pediatrics Authors: Susu Du Nan Zhou Wen Zheng Xiaolei Zhu Ru Ling Wei Zhou Xiaonan Li Source Type: research
Polycystic Ovary Syndrome and Oxidative Stress. Natural Treatments
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673270372231130071320. Online ahead of print.ABSTRACTPolycystic ovary syndrome (PCOS) is one of the most frequent endocrinopathology affecting women in their reproductive ages. However, PCOS is also related to metabolic abnormalities such as metabolic syndrome (MS), insulin resistance (IR), and type 2 diabetes, among others. Consequently, an inflammatory and pro-oxidative status is also present in these patients, aggravating the syndrome's symptoms. This work aims to discuss some late treatments that focus on oxidative stress (OS) as a central feature related to primary PCOS ...
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Alicia Beatriz Motta Source Type: research
The Protective Effects of Curcumin against Renal Toxicity
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673271161231121061148. Online ahead of print.ABSTRACTCurcumin is a naturally polyphenolic compound used for hepatoprotective, thrombosuppressive, neuroprotective, cardioprotective, antineoplastic, antiproliferative, hypoglycemic, and antiarthritic effects. Kidney disease is a major public health problem associated with severe clinical complications worldwide. The protective effects of curcumin against nephrotoxicity have been evaluated in several experimental models. In this review, we discussed how curcumin exerts its protective effect against renal toxicity and also illustr...
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Jianan Zhai Zhengguo Chen Qi Zhu Zhifang Guo Ningning Wang Cong Zhang Haoyuan Deng Shaopeng Wang Guang Yang Source Type: research
The Protective Effects of Curcumin against Renal Toxicity
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673271161231121061148. Online ahead of print.ABSTRACTCurcumin is a naturally polyphenolic compound used for hepatoprotective, thrombosuppressive, neuroprotective, cardioprotective, antineoplastic, antiproliferative, hypoglycemic, and antiarthritic effects. Kidney disease is a major public health problem associated with severe clinical complications worldwide. The protective effects of curcumin against nephrotoxicity have been evaluated in several experimental models. In this review, we discussed how curcumin exerts its protective effect against renal toxicity and also illustr...
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Jianan Zhai Zhengguo Chen Qi Zhu Zhifang Guo Ningning Wang Cong Zhang Haoyuan Deng Shaopeng Wang Guang Yang Source Type: research
Polycystic Ovary Syndrome and Oxidative Stress. Natural Treatments
Curr Med Chem. 2024 Feb 16. doi: 10.2174/0109298673270372231130071320. Online ahead of print.ABSTRACTPolycystic ovary syndrome (PCOS) is one of the most frequent endocrinopathology affecting women in their reproductive ages. However, PCOS is also related to metabolic abnormalities such as metabolic syndrome (MS), insulin resistance (IR), and type 2 diabetes, among others. Consequently, an inflammatory and pro-oxidative status is also present in these patients, aggravating the syndrome's symptoms. This work aims to discuss some late treatments that focus on oxidative stress (OS) as a central feature related to primary PCOS ...
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Alicia Beatriz Motta Source Type: research
Curcumin Inhibits the PPAR δ-p-Akt-GLUT1 Pathway and Ameliorates the Antiproliferative Effects of Doxorubicin in MDA-MB-231 Cells
CONCLUSION: Our study demonstrates that regulation of GLUT1 by curcumin via the PPARδ/Akt signaling improves the efficacy of doxorubicin by promoting its growth inhibitory effects in MDA-MB-231 cells.PMID:38546086 | DOI:10.31557/APJCP.2024.25.3.1035 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - March 28, 2024 Category: Cancer & Oncology Authors: Padmamalini Thulasiraman Marie Foret Renu Pandit Kathleen McAlister Source Type: research
Compound SJ-12 attenuates streptozocin-induced diabetic cardiomyopathy by stabilizing SERCA2a
Biochim Biophys Acta Mol Basis Dis. 2024 Mar 26:167140. doi: 10.1016/j.bbadis.2024.167140. Online ahead of print.ABSTRACTHeart failure (HF) is one of the major causes of death among diabetic patients. Although studies have shown that curcumin analog C66 can remarkably relieve diabetes-associated cardiovascular and kidney complications, the role of SJ-12, SJ-12, a novel curcumin analog, in diabetic cardiomyopathy and its molecular targets are unknown. 7-week-old male C57BL/6 mice were intraperitoneally injected with single streptozotocin (STZ) (160 mg/kg) to develop diabetic cardiomyopathy (DCM). The diabetic mice were then...
Source: Biochimica et Biophysica Acta - March 28, 2024 Category: Biochemistry Authors: Shuaijie Lou Weiwei Zhu Tianxiang Yu Qianhui Zhang Minxiu Wang Leiming Jin Yongqiang Xiong Jiachen Xu Qinyan Wang Gaozhi Chen Guang Liang Xiang Hu Wu Luo Source Type: research
