Curcumin/TGF- β1 siRNA loaded solid lipid nanoparticles alleviate cerebral injury after intracerebral hemorrhage by transnasal brain targeting

In conclusion, our designed siRNA/CUR@SLN showed good brain targeting and anti-inflammatory effect ability after nasal administration, which lays the foundation for the treatment of inflammation caused by ICH and offers a novel approach for brain-targeted drug delivery and brings new hope.PMID:38552289 | DOI:10.1016/j.colsurfb.2024.113857

Source: Colloids and Surfaces - March 29, 2024 Category: Biotechnology Authors: Munire Abudurexiti Jun Xue Xianzhe Li Xiaofeng Zhang Yongyi Qiu Senjie Xiong Guojing Liu Sangui Yuan Rongrui Tang Source Type: research