Curcumin Effects on Age-Related Changes in Oral Immunity: An < em > In Vivo < /em > Study
Br J Nutr. 2024 Apr 18:1-21. doi: 10.1017/S0007114524000801. Online ahead of print.ABSTRACTThe current study aimed to investigate the effects of ageing on oral immunity using β-defensin (DEFB) 1/2 as a marker and evaluate the effects of curcumin (CUR) on these processes. The study sample included 30 male C57BL/6J mice divided into three groups based on the treatment method used. The young control (YC) and old control (OC) groups received 0.5% methylcellulose-400 (curcumin vehicle) orally for five days, whereas the CUR group of older mice received a curcumin solution suspended in 0.5% methylcellulose-400 (dose: 3.0 mg/kg b...
Source: The British Journal of Nutrition - April 18, 2024 Category: Nutrition Authors: Ippei Uemura Natsuko Takahashi-Suzuki Akari Sano Shogo Yamada Akifumi Nakata Takashi Satoh Source Type: research
Repellent activity of Vitex negundo and Curcuma longa herbal extract against simulium species in India
CONCLUSION: At an optimum concentration of 10%, the methanolic extract of vitex negundo cream provided complete protection times (CPTs) 320.4, 358.6, and 346.4 minutes, respectively. This finding offers confirmation of the methanolic extract and chloroform extract potential for use in new blackfly repellents.PMID:38634372 | DOI:10.4103/JVBD.JVBD_181_23 (Source: Journal of Vector Borne Diseases)
Source: Journal of Vector Borne Diseases - April 18, 2024 Category: Infectious Diseases Authors: Chinmoy Bhuyan Dipankar Saha Bipul Rabha Source Type: research
Future aspects of plant derived bioactive metabolites as therapeutics to combat benign prostatic hyperplasia
CONCLUSION: The review proposes and endorses careful utilization of conventional medications that may be investigated further to discover possible PDE-5, 5 alpha-reductase, an alpha-blocker inhibitor for managing BPH. Even though most conventional formulations, such as 5 alpha-reductase, are readily available, systemic assessment of the effectiveness and mechanism of action of the herbal constituents is still necessary to identify novel chemical moieties that can be further developed for maximum efficacy. However, there exist abundant botanicals and medicinal plants across several regions of Africa, Asia, and the Americas,...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Raman Krishnamoorthi Anand Ganapathy A Hari Priya V M Alaganandam Kumaran Source Type: research
Curcumin Effects on Age-Related Changes in Oral Immunity: An < em > In Vivo < /em > Study
Br J Nutr. 2024 Apr 18:1-21. doi: 10.1017/S0007114524000801. Online ahead of print.ABSTRACTThe current study aimed to investigate the effects of ageing on oral immunity using β-defensin (DEFB) 1/2 as a marker and evaluate the effects of curcumin (CUR) on these processes. The study sample included 30 male C57BL/6J mice divided into three groups based on the treatment method used. The young control (YC) and old control (OC) groups received 0.5% methylcellulose-400 (curcumin vehicle) orally for five days, whereas the CUR group of older mice received a curcumin solution suspended in 0.5% methylcellulose-400 (dose: 3.0 mg/kg b...
Source: The British Journal of Nutrition - April 18, 2024 Category: Nutrition Authors: Ippei Uemura Natsuko Takahashi-Suzuki Akari Sano Shogo Yamada Akifumi Nakata Takashi Satoh Source Type: research
Repellent activity of Vitex negundo and Curcuma longa herbal extract against simulium species in India
CONCLUSION: At an optimum concentration of 10%, the methanolic extract of vitex negundo cream provided complete protection times (CPTs) 320.4, 358.6, and 346.4 minutes, respectively. This finding offers confirmation of the methanolic extract and chloroform extract potential for use in new blackfly repellents.PMID:38634372 | DOI:10.4103/JVBD.JVBD_181_23 (Source: Journal of Vector Borne Diseases)
Source: Journal of Vector Borne Diseases - April 18, 2024 Category: Infectious Diseases Authors: Chinmoy Bhuyan Dipankar Saha Bipul Rabha Source Type: research
The Combined Impact of Curcumin: Piperine and Sorafenib on microRNAs and Different Pathways in Breast Cancer Cells
This study suggests that the combination of sorafenib and curcumin: piperine can combat breast cancer by modulating several microRNAs and signaling pathways involved in the development and progression of breast cancer. (Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - April 18, 2024 Category: Biochemistry Source Type: research
Cancers, Vol. 16, Pages 1554: The Role of Curcumin in Cancer: A Focus on the PI3K/Akt Pathway
os A. Alexiou
Cancer is a life-threatening disease and one of the leading causes of death worldwide. Despite significant advancements in therapeutic options, most available anti-cancer agents have limited efficacy. In this context, natural compounds with diverse chemical structures have been investigated for their multimodal anti-cancer properties. Curcumin is a polyphenol isolated from the rhizomes of Curcuma longa and has been widely studied for its anti-inflammatory, anti-oxidant, and anti-cancer effects. Curcumin acts on the regulation of different aspects of cancer development, including initiation, metastasis, an...
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Vasiliki Zoi Athanassios P. Kyritsis Vasiliki Galani Diamanto Lazari Chrissa Sioka Spyridon Voulgaris Georgios A. Alexiou Tags: Review Source Type: research
Enhanced environmental stress resistance and functional properties of the curcumin-shellac nano-delivery system: Anti-flocculation of poly- γ-glutamic acid
Int J Biol Macromol. 2024 Apr 15:131607. doi: 10.1016/j.ijbiomac.2024.131607. Online ahead of print.ABSTRACTCurcumin was widely designed as nanoparticles to remove application restrictions. The occurrence of flocculation is a primary factor limiting the application of the curcumin nano-delivery system. To enhance the environmental stress resistance and functional properties of shellac-curcumin nanoparticles (S-Cur-NPs), γ-polyglutamic acid (γ-PGA) was utilized as an anti-flocculant. The encapsulation efficiency and loading capacity of S-Cur-NPs were also improved with γ-PGA incorporation. FTIR and XRD analysis confirmed...
Source: International Journal of Biological Macromolecules - April 17, 2024 Category: Biochemistry Authors: Di Zhuang Yafang Wang Shancan Wang Rui Li Hafiz Nabeel Ahmad Jie Zhu Source Type: research
Recoverable and degradable carboxymethyl chitosan polyelectrolyte hydrogel film for ultra stable encapsulation of curcumin
Int J Biol Macromol. 2024 Apr 15:131616. doi: 10.1016/j.ijbiomac.2024.131616. Online ahead of print.ABSTRACTHydrogels have shown great potential for application in food science due to their diverse functionalities. However, most hydrogels inevitably contain toxic chemical cross-linking agent residues, posing serious food safety concerns. In this paper, a curcumin/sodium alginate/carboxymethyl chitosan hydrogels (CSCH) were prepared by self-assembly of two oppositely charged polysaccharides, carboxymethyl chitosan and sodium alginate, to form a three-dimensional network encapsulating curcumin for extending food shelf life. ...
Source: International Journal of Biological Macromolecules - April 17, 2024 Category: Biochemistry Authors: Yuwei Zhang Dengshuang Guo Xi Shen Zhongfeng Tang Baofeng Lin Source Type: research
Effects of curcumin supplementation on abdominal surgical wound healing
CONCLUSIONS: Curcumin supplementation was able to significantly reduce inflammatory parameters in both pre-and post-operative phases of abdominal surgical wounds in rats.PMID:38629652 | PMC:PMC11020632 | DOI:10.1590/acb392124 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - April 17, 2024 Category: Surgery Authors: Melquesedeque Dos Santos Eurico Cleto Ribeiro de Campos Rivair Gon çalves Junior Adriana Yuriko Koga Pedro Afonso Kono Matheus Von Jelita Salina Elder Dalazoana Filho Alceu de Oliveira Toledo Junior Leandro Cavalcante Lipinski Source Type: research
Effects of curcumin supplementation on abdominal surgical wound healing
CONCLUSIONS: Curcumin supplementation was able to significantly reduce inflammatory parameters in both pre-and post-operative phases of abdominal surgical wounds in rats.PMID:38629652 | PMC:PMC11020632 | DOI:10.1590/acb392124 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - April 17, 2024 Category: Surgery Authors: Melquesedeque Dos Santos Eurico Cleto Ribeiro de Campos Rivair Gon çalves Junior Adriana Yuriko Koga Pedro Afonso Kono Matheus Von Jelita Salina Elder Dalazoana Filho Alceu de Oliveira Toledo Junior Leandro Cavalcante Lipinski Source Type: research
Effects of curcumin supplementation on abdominal surgical wound healing
CONCLUSIONS: Curcumin supplementation was able to significantly reduce inflammatory parameters in both pre-and post-operative phases of abdominal surgical wounds in rats.PMID:38629652 | PMC:PMC11020632 | DOI:10.1590/acb392124 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - April 17, 2024 Category: Surgery Authors: Melquesedeque Dos Santos Eurico Cleto Ribeiro de Campos Rivair Gon çalves Junior Adriana Yuriko Koga Pedro Afonso Kono Matheus Von Jelita Salina Elder Dalazoana Filho Alceu de Oliveira Toledo Junior Leandro Cavalcante Lipinski Source Type: research
Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration
In conclusion, a comprehensive understanding of the complex pathophysiology of AD and the exploration of herbal interventions offer a holistic approach to managing this devastating disease. Future research should address the limitations associated with herbal drugs and further evaluate the efficacy of promising natural products in clinical settings.PMID:38623983 | DOI:10.2174/0115672050309057240404075003 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 16, 2024 Category: Neurology Authors: Debasis Sen Sunny Rathee Vishal Pandey Sanjay K Jain Umesh K Patil Source Type: research
Preparation of pH-sensitive porous polylactic acid-based medical dressing with self-pumping function
In this study, we fabricated a pH-sensitive colorimetric chronic wound dressing with self-pumping function using electrostatic spinning technology. It consisted of three layers: a polylactic acid-curcumin (PCPLLA) hydrophobic layer, a hydrolyzed polyacrylonitrile (HPAN) transfer layer, and a polyacrylonitrile-purple kale anthocyanin (PAN-PCA) hydrophilic layer. The results showed that the preparation of porous PLLA fiber membrane loaded with 0.2 % Cur was achieved by adjusting the spinning-related parameters, which could ensure that the composite dressing had sufficient anti-inflammatory, antibacterial and antioxidant prop...
Source: International Journal of Biological Macromolecules - April 16, 2024 Category: Biochemistry Authors: Zijian Zhang Jianyong Li Yi Wang Xiaojie Wang Liming Wang Yinghua Qiu Fangyi Li Jianfeng Li Maocheng Ji Jia Man Source Type: research
Curcumin regulates pulmonary extracellular matrix remodeling and mitochondrial function to attenuate pulmonary fibrosis by regulating the miR-29a-3p/DNMT3A axis
Biomed Pharmacother. 2024 Apr 15;174:116572. doi: 10.1016/j.biopha.2024.116572. Online ahead of print.ABSTRACTEpigenetic regulation and mitochondrial dysfunction are essential to the progression of idiopathic pulmonary fibrosis (IPF). Curcumin (CCM) in inhibits the progression of pulmonary fibrosis by regulating the expression of specific miRNAs and pulmonary fibroblast mitochondrial function; however, the underlying mechanism is unclear. C57BL/6 mice were intratracheally injected with bleomycin (5 mg/kg) and treated with CCM (25 mg/kg body weight/3 times per week, intraperitoneal injection) for 28 days. Verhoeff-Van Gieso...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 16, 2024 Category: Drugs & Pharmacology Authors: Meng-Hsuan Cheng Hsuan-Fu Kuo Chia-Yuan Chang Jui-Chi Chang I-Fan Liu Chong-Chao Hsieh Chih-Hsin Hsu Chia-Yang Li Shu-Chi Wang Yung-Hsiang Chen Chuang-Rung Chang Tsung-Ying Lee Yu-Ru Liu Chi-Yuan Huang Szu-Hui Wu Wei-Lun Liu Po-Len Liu Source Type: research
