Advancements in research on the immune-inflammatory mechanisms mediated by NLRP3 inflammasome in ischemic stroke and the regulatory role of natural plant products
Ischemic stroke (IS) is a major cause of mortality and disability among adults. Recanalization of blood vessels to facilitate timely reperfusion is the primary clinical approach; however, reperfusion itself may trigger cerebral ischemia-reperfusion injury. Emerging evidence strongly implicates the NLRP3 inflammasome as a potential therapeutic target, playing a key role in cerebral ischemia and reperfusion injury. The aberrant expression and function of NLRP3 inflammasome-mediated inflammation in cerebral ischemia have garnered considerable attention as a recent research focus. Accordingly, this review provides a comprehens...
Source: Frontiers in Pharmacology - March 27, 2024 Category: Drugs & Pharmacology Source Type: research
Dietary Supplement-Induced Hepatotoxicity: A Clinical Perspective
This article delves into the clinical perspective of DS-related hepatotoxicity, highlighting key concepts such as a systematic diagnostic approach. The discussion extends to notable examples of both currently popular and potential future dietary supplements, such as garcinia cambogia, turmeric, and ashwagandha, accompanied by an overview of recent findings. Causality assessment tools play a crucial role in establishing a connection between these products and instances of liver injury, with consideration of the advantages and disadvantages associated with their use. Fostering a comprehensive understanding of regulatory stan...
Source: Journal of Dietary Supplements - March 26, 2024 Category: Nutrition Authors: Jordan Carty Victor J Navarro Source Type: research
Discovery of cinnamylaldehyde-derived mono-carbonyl curcumin analogs as anti-gastric cancer agents via suppression of STAT3 and AKT pathway
Bioorg Chem. 2024 Mar 24;146:107306. doi: 10.1016/j.bioorg.2024.107306. Online ahead of print.ABSTRACTThe structural modification of curcumin has always been a hotspot in drug development. In this paper, a class of cinnamylaldehyde-derived mono-carbonyl curcumin analogs (MCAs) with 7-carbon-links were designed and synthesized and their anticancer properties were evaluated. Through screening anti-gastric cancer activity of these compounds, H1 exhibited the strongest cytotoxic activity by inhibiting cell viability and colony formation, inducing cell cycle G2/M phase arrest in vitro (SGC-7901 and AGS gastric cancer cells). Mo...
Source: Bioorganic Chemistry - March 26, 2024 Category: Chemistry Authors: Xi Chen Peiqin Zhang Huating Zhang Xueqiang Ma Ye Zhang Yajie Wu Kaiwen Jin Jiabing Wang Jianzhang Wu Source Type: research
Dietary Supplement-Induced Hepatotoxicity: A Clinical Perspective
This article delves into the clinical perspective of DS-related hepatotoxicity, highlighting key concepts such as a systematic diagnostic approach. The discussion extends to notable examples of both currently popular and potential future dietary supplements, such as garcinia cambogia, turmeric, and ashwagandha, accompanied by an overview of recent findings. Causality assessment tools play a crucial role in establishing a connection between these products and instances of liver injury, with consideration of the advantages and disadvantages associated with their use. Fostering a comprehensive understanding of regulatory stan...
Source: Journal of Dietary Supplements - March 26, 2024 Category: Nutrition Authors: Jordan Carty Victor J Navarro Source Type: research
Discovery of cinnamylaldehyde-derived mono-carbonyl curcumin analogs as anti-gastric cancer agents via suppression of STAT3 and AKT pathway
Bioorg Chem. 2024 Mar 24;146:107306. doi: 10.1016/j.bioorg.2024.107306. Online ahead of print.ABSTRACTThe structural modification of curcumin has always been a hotspot in drug development. In this paper, a class of cinnamylaldehyde-derived mono-carbonyl curcumin analogs (MCAs) with 7-carbon-links were designed and synthesized and their anticancer properties were evaluated. Through screening anti-gastric cancer activity of these compounds, H1 exhibited the strongest cytotoxic activity by inhibiting cell viability and colony formation, inducing cell cycle G2/M phase arrest in vitro (SGC-7901 and AGS gastric cancer cells). Mo...
Source: Bioorganic Chemistry - March 26, 2024 Category: Chemistry Authors: Xi Chen Peiqin Zhang Huating Zhang Xueqiang Ma Ye Zhang Yajie Wu Kaiwen Jin Jiabing Wang Jianzhang Wu Source Type: research
Dietary Supplement-Induced Hepatotoxicity: A Clinical Perspective
This article delves into the clinical perspective of DS-related hepatotoxicity, highlighting key concepts such as a systematic diagnostic approach. The discussion extends to notable examples of both currently popular and potential future dietary supplements, such as garcinia cambogia, turmeric, and ashwagandha, accompanied by an overview of recent findings. Causality assessment tools play a crucial role in establishing a connection between these products and instances of liver injury, with consideration of the advantages and disadvantages associated with their use. Fostering a comprehensive understanding of regulatory stan...
Source: Journal of Dietary Supplements - March 26, 2024 Category: Nutrition Authors: Jordan Carty Victor J Navarro Source Type: research
Phytocompounds targeting epigenetic modulations: an assessment in cancer
For centuries, plants have been serving as sources of potential therapeutic agents. In recent years, there has been a growing interest in investigating the effects of plant-derived compounds on epigenetic processes, a novel and captivating Frontier in the field of epigenetics research. Epigenetic changes encompass modifications to DNA, histones, and microRNAs that can influence gene expression. Aberrant epigenetic changes can perturb key cellular processes, including cell cycle control, intercellular communication, DNA repair, inflammation, stress response, and apoptosis. Such disruptions can contribute to cancer developme...
Source: Frontiers in Pharmacology - March 26, 2024 Category: Drugs & Pharmacology Source Type: research
Evaluation of Efficacy of Curcumin and Caffeic Acid Phenethyl Ester in Breast Cancer by Preclinical Studies
CONCLUSION: The observations suggest that the combination of curcumin plus CAPE may be better in comparison to individual molecules. Other: The study opens a window for analysing the efficacy of the combination of CAPE and curcumin in animal studies. This will provide a basis for examining the combined efficacy of two agents in a clinical trial.PMID:38523543 | DOI:10.2174/0109298673284600231230093955 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 25, 2024 Category: Chemistry Authors: Sumit Singh Verma None Avadhesh Ankit Srivastava Anusmita Shekher Anupam Dhasmana Acharan Singh Narula Subash Chandra Gupta Source Type: research
Evaluation of Efficacy of Curcumin and Caffeic Acid Phenethyl Ester in Breast Cancer by Preclinical Studies
CONCLUSION: The observations suggest that the combination of curcumin plus CAPE may be better in comparison to individual molecules. Other: The study opens a window for analysing the efficacy of the combination of CAPE and curcumin in animal studies. This will provide a basis for examining the combined efficacy of two agents in a clinical trial.PMID:38523543 | DOI:10.2174/0109298673284600231230093955 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 25, 2024 Category: Chemistry Authors: Sumit Singh Verma None Avadhesh Ankit Srivastava Anusmita Shekher Anupam Dhasmana Acharan Singh Narula Subash Chandra Gupta Source Type: research
Colon-targeted hydroxyethyl starch-curcumin microspheres with high loading capacity ameliorate ulcerative colitis via alleviating oxidative stress, regulating inflammation, and modulating gut microbiota
This study presents hydroxyethyl starch-curcumin microspheres (HC-MSs) with excellent CUR loading capacity (54.52 %), and the HC-MSs can further encapsulate anti-inflammatory drugs dexamethasone (DEX) to obtain a combination formulation (DHC-MSs) with high DEX loading capacity (19.91 %), for combination therapy of UC. The microspheres were successfully engineered, retaining the anti-oxidative and anti-inflammatory activities of parental CUR and demonstrating excellent biocompatibility and controlled release properties, notably triggered by α-amylase, facilitating targeted drug delivery to inflamed sites. In a mouse UC mod...
Source: International Journal of Biological Macromolecules - March 25, 2024 Category: Biochemistry Authors: Da Huang Yongming Wang Chenlan Xu Minglang Zou Yangcan Ming Fang Luo Zhenjin Xu Ying Miao Na Wang Zhenyu Lin Zuquan Weng Source Type: research
Molecules, Vol. 29, Pages 1451: Cyclocurcumin as Promising Bioactive Natural Compound: An Overview
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Although identical in molecular formula and weight, curcumin and cyclocurcumin show remarkable differences in their reactivity. Both are natural compounds isolated from the rhizome of turmeric, the former is involved in the diketo/keto-enol tautomerism through the bis-α,β-unsaturated diketone unit according to the polarity of the solvent, while the latter could react by trans-cis isomerization due to the presence of the α,β-unsaturated dihydropyranone moiety. Even if curcumin is generally considered responsible of the therapeutical properties of Curcuma longa L....
Source: Molecules - March 24, 2024 Category: Chemistry Authors: Carla Gasbarri Guido Angelini Tags: Review Source Type: research
Eggshell membrane as a novel and green platform for the preparation of highly efficient and reversible curcumin-based colorimetric sensor for the monitoring of chicken freshness
Int J Biol Macromol. 2024 Mar 21:131089. doi: 10.1016/j.ijbiomac.2024.131089. Online ahead of print.ABSTRACTHerein, for the very first time, we report a paper-like biomass, eggshell membrane (ESM), as a suitable platform for the fabrication of a colorimetric sensor (E-Cot). Green ethanolic extract, curcumin (CUR), was used as a sensing material to coat with the ESM. The present E-Cot effectively changed its color (yellow to red) in the real-time monitoring for chicken spoilage. The E-Cot exhibits barrier properties due to its inherent semi-permeability characteristics. Interestingly, the E-Cot showed a significant change i...
Source: International Journal of Biological Macromolecules - March 23, 2024 Category: Biochemistry Authors: Muhammad Asim Iqbal Sabeen Gohar Chunhong Zhu Mayakrishnan Gopiraman Ick Soo Kim Source Type: research
