Identification of CH < sub > 2 < /sub > -linked quinolone-aminopyrimidine hybrids as potent anti-MRSA agents: Low resistance potential and lack of cross-resistance with fluoroquinolone antibiotics
Eur J Med Chem. 2024 Apr 11;271:116399. doi: 10.1016/j.ejmech.2024.116399. Online ahead of print.ABSTRACTThe structural optimization of B14, an antibacterial agent we previously obtained, has led to the discovery of a new class of CH2-linked quinolone-aminopyrimidine hybrids with potent anti-MRSA activities. Surprisingly, the hybrids lacking a C-6 fluoro atom at the quinolone nucleus showed equal or even stronger anti-MRSA activities than their corresponding 6-fluoro counterparts, despite the well-established structure-activity relationships (SARs) indicating that the 6-fluoro substituent enhances the antibacterial activit...
Source: European Journal of Medicinal Chemistry - April 19, 2024 Category: Chemistry Authors: Hongxue Dai Yue Hu Yiwen Zhang Qi Zhu Tao Xu Peng Cui Renhua Fan Qiuqin He Source Type: research
Mechanisms for more efficient antibiotics and antibiotic resistance genes removal during industrialized treatment of over 200 tons of tylosin and spectinomycin mycelial dregs by integrated meta-omics
Bioresour Technol. 2024 Apr 17:130715. doi: 10.1016/j.biortech.2024.130715. Online ahead of print.ABSTRACTTo mitigate the environmental risks posed by the accumulation of antibiotic mycelial dregs (AMDs), this study first attempted over 200 tons of mass production fermentation (MP) using tylosin and spectinomycin mycelial dregs alongside pilot-scale fermentation (PS) for comparison, utilizing the integrated-omics and qPCR approaches. Co-fermentation results showed that both antibiotics were effectively removed in all treatments, with an average removal rate of 92%. Antibiotic resistance gene (ARG)-related metabolic pathway...
Source: Bioresource Technology - April 19, 2024 Category: Biotechnology Authors: Guomeng Sha Zhengwen Wu Tong Chen Guangen Zhang Jianguo Shen Xiaogang Zhao Lushan Wang Source Type: research
Beyond surface modification strategies to control infections associated with implanted biomaterials and devices - Addressing the opportunities offered by nanotechnology
Biomaterials. 2024 Apr 16;308:122576. doi: 10.1016/j.biomaterials.2024.122576. Online ahead of print.ABSTRACTBiomaterial-associated infection (BAI) is considered a unique infection due to the presence of a biomaterial yielding frustrated immune-cells, ineffective in clearing local micro-organisms. The involvement of surface-adherent/surface-adapted micro-organisms in BAI, logically points to biomaterial surface-modifications for BAI-control. Biomaterial surface-modification is most suitable for prevention before adhering bacteria have grown into a mature biofilm, while BAI-treatment is virtually impossible through surface-...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Da-Yuan Wang Linzhu Su Kees Poelstra David W Grainger Henny C van der Mei Linqi Shi Henk J Busscher Source Type: research
Beyond surface modification strategies to control infections associated with implanted biomaterials and devices - Addressing the opportunities offered by nanotechnology
Biomaterials. 2024 Apr 16;308:122576. doi: 10.1016/j.biomaterials.2024.122576. Online ahead of print.ABSTRACTBiomaterial-associated infection (BAI) is considered a unique infection due to the presence of a biomaterial yielding frustrated immune-cells, ineffective in clearing local micro-organisms. The involvement of surface-adherent/surface-adapted micro-organisms in BAI, logically points to biomaterial surface-modifications for BAI-control. Biomaterial surface-modification is most suitable for prevention before adhering bacteria have grown into a mature biofilm, while BAI-treatment is virtually impossible through surface-...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Da-Yuan Wang Linzhu Su Kees Poelstra David W Grainger Henny C van der Mei Linqi Shi Henk J Busscher Source Type: research
Severe cellulitis from methicillin-resistant Staphylococcus aureus (MRSA) in a couple of preterm twins: a case report
Preterms are at risk of systemic infections as the barrier function of their immature skin is insufficient. The long period of hospitalization and the huge number of invasive procedures represent a risk factor... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - April 19, 2024 Category: Pediatrics Authors: Noemi Zampatti, Irene Bonato, Andrea Calandrino, Carolina Saffioti, Alessandro Parodi, Giorgia Brigati, Diego Minghetti and Luca Antonio Ramenghi Tags: Case report Source Type: research
Severe cellulitis from methicillin-resistant Staphylococcus aureus (MRSA) in a couple of preterm twins: a case report
ConclusionsDue to the characteristic antibiotic resistance of MRSA and the potential complications of those infections in such delicate patients, basic prevention measures still represent the key to avoid the spreading of neonatal MRSA infections in NICUs, which include hand hygiene and strict precautions, as well as screening of patients for MRSA on admission and during hospital stay, routine prophylactic topical antibiotic of patients, enhanced environmental cleaning, cohorting and isolation of positive patients, barrier precautions, avoidance of ward crowding, and, in some units, surveillance, education and decolonizati...
Source: Italian Journal of Pediatrics - April 19, 2024 Category: Pediatrics Source Type: research
Significance of colonization by antibiotic-resistant organisms prior to congenital heart disease surgery in children from low- to middle-income countries sent by non-governmental organizations to Switzerland
ConclusionPrevalence of AMROs carriage is high in children from LMIC and has a limited impact on patients ’ outcome. However, ARMOs carriage leads to higher consumption of antibiotics. Screening may help saving use of broad-spectrum antibiotic in non-carrier patients. (Source: Infection)
Source: Infection - April 18, 2024 Category: Infectious Diseases Source Type: research
Correlation between the development of phage resistance and the original antibiotic resistance of host bacteria under the co-exposure of antibiotic and bacteriophage
This study explores phage resistance development in hosts with different antibiotic resistance and helps to understand the limitations and possible solutions of phage-based technologies.PMID:38631474 | DOI:10.1016/j.envres.2024.118921 (Source: Environmental Research)
Source: Environmental Research - April 17, 2024 Category: Environmental Health Authors: Lingli Li Mengya Zhou Ming Yu Xu Ren Linzhi Li Chunjun Shen Chunping Deng Yucheng Liu Bing Yang Source Type: research
Tragacanth gum-based copper oxide nanoparticles: Comprehensive characterization, antibiofilm, antimicrobial and photocatalytic potentials
In conclusion, the findings underline the promising multifunctional properties of TG-based CuO NPs for different practical applications.PMID:38631575 | DOI:10.1016/j.ijbiomac.2024.131600 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 17, 2024 Category: Biochemistry Authors: Sumayyah Ihsan Hira Munir Zihui Meng Muhammad Tayyab Nadia Zeeshan Ajwa Rehman Sawaira Nadeem Muhammad Irfan Source Type: research
Correlation between the development of phage resistance and the original antibiotic resistance of host bacteria under the co-exposure of antibiotic and bacteriophage
This study explores phage resistance development in hosts with different antibiotic resistance and helps to understand the limitations and possible solutions of phage-based technologies.PMID:38631474 | DOI:10.1016/j.envres.2024.118921 (Source: Environmental Research)
Source: Environmental Research - April 17, 2024 Category: Environmental Health Authors: Lingli Li Mengya Zhou Ming Yu Xu Ren Linzhi Li Chunjun Shen Chunping Deng Yucheng Liu Bing Yang Source Type: research
Biofilm Growth on Orthopaedic Cerclage Materials: Non-metallic Polymers Are Less Resistant to Methicillin-Resistant Staphylococcus Aureus Bacterial Adhesion
Data on bacterial adhesion to cerclage cables is sparse. We aimed to compare five cerclage products for methicillin-resistant Staphylococcus aureus (MRSA) adhesion to determine: Are non-metallic polymer cables more resistant to bacterial adhesion than common metallic wires and cables? (Source: The Journal of Arthroplasty)
Source: The Journal of Arthroplasty - April 17, 2024 Category: Orthopaedics Authors: Kyle H. Cichos, Matthew C. Christie, Brent A. Ponce, Elie S. Ghanem Tags: 2023 AAHKS Proceedings Source Type: research
Methicillin-Resistant < em > Staphylococcus aureus < /em > Carriage among Neonate Mothers, Healthcare Workers, and Environmental Samples in Neonatal Intensive Care Units: A Systematic Review
CONCLUSION: With a significant heterogeneity, our systematic review found high MRSA carriage rates in neonate mothers, healthcare workers, and across various environmental surfaces in NICUs, posing a potential risk of nosocomial infections. Urgent interventions, including regular screening and decolonization of MRSA carriers, reinforcing infection control measures, and enhancing cleaning and disinfection procedures within NICUs, are crucial. This trial is registered with CRD42023407114.PMID:38623471 | PMC:PMC11018372 | DOI:10.1155/2024/5675786 (Source: Biomed Res)
Source: Biomed Res - April 16, 2024 Category: Research Authors: Nene Kaah Keneh Sebastien Kenmoe Arnol Bowo-Ngandji Jane-Francis Tatah Kihla Akoachere Hortense Gonsu Kamga Roland Ndip Ndip Jean Thierry Ebogo-Belobo Cyprien Kengne-Nd é Donatien Serge Mbaga Nicholas Tendongfor Jean Paul Assam Assam Lucy Mande Ndip Sera Source Type: research
Methicillin-Resistant < em > Staphylococcus aureus < /em > Carriage among Neonate Mothers, Healthcare Workers, and Environmental Samples in Neonatal Intensive Care Units: A Systematic Review
CONCLUSION: With a significant heterogeneity, our systematic review found high MRSA carriage rates in neonate mothers, healthcare workers, and across various environmental surfaces in NICUs, posing a potential risk of nosocomial infections. Urgent interventions, including regular screening and decolonization of MRSA carriers, reinforcing infection control measures, and enhancing cleaning and disinfection procedures within NICUs, are crucial. This trial is registered with CRD42023407114.PMID:38623471 | PMC:PMC11018372 | DOI:10.1155/2024/5675786 (Source: Biomed Res)
Source: Biomed Res - April 16, 2024 Category: Research Authors: Nene Kaah Keneh Sebastien Kenmoe Arnol Bowo-Ngandji Jane-Francis Tatah Kihla Akoachere Hortense Gonsu Kamga Roland Ndip Ndip Jean Thierry Ebogo-Belobo Cyprien Kengne-Nd é Donatien Serge Mbaga Nicholas Tendongfor Jean Paul Assam Assam Lucy Mande Ndip Sera Source Type: research
Prevalence and genetic characteristics of Staphylococcus aureus isolates from cell phones of medical students from Iran
Acta Microbiol Immunol Hung. 2024 Apr 15. doi: 10.1556/030.2024.02193. Online ahead of print.ABSTRACTAlthough mobile phones as a rapid communication vehicle can lead to improved quality of healthcare, they can also facilitate the transmission of pathogens to patients. This current research focuses on genetic diversity, and genes involved in resistance and biofilm production of Staphylococcus aureus isolates from mobile phones of medical students. Antibiotic resistance profiling and polymerase chain reaction (PCR) amplification of antibiotic resistance and biofilm-related genes were investigated and statistically analyzed. ...
Source: Acta Microbiologica et Immunologica Hungarica - April 15, 2024 Category: Microbiology Authors: Fatemeh Behrouzmanesh Sahar Ahmad Samali Rozhin Nasehi Ali Shivaee Mehdi Goudarzi Source Type: research
