Relapsing bronchopneumonia due to community-associated methicillin-resistant Staphylococcus aureus: a case report
The emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has increased the incidence of community-onset MRSA infection. Respiratory tract infections caused by MRSA has been note... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 4, 2024 Category: Infectious Diseases Authors: Sho Shimada, Tetsuo Yamaguchi, Satsuki Mikoshiba, Kazuaki Sato, Takahiro Mitsumura, Kohji Komori, Takashi Yamana, Yuki Iijima, Rie Sakakibara, Sho Shibata, Takayuki Honda, Tsuyoshi Shirai, Tsukasa Okamoto, Haruhiko Furusawa, Tomoya Tateishi and Yasunari M Tags: Case Report Source Type: research
CXCR2 perturbation promotes < em > Staphylococcus aureus < /em > implant-associated infection
Conclusion. Our results demonstrate that CXCR2 plays an essential role in regulating the severity of S. aureus implant-associated infections. Interestingly, however, perturbation of CXCR2 expression or signalling both resulted in enhanced Cxcr2 transcription and elevated implant-associated bacterial burdens. Thus, CXCR2 appears finely tuned to efficiently recruit effector cells and mediate control of S. aureus biofilm-mediated infection.PMID:38567642 | DOI:10.1099/jmm.0.001821 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 3, 2024 Category: Microbiology Authors: Mike Akaraphanth Tara M Nordgren Casey M Gries Source Type: research
Nano-CeO < sub > 2 < /sub > activates physical and chemical defenses of garlic (Allium sativum L.) for reducing antibiotic resistance genes in plant endosphere
Ecotoxicol Environ Saf. 2024 Apr 2:116289. doi: 10.1016/j.ecoenv.2024.116289. Online ahead of print.ABSTRACTThe transmission of manure- and wastewater-borne antibiotic-resistant bacteria (ARB) to plants contributes to the proliferation of antimicrobial resistance in agriculture, necessitating effective strategies for preventing the spread of antibiotic resistance genes (ARGs) from ARB in the environment to humans. Nanomaterials are potential candidates for efficiently controlling the dissemination of ARGs. The present study investigated the abundance of ARGs in hydroponically grown garlic (Allium sativum L.) following nano...
Source: Ecotoxicology and Environmental Safety - April 3, 2024 Category: Environmental Health Authors: Yinuo Xu Mengna Tao Wei Xu Lanqing Xu Le Yue Xuesong Cao Feiran Chen Zhenyu Wang Source Type: research
Poly-l-lysine modified MOF nanoparticles with pH/ROS sensitive CIP release and CUR triggered photodynamic therapy against drug-resistant bacterial infection
Int J Biol Macromol. 2024 Apr 1:131330. doi: 10.1016/j.ijbiomac.2024.131330. Online ahead of print.ABSTRACTThe challenge of drug resistance in bacteria caused by the over use of biotics is increasing during the therapy process, which has attracted great attentions of the clinicians and scientists around the world. Recently, photodynamic therapy (PDT) triggered by photosensitizer (PS) has become a promising treatment method because of its high efficacy, easy operation, and low side effect. Herein, the poly-l-lysine (PLL) modified metal-organic framework (MOF) nanoparticles, ZIF/PLL-CIP/CUR, were synthesized to allow both re...
Source: International Journal of Biological Macromolecules - April 3, 2024 Category: Biochemistry Authors: Ya-Li Xiang De-Yu Tang Ling-Ling Yan Luo-Lin Deng Xing-Han Wang Xin-Yang Liu Qing-Han Zhou Source Type: research
Characterization of < em > Acinetobacter baumannii-calcoaceticus < /em > complex isolates and microbiological outcome for patients treated with sulbactam-durlobactam in a phase 3 trial (ATTACK)
This report describes the characterization of the baseline ABC isolates from patients enrolled in ATTACK, including an analysis of the correlation of microbiological outcomes with SUL-DUR MIC values and the molecular drivers of SUL-DUR resistance.PMID:38567976 | DOI:10.1128/aac.01698-23 (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - April 3, 2024 Category: Microbiology Authors: Alita A Miller Samir H Moussa Sarah M McLeod Source Type: research
Virulence-associated factors as targets for phage infection
Curr Opin Microbiol. 2024 Apr 2;79:102471. doi: 10.1016/j.mib.2024.102471. Online ahead of print.ABSTRACTBacterial pathogens can infect a wide range of hosts and pose a threat to public and animal health as well as to agriculture. The emergence of antibiotic-resistant strains has increased this risk by making the treatment of bacterial infections even more challenging. Pathogenic bacteria thrive in various ecological niches, but they can also be specifically targeted and killed by bacteriophages (phages). Lytic phages are now investigated and even used, in some cases, as alternatives or complements to antibiotics for preve...
Source: Current Opinion in Microbiology - April 3, 2024 Category: Microbiology Authors: Alessandra G de Melo Carlee Morency Sylvain Moineau Source Type: research
CXCR2 perturbation promotes < em > Staphylococcus aureus < /em > implant-associated infection
Conclusion. Our results demonstrate that CXCR2 plays an essential role in regulating the severity of S. aureus implant-associated infections. Interestingly, however, perturbation of CXCR2 expression or signalling both resulted in enhanced Cxcr2 transcription and elevated implant-associated bacterial burdens. Thus, CXCR2 appears finely tuned to efficiently recruit effector cells and mediate control of S. aureus biofilm-mediated infection.PMID:38567642 | DOI:10.1099/jmm.0.001821 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 3, 2024 Category: Microbiology Authors: Mike Akaraphanth Tara M Nordgren Casey M Gries Source Type: research
Nano-CeO < sub > 2 < /sub > activates physical and chemical defenses of garlic (Allium sativum L.) for reducing antibiotic resistance genes in plant endosphere
Ecotoxicol Environ Saf. 2024 Apr 2:116289. doi: 10.1016/j.ecoenv.2024.116289. Online ahead of print.ABSTRACTThe transmission of manure- and wastewater-borne antibiotic-resistant bacteria (ARB) to plants contributes to the proliferation of antimicrobial resistance in agriculture, necessitating effective strategies for preventing the spread of antibiotic resistance genes (ARGs) from ARB in the environment to humans. Nanomaterials are potential candidates for efficiently controlling the dissemination of ARGs. The present study investigated the abundance of ARGs in hydroponically grown garlic (Allium sativum L.) following nano...
Source: Ecotoxicology and Environmental Safety - April 3, 2024 Category: Environmental Health Authors: Yinuo Xu Mengna Tao Wei Xu Lanqing Xu Le Yue Xuesong Cao Feiran Chen Zhenyu Wang Source Type: research
Virulence-associated factors as targets for phage infection
Curr Opin Microbiol. 2024 Apr 2;79:102471. doi: 10.1016/j.mib.2024.102471. Online ahead of print.ABSTRACTBacterial pathogens can infect a wide range of hosts and pose a threat to public and animal health as well as to agriculture. The emergence of antibiotic-resistant strains has increased this risk by making the treatment of bacterial infections even more challenging. Pathogenic bacteria thrive in various ecological niches, but they can also be specifically targeted and killed by bacteriophages (phages). Lytic phages are now investigated and even used, in some cases, as alternatives or complements to antibiotics for preve...
Source: Current Opinion in Microbiology - April 3, 2024 Category: Microbiology Authors: Alessandra G de Melo Carlee Morency Sylvain Moineau Source Type: research
CXCR2 perturbation promotes < em > Staphylococcus aureus < /em > implant-associated infection
Conclusion. Our results demonstrate that CXCR2 plays an essential role in regulating the severity of S. aureus implant-associated infections. Interestingly, however, perturbation of CXCR2 expression or signalling both resulted in enhanced Cxcr2 transcription and elevated implant-associated bacterial burdens. Thus, CXCR2 appears finely tuned to efficiently recruit effector cells and mediate control of S. aureus biofilm-mediated infection.PMID:38567642 | DOI:10.1099/jmm.0.001821 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 3, 2024 Category: Microbiology Authors: Mike Akaraphanth Tara M Nordgren Casey M Gries Source Type: research
CXCR2 perturbation promotes < em > Staphylococcus aureus < /em > implant-associated infection
Conclusion. Our results demonstrate that CXCR2 plays an essential role in regulating the severity of S. aureus implant-associated infections. Interestingly, however, perturbation of CXCR2 expression or signalling both resulted in enhanced Cxcr2 transcription and elevated implant-associated bacterial burdens. Thus, CXCR2 appears finely tuned to efficiently recruit effector cells and mediate control of S. aureus biofilm-mediated infection.PMID:38567642 | DOI:10.1099/jmm.0.001821 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 3, 2024 Category: Microbiology Authors: Mike Akaraphanth Tara M Nordgren Casey M Gries Source Type: research
CXCR2 perturbation promotes < em > Staphylococcus aureus < /em > implant-associated infection
Conclusion. Our results demonstrate that CXCR2 plays an essential role in regulating the severity of S. aureus implant-associated infections. Interestingly, however, perturbation of CXCR2 expression or signalling both resulted in enhanced Cxcr2 transcription and elevated implant-associated bacterial burdens. Thus, CXCR2 appears finely tuned to efficiently recruit effector cells and mediate control of S. aureus biofilm-mediated infection.PMID:38567642 | DOI:10.1099/jmm.0.001821 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 3, 2024 Category: Microbiology Authors: Mike Akaraphanth Tara M Nordgren Casey M Gries Source Type: research
CXCR2 perturbation promotes < em > Staphylococcus aureus < /em > implant-associated infection
Conclusion. Our results demonstrate that CXCR2 plays an essential role in regulating the severity of S. aureus implant-associated infections. Interestingly, however, perturbation of CXCR2 expression or signalling both resulted in enhanced Cxcr2 transcription and elevated implant-associated bacterial burdens. Thus, CXCR2 appears finely tuned to efficiently recruit effector cells and mediate control of S. aureus biofilm-mediated infection.PMID:38567642 | DOI:10.1099/jmm.0.001821 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 3, 2024 Category: Microbiology Authors: Mike Akaraphanth Tara M Nordgren Casey M Gries Source Type: research
Molecules, Vol. 29, Pages 1607: UV-Triggered Drug Release from Mesoporous Titanium Nanoparticles Loaded with Berberine Hydrochloride: Enhanced Antibacterial Activity
ilong Qiu
Mesoporous titanium nanoparticles (MTN) have always been a concern and are considered to have great potential for overcoming antibiotic-resistant bacteria. In our study, MTN modified with functionalized UV-responsive ethylene imine polymer (PEI) was synthesized. The characterization of all products was performed by different analyses, including SEM, TEM, FT-IR, TGA, XRD, XPS, and N2 adsorption-desorption isotherms. The typical antibacterial drug berberine hydrochloride (BH) was encapsulated in MTN-PEI. The process exhibited a high drug loading capacity (22.71 &plusmn; 1.12%) and encapsulation rate (46...
Source: Molecules - April 3, 2024 Category: Chemistry Authors: Fanjiao Zuo Boyao Wang Lizhi Wang Jun He Xilong Qiu Tags: Article Source Type: research
Oxidized glutathione reverts carbapenem resistance in bla < sub > NDM-1 < /sub > -carrying Escherichia coli
This study establishes a metabolomics-based strategy to potentiate metabolism-dependent antibiotic efficacy for the treatment of antibiotic-resistant bacteria.PMID:38565805 | DOI:10.1038/s44321-024-00061-x (Source: Molecular Medicine)
Source: Molecular Medicine - April 2, 2024 Category: Molecular Biology Authors: Dongyang Ye Xiaowei Li Liang Zhao Saiwa Liu Xixi Jia Zhinan Wang Jingjing Du Lirui Ge Jianzhong Shen Xi Xia Source Type: research
