Overcoming antibiotic resistance caused by genetic mutations of Helicobacter pylori with mucin adhesive polymer-based therapeutics
Biomaterials. 2024 Mar 25;308:122541. doi: 10.1016/j.biomaterials.2024.122541. Online ahead of print.ABSTRACTHerein, we describe the 3'-sialyllactose-polyethyleneimine-chlorine e6 conjugate (3PC), meticulously engineered to effectively target Helicobacter bacteria (H. pylori) within the gastric environment. The composition of 3PC comprises polyethyleneimine, a cationic polymer, 3'-sialyllactose, which exhibits a specific binding affinity for H. pylori surface proteins, and a photosensitizer capable of generating oxygen radicals in response to specific wavelengths. The distinctive feature of 3PC lies in its capacity to enha...
Source: Biomaterials - March 28, 2024 Category: Materials Science Authors: Byoungjun Lim Kyoung Sub Kim Ji Yong Ahn Kun Na Source Type: research
Fully Characterized Effective Bacteriophages Specific against Antibiotic-Resistant < em > Enterococcus faecalis < /em > , the Causative Agent of Dental Abscess
Conclusions: The findings highlight the promise of phage therapy in dental medicine, offering a novel approach to combating antibiotic resistance and enhancing patient outcomes. Further research and clinical trials will be essential to fully understand the therapeutic potential and safety profile of these bacteriophages in human populations.PMID:38541227 | PMC:PMC10972216 | DOI:10.3390/medicina60030501 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Asmaa Ramadan Mohamed O Abdel-Monem Noha K El-Dougdoug Alsayed E Mekky Shymaa A Elaskary Abdulaziz A Al-Askar Shimaa A Metwally Ahmed F El-Sayed Gehad AbdElgayed Ebrahim Saied Mohamed Khedr Source Type: research
Allosteric Probe-Based Colorimetric Assay for Direct Identification and Sensitive Analysis of Methicillin Resistance of < em > Staphylococcus aureus < /em >
J Microbiol Biotechnol. 2024 Mar 28;34(3):681-688. doi: 10.4014/jmb.2312.12042. Epub 2024 Feb 19.ABSTRACTThe accurate and rapid detection of methicillin-resistance of Staphylococcus aureus (SA) holds significant clinical importance. However, the methicillin-resistance detection strategies commonly require complicated cell lysis and gene extraction. Herein, we devised a novel colorimetric approach for the sensitive and accurate identification of methicillin-resistance of SA by combining allosteric probe-based target recognition with self-primer elongation-based target recycling. The PBP2a aptamer in the allosteric probe suc...
Source: Journal of Microbiology and Biotechnology - March 28, 2024 Category: Biotechnology Authors: Juan Chu Xiaoqin Zhao Source Type: research
Overcoming antibiotic resistance caused by genetic mutations of Helicobacter pylori with mucin adhesive polymer-based therapeutics
Biomaterials. 2024 Mar 25;308:122541. doi: 10.1016/j.biomaterials.2024.122541. Online ahead of print.ABSTRACTHerein, we describe the 3'-sialyllactose-polyethyleneimine-chlorine e6 conjugate (3PC), meticulously engineered to effectively target Helicobacter bacteria (H. pylori) within the gastric environment. The composition of 3PC comprises polyethyleneimine, a cationic polymer, 3'-sialyllactose, which exhibits a specific binding affinity for H. pylori surface proteins, and a photosensitizer capable of generating oxygen radicals in response to specific wavelengths. The distinctive feature of 3PC lies in its capacity to enha...
Source: Biomaterials - March 28, 2024 Category: Materials Science Authors: Byoungjun Lim Kyoung Sub Kim Ji Yong Ahn Kun Na Source Type: research
Fully Characterized Effective Bacteriophages Specific against Antibiotic-Resistant < em > Enterococcus faecalis < /em > , the Causative Agent of Dental Abscess
Conclusions: The findings highlight the promise of phage therapy in dental medicine, offering a novel approach to combating antibiotic resistance and enhancing patient outcomes. Further research and clinical trials will be essential to fully understand the therapeutic potential and safety profile of these bacteriophages in human populations.PMID:38541227 | PMC:PMC10972216 | DOI:10.3390/medicina60030501 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Asmaa Ramadan Mohamed O Abdel-Monem Noha K El-Dougdoug Alsayed E Mekky Shymaa A Elaskary Abdulaziz A Al-Askar Shimaa A Metwally Ahmed F El-Sayed Gehad AbdElgayed Ebrahim Saied Mohamed Khedr Source Type: research
Allosteric Probe-Based Colorimetric Assay for Direct Identification and Sensitive Analysis of Methicillin Resistance of < em > Staphylococcus aureus < /em >
J Microbiol Biotechnol. 2024 Mar 28;34(3):681-688. doi: 10.4014/jmb.2312.12042. Epub 2024 Feb 19.ABSTRACTThe accurate and rapid detection of methicillin-resistance of Staphylococcus aureus (SA) holds significant clinical importance. However, the methicillin-resistance detection strategies commonly require complicated cell lysis and gene extraction. Herein, we devised a novel colorimetric approach for the sensitive and accurate identification of methicillin-resistance of SA by combining allosteric probe-based target recognition with self-primer elongation-based target recycling. The PBP2a aptamer in the allosteric probe suc...
Source: Journal of Microbiology and Biotechnology - March 28, 2024 Category: Biotechnology Authors: Juan Chu Xiaoqin Zhao Source Type: research
Fully Characterized Effective Bacteriophages Specific against Antibiotic-Resistant < em > Enterococcus faecalis < /em > , the Causative Agent of Dental Abscess
Conclusions: The findings highlight the promise of phage therapy in dental medicine, offering a novel approach to combating antibiotic resistance and enhancing patient outcomes. Further research and clinical trials will be essential to fully understand the therapeutic potential and safety profile of these bacteriophages in human populations.PMID:38541227 | PMC:PMC10972216 | DOI:10.3390/medicina60030501 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Asmaa Ramadan Mohamed O Abdel-Monem Noha K El-Dougdoug Alsayed E Mekky Shymaa A Elaskary Abdulaziz A Al-Askar Shimaa A Metwally Ahmed F El-Sayed Gehad AbdElgayed Ebrahim Saied Mohamed Khedr Source Type: research
Allosteric Probe-Based Colorimetric Assay for Direct Identification and Sensitive Analysis of Methicillin Resistance of < em > Staphylococcus aureus < /em >
J Microbiol Biotechnol. 2024 Mar 28;34(3):681-688. doi: 10.4014/jmb.2312.12042. Epub 2024 Feb 19.ABSTRACTThe accurate and rapid detection of methicillin-resistance of Staphylococcus aureus (SA) holds significant clinical importance. However, the methicillin-resistance detection strategies commonly require complicated cell lysis and gene extraction. Herein, we devised a novel colorimetric approach for the sensitive and accurate identification of methicillin-resistance of SA by combining allosteric probe-based target recognition with self-primer elongation-based target recycling. The PBP2a aptamer in the allosteric probe suc...
Source: Journal of Microbiology and Biotechnology - March 28, 2024 Category: Biotechnology Authors: Juan Chu Xiaoqin Zhao Source Type: research
Fully Characterized Effective Bacteriophages Specific against Antibiotic-Resistant < em > Enterococcus faecalis < /em > , the Causative Agent of Dental Abscess
Conclusions: The findings highlight the promise of phage therapy in dental medicine, offering a novel approach to combating antibiotic resistance and enhancing patient outcomes. Further research and clinical trials will be essential to fully understand the therapeutic potential and safety profile of these bacteriophages in human populations.PMID:38541227 | PMC:PMC10972216 | DOI:10.3390/medicina60030501 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Asmaa Ramadan Mohamed O Abdel-Monem Noha K El-Dougdoug Alsayed E Mekky Shymaa A Elaskary Abdulaziz A Al-Askar Shimaa A Metwally Ahmed F El-Sayed Gehad AbdElgayed Ebrahim Saied Mohamed Khedr Source Type: research
Fully Characterized Effective Bacteriophages Specific against Antibiotic-Resistant < em > Enterococcus faecalis < /em > , the Causative Agent of Dental Abscess
Conclusions: The findings highlight the promise of phage therapy in dental medicine, offering a novel approach to combating antibiotic resistance and enhancing patient outcomes. Further research and clinical trials will be essential to fully understand the therapeutic potential and safety profile of these bacteriophages in human populations.PMID:38541227 | PMC:PMC10972216 | DOI:10.3390/medicina60030501 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Asmaa Ramadan Mohamed O Abdel-Monem Noha K El-Dougdoug Alsayed E Mekky Shymaa A Elaskary Abdulaziz A Al-Askar Shimaa A Metwally Ahmed F El-Sayed Gehad AbdElgayed Ebrahim Saied Mohamed Khedr Source Type: research
Fully Characterized Effective Bacteriophages Specific against Antibiotic-Resistant < em > Enterococcus faecalis < /em > , the Causative Agent of Dental Abscess
Conclusions: The findings highlight the promise of phage therapy in dental medicine, offering a novel approach to combating antibiotic resistance and enhancing patient outcomes. Further research and clinical trials will be essential to fully understand the therapeutic potential and safety profile of these bacteriophages in human populations.PMID:38541227 | PMC:PMC10972216 | DOI:10.3390/medicina60030501 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Asmaa Ramadan Mohamed O Abdel-Monem Noha K El-Dougdoug Alsayed E Mekky Shymaa A Elaskary Abdulaziz A Al-Askar Shimaa A Metwally Ahmed F El-Sayed Gehad AbdElgayed Ebrahim Saied Mohamed Khedr Source Type: research
Fully Characterized Effective Bacteriophages Specific against Antibiotic-Resistant < em > Enterococcus faecalis < /em > , the Causative Agent of Dental Abscess
Conclusions: The findings highlight the promise of phage therapy in dental medicine, offering a novel approach to combating antibiotic resistance and enhancing patient outcomes. Further research and clinical trials will be essential to fully understand the therapeutic potential and safety profile of these bacteriophages in human populations.PMID:38541227 | PMC:PMC10972216 | DOI:10.3390/medicina60030501 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Asmaa Ramadan Mohamed O Abdel-Monem Noha K El-Dougdoug Alsayed E Mekky Shymaa A Elaskary Abdulaziz A Al-Askar Shimaa A Metwally Ahmed F El-Sayed Gehad AbdElgayed Ebrahim Saied Mohamed Khedr Source Type: research
Fully Characterized Effective Bacteriophages Specific against Antibiotic-Resistant < em > Enterococcus faecalis < /em > , the Causative Agent of Dental Abscess
Conclusions: The findings highlight the promise of phage therapy in dental medicine, offering a novel approach to combating antibiotic resistance and enhancing patient outcomes. Further research and clinical trials will be essential to fully understand the therapeutic potential and safety profile of these bacteriophages in human populations.PMID:38541227 | PMC:PMC10972216 | DOI:10.3390/medicina60030501 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Asmaa Ramadan Mohamed O Abdel-Monem Noha K El-Dougdoug Alsayed E Mekky Shymaa A Elaskary Abdulaziz A Al-Askar Shimaa A Metwally Ahmed F El-Sayed Gehad AbdElgayed Ebrahim Saied Mohamed Khedr Source Type: research
Fully Characterized Effective Bacteriophages Specific against Antibiotic-Resistant < em > Enterococcus faecalis < /em > , the Causative Agent of Dental Abscess
Conclusions: The findings highlight the promise of phage therapy in dental medicine, offering a novel approach to combating antibiotic resistance and enhancing patient outcomes. Further research and clinical trials will be essential to fully understand the therapeutic potential and safety profile of these bacteriophages in human populations.PMID:38541227 | PMC:PMC10972216 | DOI:10.3390/medicina60030501 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Asmaa Ramadan Mohamed O Abdel-Monem Noha K El-Dougdoug Alsayed E Mekky Shymaa A Elaskary Abdulaziz A Al-Askar Shimaa A Metwally Ahmed F El-Sayed Gehad AbdElgayed Ebrahim Saied Mohamed Khedr Source Type: research
Fully Characterized Effective Bacteriophages Specific against Antibiotic-Resistant < em > Enterococcus faecalis < /em > , the Causative Agent of Dental Abscess
Conclusions: The findings highlight the promise of phage therapy in dental medicine, offering a novel approach to combating antibiotic resistance and enhancing patient outcomes. Further research and clinical trials will be essential to fully understand the therapeutic potential and safety profile of these bacteriophages in human populations.PMID:38541227 | PMC:PMC10972216 | DOI:10.3390/medicina60030501 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Asmaa Ramadan Mohamed O Abdel-Monem Noha K El-Dougdoug Alsayed E Mekky Shymaa A Elaskary Abdulaziz A Al-Askar Shimaa A Metwally Ahmed F El-Sayed Gehad AbdElgayed Ebrahim Saied Mohamed Khedr Source Type: research
