Ligand-Free Silver Nanoparticles: An Innovative Strategy against Viruses and Bacteria
Microorganisms. 2024 Apr 18;12(4):820. doi: 10.3390/microorganisms12040820.ABSTRACTThe spread of antibiotic-resistant bacteria and the rise of emerging and re-emerging viruses in recent years constitute significant public health problems. Therefore, it is necessary to develop new antimicrobial strategies to overcome these challenges. Herein, we describe an innovative method to synthesize ligand-free silver nanoparticles by Pulsed Laser Ablation in Liquid (PLAL-AgNPs). Thus produced, nanoparticles were characterized by total X-ray fluorescence, zeta potential analysis, transmission electron microscopy (TEM), and nanoparticl...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Maria Vittoria Morone Annalisa Chianese Federica Dell'Annunziata Veronica Folliero Erwin Pavel Lamparelli Giovanna Della Porta Carla Zannella Anna De Filippis Gianluigi Franci Massimiliano Galdiero Antonio Morone Source Type: research
Investigation of the Antibacterial Synergistic Activity of Fosfomycin-Teicoplanin Combination in Methicillin-Resistant Staphylococcus aureus Strains Isolated from Various Clinical Sample
Mikrobiyol Bul. 2024 Apr;58(2):113-124. doi: 10.5578/mb.202498156.ABSTRACTThe aim of this study was to investigate the detection of teicoplanin and fosfomycin antibiotic susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) strains by different methods and to evaluate the antibacterial synergistic effect of teicoplanin-fosfomycin combination by using checkerboard assay and time kill curve assay. Forty-five MRSA strains isolated from clinical samples in routine medical microbiology laboratory of Göztepe Prof. Dr. Süleyman Yalçın City Hospital were included in the study. In the first stage of the combinati...
Source: Mikrobiyoloji Bulteni - April 27, 2024 Category: Microbiology Authors: R ümeysa Tuba Biçer Tuncer Özekinci M ücahide Esra Koçoğlu Source Type: research
OriPlex: Origami-enabled multiplexed detection of respiratory pathogens
Biosens Bioelectron. 2024 Apr 25;257:116341. doi: 10.1016/j.bios.2024.116341. Online ahead of print.ABSTRACTOrigami biosensors leverage paper foldability to develop total analysis systems integrated in a single piece of paper. This capability can also be utilized to incorporate additional features that would be difficult to achieve with rigid substrates. In this article, we report a new design for 3D origami biosensors called OriPlex, which leverages the foldability of filter paper for the multiplexed detection of bacterial pathogens. OriPlex immunosensors detect pathogens by folding nanoparticle reservoirs containing diff...
Source: Biosensors and Bioelectronics - April 27, 2024 Category: Biotechnology Authors: Andreu Vaquer Cristina Adrover-Jaume Antonio Clemente Julia Viana Roc ío Rodríguez Estrella Rojo-Molinero Antonio Oliver Roberto de la Rica Source Type: research
Ligand-Free Silver Nanoparticles: An Innovative Strategy against Viruses and Bacteria
Microorganisms. 2024 Apr 18;12(4):820. doi: 10.3390/microorganisms12040820.ABSTRACTThe spread of antibiotic-resistant bacteria and the rise of emerging and re-emerging viruses in recent years constitute significant public health problems. Therefore, it is necessary to develop new antimicrobial strategies to overcome these challenges. Herein, we describe an innovative method to synthesize ligand-free silver nanoparticles by Pulsed Laser Ablation in Liquid (PLAL-AgNPs). Thus produced, nanoparticles were characterized by total X-ray fluorescence, zeta potential analysis, transmission electron microscopy (TEM), and nanoparticl...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Maria Vittoria Morone Annalisa Chianese Federica Dell'Annunziata Veronica Folliero Erwin Pavel Lamparelli Giovanna Della Porta Carla Zannella Anna De Filippis Gianluigi Franci Massimiliano Galdiero Antonio Morone Source Type: research
Investigation of the Antibacterial Synergistic Activity of Fosfomycin-Teicoplanin Combination in Methicillin-Resistant Staphylococcus aureus Strains Isolated from Various Clinical Sample
Mikrobiyol Bul. 2024 Apr;58(2):113-124. doi: 10.5578/mb.202498156.ABSTRACTThe aim of this study was to investigate the detection of teicoplanin and fosfomycin antibiotic susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) strains by different methods and to evaluate the antibacterial synergistic effect of teicoplanin-fosfomycin combination by using checkerboard assay and time kill curve assay. Forty-five MRSA strains isolated from clinical samples in routine medical microbiology laboratory of Göztepe Prof. Dr. Süleyman Yalçın City Hospital were included in the study. In the first stage of the combinati...
Source: Mikrobiyoloji Bulteni - April 27, 2024 Category: Microbiology Authors: R ümeysa Tuba Biçer Tuncer Özekinci M ücahide Esra Koçoğlu Source Type: research
Synthesis of a tetralone derivative of ampicillin to control ampicillin-resistant Staphylococcusaureus
Biochem Biophys Res Commun. 2024 Apr 20;714:149974. doi: 10.1016/j.bbrc.2024.149974. Online ahead of print.ABSTRACTDue to the rapid emergence of antibiotic resistant new bacterial strains and new infections, there is an urgent need for novel or newly modified and efficient alternatives of treatment. However, conventional antibiotics are still used in therapeutic settings but their efficacy is uncertain due to the rapid evolution of drug resistance. In the present study, we have synthesized a new derivative of conventional antibiotic ampicillin using SN2-type substitution reaction. NMR and mass analysis of the newly synthes...
Source: Biochemical and Biophysical Research communications - April 25, 2024 Category: Biochemistry Authors: Sourav Chakraborty Piyush Baindara Suresh K Mondal Dinata Roy Santi M Mandal Source Type: research
A dual-channel electrochemical biosensor enables concurrent detection of pathogens and antibiotic resistance
Biosens Bioelectron. 2024 Apr 20;257:116314. doi: 10.1016/j.bios.2024.116314. Online ahead of print.ABSTRACTDiarrheagenic E. coli infections, commonly treated with β-lactam antibiotics, contribute to antibiotic resistance - a pressing public health concern. Rapid monitoring of pathogen antibiotic resistance is vital to combat antimicrobial spread. Current bacterial diagnosis methods identify pathogens or determine antibiotic resistance separately, necessitating multiple assays. There is an urgent need for tools that simultaneously identify infectious agents and their antibiotic resistance at the point of care (POC). We de...
Source: Biosensors and Bioelectronics - April 25, 2024 Category: Biotechnology Authors: Dharanivasan Gunasekaran Irina Rostovsky David Taussig Talya Bar-Am Yariv Wine Neta Sal-Man Sefi Vernick Source Type: research
Broad-Spectrum Activity of Membranolytic Cationic Macrocyclic Peptides Against Multi-Drug Resistant Bacteria and Fungi
Eur J Pharm Sci. 2024 Apr 23:106776. doi: 10.1016/j.ejps.2024.106776. Online ahead of print.ABSTRACTThe emergence of multidrug-resistant (MDR) strains causes severe problems in the treatment of microbial infections owing to limited treatment options. Antimicrobial peptides (AMPs) are drawing considerable attention as promising antibiotic alternative candidates to combat MDR bacterial and fungal infections. Herein, we present a series of small amphiphilic membrane-active cyclic peptides composed, in part, of various nongenetically encoded hydrophilic and hydrophobic amino acids. Notably, lead cyclic peptides 3b and 4b showe...
Source: European Journal of Pharmaceutical Sciences - April 25, 2024 Category: Drugs & Pharmacology Authors: Sandeep Lohan Anastasia G Konshina Rakesh K Tiwari Roman G Efremov Innokentiy Maslennikov Keykavous Parang Source Type: research
Synthesis of a tetralone derivative of ampicillin to control ampicillin-resistant Staphylococcusaureus
Biochem Biophys Res Commun. 2024 Apr 20;714:149974. doi: 10.1016/j.bbrc.2024.149974. Online ahead of print.ABSTRACTDue to the rapid emergence of antibiotic resistant new bacterial strains and new infections, there is an urgent need for novel or newly modified and efficient alternatives of treatment. However, conventional antibiotics are still used in therapeutic settings but their efficacy is uncertain due to the rapid evolution of drug resistance. In the present study, we have synthesized a new derivative of conventional antibiotic ampicillin using SN2-type substitution reaction. NMR and mass analysis of the newly synthes...
Source: Biochemical and Biophysical Research communications - April 25, 2024 Category: Biochemistry Authors: Sourav Chakraborty Piyush Baindara Suresh K Mondal Dinata Roy Santi M Mandal Source Type: research
