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CXCR2 perturbation promotes Staphylococcus aureus implant-associated infection
Conclusion. Our results demonstrate that CXCR2 plays an essential role in regulating the severity of S. aureus implant-associated infections. Interestingly, however, perturbation of CXCR2 expression or signalling both resulted in enhanced Cxcr2 transcription and elevated implant-associated bacterial burdens. Thus, CXCR2 appears finely tuned to efficiently recruit effector cells and mediate control of S. aureus biofilm-mediated infection.PMID:38567642 | DOI:10.1099/jmm.0.001821 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 3, 2024 Category: Microbiology Authors: Mike Akaraphanth Tara M Nordgren Casey M Gries Source Type: research

Molecules, Vol. 29, Pages 1607: UV-Triggered Drug Release from Mesoporous Titanium Nanoparticles Loaded with Berberine Hydrochloride: Enhanced Antibacterial Activity
ilong Qiu Mesoporous titanium nanoparticles (MTN) have always been a concern and are considered to have great potential for overcoming antibiotic-resistant bacteria. In our study, MTN modified with functionalized UV-responsive ethylene imine polymer (PEI) was synthesized. The characterization of all products was performed by different analyses, including SEM, TEM, FT-IR, TGA, XRD, XPS, and N2 adsorption-desorption isotherms. The typical antibacterial drug berberine hydrochloride (BH) was encapsulated in MTN-PEI. The process exhibited a high drug loading capacity (22.71 &plusmn; 1.12%) and encapsulation rate (46...
Source: Molecules - April 3, 2024 Category: Chemistry Authors: Fanjiao Zuo Boyao Wang Lizhi Wang Jun He Xilong Qiu Tags: Article Source Type: research

Oxidized glutathione reverts carbapenem resistance in bla NDM-1 -carrying Escherichia coli
This study establishes a metabolomics-based strategy to potentiate metabolism-dependent antibiotic efficacy for the treatment of antibiotic-resistant bacteria.PMID:38565805 | DOI:10.1038/s44321-024-00061-x (Source: Molecular Medicine)
Source: Molecular Medicine - April 2, 2024 Category: Molecular Biology Authors: Dongyang Ye Xiaowei Li Liang Zhao Saiwa Liu Xixi Jia Zhinan Wang Jingjing Du Lirui Ge Jianzhong Shen Xi Xia Source Type: research

Evaluation of the Effect of Lactobacillus acidophilus ATCC 4356 Bacteriocin against Staphylococcus aureus 
CONCLUSION: The growth inhibition of S. aureus in overlay soft agar method may be due to the production of bacteriocin-like substances. The overlay soft agar method is a qualitative test, so there is a need for further study to optimize the conditions for the production of bacteriocin-like substances in the culture supernatant and precise comparison between the inhibitory activity and pheromone secretion of different strains.PMID:38559901 | PMC:PMC10980545 | DOI:10.1155/2024/4119960 (Source: Biomed Res)
Source: Biomed Res - April 1, 2024 Category: Research Authors: Zeinab Fagheei Aghmiyuni Horieh Saderi Parviz Owlia Navid Saidi Source Type: research

Molecules, Vol. 29, Pages 1576: Physicochemical Properties and Biological Activities of Quinoa Polysaccharides
In this study, two crude polysaccharide extracts of quinoa (Q-40 and Q-60) were obtained through sequential precipitation with 40% and 60% ethanol, with purities of 58.29% (HPLC) and 62.15% (HPLC) and a protein content of 8.27% and 9.60%, respectively. Monosaccharide analysis revealed that Q-40 contained glucose (Glc), galacturonic acid (GalA), and arabinose (Ara) in a molar ratio of 0.967:0.027:0.006. Q-60 was composed of xylose (xyl), arabinose (Ara), galactose, and galacturonic acid (GalA) with a molar ratio of 0.889:0.036:0.034:0.020. The average molecular weight of Q-40 ranged from 47,484 to 626,488 Da, while Q-60 sho...
Source: Molecules - April 1, 2024 Category: Chemistry Authors: Xucheng Zhu Guiyan Yang Yingbin Shen Liqiong Niu Yao Peng Haiting Chen Haimei Li Xinquan Yang Tags: Article Source Type: research

Automated detection of methicillin-resistant Staphylococcus aureus with the MRSA CHROM imaging application on BD Kiestra Total Lab Automation System
Journal of Clinical Microbiology, Ahead of Print. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - April 1, 2024 Category: Microbiology Authors: Erin McElvaniaSusan MindelJaap LemstraKarin BrandsParul PatelCaryn E. GoodDidier MorelCedrick OrnyJean-Marc VolleMarc DesjardinsDaniel Rhoads1Northshore University Health System, Evanston, Illinois, USA2Becton, Dickinson and Company – Integrated Diagnos Source Type: research

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future Applications
Med Sci Monit. 2024 Mar 31;30:e943168. doi: 10.12659/MSM.943168.ABSTRACTNative vertebral osteomyelitis, also termed spondylodiscitis, is an antibiotic-resistant disease that requires long-term treatment. Without proper treatment, NVO can lead to severe nerve damage or even death. Therefore, it is important to accurately diagnose the cause of NVO, especially in spontaneous cases. Infectious NVO is characterized by the involvement of 2 adjacent vertebrae and intervertebral discs, and common infectious agents include Staphylococcus aureus, Mycobacterium tuberculosis, Brucella abortus, and fungi. Clinical symptoms are generall...
Source: Medical Science Monitor - March 31, 2024 Category: Research Authors: Weijian Zhu Sirui Zhou Jinming Zhang Li Li Pin Liu Wei Xiong Source Type: research

Decrypting the multi-genome data for chimeric vaccine designing against the antibiotic resistant Yersinia pestis
In this study, vaccinomics-assisted immunoinformatics techniques were used to find possible vaccine candidates by utilizing the core proteome prepared from 58 complete genomes of Y. pestis. Human non-homologous, pathogen-essential, virulent, and extracellular and membrane proteins are potential vaccine targets. Two antigenic proteins were prioritized for the prediction of lead epitopes by utilizing reverse vaccinology approaches. Four vaccine designs were formulated using the selected B- and T-cell epitopes coupled with appropriate linkers and adjuvant sequences capable of inducing potent immune responses. The HLA allele p...
Source: International Immunopharmacology - March 31, 2024 Category: Allergy & Immunology Authors: Asifa Sarfraz Sayyada Qurrat-Ul-Ain Fatima Muhammad Shehroz Iqra Ahmad Aqal Zaman Umar Nishan Muhammad Tayyab None Sheheryar Arlindo Alencar Moura Riaz Ullah Essam A Ali Mohibullah Shah Source Type: research

Changing dynamics of antibiotic resistant Escherichia in Caspian gulls shows the importance of longitudinal environmental studies
This study is focused on Escherichia spp. isolates resistant to critically important antibiotics (cefotaxime, ciprofloxacin and colistin) among Caspian gull's (Larus cachinnans) chicks nesting in the Nove Mlyny Water Reservoir, Czech Republic. The prevalence of antimicrobial resistance (AMR) in bacteria within wild birds is commonly evaluated using a single sampling event, capturing only a brief and momentary snapshot at a particular location. Therefore, the Caspian gulls in our study were sampled in May 2018 (n = 72) and May 2019 (n = 45), and a water sample was taken from the reservoir (2019). We obtained 197 isolates id...
Source: Environment International - March 30, 2024 Category: Environmental Health Authors: Kristina Nesporova Michaela Ruzickova Hassan Tarabai Simon Krejci Martina Masarikova Jarmila Lausova Ivan Literak Monika Dolejska Source Type: research

Carbonaceous particulate matter promotes the horizontal transfer of antibiotic resistance genes
In this study, we investigated the effects of virous types... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Environ. Monit. latest articles)
Source: RSC - J. Environ. Monit. latest articles - March 29, 2024 Category: Environmental Health Authors: Xuexia Peng Source Type: research

A comparative study on antibiotic resistant Escherichia coli isolates from Austrian patients and wastewater-influenced Danube River water and biofilms
In this study, AMR patterns of Escherichia coli isolates from urinary tract infections and colonised urinary catheters of inpatients and outpatients were compared to isolates from the Danube River within the same catchment in Austria to potentially link environmental with clinical resistance patterns. Susceptibility to 20 antibiotics was tested for 697 patient, 489 water and 440 biofilm isolates. The resistance ratios in patient isolates were significantly higher than in the environmental isolates and higher resistance ratios were found in biofilm in comparison to water isolates. The role of the biofilm as potential sink o...
Source: International Journal of Hygiene and Environmental health - March 29, 2024 Category: Environmental Health Authors: Melanie Leopold Angelika Kabicher Ildiko-Julia Pap Barbara Str öbele Gernot Zarfel Andreas H Farnleitner Alexander K T Kirschner Source Type: research