Molecules, Vol. 29, Pages 1385: Phytochemical Evaluation of Terminalia canescens DC. Radlk. Extracts with Antibacterial and Antibiotic Potentiation Activities against Selected & beta;-Lactam Drug-Resistant Bacteria
This study identified two synergistic, eleven additive, eleven non-interactive and eight antagonistic interactions. The toxicities of the plant extracts were examined in the Artemia franciscana nauplii assay and were found to be non-toxic, except the aqueous extract, which showed toxicity. Metabolomic liquid chromatography–mass spectrometry (LC-MS) analyses highlighted and identified several flavonoids, including vitexin, quercetin, orientin and kaempferol, as well as the tannins ellagic acid and pyrogallol, which may contribute to the antibacterial activities observed herein. The possible mechanism of action...
Source: Molecules - March 20, 2024 Category: Chemistry Authors: Muhammad Jawad Zai Matthew James Cheesman Ian Edwin Cock Tags: Article Source Type: research
Exploring secretory proteome and cytokine kinetic of human peripheral blood mononuclear cells exposed to methicillin-resistant Staphylococcus aureus biofilms and planktonic bacteria
Staphylococcus aureus is a highly successful pathogen infecting various body parts and forming biofilms on natural and artificial surfaces resulting in difficult-to-treat and chronic infections. We investigated the secreted cytokines and proteomes of isolated peripheral blood mononuclear cells (PBMCs) from healthy volunteers exposed to methicillin-resistant S. aureus (MRSA) biofilms or planktonic bacteria. Additionally, the cytokine profiles in sera from patients with community-acquired pneumonia (CAP) caused by S. aureus were investigated. The aim was to gain insights into the immune response involved and differentiate be...
Source: Frontiers in Immunology - March 20, 2024 Category: Allergy & Immunology Source Type: research
Molecular characterization of antibiotic resistant Salmonella enterica across the poultry production chain in Costa Rica: A cross-sectional study
Int J Food Microbiol. 2024 Mar 7;416:110663. doi: 10.1016/j.ijfoodmicro.2024.110663. Online ahead of print.ABSTRACTAntibiotic resistant Salmonella enterica are on the increase, worldwide. Given the scarcity of data, this study aimed to investigate its occurrence, virulence, and antibiotic resistance in Costa Rica's food chain. In total, 65 chicken meat- and 171 chicken caecal samples were collected and examined for Salmonella. High frequencies of Salmonella were found in chicken meat (58.5 %, n/N = 38/65) and poultry farms (38.0 %, n/N = 65/171). The majority of Salmonella from chicken meat (89.5 %, n/N = 34/38) and caecum...
Source: International Journal of Food Microbiology - March 19, 2024 Category: Food Science Authors: Andrea Molina Thorsten Thye Lohendy Mu ñoz-Vargas Rebeca Zamora-Sanabria Daniel Haile Chercos Raquel Hern ández-Rojas Noelia Robles Daniela Aguilar J ürgen May Denise Dekker Source Type: research
Molecular characterization of antibiotic resistant Salmonella enterica across the poultry production chain in Costa Rica: A cross-sectional study
Int J Food Microbiol. 2024 Mar 7;416:110663. doi: 10.1016/j.ijfoodmicro.2024.110663. Online ahead of print.ABSTRACTAntibiotic resistant Salmonella enterica are on the increase, worldwide. Given the scarcity of data, this study aimed to investigate its occurrence, virulence, and antibiotic resistance in Costa Rica's food chain. In total, 65 chicken meat- and 171 chicken caecal samples were collected and examined for Salmonella. High frequencies of Salmonella were found in chicken meat (58.5 %, n/N = 38/65) and poultry farms (38.0 %, n/N = 65/171). The majority of Salmonella from chicken meat (89.5 %, n/N = 34/38) and caecum...
Source: International Journal of Food Microbiology - March 19, 2024 Category: Food Science Authors: Andrea Molina Thorsten Thye Lohendy Mu ñoz-Vargas Rebeca Zamora-Sanabria Daniel Haile Chercos Raquel Hern ández-Rojas Noelia Robles Daniela Aguilar J ürgen May Denise Dekker Source Type: research
Global epidemiology of asymptomatic colonisation of methicillin-resistant Staphylococcus aureus in the upper respiratory tract of young children: a systematic review and meta-analysis
Conclusion
This study provides evidence of increased MRSA colonisation globally among young children, underlining the critical role of asymptomatic carriers in MRSA transmission and the need for control measures.
PROSPERO registration number
CRD 42022328385. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - March 19, 2024 Category: Pediatrics Authors: Yang, L., Dharmaratne, P., Zhu, C., Sapugahawatte, D. N., Rahman, N., Barua, N., Li, C., Kwok, K. O., Luo, M., Liyanapathirana, V., Ip, M. Tags: Open access, ADC Global child health Source Type: research
Salinity-mediated enhancement of quaternary ammonium compounds resistance and removal in endophytic bacteria LSE01
In this study, different inorganic salts (NaCl, KCl, CaCl2, MgCl2) were used to induce endophytes LSE01 isolated from hyperaccumulating plants. After five generations of cultivation under 80 g/L NaCl, the minimum inhibitory concentration (MIC) of LSE01 to QACs increased by about 3-fold, while its degradation extent increased from 8% to 84% for C12BDMA-Cl and 5%-89% for C14BDMA-Cl. Transmission electron microscopy (TEM) and three-dimensional fluorescence spectra indicated that the cells induced by high concentration of salt caused plasmolysis and secreted more bound extracellular polymeric substances (B-EPS); these changes ...
Source: Environmental Research - March 17, 2024 Category: Environmental Health Authors: Xiao Xiao Junjie Li Xiaotong Wang Lin Ding Shengju Shen Ting Liu Zhong Ren Xubiao Luo Source Type: research
Effect of ciprofloxacin on the one-stage partial nitrification and anammox biofilm system: A multivariate analysis focusing on size-fractionated organic components
Chemosphere. 2024 Mar 15:141731. doi: 10.1016/j.chemosphere.2024.141731. Online ahead of print.ABSTRACTThe impact of ciprofloxacin (CIP) in the partial nitrification and anammox biofilm system was investigated by multivariate analysis, focusing on size-fractionated organic components. The CIP dose of 10 μg/L did not inhibit the total nitrogen (TN) removal efficiency, even though the abundance of antibiotic resistant genes (ARGs) (i.e., qnrD, qnrB, qnrA, qnrS, and arcA) was elevated. However, a gradual higher CIP dosing up to 100 μg/L inhibited the TN removal efficiency, while the abundance of ARGs was still increased. Mo...
Source: Chemosphere - March 17, 2024 Category: Chemistry Authors: Keke Xiao Gudrun Abbt-Braun Robert Pleitner Harald Horn Source Type: research
Effect of ciprofloxacin on the one-stage partial nitrification and anammox biofilm system: A multivariate analysis focusing on size-fractionated organic components
Chemosphere. 2024 Mar 15:141731. doi: 10.1016/j.chemosphere.2024.141731. Online ahead of print.ABSTRACTThe impact of ciprofloxacin (CIP) in the partial nitrification and anammox biofilm system was investigated by multivariate analysis, focusing on size-fractionated organic components. The CIP dose of 10 μg/L did not inhibit the total nitrogen (TN) removal efficiency, even though the abundance of antibiotic resistant genes (ARGs) (i.e., qnrD, qnrB, qnrA, qnrS, and arcA) was elevated. However, a gradual higher CIP dosing up to 100 μg/L inhibited the TN removal efficiency, while the abundance of ARGs was still increased. Mo...
Source: Chemosphere - March 17, 2024 Category: Chemistry Authors: Keke Xiao Gudrun Abbt-Braun Robert Pleitner Harald Horn Source Type: research
Ultrasound-driven radical chain reaction and immunoregulation of piezoelectric-based hybrid coating for treating implant infection
Biomaterials. 2024 Mar 14;307:122532. doi: 10.1016/j.biomaterials.2024.122532. Online ahead of print.ABSTRACTThe poor efficiency of US-responsive coatings on implants restricts their practical application. Immunotherapy that stimulates immune cells to enhance their antibacterial activity is expected to synergize with sonodynamic therapy for treating implant infection effectively and safely. Herein, US-responsive hybrid coatings composed of the oxygen-deficient BaTiO3 nanorod arrays and l-arginine (BaTiO3-x/LA) are designed and prepared on titanium implants for sonocatalytic therapy-cooperated immunotherapy to treat Methici...
Source: Biomaterials - March 17, 2024 Category: Materials Science Authors: Menglin Sun Jiameng Wang Xiaobo Huang Ruiqiang Hang Peide Han Jiqiang Guo Xiaohong Yao Paul K Chu Xiangyu Zhang Source Type: research
Salinity-mediated enhancement of quaternary ammonium compounds resistance and removal in endophytic bacteria LSE01
In this study, different inorganic salts (NaCl, KCl, CaCl2, MgCl2) were used to induce endophytes LSE01 isolated from hyperaccumulating plants. After five generations of cultivation under 80 g/L NaCl, the minimum inhibitory concentration (MIC) of LSE01 to QACs increased by about 3-fold, while its degradation extent increased from 8% to 84% for C12BDMA-Cl and 5%-89% for C14BDMA-Cl. Transmission electron microscopy (TEM) and three-dimensional fluorescence spectra indicated that the cells induced by high concentration of salt caused plasmolysis and secreted more bound extracellular polymeric substances (B-EPS); these changes ...
Source: Environmental Research - March 17, 2024 Category: Environmental Health Authors: Xiao Xiao Junjie Li Xiaotong Wang Lin Ding Shengju Shen Ting Liu Zhong Ren Xubiao Luo Source Type: research
Effect of ciprofloxacin on the one-stage partial nitrification and anammox biofilm system: A multivariate analysis focusing on size-fractionated organic components
Chemosphere. 2024 Mar 15:141731. doi: 10.1016/j.chemosphere.2024.141731. Online ahead of print.ABSTRACTThe impact of ciprofloxacin (CIP) in the partial nitrification and anammox biofilm system was investigated by multivariate analysis, focusing on size-fractionated organic components. The CIP dose of 10 μg/L did not inhibit the total nitrogen (TN) removal efficiency, even though the abundance of antibiotic resistant genes (ARGs) (i.e., qnrD, qnrB, qnrA, qnrS, and arcA) was elevated. However, a gradual higher CIP dosing up to 100 μg/L inhibited the TN removal efficiency, while the abundance of ARGs was still increased. Mo...
Source: Chemosphere - March 17, 2024 Category: Chemistry Authors: Keke Xiao Gudrun Abbt-Braun Robert Pleitner Harald Horn Source Type: research
Effect of ciprofloxacin on the one-stage partial nitrification and anammox biofilm system: A multivariate analysis focusing on size-fractionated organic components
Chemosphere. 2024 Mar 15:141731. doi: 10.1016/j.chemosphere.2024.141731. Online ahead of print.ABSTRACTThe impact of ciprofloxacin (CIP) in the partial nitrification and anammox biofilm system was investigated by multivariate analysis, focusing on size-fractionated organic components. The CIP dose of 10 μg/L did not inhibit the total nitrogen (TN) removal efficiency, even though the abundance of antibiotic resistant genes (ARGs) (i.e., qnrD, qnrB, qnrA, qnrS, and arcA) was elevated. However, a gradual higher CIP dosing up to 100 μg/L inhibited the TN removal efficiency, while the abundance of ARGs was still increased. Mo...
Source: Chemosphere - March 17, 2024 Category: Chemistry Authors: Keke Xiao Gudrun Abbt-Braun Robert Pleitner Harald Horn Source Type: research
Ultrasound-driven radical chain reaction and immunoregulation of piezoelectric-based hybrid coating for treating implant infection
Biomaterials. 2024 Mar 14;307:122532. doi: 10.1016/j.biomaterials.2024.122532. Online ahead of print.ABSTRACTThe poor efficiency of US-responsive coatings on implants restricts their practical application. Immunotherapy that stimulates immune cells to enhance their antibacterial activity is expected to synergize with sonodynamic therapy for treating implant infection effectively and safely. Herein, US-responsive hybrid coatings composed of the oxygen-deficient BaTiO3 nanorod arrays and l-arginine (BaTiO3-x/LA) are designed and prepared on titanium implants for sonocatalytic therapy-cooperated immunotherapy to treat Methici...
Source: Biomaterials - March 17, 2024 Category: Materials Science Authors: Menglin Sun Jiameng Wang Xiaobo Huang Ruiqiang Hang Peide Han Jiqiang Guo Xiaohong Yao Paul K Chu Xiangyu Zhang Source Type: research
Ultrasound-driven radical chain reaction and immunoregulation of piezoelectric-based hybrid coating for treating implant infection
Biomaterials. 2024 Mar 14;307:122532. doi: 10.1016/j.biomaterials.2024.122532. Online ahead of print.ABSTRACTThe poor efficiency of US-responsive coatings on implants restricts their practical application. Immunotherapy that stimulates immune cells to enhance their antibacterial activity is expected to synergize with sonodynamic therapy for treating implant infection effectively and safely. Herein, US-responsive hybrid coatings composed of the oxygen-deficient BaTiO3 nanorod arrays and l-arginine (BaTiO3-x/LA) are designed and prepared on titanium implants for sonocatalytic therapy-cooperated immunotherapy to treat Methici...
Source: Biomaterials - March 17, 2024 Category: Materials Science Authors: Menglin Sun Jiameng Wang Xiaobo Huang Ruiqiang Hang Peide Han Jiqiang Guo Xiaohong Yao Paul K Chu Xiangyu Zhang Source Type: research
Ultrasound-driven radical chain reaction and immunoregulation of piezoelectric-based hybrid coating for treating implant infection
Biomaterials. 2024 Mar 14;307:122532. doi: 10.1016/j.biomaterials.2024.122532. Online ahead of print.ABSTRACTThe poor efficiency of US-responsive coatings on implants restricts their practical application. Immunotherapy that stimulates immune cells to enhance their antibacterial activity is expected to synergize with sonodynamic therapy for treating implant infection effectively and safely. Herein, US-responsive hybrid coatings composed of the oxygen-deficient BaTiO3 nanorod arrays and l-arginine (BaTiO3-x/LA) are designed and prepared on titanium implants for sonocatalytic therapy-cooperated immunotherapy to treat Methici...
Source: Biomaterials - March 17, 2024 Category: Materials Science Authors: Menglin Sun Jiameng Wang Xiaobo Huang Ruiqiang Hang Peide Han Jiqiang Guo Xiaohong Yao Paul K Chu Xiangyu Zhang Source Type: research
