Cost-effectiveness and impact on infections and associated antimicrobial resistance of 20-valent pneumococcal conjugate vaccine in US children previously immunized with PCV13
CONCLUSIONS: A PCV20 catch-up program could prevent pneumococcal infections, antibiotic prescriptions and antimicrobial-resistant infections and would be cost saving in the US.PMID:38577742 | DOI:10.1080/13696998.2024.2339638 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 5, 2024 Category: Health Management Authors: Mark H Rozenbaum Liping Huang Alejandro Cane Adriano Arguedas Ruth Chapman Desmond Dillon-Murphy Maria Tort Vincenza Snow Erica Chilson Raymond Farkouh Source Type: research
Evaluation of the in vitro and in vivo antimicrobial activity of alkaloids prepared from Chelidonium majus L. using MRSA- infected C. elegans as a model host
This study aimed to extract alkaloids from C. majus L. (total alkaloids) and evaluate their antibacterial activity both in vitro and in vivo. Reflux extraction was carried out on C. majus L., and the extract was purified with HPD-600 macroporous resin and 732 cation exchange resin exchange columns. Infection modeling of Caenorhabditis elegans (C. elegans) was established to investigate the impact of Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-sensitive Staphylococcus aureus (MSSA) on the motility, longevity, and reactive oxygen species (ROS) levels of wild-type worms (N2 strain). The effects of total...
Source: Fitoterapia - April 5, 2024 Category: Biochemistry Authors: Jinchai Qi Xinyun Zhang Xiaochen Guo Yuping Yang Xiaoxiao Fan Yunfeng Han Yonggang Liu Source Type: research
Discovery of a novel class of rosmarinic acid derivatives as antibacterial agents: Synthesis, structure-activity relationship and mechanism of action
Bioorg Chem. 2024 Mar 28;146:107318. doi: 10.1016/j.bioorg.2024.107318. Online ahead of print.ABSTRACTTwenty-seven rosmarinic acid derivatives were synthesized, among which compound RA-N8 exhibited the most potent antibacterial ability. The minimum inhibition concentration of RA-N8 against both S. aureus (ATCC 29213) and MRSA (ATCC BAA41 and ATCC 43300) was found to be 6 μg/mL, and RA-N8 killed E. coli (ATCC 25922) at 3 μg/mL in the presence of polymyxin B nonapeptide (PMBN) which increased the permeability of E. coli. RA-N8 exhibited a weak hemolytic effect at the minimum inhibitory concentration. SYTOX Green assay, SEM...
Source: Bioorganic Chemistry - April 5, 2024 Category: Chemistry Authors: Yong Wang Zhiguang Liang Yihui Cao Cheung-Hin Hung Ruolan Du Alan Siu-Lun Leung Pui-Kin So Pak-Ho Chan Wing-Leung Wong Yun-Chung Leung Kwok-Yin Wong Source Type: research
Cost-effectiveness and impact on infections and associated antimicrobial resistance of 20-valent pneumococcal conjugate vaccine in US children previously immunized with PCV13
CONCLUSIONS: A PCV20 catch-up program could prevent pneumococcal infections, antibiotic prescriptions and antimicrobial-resistant infections and would be cost saving in the US.PMID:38577742 | DOI:10.1080/13696998.2024.2339638 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 5, 2024 Category: Health Management Authors: Mark H Rozenbaum Liping Huang Alejandro Cane Adriano Arguedas Ruth Chapman Desmond Dillon-Murphy Maria Tort Vincenza Snow Erica Chilson Raymond Farkouh Source Type: research
Evaluation of the in vitro and in vivo antimicrobial activity of alkaloids prepared from Chelidonium majus L. using MRSA- infected C. elegans as a model host
This study aimed to extract alkaloids from C. majus L. (total alkaloids) and evaluate their antibacterial activity both in vitro and in vivo. Reflux extraction was carried out on C. majus L., and the extract was purified with HPD-600 macroporous resin and 732 cation exchange resin exchange columns. Infection modeling of Caenorhabditis elegans (C. elegans) was established to investigate the impact of Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-sensitive Staphylococcus aureus (MSSA) on the motility, longevity, and reactive oxygen species (ROS) levels of wild-type worms (N2 strain). The effects of total...
Source: Fitoterapia - April 5, 2024 Category: Biochemistry Authors: Jinchai Qi Xinyun Zhang Xiaochen Guo Yuping Yang Xiaoxiao Fan Yunfeng Han Yonggang Liu Source Type: research
IL-10 Counteracts IFN- γ to Alleviate Acute Lung Injury in a Viral-Bacterial Superinfection Model
Am J Respir Cell Mol Biol. 2024 Apr 4. doi: 10.1165/rcmb.2023-0437OC. Online ahead of print.ABSTRACTImmune activation is essential for lung control of viral and bacterial infection, but an overwhelming inflammatory response often leads to the onset of acute respiratory distress syndrome (ARDS). Interleukin-10 (IL-10) plays a crucial role in regulating the balance between antimicrobial immunity and immunopathology. In the current study, we have investigated the role of IL-10 in acute lung injury (ALI) induced by influenza A virus (IAV) and methicillin-resistant Staphylococcus aureus (MRSA) coinfection. This unique coinfecti...
Source: Mol Biol Cell - April 4, 2024 Category: Molecular Biology Authors: Michael McKelvey Md Bashir Uddin Sunil Palani Shengjun Shao Keer Sun Source Type: research
Comparison of methods proposed for monitoring cefotaxime-resistant < em > Escherichia coli < /em > in the water environment
This study helps to advance globally coordinated AMR in water environments and suggests that the TriCycle Protocol is adaptable to other standard methods that may be required in different locales, while also offering a means to improve specificity by decreasing the frequency of false-positive identification of cefotaxime-resistant E. coli by modifying incubation conditions.IMPORTANCEAs antibiotic-resistant bacteria in water environments are increasingly recognized as contributors to the global antibiotic resistance crisis, the need for a monitoring subject that captures antibiotic resistance trends on a global scale increa...
Source: Applied and Environmental Microbiology - April 4, 2024 Category: Microbiology Authors: Jeanette Calarco Amy Pruden Valerie J Harwood Source Type: research
IL-10 Counteracts IFN- γ to Alleviate Acute Lung Injury in a Viral-Bacterial Superinfection Model
Am J Respir Cell Mol Biol. 2024 Apr 4. doi: 10.1165/rcmb.2023-0437OC. Online ahead of print.ABSTRACTImmune activation is essential for lung control of viral and bacterial infection, but an overwhelming inflammatory response often leads to the onset of acute respiratory distress syndrome (ARDS). Interleukin-10 (IL-10) plays a crucial role in regulating the balance between antimicrobial immunity and immunopathology. In the current study, we have investigated the role of IL-10 in acute lung injury (ALI) induced by influenza A virus (IAV) and methicillin-resistant Staphylococcus aureus (MRSA) coinfection. This unique coinfecti...
Source: American Journal of Respiratory Cell and Molecular Biology - April 4, 2024 Category: Molecular Biology Authors: Michael McKelvey Md Bashir Uddin Sunil Palani Shengjun Shao Keer Sun Source Type: research
IL-10 Counteracts IFN- γ to Alleviate Acute Lung Injury in a Viral-Bacterial Superinfection Model
Am J Respir Cell Mol Biol. 2024 Apr 4. doi: 10.1165/rcmb.2023-0437OC. Online ahead of print.ABSTRACTImmune activation is essential for lung control of viral and bacterial infection, but an overwhelming inflammatory response often leads to the onset of acute respiratory distress syndrome (ARDS). Interleukin-10 (IL-10) plays a crucial role in regulating the balance between antimicrobial immunity and immunopathology. In the current study, we have investigated the role of IL-10 in acute lung injury (ALI) induced by influenza A virus (IAV) and methicillin-resistant Staphylococcus aureus (MRSA) coinfection. This unique coinfecti...
Source: Am J Respir Cell Mol... - April 4, 2024 Category: Respiratory Medicine Authors: Michael McKelvey Md Bashir Uddin Sunil Palani Shengjun Shao Keer Sun Source Type: research
IL-10 Counteracts IFN- γ to Alleviate Acute Lung Injury in a Viral-Bacterial Superinfection Model
Am J Respir Cell Mol Biol. 2024 Apr 4. doi: 10.1165/rcmb.2023-0437OC. Online ahead of print.ABSTRACTImmune activation is essential for lung control of viral and bacterial infection, but an overwhelming inflammatory response often leads to the onset of acute respiratory distress syndrome (ARDS). Interleukin-10 (IL-10) plays a crucial role in regulating the balance between antimicrobial immunity and immunopathology. In the current study, we have investigated the role of IL-10 in acute lung injury (ALI) induced by influenza A virus (IAV) and methicillin-resistant Staphylococcus aureus (MRSA) coinfection. This unique coinfecti...
Source: Mol Biol Cell - April 4, 2024 Category: Molecular Biology Authors: Michael McKelvey Md Bashir Uddin Sunil Palani Shengjun Shao Keer Sun Source Type: research
Comparison of methods proposed for monitoring cefotaxime-resistant < em > Escherichia coli < /em > in the water environment
This study helps to advance globally coordinated AMR in water environments and suggests that the TriCycle Protocol is adaptable to other standard methods that may be required in different locales, while also offering a means to improve specificity by decreasing the frequency of false-positive identification of cefotaxime-resistant E. coli by modifying incubation conditions.IMPORTANCEAs antibiotic-resistant bacteria in water environments are increasingly recognized as contributors to the global antibiotic resistance crisis, the need for a monitoring subject that captures antibiotic resistance trends on a global scale increa...
Source: Applied and Environmental Microbiology - April 4, 2024 Category: Microbiology Authors: Jeanette Calarco Amy Pruden Valerie J Harwood Source Type: research
IL-10 Counteracts IFN- γ to Alleviate Acute Lung Injury in a Viral-Bacterial Superinfection Model
Am J Respir Cell Mol Biol. 2024 Apr 4. doi: 10.1165/rcmb.2023-0437OC. Online ahead of print.ABSTRACTImmune activation is essential for lung control of viral and bacterial infection, but an overwhelming inflammatory response often leads to the onset of acute respiratory distress syndrome (ARDS). Interleukin-10 (IL-10) plays a crucial role in regulating the balance between antimicrobial immunity and immunopathology. In the current study, we have investigated the role of IL-10 in acute lung injury (ALI) induced by influenza A virus (IAV) and methicillin-resistant Staphylococcus aureus (MRSA) coinfection. This unique coinfecti...
Source: American Journal of Respiratory Cell and Molecular Biology - April 4, 2024 Category: Molecular Biology Authors: Michael McKelvey Md Bashir Uddin Sunil Palani Shengjun Shao Keer Sun Source Type: research
Multifunctional fucoidan-loaded Zn-MOF-encapsulated microneedles for MRSA-infected wound healing
Infected wound healing remains a challenging task in clinical practice due to several factors: (I) drug-resistant infections caused by various pathogens, (II) persistent inflammation that hinders tissue regene... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 4, 2024 Category: Nanotechnology Authors: Zichao Jiang, Jingyi Li, Jiahao Wang, Yixiao Pan, Shuailong Liang, Yihe Hu and Long Wang Tags: Research Source Type: research
Relapsing bronchopneumonia due to community-associated methicillin-resistant Staphylococcus aureus: a case report
The emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has increased the incidence of community-onset MRSA infection. Respiratory tract infections caused by MRSA has been note... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 4, 2024 Category: Infectious Diseases Authors: Sho Shimada, Tetsuo Yamaguchi, Satsuki Mikoshiba, Kazuaki Sato, Takahiro Mitsumura, Kohji Komori, Takashi Yamana, Yuki Iijima, Rie Sakakibara, Sho Shibata, Takayuki Honda, Tsuyoshi Shirai, Tsukasa Okamoto, Haruhiko Furusawa, Tomoya Tateishi and Yasunari M Tags: Case Report Source Type: research
CXCR2 perturbation promotes < em > Staphylococcus aureus < /em > implant-associated infection
Conclusion. Our results demonstrate that CXCR2 plays an essential role in regulating the severity of S. aureus implant-associated infections. Interestingly, however, perturbation of CXCR2 expression or signalling both resulted in enhanced Cxcr2 transcription and elevated implant-associated bacterial burdens. Thus, CXCR2 appears finely tuned to efficiently recruit effector cells and mediate control of S. aureus biofilm-mediated infection.PMID:38567642 | DOI:10.1099/jmm.0.001821 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 3, 2024 Category: Microbiology Authors: Mike Akaraphanth Tara M Nordgren Casey M Gries Source Type: research
