Palpitations and presyncope in a 40-something
Discussion: Putting all of the information together this patient is most likely suffering from arrhythmogenic cardiomyopathy (AC) better known as ARVC. The medical hx is typical, with sudden onset tachydysrhythmia during physical exertion. It is not uncommon for the initial presentation to be sudden cardiac death (SCD). In fact it is one of the leading causes of SCD in people age less than 40 years. Thus it is very important to identify this disorder. AC is a disease in which myocardium is replaced by fibrofatty tissue. This usually and predominantly affects the RV free wall and apical regions, but it can affect the left v...
Source: Dr. Smith's ECG Blog - March 24, 2024 Category: Cardiology Authors: Magnus Nossen Source Type: blogs
Application and Funding Trends in Fiscal Year 2023
NIGMS continues to support a broad range of scientific topics and investigators within its research portfolio, including support for investigator-initiated research project grants (RPGs) at institutions throughout the country. As part of its commitment to transparency, NIGMS examines and publishes data on annual trends reflected in its RPG portfolio. In this post, we review and describe investigator-level trends associated with competing R01/R01-equivalent RPGs including those in the Institute’s R35 Maximizing Investigators’ Research Award (MIRA) program.
NIGMS Investigator-Level Trends Research Grants
In ord...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - March 20, 2024 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Director’s Messages Funding Trends Funding Outcomes Funding Policies MIRA NIGMS Strategic Plan R01 Source Type: blogs
The Kids Are Definitely Not All Right: An Empirical Study Establishing a Statistically Significant Negative Relationship Between Receiving Accommodations in Law School and Passing the Bar Exam
Scott DeVito (Jacksonville University), The Kids Are Definitely Not All Right: An Empirical Study Establishing a Statistically Significant Negative Relationship Between Receiving Accommodations in Law School and Passing the Bar Exam, 102 Or. L. Rev. (2023): Many factors can influence... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - March 20, 2024 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Reporting on a Nine Month Self-Experiment in Taurine Supplementation
Today's post is a report from the community on the impact of taurine supplementation on a few biomarkers of interest. Taurine is a dietary amino acid, and circulating levels of taurine influence any number of biological processes. Taurine levels decrease with age in a variety of species; in humans circulating taurine is halved by age 50. You might recall that supplementation with taurine was demonstrated to modestly extend life in mice and improve health in old non-human primates. This may be largely due to enhanced performance of the antioxidant glutathione, and you might recall that other approaches to upregulation of gl...
Source: Fight Aging! - March 18, 2024 Category: Research Authors: Reason Tags: Self-Experimentation Source Type: blogs
Will Americans Get PBM Reform in 2024? Maybe, But Many Things Need to Happen I Order to Get There. On the Upside: Insulin Has Opted Out of PBM Sales.
At the core of this post is a YouTube video which can be viewed in the middle of this blog post. The subject is about whether we ' ll get much-needed legislation passed into law to reform corrupt Pharmacy Benefit Managers (PBMs) which we know with absolute certainty were at fault for runaway insulin prices. At least that was true until March 2023, when the three largest insulin manufacturers, starting withLilly, followed byNovo Nordisk and shortly thereafter,Sanofi all announced major insulin list price reductions in the range of 70% to 78%. Think about that for a second: Imagine being able to instantly...
Source: Scott's Web Log - March 17, 2024 Category: Endocrinology Tags: 2024 Congress insulin prices PBM rebates reform Source Type: blogs
Will Americans Get PBM Reform in 2024? Maybe, But Many Things Need to Happen In Order to Get There. On the Upside: Insulin Has Opted Out of PBM Sales.
At the core of this post is a YouTube video which can be viewed in the middle of this blog post. The subject is about whether we ' ll get much-needed legislation passed into law to reform corrupt Pharmacy Benefit Managers (PBMs) which we know with absolute certainty were at fault for runaway insulin prices. At least that was true until March 2023, when the three largest insulin manufacturers, starting withLilly, followed byNovo Nordisk and shortly thereafter,Sanofi all announced major insulin list price reductions in the range of 70% to 78%. Think about that for a second: Imagine being able to instantly...
Source: Scott's Web Log - March 17, 2024 Category: Endocrinology Tags: 2024 Congress insulin prices PBM rebates reform Source Type: blogs
What is the risk of ACS after PCI in a CTO related artery ?
CTOs are opened primarily for four reasons
Angina which is refractory to drugs
Stress test positivity with or without angina
Anxiety of having a blocked coronary artery in a self educated patient
Cardiologist’s clandestine pride & pursuit*
* Personal experience included
Some evidence based observation
Most of the studies as on today do not give survival advantage of opening a CTO.(DECISION-CTO,EURO-CTO,EXPLORE,IMPACTOR)
Opening a CTO, for reasons other than angina (i.e. for relief of dyspnea or improving functional capacity) is largely conjectural and based on randomly accrued data back...
Source: Dr.S.Venkatesan MD - March 16, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized cto cto hardware cto trials jcto score open artery hypothesisacc esc aha guidelines Source Type: blogs
Further Progress Towards Regeneration of Sensory Hair Cells to Treat Deafness
In recent years, researchers have attempted to provoke the regeneration of lost sensory hair cells in the inner ear, a potential treatment for forms of deafness. Various genes related to the creation of these cells during development have been identified, and gene therapy interventions attempted in animal models. Progress has been made, but it is incremental, and the results not yet satisfactory. Noted here is a recent example of this sort of work, in which a cocktail of genes is employed rather than focusing on single gene interventions.
The transcription factors (genes) Gfi1, Atoh1, Pou4f3, and Six1 (known colle...
Source: Fight Aging! - March 14, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
CentralReach Announces Acquisition of SILAS, a Rapidly Growing, New Jersey-Based Provider of SEL and Behavior Solutions for PreK-12 Students in Any Type of Classroom
SILAS Adds Social, Emotional, Executive Functioning, and Vocational Curricula Delivered via an Interactive, Animated App, Extending the Reach of CentralReach’s Market-Leading Education Platform
CentralReach, the leading provider of Autism and IDD software, today announced the acquisition of SILAS – a social and emotional learning (SEL) and behavior solution for PreK-12 general, special, and transition vocational education programs. The SILAS software will be incorporated into CentralReach’s suite of education solutions, which currently includes ABLLS-R|AFLS digital assessments, IEP management and student rosterin...
Source: EMR and HIPAA - March 12, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Alexander Fertig Bright Beginnings CentralReach Chris Dudick Chris Sullens Dr. George McCloskey Ettie Luban Health IT Acquisitions Healthcare M&A SILAS Source Type: blogs
Navigating Cyber Threats: Cost-Effective Cybersecurity for Healthtech
Conclusion
Understanding and managing the nuances of cyber insurance costs have become top-of-mind for healthtech leaders. As insurers shift from reactive to proactive, requiring prior qualifications before binding policies, healthtech leaders must follow suit. A proactive approach to cost-effective cybersecurity is key. Let’s embrace these strategies together, fortifying our defenses and ensuring a safer future for the healthtech industry.
About Justin Kozak
Justin Kozak is the Executive VP at Founder Shield, a tech-enabled commercial insurance brokerage. He leads the Life Sciences practice, having 10+ years of expe...
Source: EMR and HIPAA - March 11, 2024 Category: Information Technology Authors: Guest Author Tags: Ambulatory C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System LTPAC Security and Privacy Cost Effective Cybersecurity Cyber Insurance Cyber Threats Founder Shield Healthcare Cyber Insurance Healthcare Cyber Source Type: blogs
Fight Aging! Newsletter, March 11th 2024
In conclusion, this Mendelian randomization study found that Streptococcus was causally associated with Bioage acceleration. Further randomized controlled trials are needed to investigate its role in the aging process.
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Considering the Mechanisms of Vascular Calcification
https://www.fightaging.org/archives/2024/03/considering-the-mechanisms-of-vascular-calcification/
Harmful calcification of structures in the cardiovascular system proceeds alongside the development of the fatty lesions of atherosclerosis. Both disease processes are accelerated by chronic inflammation, but d...
Source: Fight Aging! - March 10, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Why you (and your patients) should have a mindfulness practice
Nobody can question the fact that the world has a mental health problem. Nowhere is this more pronounced than in the medical health profession. American Medical Association statistics show that in 2021, physician burnout rates were 63 percent, which was almost double the rates in 2020. The CDC reports that 1 out of every five
Read more…
Why you (and your patients) should have a mindfulness practice originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 5, 2024 Category: General Medicine Authors: Adam Rosen, DO Tags: Conditions Psychiatry Source Type: blogs
A Genome-Wide Genetic Association Study of Sleep Duration and Longevity
In this study, we firstly studied the genome-wide genetic association between four sleep behaviors (short sleep duration, long sleep duration, insomnia, and sleep chronotype) and lifespan using GWAS summary statistics, and both sleep duration time and insomnia were negatively correlated with lifespan. Then, two-sample Mendelian randomization (MR) and multivariable MR analyses were applied to explore the causal effects between sleep behaviors and lifespan.
We found that genetically predicted short sleep duration was causally and negatively associated with lifespan in univariable and multivariable MR analyses, and thi...
Source: Fight Aging! - March 4, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Medical debt-driven homelessness
The fictional 2007 television story depicting the plight of a widow with two daughters who, as a family, became homeless due to medical debt incurred during her since-deceased husband’s health care, is an eye-opener and heartbreaking. However, nowadays, the fact is emulating that fiction when statistics of homelessness risk due to medical debt are bewildering
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Medical debt-driven homelessness originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 3, 2024 Category: General Medicine Authors: Deepak Gupta, MD Tags: Physician Public Health & Policy Source Type: blogs
Fight Aging! Newsletter, February 26th 2024
In conclusion, mTORC1 signaling contributes to the ISC fate decision, enabling regional control of intestinal cell differentiation in response to nutrition.
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Reviewing the Development of Senotherapeutics to Treat Aging
https://www.fightaging.org/archives/2024/02/reviewing-the-development-of-senotherapeutics-to-treat-aging/
Senescent cells accumulate with age and contribute meaningfully to chronic inflammation and degenerative aging. Destroying these cells produces rapid and sizable reversal of age-related diseases in mice, demonstrating that the presence of senescence cells ...
Source: Fight Aging! - February 25, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
