Steroid therapy for patients with septic shock: A multicenter observational study conducted in Japan
Conclusions There was considerable variation in the criteria for the selection of patients and in the decision to use continuous or intermittent steroid infusion.PMID:38719604 | DOI:10.2169/internalmedicine.1511-22 (Source: Internal Medicine)
Source: Internal Medicine - May 8, 2024 Category: Internal Medicine Authors: Maki Murata Sayaka Shimizu Ryohei Yamamoto Tsukasa Kamitani Hajime Yamazaki Yusuke Ogawa Shunichi Fukuhara Hideto Yasuda Yosuke Yamamoto AMOR-VENUS study group Source Type: research
Mediastinitis and septic shock complicating spontaneous esophageal rupture “Boerhaave’s syndrome”: a case report
AbstractBoerhaave ’s syndrome, also known as spontaneous esophageal rupture, is a rare but life-threatening condition characterized by a tear in the esophagus. It is most commonly caused by a sudden increase in intraesophageal pressure, often due to severe vomiting or retching.Early diagnosis of Boerhaave ’s syndrome is crucial for improving patient outcomes. The classic triad of symptoms includes severe chest pain, vomiting, and subcutaneous emphysema (air under the skin). However, not all patients present with this triad, and the diagnosis can be challenging, especially in patients without the ty pical symptoms.In th...
Source: International Journal of Emergency Medicine - May 8, 2024 Category: Emergency Medicine Source Type: research
“Time is the Ultimate Commodity”: A Call For a Combined Training Pathway in Advanced Heart Failure and Critical Care.”
"I'm not going anywhere," I repeated as I gazed upon my once-triumphant, 4 ’10” yet larger-than-life mother. Despite her lifelong battle with congenital renal failure, she achieved her dreams of traveling the world. She now lay sarcopenic in her Cardiac Intensive Care Unit (CICU) bed, a buzzing wound-vac over her abdomen, an arterial line in her right axilla, a dialysi s catheter in her internal jugular vein, a tracheostomy connected to her life-sustaining ventilator. Her single functioning transplanted kidney, gifted by her sister 27 years earlier, had abruptly failed and was followed by a proximal LAD STEMI, hemorrha...
Source: Journal of Cardiac Failure - May 8, 2024 Category: Cardiology Authors: Syed Zain Ali, Anuradha Lala-Trindade, Deepika Misra, Anthony P. Carnicelli Source Type: research
Outcomes and risk factors for mortality in clostridioides difficile infection in patients with NAFLD and NASH
CONCLUSIONS: Patients with NASH had a higher rate of liver-related complications, progression to septic shock, and mortality rate following CDI infection compared to the CDI only cohort.PMID:38714224 | DOI:10.1016/j.aohep.2024.101510 (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 7, 2024 Category: Gastroenterology Authors: Ankoor H Patel Gaurav N Pathak Alexander Chen Patricia Greenberg Natale Mazzaferro Anish Patel Naveen Mallangada Carlos D Minacapelli Kaitlyn Catalano Hansel Suthar Vinod K Rustgi Source Type: research
Sa1514 ELEVATED NEUTROPHIL TO LYMPHOCYTE RATIO UPON HOSPITALIZATION IS ASSOCIATED WITH INCREASED RISK OF DEVELOPING SEPTIC SHOCK AND MORTALITY IN PATIENTS WITH ACUTE CHOLANGITIS
(Source: Gastroenterology)
Source: Gastroenterology - May 6, 2024 Category: Gastroenterology Authors: Parth Patel, Shahin Isha, Eli A. Zaher, Mohamed A. Ebrahim Tags: AGA Abstracts Source Type: research
Cytomegalovirus infection and disease in systemic lupus erythematosus patients at a high-complexity hospital in southwestern Colombia
Lupus. 2024 May 6:9612033241247103. doi: 10.1177/09612033241247103. Online ahead of print.ABSTRACTCytomegalovirus (CMV) infection and disease is a condition usually described in immunocompromised patients, but among them, those with connective tissue diseases are poorly represented. Here we present the clinical, laboratory characteristics, management and outcomes of systemic lupus erythematosus (SLE) patients who presented with a CMV infection/disease to a high complexity hospital in southwestern Colombia between 2011 and 2020. 16 SLE patients were found to have a CMV infection. SLE was predominantly characterized by renal...
Source: Lupus - May 6, 2024 Category: Rheumatology Authors: Juan Fernando Contreras-Valero Ingrid Ru íz-Ordóñez Gabriel D Pinilla-Monsalve Mario Bautista-Vargas Vanessa Ocampo-Piraquive David Aguirre-Valencia Source Type: research
Cytomegalovirus infection and disease in systemic lupus erythematosus patients at a high-complexity hospital in southwestern Colombia
Lupus. 2024 May 6:9612033241247103. doi: 10.1177/09612033241247103. Online ahead of print.ABSTRACTCytomegalovirus (CMV) infection and disease is a condition usually described in immunocompromised patients, but among them, those with connective tissue diseases are poorly represented. Here we present the clinical, laboratory characteristics, management and outcomes of systemic lupus erythematosus (SLE) patients who presented with a CMV infection/disease to a high complexity hospital in southwestern Colombia between 2011 and 2020. 16 SLE patients were found to have a CMV infection. SLE was predominantly characterized by renal...
Source: Lupus - May 6, 2024 Category: Rheumatology Authors: Juan Fernando Contreras-Valero Ingrid Ru íz-Ordóñez Gabriel D Pinilla-Monsalve Mario Bautista-Vargas Vanessa Ocampo-Piraquive David Aguirre-Valencia Source Type: research
Cytomegalovirus infection and disease in systemic lupus erythematosus patients at a high-complexity hospital in southwestern Colombia
Lupus. 2024 May 6:9612033241247103. doi: 10.1177/09612033241247103. Online ahead of print.ABSTRACTCytomegalovirus (CMV) infection and disease is a condition usually described in immunocompromised patients, but among them, those with connective tissue diseases are poorly represented. Here we present the clinical, laboratory characteristics, management and outcomes of systemic lupus erythematosus (SLE) patients who presented with a CMV infection/disease to a high complexity hospital in southwestern Colombia between 2011 and 2020. 16 SLE patients were found to have a CMV infection. SLE was predominantly characterized by renal...
Source: Lupus - May 6, 2024 Category: Rheumatology Authors: Juan Fernando Contreras-Valero Ingrid Ru íz-Ordóñez Gabriel D Pinilla-Monsalve Mario Bautista-Vargas Vanessa Ocampo-Piraquive David Aguirre-Valencia Source Type: research
Hemorrhage and thrombosis in COVID-19-patients supported with extracorporeal membrane oxygenation: an international study based on the COVID-19 critical care consortium
ConclusionsCoagulation disorders are frequent in COVID-19 ARDS patients receiving ECMO. Bleeding events contribute substantially to mortality in this cohort. However, this risk may be lower than previously reported in single-nation studies or early case reports.Trial registration ACTRN12620000421932 (https://covid19.cochrane.org/studies/crs-13513201). (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - May 6, 2024 Category: Intensive Care Source Type: research
Perianal tuberculosis presenting as a Fournier's gangrene
Surgical treatment of perianal tuberculosis presenting as a Fournier ’s Gangrene: surgical perineal debridement (A, B); vacuum therapy of the perineum—sponge with sorbact (C, D); clean perineum after vacuum therapy (E). Key Clinical MessageIn the setting of Fournier's gangrene, atypical clinical manifestations and complications in an immunocompetent patient warrant consideration of perineal tuberculosis as a potential underlying cause.AbstractTuberculosis cutis orificialis is a rare form of extrapulmonary tuberculosis that affects the perianal region. Fournier's gangrene is an aggressive necrotizing fasciitis that prim...
Source: Clinical Case Reports - May 3, 2024 Category: General Medicine Authors: Raquel Lalanda,
Andreia Bar ão,
Beatriz Draiblate,
Ester Malcato,
Hélder Matos,
José Girão,
Rosário Rosa,
José Paulo Freire,
Luís Miranda Tags: CASE REPORT Source Type: research
A case –control study of the clinical and economic impact of infections caused by Carbapenemase-producing Enterobacterales (CPE)
ConclusionsThe CPE group was associated with worse clinical outcomes, but this was mainly due to a higher comorbidity burden, more severe illness, and more frequent inappropriate antibiotic treatment rather than resistance patterns as such. However, the CPE group consumed more healthcare resources and incurred higher costs. (Source: Infection)
Source: Infection - May 3, 2024 Category: Infectious Diseases Source Type: research
Emerging Toxicities of Antibody-Drug Conjugates for Breast Cancer: Clinical Prioritization of Adverse Events from the FDA Adverse Event Reporting System
ConclusionThe heterogeneous spectrum of post-marketing toxicities for ADCs used in breast cancer, as emerging from the FAERS, is largely in line with preapproval evidence. Although causality cannot be proved, we call for increased awareness by oncologists on potential serious unexpected reactions, including early onset of septic shock and neutropenic colitis with SG, and late emergence of pulmonary embolism with T-DM1. (Source: Targeted Oncology)
Source: Targeted Oncology - May 2, 2024 Category: Cancer & Oncology Source Type: research
Navigating the challenges: a case report on managing a complicated postpartum course in type 3 von Willebrand disease with alloantibodies
CONCLUSION: The current case emphasizes the postpartum clinical challenges of patients with type 3 VWD and alloantibodies. It underscores the potential role of emicizumab in maintaining hemostatic control.PMID:38689620 | PMC:PMC11058073 | DOI:10.1016/j.rpth.2024.102399 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - May 1, 2024 Category: Hematology Authors: Konrad van der Zwet Karin P M van Galen Annemiek C C Evers Kathelijn Fischer Roger E G Schutgens Lize F D van Vulpen Source Type: research
