Characterization of a proteomic profile associated with organ dysfunction and mortality of sepsis and septic shock
ConclusionIn sepsis there are proteomic patterns associated with organ dysfunction and mortality. (Source: PLoS One)
Source: PLoS One - December 2, 2022 Category: Biomedical Science Authors: Adolfo Ruiz-Sanmart ín Source Type: research

Evaluation of ferritin and the ferritin index as prognostic biomarkers in septic shock
Ferritin, an acute phase reactant, and the ferritin index (FI  = observed ferritin level/upper limit of normal level for age and sex) may be prognostic biomarkers in septic shock and cardiac surgery patients. (Source: Australian Critical Care)
Source: Australian Critical Care - December 2, 2022 Category: Nursing Authors: Chandrasekaran Gunasekaran, Glenn M. Eastwood, Leah Peck, Helen Young, Ary Serpa Neto, Rinaldo Bellomo Tags: Research paper Source Type: research

Novel Identification of Myeloid-Derived Suppressor Cells in Children With Septic Shock
CONCLUSIONS: This article is the first to describe increased MDSCs in children with septic shock, along with an association between early increase in MDSCs and adverse OD outcomes in this population. It remains unclear if MDSCs play a causative role in sepsis-induced immune suppression in children. Additional studies are warranted to establish MDSC as a potential therapeutic target. (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - December 1, 2022 Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

Validation of IDSA/ATS guidelines for ICU admission in very elderly patients with community-acquired pneumonia
Conclusion: IDSA/ATS criteria for severe CAP predict ICU admission in VEP moderately well. While patients with septic shock should warrant ICU admission, even if previously stabilized, severe CAP without major severity criteria may be acceptably manageable in wards. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Cilloniz Campos, C., Ferrer, M., Pericas, J. M., Serrano, L., Mendez, R., Menendez, R., Ruiz, L. A., Torres, A. Tags: 10.01 - Respiratory infections and bronchiectasis Source Type: research

Kinetics of serum chemerin in critically ill patients with sepsis: a prospective study
Conclusions: Circulating chemerin is increased in sepsis and may be a valuable diagnostic biomarker in critically ill patients. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Karampela, I., Christodoulatos, G., Vallianou, N., Tsilingiris, D., Chrysanthopoulou, E., Skyllas, G., Antonakos, G., Marinou, I., Vogiatzakis, E., Armaganidis, A., Dalamaga, M. Tags: 02.01 - Acute critical care Source Type: research

Lung hydatidosis treatment: which are the associated morbidity and mortality risk factors ?
Conclusion: The earlier surgery is performed for LH (before complications set in), the better the prognosis of curative surgery is. Severe complications and death can be avoided after knowing the different associated risk factors. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Chaari, Z., Hentati, A., Ben Ayed, A., Abid, W., Frikha, I. Tags: 10.01 - Respiratory infections and bronchiectasis Source Type: research

Fungal infections in the ICU during the COVID-19 era
Conclusions: Fungal infections are a significant co-infection in critically ill COVID-19 patients. Those patients seem to have more severe respiratory failure on admission, be on higher doses of corticosteroids and in need of organ failure support. They also seem to develop more complications of COVID-19 and be at a higher risk of dying. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Koukaki, E., Rovina, N., Tzannis, K., Ampelioti, S., Romanou, V., Koutsoukou, A., Dimopoulos, G. Tags: 10.01 - Respiratory infections and bronchiectasis Source Type: research

Predictors of perioperative morbidity and mortality in patients with Antiphospholipid antibody syndrome (APS) and chronic thromboembolic pulmonary hypertension (CTPEH) after Endarterectomy Pulmonary
Conclusions: The autoimmune component related to the lower level of lymphocytes was associated with higher mortality, but this parameter is something seen in patients with CTEPH in other studies. We concluded that it is not a relevant factor that increase the mortality. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Bermudez, E., Zebadua, R., Lopez, J., Pozas, M., Zorrilla, L., Pulido, T., Sandoval, J., Zayas Hdz., N. G. Tags: 13.02 - Pulmonary embolism Source Type: research

A plea for personalization of the hemodynamic management of septic shock
Although guidelines provide excellent expert guidance for managing patients with septic shock, they leave room for personalization according to patients ’ condition. Hemodynamic monitoring depends on the evolut... (Source: Critical Care)
Source: Critical Care - December 1, 2022 Category: Intensive Care Authors: Daniel De Backer, Maurizio Cecconi, Michelle S. Chew, Ludhmila Hajjar, Xavier Monnet, Gustavo A. Ospina-Tasc ón, Marlies Ostermann, Michael R. Pinsky and Jean-Louis Vincent Tags: Review Source Type: research

Metabolic fingerprint of patients showing responsiveness to treatment of septic shock in intensive care unit
DISCUSSION: The study gave these metabolic signatures identifying patients' responsiveness to treatment. The results of the study will aid in the development of targeted therapy for ICU patients.PMID:36449125 | DOI:10.1007/s10334-022-01049-9 (Source: Magma)
Source: Magma - November 30, 2022 Category: Radiology Authors: Swarnima Pandey Mohd Adnan Siddiqui Afzal Azim Neeraj Sinha Source Type: research

Metabolic fingerprint of patients showing responsiveness to treatment of septic shock in intensive care unit
DISCUSSION: The study gave these metabolic signatures identifying patients' responsiveness to treatment. The results of the study will aid in the development of targeted therapy for ICU patients.PMID:36449125 | DOI:10.1007/s10334-022-01049-9 (Source: Magma)
Source: Magma - November 30, 2022 Category: Radiology Authors: Swarnima Pandey Mohd Adnan Siddiqui Afzal Azim Neeraj Sinha Source Type: research

Metabolic fingerprint of patients showing responsiveness to treatment of septic shock in intensive care unit
MAGMA. 2022 Nov 30. doi: 10.1007/s10334-022-01049-9. Online ahead of print.NO ABSTRACTPMID:36449125 | DOI:10.1007/s10334-022-01049-9 (Source: Magma)
Source: Magma - November 30, 2022 Category: Radiology Authors: Swarnima Pandey Mohd Adnan Siddiqui Afzal Azim Neeraj Sinha Source Type: research

Metabolic fingerprint of patients showing responsiveness to treatment of septic shock in intensive care unit
MAGMA. 2022 Nov 30. doi: 10.1007/s10334-022-01049-9. Online ahead of print.NO ABSTRACTPMID:36449125 | DOI:10.1007/s10334-022-01049-9 (Source: Magma)
Source: Magma - November 30, 2022 Category: Radiology Authors: Swarnima Pandey Mohd Adnan Siddiqui Afzal Azim Neeraj Sinha Source Type: research

The Olfactomedin-4-Defined Human Neutrophil Subsets Differ in Proteomic Profile in Healthy Individuals and Patients with Septic Shock
The specific granule glycoprotein olfactomedin-4 (Olfm4) marks a subset (1 –70%) of human neutrophils and the Olfm4-high (Olfm4-H) proportion has been found to correlate with septic shock severity. The aim of this study was to decipher proteomic differences between the subsets in healthy individuals, hypothesizing that Olfm4-H neutrophils have a proteomic profile distinc t from that of Olfm4 low (Olfm4-L) neutrophils. We then extended the investigation to septic shock. A novel protocol for the preparation of fixed, antibody-stained, and sorted neutrophils for LC-MS/MS was developed. In healthy individuals, 39 proteins sh...
Source: Journal of Innate Immunity - November 30, 2022 Category: Allergy & Immunology Source Type: research

Metabolic fingerprint of patients showing responsiveness to treatment of septic shock in intensive care unit
DiscussionThe study gave these metabolic signatures identifying patients ’ responsiveness to treatment. The results of the study will aid in the development of targeted therapy for ICU patients. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - November 30, 2022 Category: Materials Science Source Type: research