What is Sepsis Anyway?
Don’t feel bad if you don’t have a really good answer. Most of us don’t. Before I started researching the question two years ago, I didn’t have much of an answer either. People get sick. Some get better. Some get worse. If they get really sick they transition into septic shock. End of story. As an EMS educator, I didn’t go into too much more detail than that, so my own lack of knowledge was carried forward by my EMT students and the cycle continued. Sure, I could turn around and blame my instructor, but here’s a better idea, let’s end the cycle right now. Here is your one stop shopping guide to the path...
Source: The EMT Spot - November 7, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs

90 year old with acute chest and epigastric pain, and diffuse ST depression with reciprocal STE in aVR: activate the cath lab?
ConclusionsSTE-aVR with multilead ST depression was associated with acutely thrombotic coronary occlusion in only 10% of patients. Routine STEMI activation in STE-aVR for emergent revascularization is not warranted, although urgent, rather than emergent, catheterization appears to be important.===================================MY Comment, by KEN GRAUER, MD (11/5/2022):===================================Our thanks to Drs. El-Baba and McLaren — for their presentation in today’s post about an important topic worthy of our periodic reminders. We’ve presented many variations on this theme on...
Source: Dr. Smith's ECG Blog - November 4, 2022 Category: Cardiology Authors: Jesse McLaren Source Type: blogs

Fight Aging! Newsletter, August 22nd 2022
In conclusion, application of a multi-species bat epigenetic clock provides strong evidence that hibernation is associated with slower epigenetic ageing. The multi-species clock explains 94% of the variation in the chronological ages of both hibernating and non-hibernating big brown bats; however, the clock estimates are equal to or greater than the chronological age, suggesting big brown bats age slightly faster than a 'typical' bat, especially during the active period. (Source: Fight Aging!)
Source: Fight Aging! - August 21, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Sepsis and Immunosenescence
Sepsis is a runaway inflammatory event resulting from infection, in which the lack of resolution to the inflammatory response leads to organ damage and death. One of the lasting consequences for survivors is a suppression of the immune system's effectiveness, and in today's open access paper researchers draw parallels between this state and the natural aging of the immune system leading to immunosenescence, a loss of the capacity to destroy pathogens and errant cells alike. Aging does make sepsis worse. The immune system is already in a state of chronic inflammation as a result of the damage of aging: pro-inflammato...
Source: Fight Aging! - August 16, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Weekly Overseas Health IT Links – 30th July2022.
Here are a few I came across last week.Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment-----https://ehrintelligence.com/news/internal-email-outlines-changes-to-oracle-cerner-ehr-business-unitInternal Email Outlines Changes to Oracle Cerner EHR Business UnitUpon its acquisition, the Cerner EHR business is now called Oracle Health, one of Oracle ’s global industry units (GIUs).ByHannah NelsonJuly 22, 2022 - An internal email from an Oracle executive...
Source: Australian Health Information Technology - July 30, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
July 28, 2022 Edition-----Sadly the war drags on, Biden seems to be pretty impotent on most policy fronts and the US seems to be heading into a recession. Not good,In the UK the choosing the next PM is off and running as the country and Europe are cooling down after a heatwave (for them) of biblical proportions!In OZ Parliament is meeting which is when the rubber will really hit the road as a new virus wave runs out of control still! We need to do more to control it as we realise just how bad long COVID is!-----Major Issues.-----https://www.afr.com/policy/economy/how-a-nobel-laureate-got-australian-economists-offside-...
Source: Australian Health Information Technology - July 28, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

What is the narrative that you hear when faced with uncertainty?
The first week of my big attending job, I saw a patient with fever, sore throat, no cough, and tonsillar exudates. Well-trained to manage septic shock, but having no idea how to practice in a primary care clinic, I crafted a vast array of infectious and inflammatory diagnoses. With a quick glance, my senior partner Read more… What is the narrative that you hear when faced with uncertainty? originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 15, 2022 Category: General Medicine Authors: Tags: Physician Hospital-Based Medicine Primary Care Source Type: blogs

Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Delivering Catalase to Treat Sepsis
Sepsis is a state of runaway inflammation in response to infection, a condition that is more serious and more often fatal in older individuals. With age, the immune system becomes every more overactive and inflammatory, reacting to signals created by the damaged environment of the body. This background of chronic inflammation makes it ever less likely that any given incident of greatly raised inflammatory signaling will successfully resolve. Instead inflammation can rage to the point of causing serious harm and organ failure. At present, treatments for sepsis are largely palliative, or focus on removing the infectio...
Source: Fight Aging! - December 21, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

The syndrome of vanishing ACS : Who activates spontaneous thrombolysis doctor ?
Background “Your husband was really lucky, his heart attack got spontaneously aborted. His ECG is near normal now. The angiogram is normal.No stent, no lysis. He secreted his own Tpa and got rid of the clot. We will discharge him to tomorrow.” Thank you very much, Doctor. How did this happen, doctor? Don’t thank me. Definitely, I don’t have an answer. Spontaneous successful thrombolysis (Ref 4) happens up to 15 % of ACS. All I can say is he has a very disciplined mast cell network and fibrinolytic system. Vascular events: Pathobiology Vascular highway accidents that happen with sudden freezing...
Source: Dr.S.Venkatesan MD - October 8, 2021 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized anti fibrinolytic system thrombolysis Source Type: blogs

The syndrome of vanishing ACS : Who activates spontaneous thrombolysis ?
Background “Your husband was really lucky, his heart attack got spontaneously aborted. His ECG is near normal now. The angiogram is normal.No stent, no lysis. He secreted his own Tpa and got rid of the clot. We will discharge him to tomorrow.” Thank you very much, Doctor. How did this happen, doctor? Don’t thank me. Definitely, I don’t have an answer. Spontaneous successful thrombolysis (Ref 4) happens up to 15 % of ACS. All I can say is he has a very disciplined mast cell network and fibrinolytic system. Vascular events: Pathobiology Vascular highway accidents that happen due to the sudden fr...
Source: Dr.S.Venkatesan MD - October 8, 2021 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized anti fibrinolytic system thrombolysis Source Type: blogs

Staying Safe From Sepsis
This post was adapted with permission from the NIH News in Health article, “Staying Safe From Sepsis.” Your immune system is on patrol every day. It protects your body from bacteria, viruses, and other germs. But if something goes wrong, it can also cause big problems. White blood cells undergoing a cascade of biochemical changes that is part of the immune response. Credit: Xiaolei Su, HHMI Whitman Center of the Marine Biological Laboratory. Sepsis happens when your body’s response to an infection spirals out of control. Your body releases molecules into the blood called cytokines to fight the infecti...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - September 15, 2021 Category: Research Authors: Chrissa Chverchko Tags: Injury and Illness Infectious Diseases Sepsis Source Type: blogs

Biomaterial-Based Vaccine Against Bacterial Infection
Researchers at the Harvard Wyss Institute have developed a biomaterial-based vaccine technology that could provide prophylactic protection against bacterial infection and septic shock. The technology is delivered as a biomaterial scaffold. Once inside the body, it captures bacterial pathogens and then recruits and activates dendritic cells to initiate a broad immune response against the pathogen of choice. So far, the technology has demonstrated protective efficacy against sepsis in animals. Bacterial infections, once largely controllable with antibiotics, are becoming a growing problem with the rise of bacterial resist...
Source: Medgadget - July 12, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Critical Care Materials Medicine Source Type: blogs

Why this critical care doctor got the COVID-19 vaccine
December is typically busy in the ICU. Flu and respiratory viral pneumonia cases start trickling into the ICU, interspersed with cardiac arrests, strokes, pulmonary emboli, septic shock, and COPD exacerbations. The ICU census starts creeping up. December 2020 has been unique and challenging. There were seemingly endless days of patients coming to the ICU, only […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 15, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/rizwana-khan" rel="tag" > Rizwana Khan, MD < /a > < /span > Tags: Conditions COVID-19 coronavirus Infectious Disease Source Type: blogs

Funding Opportunity: R21/R33 to Test Existing or New Biospecimens from Sepsis Patients
We’ve issued a new funding opportunity announcement (FOA): Exploring the Scientific Value of Existing or New Sepsis Human Biospecimen Collections (R21/R33 – Clinical Trial Not Allowed) (PAR-21-077). This FOA aims to promote the optimal use, testing, and sharing of patient-derived materials. It stems from recommendations of the NAGMSC working group on sepsis and input from the scientific community for strategies to rebalance NIGMS’ investment in sepsis research. This two-phase FOA supports a 2-year R21 award for up to $275,000 direct costs in the first phase, and a 2-year R33 award with a budget cap of $500...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - November 17, 2020 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Funding Opportunities Sepsis Research Source Type: blogs