IIG Seminar - Why so many ways to Die?
Intracellular lipopolysaccharide (LPS) from Gram-negative bacteria activates caspase-11 causing inflammatory cell death (pyroptosis), IL-1b processing, and lethal septic shock. How caspase-11 drove these downstream signaling events was largely unknown. In 2015, we showed that Gasdermin-D (Gsdmd) is essential for caspase-11-dependent pyroptosis and IL-1b release. Macrophages from Gsdmd – / – mice generated by gene targeting exhibited defective pyroptosis and IL-1b release in response to cytoplasmic LPS or Gram-negative bacteria. Mechanistically, caspase-11 cleaved Gsdmd and the newly generated N-t...
Source: Videocast - All Events - March 11, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
CC Grand Rounds: 1) Reassessing the Management of Sepsis and Septic Shock and 2) Surviving Sepsis: By Draining the Swamps?
For more information go tohttp://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 6/28/2017 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - May 16, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
