Use of Landiolol for Patients With Septic Shock and Organ Failure
To the Editor The use of β-blockers during septic shock aims to counter adrenergic stress and may be justified by the early reduction in deleterious effects resulting from sympathetic overactivation. Contrary to a previous study, the authors of the Study Into the Reversal of Septic Shock With Landiolol (STRESS-L) conclude that an infusion of landiolol did not reduce organ failure, and thus, the results of the study do not support its use among patients treated with norepinephrine for established septic shock. (Source: JAMA)
Source: JAMA - February 27, 2024 Category: General Medicine Source Type: research
Use of Landiolol for Patients With Septic Shock and Organ Failure –Reply
In Reply We thank Dr Mantzarlis and colleagues for their interest in the STRESS-L study. It is worth highlighting that our research hypothesis was that more selective β1-receptor blockade would bring about myocardial protection and immunomodulation to confer benefits to a high-risk population with septic shock. Tachycardia was used as a surrogate to define this high-risk population. We did not mandate Svo2 or other cardiac output monitoring in our protocol. The trial was stopped after only 126 of a planned 340 patients were recruited. (Source: JAMA)
Source: JAMA - February 27, 2024 Category: General Medicine Source Type: research
Induction of MTHFD2 in Macrophages Inhibits Reactive Oxygen Species-mediated NF- κB Activation and Protects against Inflammatory Responses
In this study, we show that MTHFD2 was upregulated by LPS in murine macrophages upon activation of the TLR4-MyD88-IKKα/β-NF-κB signaling pathway. MTHFD2 significantly attenuated LPS-induced macrophage proinflammatory cytokine production through its enzymatic activity. Notably, ablation of myeloid MTHFD2 rendered mice more sensitive to septic shock and CCl4-induced acute hepatitis. Mechanistically, MTHFD2 restrained IKKα/β-NF-κB activation and macrophage inflammatory phenotype by scavenging reactive oxygen species through the generation of NADPH. Our study reveals MTHFD2 as a "self-control" mechanism in macrophage-med...
Source: Journal of Immunology - February 26, 2024 Category: Allergy & Immunology Authors: Yan Cui Zihan Li Lina Ni Sujun Yu Xiao Shan Penghui Hu Zemin Ji Weijia Jing Yanzhao Zhou Baochen Wang Hongyuan Dong Jinxue Zhou Keliang Xie Qiujing Yu Source Type: research
Induction of MTHFD2 in Macrophages Inhibits Reactive Oxygen Species-mediated NF- κB Activation and Protects against Inflammatory Responses
In this study, we show that MTHFD2 was upregulated by LPS in murine macrophages upon activation of the TLR4-MyD88-IKKα/β-NF-κB signaling pathway. MTHFD2 significantly attenuated LPS-induced macrophage proinflammatory cytokine production through its enzymatic activity. Notably, ablation of myeloid MTHFD2 rendered mice more sensitive to septic shock and CCl4-induced acute hepatitis. Mechanistically, MTHFD2 restrained IKKα/β-NF-κB activation and macrophage inflammatory phenotype by scavenging reactive oxygen species through the generation of NADPH. Our study reveals MTHFD2 as a "self-control" mechanism in macrophage-med...
Source: Cancer Control - February 26, 2024 Category: Cancer & Oncology Authors: Yan Cui Zihan Li Lina Ni Sujun Yu Xiao Shan Penghui Hu Zemin Ji Weijia Jing Yanzhao Zhou Baochen Wang Hongyuan Dong Jinxue Zhou Keliang Xie Qiujing Yu Source Type: research
Induction of MTHFD2 in Macrophages Inhibits Reactive Oxygen Species-mediated NF- κB Activation and Protects against Inflammatory Responses
In this study, we show that MTHFD2 was upregulated by LPS in murine macrophages upon activation of the TLR4-MyD88-IKKα/β-NF-κB signaling pathway. MTHFD2 significantly attenuated LPS-induced macrophage proinflammatory cytokine production through its enzymatic activity. Notably, ablation of myeloid MTHFD2 rendered mice more sensitive to septic shock and CCl4-induced acute hepatitis. Mechanistically, MTHFD2 restrained IKKα/β-NF-κB activation and macrophage inflammatory phenotype by scavenging reactive oxygen species through the generation of NADPH. Our study reveals MTHFD2 as a "self-control" mechanism in macrophage-med...
Source: Journal of Immunology - February 26, 2024 Category: Allergy & Immunology Authors: Yan Cui Zihan Li Lina Ni Sujun Yu Xiao Shan Penghui Hu Zemin Ji Weijia Jing Yanzhao Zhou Baochen Wang Hongyuan Dong Jinxue Zhou Keliang Xie Qiujing Yu Source Type: research
