A novel fatty acid analogue triggers CD36-GPR120 interaction and exerts anti-inflammatory action in endotoxemia
Cell Mol Life Sci. 2024 Apr 10;81(1):176. doi: 10.1007/s00018-024-05207-1.ABSTRACTInflammation is a mediator of a number of chronic pathologies. We synthesized the diethyl (9Z,12Z)-octadeca-9,12-dien-1-ylphosphonate, called NKS3, which decreased lipopolysaccharide (LPS)-induced mRNA upregulation of proinflammatory cytokines (IL-1β, IL-6 and TNF-α) not only in primary intraperitoneal and lung alveolar macrophages, but also in freshly isolated mice lung slices. The in-silico studies suggested that NKS3, being CD36 agonist, will bind to GPR120. Co-immunoprecipitation and proximity ligation assays demonstrated that NKS3 indu...
Source: Cellular and Molecular Life Sciences : CMLS - April 10, 2024 Category: Cytology Authors: Pierre-Marie Boutanquoi Amira Sayed Khan Lidia Cabeza Lucas Jantzen Thomas Gautier Semen Yesylevskyy Christophe Ramseyer David Masson Vincent Van Waes Aziz Hichami Naim Akhtar Khan Source Type: research
Medial Femoral Condyle Free Flap: A Systematic Review and Proportional Meta-analysis of Applications and Surgical Outcomes
CONCLUSION: The medial femoral condyle flap is a versatile option for bone reconstruction with high success rates and low donor site morbidity.PMID:38596574 | PMC:PMC11000773 | DOI:10.1097/GOX.0000000000005708 (Source: Hand Surgery)
Source: Hand Surgery - April 10, 2024 Category: Surgery Authors: Matteo Scampa Vladimir M égevand J érôme Martineau Dirk J Schaefer Daniel F Kalbermatten Carlo M Oranges Source Type: research
Real World Data on Peripheral Vasopressors in Septic Shock
Chest. 2024 Apr;165(4):762-763. doi: 10.1016/j.chest.2023.11.005.NO ABSTRACTPMID:38599747 | DOI:10.1016/j.chest.2023.11.005 (Source: Chest)
Source: Chest - April 10, 2024 Category: Respiratory Medicine Authors: Ian J Barbash Source Type: research
A novel fatty acid analogue triggers CD36-GPR120 interaction and exerts anti-inflammatory action in endotoxemia
Cell Mol Life Sci. 2024 Apr 10;81(1):176. doi: 10.1007/s00018-024-05207-1.ABSTRACTInflammation is a mediator of a number of chronic pathologies. We synthesized the diethyl (9Z,12Z)-octadeca-9,12-dien-1-ylphosphonate, called NKS3, which decreased lipopolysaccharide (LPS)-induced mRNA upregulation of proinflammatory cytokines (IL-1β, IL-6 and TNF-α) not only in primary intraperitoneal and lung alveolar macrophages, but also in freshly isolated mice lung slices. The in-silico studies suggested that NKS3, being CD36 agonist, will bind to GPR120. Co-immunoprecipitation and proximity ligation assays demonstrated that NKS3 indu...
Source: Cellular and Molecular Life Sciences : CMLS - April 10, 2024 Category: Cytology Authors: Pierre-Marie Boutanquoi Amira Sayed Khan Lidia Cabeza Lucas Jantzen Thomas Gautier Semen Yesylevskyy Christophe Ramseyer David Masson Vincent Van Waes Aziz Hichami Naim Akhtar Khan Source Type: research
Real World Data on Peripheral Vasopressors in Septic Shock
Chest. 2024 Apr;165(4):762-763. doi: 10.1016/j.chest.2023.11.005.NO ABSTRACTPMID:38599747 | DOI:10.1016/j.chest.2023.11.005 (Source: Chest)
Source: Chest - April 10, 2024 Category: Respiratory Medicine Authors: Ian J Barbash Source Type: research
Real World Data on Peripheral Vasopressors in Septic Shock
Chest. 2024 Apr;165(4):762-763. doi: 10.1016/j.chest.2023.11.005.NO ABSTRACTPMID:38599747 | DOI:10.1016/j.chest.2023.11.005 (Source: Chest)
Source: Chest - April 10, 2024 Category: Respiratory Medicine Authors: Ian J Barbash Source Type: research
Real World Data on Peripheral Vasopressors in Septic Shock
Chest. 2024 Apr;165(4):762-763. doi: 10.1016/j.chest.2023.11.005.NO ABSTRACTPMID:38599747 | DOI:10.1016/j.chest.2023.11.005 (Source: Chest)
Source: Chest - April 10, 2024 Category: Respiratory Medicine Authors: Ian J Barbash Source Type: research
Real World Data on Peripheral Vasopressors in Septic Shock
Chest. 2024 Apr;165(4):762-763. doi: 10.1016/j.chest.2023.11.005.NO ABSTRACTPMID:38599747 | DOI:10.1016/j.chest.2023.11.005 (Source: Chest)
Source: Chest - April 10, 2024 Category: Respiratory Medicine Authors: Ian J Barbash Source Type: research
Effects of restrictive fluid therapy on the time to resolution of hyperlactatemia in ICU patients with septic shock. A secondary post hoc analysis of the CLASSIC randomized trial
ConclusionIn this post hoc retrospective analysis of a multicenter randomized controlled trial (RCT), a restrictive intravenous fluid strategy did not seem to affect the time to resolution of hyperlactatemia in adult ICU patients with septic shock. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - April 10, 2024 Category: Intensive Care Source Type: research
Value of modified qSOFA, glucose and lactate in predicting prognosis in children with sepsis in the PICU
Ann Med. 2024 Dec;56(1):2337714. doi: 10.1080/07853890.2024.2337714. Epub 2024 Apr 8.ABSTRACTThe purpose was to investigate how well age-adjusted modified quick Sequential Organ Failure Assessment (qSOFA) scores paired with blood glucose and lactate levels predict the outcomes of septicemic children in the pediatric intensive care unit (PICU). One hundred children who were diagnosed with sepsis and septic shock in the PICU of Henan Children's Hospital were eligible, and other 20 patients in the same hospital at different times were selected as a validation set. Respiratory rate (RR), heart rate (HR), capillary refill time ...
Source: Annals of Medicine - April 9, 2024 Category: Internal Medicine Authors: Wanyu Jia Xue Zhang Ruiyang Sun Peng Li Daobin Wang Xue Gu Chunlan Song Source Type: research
Immune profile of patients ‑a new approach in management of sepsis and septic shock?
Exp Ther Med. 2024 Mar 15;27(5):203. doi: 10.3892/etm.2024.12489. eCollection 2024 May.ABSTRACTThe present study was a prospective observational single center study, enrolling 102 patients with sepsis, admitted in the Intensive Care Unit of the County Emergency Clinical Hospital in Târgu Mureș (Mureș, Romania). The main goal of the present study was to compare the changes of the following parameters on day 1 compared with day 5, in sepsis compared with septic shock, as well as in survivors compared with non-survivors: Cell blood count parameters, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic inflam...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Anca Bac ârea Oana Coman Vladimir Constantin Bac ârea Anca Meda V ăsieşiu Irina S ăplăcan Raluca Śtefania Fodor Bianca Liana Grigorescu Source Type: research
Single-cell RNA sequencing reveals cell-cell communication and potential biomarker in sepsis and septic shock patients
CONCLUSIONS: In summary, our work demonstrates changes in cell-cell communication of healthy controls, sepsis and septic shock, confirming that the molecules CAP-1 and IL16 on monocytes may serve as potential diagnostic markers for sepsis and septic shock, respectively. These findings provide new insights for early diagnosis and stratified treatment of the disease.PMID:38593502 | DOI:10.1016/j.intimp.2024.111938 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 9, 2024 Category: Allergy & Immunology Authors: Guilin Li Zhaoxu Yang Chen Yang Yaochen Xie Shuchen Gong Shuying Lv Boneng Xiao Jiajia Wang Qinjie Weng Jincheng Wang Feng Yu Source Type: research
Value of modified qSOFA, glucose and lactate in predicting prognosis in children with sepsis in the PICU
Ann Med. 2024 Dec;56(1):2337714. doi: 10.1080/07853890.2024.2337714. Epub 2024 Apr 8.ABSTRACTThe purpose was to investigate how well age-adjusted modified quick Sequential Organ Failure Assessment (qSOFA) scores paired with blood glucose and lactate levels predict the outcomes of septicemic children in the pediatric intensive care unit (PICU). One hundred children who were diagnosed with sepsis and septic shock in the PICU of Henan Children's Hospital were eligible, and other 20 patients in the same hospital at different times were selected as a validation set. Respiratory rate (RR), heart rate (HR), capillary refill time ...
Source: Annals of Medicine - April 9, 2024 Category: Internal Medicine Authors: Wanyu Jia Xue Zhang Ruiyang Sun Peng Li Daobin Wang Xue Gu Chunlan Song Source Type: research
Single-cell RNA sequencing reveals cell-cell communication and potential biomarker in sepsis and septic shock patients
CONCLUSIONS: In summary, our work demonstrates changes in cell-cell communication of healthy controls, sepsis and septic shock, confirming that the molecules CAP-1 and IL16 on monocytes may serve as potential diagnostic markers for sepsis and septic shock, respectively. These findings provide new insights for early diagnosis and stratified treatment of the disease.PMID:38593502 | DOI:10.1016/j.intimp.2024.111938 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 9, 2024 Category: Allergy & Immunology Authors: Guilin Li Zhaoxu Yang Chen Yang Yaochen Xie Shuchen Gong Shuying Lv Boneng Xiao Jiajia Wang Qinjie Weng Jincheng Wang Feng Yu Source Type: research
Efficacy of dietary supplements on mortality and clinical outcomes in adults with sepsis and septic shock: a systematic review and network meta-analysis
The aim of this network meta-analysis (NMA) was to investigate the effects of different dietary supplements on the mortality and clinical status of adults with sepsis. (Source: Clinical Nutrition)
Source: Clinical Nutrition - April 9, 2024 Category: Nutrition Authors: Maryam Safabakhsh, Hossein Imani, Hossein Shahinfar, Masoud Mohammadpour, Pejman Rohani, Sakineh Shab-Bidar Source Type: research
