Real-world experience with meropenem/vaborbactam for the treatment of infections caused by ESBL-producing Enterobacterales and carbapenem-resistant Klebsiella pneumoniae
ConclusionsM/V is a promising therapeutic option against infections caused by difficult-to-treat ESBL-producing Enterobacterales and CR-Kp. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 20, 2024 Category: Microbiology Source Type: research
Phoenix sepsis score: redefining paediatric sepsis
These four fascinating papers are worthwhile reading together because they are a great example of predictive score development and validation, working with large data (a data-driven approach) and working with a huge number of teams (Society of Critical Care Medicine (SCCM) Pediatric Sepsis Definition Task Force) across low to middle to high-income countries and giving generalisability. Sanchez-Pinto et al (JAMA 2024. doi:10.1001/jama.2024.0196) have conducted this multicentre, international, retrospective cohort study in 10 health systems in the USA, Colombia, Bangladesh, China and Kenya, including 3049699 children aged le...
Source: Archives of Disease in Childhood - February 19, 2024 Category: Pediatrics Tags: Miscellanea Source Type: research
Sepsis incidence, suspicion, prediction and mortality in emergency medical services: a cohort study related to the current international sepsis guideline
ConclusionIncidence and mortality underline the need for better sepsis awareness, documentation of vital signs and use of screening tools. Guidelines may omit MEWS and SIRS as recommendations forprehospital providers since they were inferior in all accuracy measures. Though no tool performed ideally, NEWS2 qualifies as the best tool to predict the highest proportion of septic patients and to rule out cases that are likely non-septic. (Source: Infection)
Source: Infection - February 19, 2024 Category: Infectious Diseases Source Type: research
Case report: Metagenomics next-generation sequencing in the diagnosis of septic shock due to Fusobacterium necrophorum in a 6-year-old child
We report an atypical case of a 6-year-old female patient who developed septic shock within 24 h of admission due to F. necrophorum infection in the absence of Lemierre’s syndrome. F. necrophorum was identified in a blood sample by metagenomics next-generation sequencing (mNGS) but not by standard blood culture. The patient was finally cured and discharged after receiving timely and effective targeted anti-infection treatment. In the present case study, it was observed that the heightened virulence and invasiveness of F. necrophorum contribute significantly to its role as a primary pathogen in pediatric septic shock. Thi...
Source: Frontiers in cellular and infection microbiology - February 16, 2024 Category: Microbiology Source Type: research
The prehospital NEW score to assess septic shock in-hospital, 30-day and 90-day mortality
The early identification of sepsis presenting a high risk of deterioration is a daily challenge to optimise patient pathway. This is all the most crucial in the prehospital setting to optimize triage and admis... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - February 16, 2024 Category: Infectious Diseases Authors: Romain Jouffroy, Florian N égrello, Jean Limery, Basile Gilbert, Stéphane Travers, Emmanuel Bloch-Laine, Patrick Ecollan, Josiane Boularan, Vincent Bounes, Benoit Vivien and Papa Gueye Tags: Research Source Type: research
Administration of methylene blue in septic shock: pros and cons
Septic shock typically requires the administration of vasopressors. Adrenergic agents remain the first choice, namely norepinephrine. However, their use to counteract life-threatening hypotension comes with po... (Source: Critical Care)
Source: Critical Care - February 16, 2024 Category: Intensive Care Authors: Julian Arias-Ortiz and Jean-Louis Vincent Tags: Perspective Source Type: research
Vasoconstriction in septic shock
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - February 15, 2024 Category: Intensive Care Source Type: research
Assessment of outcomes in patients with heart failure and end-stage kidney disease following fluid resuscitation for sepsis and septic shock
Sepsis fluid resuscitation is controversial, especially for patients with volume overload risk. The Surviving Sepsis Campaign recommends a 30 mL/kg crystalloid fluid bolus for patients with sepsis-induced hypoperfusion. Criticism of this approach includes excessive fluid resuscitation in certain patients. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - February 15, 2024 Category: Emergency Medicine Authors: John Michael Herndon, Sarah B. Blackwell, Nathan Pinner, Thomas S. Achey, Hillary B. Holder, Cruz Tidwell Tags: Original Contributions Source Type: research
Assessment of Outcomes in Patients with Heart Failure and End-Stage Kidney Disease after Fluid Resuscitation for Sepsis and Septic Shock
Sepsis fluid resuscitation is controversial, especially for patients with volume overload risk. The Surviving Sepsis Campaign recommends a 30-mL/kg crystalloid fluid bolus for patients with sepsis-induced hypoperfusion. Criticism of this approach includes excessive fluid resuscitation in certain patients. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - February 15, 2024 Category: Emergency Medicine Authors: John Michael Herndon, Sarah B. Blackwell, Nathan Pinner, Thomas S. Achey, Hillary B. Holder, Cruz Tidwell Tags: Original Contributions Source Type: research
