The quality and clinical translation of radiomics studies based on MRI for predicting Ki-67 levels in patients with breast cancer
CONCLUSION: Ki-67 index is a common tumor biomarker with high clinical value. Radiomics is an ever-growing quantitative data-mining method helping predict tumor biomarkers from medical images. However, the quality of the reviewed studies evaluated by the RQS was not so satisfactory and there are ample opportunities for improvement. Open science and data, external validation, phantom study, publicly open radiomics database and standardization in the radiomics practice are what researchers should pay more attention to in the future.ADVANCES IN KNOWLEDGE: The RQS tool considered the radiomics used to predict the Ki-67 level w...
Source: The British Journal of Radiology - September 19, 2023 Category: Radiology Authors: Min Wang Ting Mei Youling Gong Source Type: research

Prelicensure Nursing Students' Attitudes Regarding Breastfeeding Education
Nurs Educ Perspect. 2023 Sep 19. doi: 10.1097/01.NEP.0000000000001191. Online ahead of print.ABSTRACTBreast milk feeding is vital to the health outcomes of the breastfeeding dyad. Nurses have a significant role to promote, educate, and support breastfeeding practices for breastfeeding dyads in diverse settings. Nurses should also promote breastfeeding awareness to normalize breastfeeding as the optimal food for infants. This pilot study investigated the effects of a basic breastfeeding educational module on the breastfeeding attitudes of prelicensure nursing students. There was a statistically significant change in attitud...
Source: Nursing Education Perspectives - September 19, 2023 Category: Nursing Authors: Stephanie D Uhr Teresa S Johnson Murad H Taani Source Type: research

Treatment for Alpha-1-antitrypsin Deficiency: Does Augmentation Therapy Work?
Am J Respir Crit Care Med. 2023 Sep 19. doi: 10.1164/rccm.202309-1585ED. Online ahead of print.NO ABSTRACTPMID:37724887 | DOI:10.1164/rccm.202309-1585ED
Source: American Journal of Respiratory and Critical Care Medicine - September 19, 2023 Category: Respiratory Medicine Authors: Mark Brantly Source Type: research

Design and Synthesis of New bis-oxindole and Spiro(triazole-oxindole) as CDK4 Inhibitors with Potent Anti-breast Cancer Activity
CONCLUSION: According to all of the findings, bis-oxindole 3c shows promise as a cancer treatment targeting CDK4.PMID:37723960 | DOI:10.2174/1573406419666230810124855
Source: Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Thoraya A Farghaly Rami Adel Pashameah Abrar Bayazeed Amerah M Al-Soliemy Amani M R Alsaedi Marwa F Harras Source Type: research

Proteomic landscape of primary and metastatic brain tumors for heterogeneity discovery
CONCLUSIONS AND CLINICAL RELEVANCE: We characterized an extensive proteomic landscape of BrMs and gliomas. These findings have promising implications for the development of targeted therapies for BrMs and gliomas.PMID:37726528 | DOI:10.1002/prca.202300010
Source: Clinical Lung Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Shuang Yang Chengbin Zhou Lei Zhang Yueting Xiong Yongtao Zheng Liuguan Bian Xiaohui Liu Source Type: research

Twenty-Year Follow-Up of a Phase II Trial of Taxotere/Carboplatin/Herceptin in Patients With Metastatic HER2-Positive Breast Cancer
CONCLUSION: A subset of patients (10%) receiving trastuzumab in the metastatic setting have achieved long-term survival beyond 20 years.PMID:37725049 | DOI:10.1093/oncolo/oyad258
Source: The Oncologist - September 19, 2023 Category: Cancer & Oncology Authors: Juan Luis Gomez Marti Azadeh Nasrazadani Ying Ding Daniel Normolle Adam M Brufsky Source Type: research

Treatment for Alpha-1-antitrypsin Deficiency: Does Augmentation Therapy Work?
Am J Respir Crit Care Med. 2023 Sep 19. doi: 10.1164/rccm.202309-1585ED. Online ahead of print.NO ABSTRACTPMID:37724887 | DOI:10.1164/rccm.202309-1585ED
Source: Respiratory Care - September 19, 2023 Category: Respiratory Medicine Authors: Mark Brantly Source Type: research

Incidence and Survival for Patients Diagnosed With Breast, Colorectal, and Lung Cancer in an Integrated System
Conclusions Incidence rates for all-stage and localized-stage BC were consistently higher for Kaiser Permanente than for SEER. CRC and LC rates were lower. Kaiser Permanente survival rates were consistently higher than for SEER. The strengths of these findings are associated with the ability to capture "gold-standard" cancer registry data on defined Kaiser Permanente populations. However, findings should be interpreted cautiously given differences in the underlying populations and secular and regional differences between Kaiser Permanente and SEER. The Kaiser Permanente population is younger and more racially diverse than ...
Source: The Permanente journal - September 19, 2023 Category: General Medicine Authors: Erin E Hahn Debra P Ritzwoller Corrine E Munoz-Plaza Jennifer Gander Lawrence H Kushi Carmit McMullen Caryn Oshiro Douglas W Roblin Karen J Wernli Jenny Staab Source Type: research

Platycodin D induces neutrophil apoptosis by downregulating PD-L1 expression to inhibit breast cancer pulmonary metastasis
In conclusion, the administration of PlaD inhibited the PI3K/Akt signaling pathway by reducing the expression of PD-L1 in neutrophils. PlaD promoted neutrophil apoptosis, thereby inhibiting the establishment of a premetastatic niche and ultimately blocking the development of pulmonary metastasis.PMID:37724959 | DOI:10.1016/j.intimp.2023.109733
Source: International Immunopharmacology - September 19, 2023 Category: Allergy & Immunology Authors: Yiyi Ye Ying Xie Lixia Pei Ziwei Jiang Chunyu Wu Sheng Liu Source Type: research

Enantioselective De Novo Synthesis of α,α-Diaryl Ketones from Alkynes
Angew Chem Int Ed Engl. 2023 Sep 19:e202310078. doi: 10.1002/anie.202310078. Online ahead of print.ABSTRACTChiral α,α-diaryl ketones are structural motifs commonly present in bioactive molecules, and they are also valuable building blocks in synthetic organic chemistry. However, catalytic asymmetric synthesis of α,α-diaryl ketones bearing a tertiary stereogenic center remains largely unsolved. Herein, we report a catalytic de novo enantioselective synthesis of α,α-diaryl ketones from simple alkynes via chiral phosphoric acid (CPA) catalysis. A broad range of enolizable α,α-diaryl ketones are prepared in good yields...
Source: Angewandte Chemie - September 19, 2023 Category: Chemistry Authors: Xueting Zhou Qingqin Huang Jiami Guo Lei Dai Yixin Lu Source Type: research

RANK expression as an independent predictor for response to neoadjuvant chemotherapy in luminal-like breast cancer - a translational insight from the GeparX trial
CONCLUSIONS: We report RANK expression to be an independent predictive biomarker for response to NACT in luminal-like breast cancer patients.PMID:37725572 | DOI:10.1158/1078-0432.CCR-23-1801
Source: Clinical Cancer Research - September 19, 2023 Category: Cancer & Oncology Authors: Theresa Link Jens-Uwe Blohmer Wolfgang D Schmitt Jan Dominik Kuhlmann Marianne Just Michael Untch Oliver Stotzer Peter A Fasching Marc Thill Mattea Reinisch Andreas Schneeweiss Pauline Wimberger Sabine Seiler Jens Huober Christian Jackisch Kerstin Rhiem C Source Type: research

The Prognostic Significance of P16 Immunohistochemical Expression Pattern in Women with Invasive Ductal Breast Carcinoma
CONCLUSIONS: Our study demonstrated that p16 protein expression increased in ER-positive tumor tissue from patients with invasive ductal breast carcinoma. However, no correlation was found between the p16 protein expression and the other clinicopathological features.PMID:37724141 | PMC:PMC10505467 | DOI:10.52547/rbmb.12.1.83
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Alireza Rezaei Navidreza Shayan Saman Shirazinia Sara Mollazadeh Negin Ghiyasi-Moghaddam Source Type: research

Proteomic landscape of primary and metastatic brain tumors for heterogeneity discovery
CONCLUSIONS AND CLINICAL RELEVANCE: We characterized an extensive proteomic landscape of BrMs and gliomas. These findings have promising implications for the development of targeted therapies for BrMs and gliomas.PMID:37726528 | DOI:10.1002/prca.202300010
Source: Clinical Breast Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Shuang Yang Chengbin Zhou Lei Zhang Yueting Xiong Yongtao Zheng Liuguan Bian Xiaohui Liu Source Type: research

Augmentation With Aripiprazole or Bupropion, or a Switch to Nortriptyline, Effective for Treatment-Resistant Depression in Older Adults
Am Fam Physician. 2023 Sep;108(3):Online.NO ABSTRACTPMID:37725473
Source: American Family Physician - September 19, 2023 Category: Primary Care Authors: Mark H Ebell Source Type: research

Treatment for Alpha-1-antitrypsin Deficiency: Does Augmentation Therapy Work?
Am J Respir Crit Care Med. 2023 Sep 19. doi: 10.1164/rccm.202309-1585ED. Online ahead of print.NO ABSTRACTPMID:37724887 | DOI:10.1164/rccm.202309-1585ED
Source: Am J Respir Crit Car... - September 19, 2023 Category: Intensive Care Authors: Mark Brantly Source Type: research

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