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Total 222444 results found since Jan 2013.

A New Prognostic Factor of Breast Cancer: High Carboxyl Ester Lipase Expression related to Poor Survival
ConclusionsHigh CEL expression may be an independent prognostic factor for the poor survival of breast cancer.
Source: Cancer Genetics - September 19, 2019 Category: Cancer & Oncology Source Type: research

Eupalinolide J Suppresses the Growth of Triple-Negative Breast Cancer Cells via Targeting STAT3 Signaling Pathway
In conclusion, we identified that EJ suppressed the growth of TNBC cells via targeting the STAT3 signaling pathway. These results strongly support that EJ is a promising therapeutic agent for TNBC.
Source: Frontiers in Pharmacology - September 19, 2019 Category: Drugs & Pharmacology Source Type: research

Cancers, Vol. 11, Pages 1401: Prognostic and Predictive Implications of PTEN in Breast Cancer: Unfulfilled Promises but Intriguing Perspectives
a Dieci The characterization of tumor biology and consequently the identification of prognostic and predictive biomarkers represent key issues for the translational research in breast cancer (BC). Phosphatase and tensin homolog deleted on chromosome ten (PTEN), the negative regulator of the proto-oncogenic phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) pathway, constitutes one of the most intriguing tumor suppressor genes involved in a series of biological processes, such as cell growth and survival, cellular migration and genomic stability. Loss of PTEN activity, due to protein, genetic or epigenetic alte...
Source: Cancers - September 19, 2019 Category: Cancer & Oncology Authors: Luisa Carbognin Federica Miglietta Ida Paris Maria Vittoria Dieci Tags: Review Source Type: research

Correction: Deacetylation of HSPA5 by HDAC6 leads to GP78-mediated HSPA5 ubiquitination at K447 and suppresses metastasis of breast cancer
Oncogene, Published online: 19 September 2019; doi:10.1038/s41388-019-0981-5Correction: Deacetylation of HSPA5 by HDAC6 leads to GP78-mediated HSPA5 ubiquitination at K447 and suppresses metastasis of breast cancer
Source: Oncogene - September 19, 2019 Category: Cancer & Oncology Authors: Y. W. Chang C. F. Tseng M. Y. Wang W. C. Chang C. C. Lee L. T. Chen M. C. Hung J. L. Su Source Type: research

Sensors, Vol. 19, Pages 4050: Enhancement of Multimodal Microwave-Ultrasound Breast Imaging Using a Deep-Learning Technique
We present a deep learning method used in conjunction with dual-modal microwave-ultrasound imaging to produce tomographic reconstructions of the complex-valued permittivity of numerical breast phantoms. We also assess tumor segmentation performance using the reconstructed permittivity as a feature. The contrast source inversion (CSI) technique is used to create the complex-permittivity images of the breast with ultrasound-derived tissue regions utilized as prior information. However, imaging artifacts make the detection of tumors difficult. To overcome this issue we train a convolutional neural network (CNN) that takes in,...
Source: Sensors - September 19, 2019 Category: Biotechnology Authors: Vahab Khoshdel Ahmed Ashraf Joe LoVetri Tags: Article Source Type: research

ShenQi FuZheng injection as an adjunctive treatment to chemotherapy in breast cancer patients: a meta-analysis.
This study assesses the clinical effect of SFI combined with chemotherapy for breast cancer patients. Materials and methods: Both English and Chinese databases were searched covering the time period of 1999- 2018 for relevant studies comparing the effect of SFI plus chemotherapy treatment with chemotherapy alone in patients with breast cancer. Target outcomes concerning treatment effect, performance status, immune system and toxic effects were extracted and combined using Stata version 15.0 software. Quality assessment was performed using the Jadad scale. Results: Forty-nine trials were included based on certain selection ...
Source: Pharmaceutical Biology - September 18, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Chemoprevention for Breast Cancer: A ' Big Ask ' of PCPs Chemoprevention for Breast Cancer: A ' Big Ask ' of PCPs
Chemoprevention for breast cancer should be discussed at well-woman care visits, but this is a ' big ask ' of primary care physicians, says one who specializes in this area.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - September 18, 2019 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

XIST Gene Deletion in Breast Cancer Therapy
Condition:   Breast Cancer Intervention:   Genetic: XIST gene deletion Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - September 18, 2019 Category: Research Source Type: clinical trials

Sensory Nerve Coaptation in DIEP Flap Breast Reconstruction
Condition:   Breast Cancer Intervention:   Procedure: Sensory nerve coaptation Sponsor:   Maastricht University Medical Center Completed
Source: ClinicalTrials.gov - September 18, 2019 Category: Research Source Type: clinical trials

XIST Gene Deletion in Breast Cancer Therapy
Condition:   Breast Cancer Intervention:   Genetic: XIST gene deletion Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - September 18, 2019 Category: Research Source Type: clinical trials

Upstate Cancer Center to host evening devoted to breast cancer awareness Oct. 2
The evening will feature a wellness fair where experts will share the latest information on wellness, cancer prevention, screening and breast health.
Source: SUNY Upstate Medical - September 18, 2019 Category: Universities & Medical Training Source Type: news

Sensory Nerve Coaptation in DIEP Flap Breast Reconstruction
Condition:   Breast Cancer Intervention:   Procedure: Sensory nerve coaptation Sponsor:   Maastricht University Medical Center Completed
Source: ClinicalTrials.gov - September 18, 2019 Category: Research Source Type: clinical trials

Cosmetic Outcomes Equal After Partial vs Whole Breast Radiation Cosmetic Outcomes Equal After Partial vs Whole Breast Radiation
Partial breast irradiation now proves to be equal to whole breast irradiation not only in oncologic outcomes but also in cosmetic outcomes as assessed by patients themselves.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - September 18, 2019 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

XIST Gene Deletion in Breast Cancer Therapy
Condition:   Breast Cancer Intervention:   Genetic: XIST gene deletion Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - September 18, 2019 Category: Research Source Type: clinical trials

Sensory Nerve Coaptation in DIEP Flap Breast Reconstruction
Condition:   Breast Cancer Intervention:   Procedure: Sensory nerve coaptation Sponsor:   Maastricht University Medical Center Completed
Source: ClinicalTrials.gov - September 18, 2019 Category: Research Source Type: clinical trials

GSE129162 Non-CYP2D6 variants selected by GWAS improved the prediction of impaired tamoxifen metabolism in breast cancer patients
Conclusions: The four novel SNPs, tested alone or in addition to CYP2D6 genotype, improved the prediction of impaired tamoxifen to endoxifen metabolism, allowing for adjustments in dosing regimen before the treatment begins.
Source: GEO: Gene Expression Omnibus - September 18, 2019 Category: Genetics & Stem Cells Tags: Genome variation profiling by SNP array Homo sapiens Source Type: research

Independent validation of machine learning in diagnosing breast Cancer on magnetic resonance imaging within a single institution
As artificial intelligence methods for the diagnosis of disease advance, we aimed to evaluate machine learning in the predictive task of distinguishing between malignant and benign breast lesions on an indepen...
Source: Cancer Imaging - September 18, 2019 Category: Radiology Authors: Yu Ji, Hui Li, Alexandra V. Edwards, John Papaioannou, Wenjuan Ma, Peifang Liu and Maryellen L. Giger Tags: Research article Source Type: research

Reproductive characteristics are associated with gene-specific promoter methylation status in breast cancer
Reproductive characteristics are well-established risk factors for breast cancer, but the underlying mechanisms are not fully resolved. We hypothesized that altered DNA methylation, measured in tumor tissue, c...
Source: BMC Cancer - September 18, 2019 Category: Cancer & Oncology Authors: Lauren E. McCullough, Lindsay J. Collin, Kathleen Conway, Alexandra J. White, Yoon Hee Cho, Sumitra Shantakumar, Mary Beth Terry, Susan L. Teitelbaum, Alfred I. Neugut, Regina M. Santella, Jia Chen and Marilie D. Gammon Tags: Research article Source Type: research

Experience in multicatheter interstitial high-dose-rate breast brachytherapy: dose-volume histogram analysis of the first results.
Conclusions: This study is the first stage of the dosimetric evaluation of a new method. The analysis allows treating complex localizations of the breast cancer, for example, in a close position to the skin or ribs. In order to minimize the toxic effects, it is necessary to consider patient selection, catheter administration, and dose optimization. PMID: 31523236 [PubMed]
Source: Journal of Contemporary Brachytherapy - September 18, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Second breast conserving therapy after ipsilateral breast tumor recurrence - a 10-year experience of re-irradiation.
Conclusions: In case of small, low-risk IBTR, adjuvant re-irradiation using multi-catheter brachytherapy is a feasible, safe, and effective treatment method after repeated lumpectomy, and an alternative to mastectomy. PMID: 31523231 [PubMed]
Source: Journal of Contemporary Brachytherapy - September 18, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Interobserver variability in upfront dichotomous histopathological assessment of ductal carcinoma in situ of the breast: the DCISion study
Modern Pathology, Published online: 18 September 2019; doi:10.1038/s41379-019-0367-9Interobserver variability in upfront dichotomous histopathological assessment of ductal carcinoma in situ of the breast: the DCISion study
Source: Modern Pathology - September 18, 2019 Category: Pathology Authors: H élène Dano Serdar Altinay Laurent Arnould Noella Bletard Cecile Colpaert Franceska Dedeurwaerdere Benjamin Dessauvagie Val érie Duwel Giuseppe Floris Stephen Fox Clara Gerosa Shabnam Jaffer Eline Kurpershoek Magali Lacroix-Triki Andoni Laka Kathleen Source Type: research

Assessing and Explaining Geographic Variations in Mammography Screening Participation and Breast Cancer Incidence
This study examined the suitability of health insurance claims data for assessing and explaining geographic variations in mammography screening participation and breast cancer incidence at the district level. Based on screening unit data (1,181,212 mammography screening events), cancer registry data (13,241 incident breast cancer cases) and claims data (147,325 mammography screening events; 1,778 incident breast cancer cases), screening unit and claims-based standardized participation ratios (SPR) of mammography screening as well as cancer registry and claims-based standardized incidence ratios (SIR) of breast cancer betwe...
Source: Frontiers in Oncology - September 18, 2019 Category: Cancer & Oncology Source Type: research

Integrated Transcriptome and Pathway Analyses Revealed Multiple Activated Pathways in Breast Cancer
This study aimed to provide a better understanding of the altered molecular networks in BC from the gulf region. Herein, we compared the transcriptome of BC to adjacent normal tissue from six BC patients and identified 1,108 upregulated and 518 downregulated transcripts. A selected number of genes from the RNA-Seq analysis were subsequently validated using qRT-PCR. Differentially expressed (2.0-fold change, adj. p < 0.05) transcripts were subjected to ingenuity pathway analysis, which revealed a myriad of affected signaling pathways and functional categories. Activation of ERBB2, FOXM1, ESR1, and IGFBP2 mechanistic netw...
Source: Frontiers in Oncology - September 18, 2019 Category: Cancer & Oncology Source Type: research

Mucosectomy disrupting enteric nervous system causes contraction and shrinkage of gastro-intestinal flaps: Potential implications for augmentation cystoplasty
Augmenting the bladder with a sero-muscular gastro-intestinal flap is a promising alternative approach aiming for a mucus-free bladder augmentation, however the contraction (shrinkage) of the flaps remains a major concern. Enteric nervous system (ENS) abnormalities cause a failure of relaxation of the intestinal muscle layers in motility disorders like Hirschsprung ’s disease and Intestinal Neuronal Dysplasia. In mammals, the submucosal enteric nervous plexus contains nitrergic inhibitory motor neurons responsible for muscle relaxation.
Source: Journal of Pediatric Urology - September 18, 2019 Category: Urology & Nephrology Authors: D ániel Urbán, Mahmoud Marei Marei, Dániel Hajnal, Gabriella Varga, Dániel Érces, Marietta Poles, Dániel Imre, Anikó Szabó, Raimondo Cervellione, Tamas Cserni Source Type: research

Immunotherapy possibilities and results in breast cancer.
Abstract In recent years, a number of tumor types have shown significant therapeutic benefit with immunotherapy. Breast cancer has not been regarded traditionally as a typical immunogenic tumor, however, based on results so far, immunotherapy may play a role in the therapy. The most important change in attitude is that the target of therapy is not the disease but the host. A better understanding of the host's immune system and the process between the tumor and host provides an opportunity for therapeutic intervention, in this case (re-)activating anti-tumor immune processes. The purpose of this summary is to brief...
Source: Magyar Onkologia - September 18, 2019 Category: Cancer & Oncology Authors: Rubovszky G, Mûzes G Tags: Magy Onkol Source Type: research

Improving State-Mandated Breast Density Notifications
Effective written communication directly affects health care outcomes. Since 2016, the complex language of state-mandated breast density notifications (BDNs) has been challenged, as it is perceived to be beyond the comprehension of most patients. The aim of this study was to assess whether a revised BDN written at a lower reading grade level improves understanding compared with the current state-mandated BDN.
Source: Journal of the American College of Radiology : JACR - September 18, 2019 Category: Radiology Authors: Derek L. Nguyen, Emily B. Ambinder, Mary Kate Jones, Lisa A. Mullen, Susan C. Harvey Tags: Original article Source Type: research

Population prevalence of individuals meeting criteria for hereditary breast and ovarian cancer testing
ConclusionsThis study quantifies the population ‐based prevalence of HBOC criteria using objectively determined genealogy and cancer incidence data. Sporadic breast cancer likely represents a portion of the high prevalence of family cancer history seen in this study. These results underline the importance of establishing presence of a deleterio us mutation in an affected family member, per NCCN guidelines, before testing unaffected relatives.
Source: Cancer Medicine - September 18, 2019 Category: Cancer & Oncology Authors: Samantha Greenberg, Saundra S. Buys, Sandra L. Edwards, Whitney Espinel, Alison Fraser, Amanda Gammon, Brent Hafen, Kimberly A. Herget, Wendy Kohlmann, Camille Roundy, Carol Sweeney Tags: ORIGINAL RESEARCH Source Type: research

IJERPH, Vol. 16, Pages 3477: Occupational Class Differences in Long-Term Sickness Absence Due to Breast Cancer during 2005 –2013: A Population-Based Study among Finnish Women
IJERPH, Vol. 16, Pages 3477: Occupational Class Differences in Long-Term Sickness Absence Due to Breast Cancer during 2005–2013: A Population-Based Study among Finnish Women International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16183477 Authors: Johanna Suur-Uski Johanna Pekkala Jenni Blomgren Olli Pietiläinen Ossi Rahkonen Minna Mänty Breast cancer is the most common cancer among women in Western countries with clear socioeconomic differences. Higher occupational class is associated with higher breast cancer incidence but with better survival from the disease, whereas l...
Source: International Journal of Environmental Research and Public Health - September 18, 2019 Category: Environmental Health Authors: Johanna Suur-Uski Johanna Pekkala Jenni Blomgren Olli Pietil äinen Ossi Rahkonen Minna M änty Tags: Article Source Type: research

IJERPH, Vol. 16, Pages 3469: Risk of Endometriosis and Subsequent Ovary and Breast Cancers in Nurses: A Population-Based Cohort Study in Taiwan
Conclusions: Nurses are at a higher risk of developing endometriosis. However, the link between endometriosis and subsequent cancers is weak.
Source: International Journal of Environmental Research and Public Health - September 18, 2019 Category: Environmental Health Authors: Hsing-Chi Hsu Kai-Yu Tseng Hsiang-Chi Wang Fung-Chan Sung Wei-Fen Ma Tags: Article Source Type: research

Internet-based cognitive behavioral therapy aimed at alleviating treatment-induced menopausal symptoms in breast cancer survivors: moderators and mediators of treatment effects
Many young breast cancer (BC) survivors are confronted with menopausal symptoms caused by their BC treatment [1]. The most prevalent and disruptive menopausal symptoms are hot flushes and night sweats (HF/NS) which negatively affect health-related quality of life (HRQOL), and can result in women discontinuing their endocrine treatment [2 –5]. A cognitive behavioral therapy (CBT) program was developed by Hunter and colleagues to help women cope with these HF/NS [6,7]. Four randomized controlled trials (RCTs) have provided evidence of the efficacy of this program, delivered in groups or in self-help or guided self-help for...
Source: Maturitas - September 18, 2019 Category: Primary Care Authors: Vera Atema, Marieke van Leeuwen, Jacobien M. Kieffer, Hester S.A. Oldenburg, Marc van Beurden, Myra S. Hunter, Neil K. Aaronson Source Type: research

The medial breast margin sign: A new sign of pectus excavatum in adult females and comparison with classic signs
ConclusionThe medial breast margin sign is useful in diagnosing PX and is comparable to the previously described classic signs.
Source: Journal of Medical Imaging and Radiation Oncology - September 18, 2019 Category: Radiology Authors: Kamal S Hapuarachchi, Ian A Cowan Tags: Medical Imaging —Original Article Source Type: research

Developing a Novel Machine Learning-Based Classification Scheme for Predicting SPCs in Breast Cancer Survivors
In conclusion, the proposed scheme can support the important influence of personality and clinical symptom representations in all phases of the primary treatment trajectory. Our results further suggested that adaptive machine learning techniques require the incorporation of significant variables for optimal predictions.
Source: Frontiers in Genetics - September 18, 2019 Category: Genetics & Stem Cells Source Type: research

Cancers, Vol. 11, Pages 1393: Should Tumor Infiltrating Lymphocytes, Androgen Receptor, and FOXA1 Expression Predict the Clinical Outcome in Triple Negative Breast Cancer Patients?
Nicola Silvestris Tumor-infiltrating lymphocytes (TILs) are a valuable indicator of the immune microenvironment that plays the central role in new anticancer drugs. TILs have a strong prognostic role in triple negative breast cancer (TNBC). Little is known about the interaction with the androgen receptor (AR) and forkhead box A1 (FOXA1). We analyzed the relationships between TIL levels, AR, and FOXA1 expression and their clinical significance in TNBC patients. Further, we investigated their interaction with other biomarkers like programmed cell death ligand-1 (PD-L1), breast cancer type 1 susceptibility protein (BRCA...
Source: Cancers - September 18, 2019 Category: Cancer & Oncology Authors: Anita Mangia Concetta Saponaro Alessandro Vagheggini Giuseppina Opinto Matteo Centonze Chiara Vicenti Ondina Popescu Maria Pastena Francesco Giotta Nicola Silvestris Tags: Article Source Type: research

Epigenetic re-wiring of breast cancer by pharmacological targeting of C-terminal binding protein
Cell Death & Disease, Published online: 18 September 2019; doi:10.1038/s41419-019-1892-7Epigenetic re-wiring of breast cancer by pharmacological targeting of C-terminal binding protein
Source: Cell death and disease - September 18, 2019 Category: Internal Medicine Authors: Jung S. Byun Samson Park Dae Ik Yi Jee-Hye Shin Sara Gil Hernandez Stephen M. Hewitt Marc C. Nicklaus Megan L. Peach Laura Guasch Binwu Tang Lalage M. Wakefield Tingfen Yan Ambar Caban Alana Jones Mohamed Kabbout Nasreen Vohra Anna Mar ía Nápoles Sandee Source Type: research

The reconstructive journey: description of the breast reconstruction pathway in a high- volume UK-based microsurgical centre
Autologous breast reconstruction, on its own, is a complex microsurgical procedure. However, this operation is usually just one of a series of steps along a patient's reconstructive journey. This includes not just a primary major surgical event, but also the consequent recovery, potential complications and secondary surgeries required to optimise the final outcome. Unfortunately, there is limited information of what patients can expect of this reconstructive journey in the literature. The aim of this study was to characterise the journey of a consecutive cohort of patients through their whole reconstructive pathway in a la...
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - September 18, 2019 Category: Cosmetic Surgery Authors: Loren Moller, Juan Enrique Berner, Baljit Dheansa Source Type: research

CD44-Targeted Multifunctional Nanomedicines Based on a Single-Component Hyaluronic Acid Conjugate with All-Natural Precursors: Construction and Treatment of Metastatic Breast Tumors in Vivo.
Abstract Metastasis is responsible for >90% of the deaths of breast cancer patients in the clinic. Here, we report on cross-linked multifunctional hyaluronic acid nanoparticles carrying docetaxel (DTX-CMHN) for enhanced suppression of highly metastatic 4T1 breast tumors in vivo. DTX-CMHN was formed from a single and all-natural hyaluronic acid-g-polytyrosine-lipoic acid conjugate (HA-g-PTyr-LA; HA, 20 kDa; PTyr, 2.2 kDa), and the size of DTX-CMHN increased from 69 to 78 to 96 nm as the increasing degree of substitution (DS) of PTyr increased from 4 to 11 to 15, respectively. Robust encapsulation of DTX was obta...
Source: Biomacromolecules - September 18, 2019 Category: Biochemistry Authors: Fang H, Zhao X, Gu X, Sun H, Cheng R, Zhong Z, Deng C Tags: Biomacromolecules Source Type: research

Up-regulation of lysophosphatidylcholine acyltransferase 1 (LPCAT1) is linked to poor prognosis in breast cancer.
P, Wilke C, Heilenkötter U, Terracciano L, Müller V, Wilczak W, Burandt EC Abstract Dysregulation of lipid metabolism is common in cancer. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) has been implicated with various cancer types. Here we analyzed by immunohistochemistry its expression in 2,197 breast cancers. LPCAT1 staining was found in 97.8% of 1,774 interpretable tumors, including 48.1% with weak, 28.7% with moderate, and 14.4% with strong expression. The frequency of LPCAT1 positivity depended on the histological tumor type. Moderate or strong LPCAT1 positivity was more common in cancers of no special...
Source: Aging - September 18, 2019 Category: Biomedical Science Authors: Lebok P, von Hassel A, Meiners J, Hube-Magg C, Simon R, Höflmayer D, Hinsch A, Dum D, Fraune C, Göbel C, Möller K, Sauter G, Jacobsen F, Büscheck F, Prien K, Krech T, Krech RH, von der Assen A, Wölber L, Witzel I, Schmalfeldt B, Geist S, Paluchoswski Tags: Aging (Albany NY) Source Type: research

A New Prognostic Factor of Breast Cancer: High Carboxyl Ester Lipase Expression related to Poor Survival
Breast cancer is a common disease which morbidity and mortality rates have been rising over the past 50 years [1]. At present, the treatment of breast cancer is comprehensive and guided by tissue factors which includes tumor size, lymph node status, histological classification, and molecular classification [2]. The diagnosis and prognosis of breast cancer are also in the process of continuous development and improvement. In general, breast cancer has the best proven markers, including ER, PR, HER-2 [1].
Source: Cancer Genetics and Cytogenetics - September 18, 2019 Category: Genetics & Stem Cells Authors: Yingnan Cui, Yan Jiao, Keren Wang, Miao He, Zhaoying Yang Source Type: research

Comparison of Comfort between Cone Beam Breast Computed Tomography and Digital Mammography
ConclusionThe comfort of CBBCT was better than mammography.
Source: European Journal of Radiology - September 17, 2019 Category: Radiology Source Type: research

Men at High Risk for Breast Cancer May Benefit From Screening Men at High Risk for Breast Cancer May Benefit From Screening
Breast cancer in men is rare, but for those at a high risk, screening mammography may be beneficial in detecting early stage tumors.Medscape Medical News
Source: Medscape Radiology Headlines - September 17, 2019 Category: Radiology Tags: Hematology-Oncology News Source Type: news

Associations between clinical-pathological parameters and biomarkers, HER-2, TYMS, RRMI, and 21-Gene Recurrence Score in breast cancer
ConclusionOur studies showed that TNM stage and sentinel lymph node were important clinical parameters correlated with 21-gene RS results. Also, RRM1, TYMS and HER2 expressions were independent factors associated with disease progression in breast cancer patients. Future study is warranted to investigate the usefulness of these genes in treatment efficacy.
Source: Pathology Research and Practice - September 17, 2019 Category: Pathology Source Type: research

Male breast cancer screening in high-risk patients extremely successful, study says
Mammograms are more effective at detecting breast cancer in high-risk men than in women who are at average risk of developing the disease, and could provide potentially lifesaving early detection of male breast cancer.
Source: CNN.com - Health - September 17, 2019 Category: Consumer Health News Source Type: news

High expression of bone morphogenetic protein (BMP) 6 and BMP7 are associated with higher immune cell infiltration and better survival in estrogen receptor ‑positive breast cancer.
In conclusion, BMP expression profiles may be useful for prognostication. Intervention in this pathway may serve to improve outcomes, manage metastatic disease and assist in clinical decision making on optimal therapy based on the risk of recurrence or metastasis. PMID: 31524275 [PubMed - as supplied by publisher]
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Monoclonal anti ‑MUC1 antibody with novel octahydropyrazino2,1‑a:5,4‑a'diisoquinoline derivative as a potential multi‑targeted strategy in MCF‑7 breast cancer cells.
Monoclonal anti‑MUC1 antibody with novel octahydropyrazino[2,1‑a:5,4‑a']diisoquinoline derivative as a potential multi‑targeted strategy in MCF‑7 breast cancer cells. Oncol Rep. 2019 Aug 02;: Authors: Gornowicz A, Szymanowski W, Bielawska A, Szymanowska A, Czarnomysy R, Kałuża Z, Bielawski K Abstract The aim of the present study was to examine the multi‑targeted potential of a monoclonal antibody against mucin‑1 (MUC1) and novel octahydropyrazin[2,1‑a:5,4‑a']diisoquinoline derivative (OM‑86II) in estrogen receptor‑positive MCF‑7 human breast cancer cells. The cell viability wa...
Source: Oncology Reports - September 17, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Evaluation of a New Technique to Fill the Defect Generated After Conservative Surgery in Breast Cancer
Condition:   Breast Conserving Surgery Interventions:   Device: Silicone prosthesis;   Procedure: Usual practice Sponsor:   Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau Not yet recruiting
Source: ClinicalTrials.gov - September 17, 2019 Category: Research Source Type: clinical trials

Diagnostic utility of CD205 in breast cancer: Simultaneous detection of myoepithelial cells and dendritic cells in breast tissue by CD205.
CONCLUSION: Because CD205 was simultaneously detected on MECs and DCs in the same breast tissue sections, it may be useful for distinguishing tubular IDC from DCIS. PMID: 31524947 [PubMed - as supplied by publisher]
Source: Histology and Histopathology - September 17, 2019 Category: Cytology Tags: Histol Histopathol Source Type: research