This page shows you the latest news items in this category. This is page number 19.

Total 222494 results found since Jan 2013.

Reliability and Reproducibility of Bandaging in Breast Cancer
Condition:   Breast Cancer Intervention:   Other: functional compressive bandage Sponsor:   Elaine Caldeira de Oliveira Guirro Recruiting
Source: ClinicalTrials.gov - September 2, 2019 Category: Research Source Type: clinical trials

A Study of Neoadjuvant Nivolumab + Abemaciclib or Palbociclib + Anastrozole in Post-Menopausal Women and Men With Primary Breast Cancer
Conditions:   Breast Cancer;   Cancer Interventions:   Biological: Nivolumab;   Drug: Abemaciclib;   Drug: Anastrozole;   Drug: Palbociclib Sponsor:   Bristol-Myers Squibb Not yet recruiting
Source: ClinicalTrials.gov - September 2, 2019 Category: Research Source Type: clinical trials

Guidelines for breast cancer biomarkers
Recommendations on the use of biomarkers to determine treatment options in early-stage, invasive breast cancer have been updated by the American Society of Clinical Oncology.Medscape
Source: Society for Endocrinology - September 2, 2019 Category: Endocrinology Source Type: news

Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 (PREX1) is a Novel Predictor of Prognosis for Breast Cancer Patients: A Retrospective Case Series.
CONCLUSIONS PREX1 is a favorable variable of prognosis for breast cancer patients, these study results need to be confirmed in larger research studies. PMID: 31473760 [PubMed - in process]
Source: Medical Science Monitor - September 2, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Clinical value of plasma cfDNA concentration and integrity in breast cancer patients.
This study was aimed at investigating the role of cell-free DNA (cfDNA) as a potential biomarker for breast cancer diagnosis. Patients with primary breast cancer (n =110) were enrolled in the experimental group, 95 patients with benign breast tumors were in control group 1, while 90 healthy volunteers were in control group 2. Quantitative PCR was used to determine cfDNA concentration and integrity in each group. The cfDNA levels in different groups and their relationship with clinical features of breast cancer patients were analyzed. Receiver operational curves were established to analyze sensitivity and specificity of cfD...
Source: Cellular and Molecular Biology - September 2, 2019 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

Breast cancer can form 'sleeper cells' after drug treatment
Breast cancer medicines may force some cancer cells into 'sleeper mode', allowing them to potentially come back to life years after initial treatment. These are the early-stage findings from scientists at Imperial College London, who studied human breast cancer cells in the laboratory.
Source: World Pharma News - September 2, 2019 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Novel mutations in actionable breast cancer genes by targeted sequencing in an ethnically homogenous cohort
Genetic testing is becoming an essential tool for breast cancer (BC) diagnosis and treatment pathway, and particularly important for early detection and cancer prevention. The purpose of this study was to expl...
Source: BMC Medical Genetics - September 2, 2019 Category: Genetics & Stem Cells Authors: Hosneara Akter, Nasima Sultana, Nazrana Martuza, Aaysha Siddiqua, Nushrat Jahan Dity, Md. Atikur Rahaman, Bisan Samara, Ahmed Sayeed, Mohammed Basiruzzaman, Mohammad Mizanur Rahman, Md. Rashidul Hoq, Md. Robed Amin, Md. Abdul Baqui, Marc Woodbury-Smith, K Tags: Research article Source Type: research

Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population
Single nucleotide polymorphisms (SNPs) in several CYP genes have been associated with altered breast cancer (BC) risk in different populations. Despite this, there is a dearth of information on the roles of th...
Source: BMC Medical Genetics - September 2, 2019 Category: Genetics & Stem Cells Authors: Laith N. AL-Eitan, Doaa M. Rababa ’h, Mansour A. Alghamdi and Rame H. Khasawneh Tags: Research article Source Type: research

Altered lymphatic drainage patterns in re-operative sentinel lymph node biopsy for ipsilateral breast tumor recurrence
This study aimed to evaluate the impact of previous local treatment on lymphatic drainage patterns in ipsilateral breast tumor recurrence (IBTR) based on our data on re-operative sentinel lymph node biopsy (re...
Source: Radiation Oncology - September 2, 2019 Category: Cancer & Oncology Authors: Ayaka Sato, Takehiko Sakai, Takuji Iwase, Fumiko Kano, Kiyomi Kimura, Akiko Ogiya, Mitsuru Koizumi, Masahiko Tanabe, Rie Horii, Futoshi Akiyama, Takayuki Ueno and Shinji Ohno Tags: Research Source Type: research

Left breast irradiation with tangential intensity modulated radiotherapy (t-IMRT) versus tangential volumetric modulated arc therapy (t-VMAT): trade-offs between secondary cancer induction risk and optimal target coverage
Adjuvant radiotherapy is the standard treatment after breast-conserving surgery. According to meta-analyses, adjuvant 3d-conventional irradiation reduces the risk of local recurrence and thereby improves long-...
Source: Radiation Oncology - September 2, 2019 Category: Cancer & Oncology Authors: Daniel Karpf, Mazen Sakka, Martin Metzger and Gerhard G. Grabenbauer Tags: Research Source Type: research

First-degree family history of breast cancer is associated with prostate cancer risk: a systematic review and meta-analysis
The relationship between first-degree family history of female breast cancer and prostate cancer risk in the general population remains unclear. We performed a meta-analysis to determine the association betwee...
Source: BMC Cancer - September 2, 2019 Category: Cancer & Oncology Authors: Zheng-Ju Ren, De-Hong Cao, Qin Zhang, Peng-Wei Ren, Liang-Ren Liu, Qiang Wei, Wu-Ran Wei and Qiang Dong Tags: Research article Source Type: research

Dietary Phytochemical Index and Benign Breast Diseases: A Case-Control Study.
Conclusion: We found that higher DPI score is related to lower BBD OR. This simple method may be used for the improvement of dietary intake to prevent BBD. PMID: 31475586 [PubMed - as supplied by publisher]
Source: Nutrition and Cancer - September 2, 2019 Category: Cancer & Oncology Authors: Aghababayan S, Sheikhi Mobarakeh Z, Qorbani M, Abbasvandi F, Tiznobeyk Z, Aminianfar A, Sotoudeh G Tags: Nutr Cancer Source Type: research

Taxanes for adjuvant treatment of early breast cancer.
CONCLUSIONS: This review of studies supports the use of taxane-containing adjuvant chemotherapy regimens, with improvement in overall survival and disease-free survival for women with operable early breast cancer. This benefit persisted when analyses strictly compared a taxane-containing regimen versus the same regimen without a taxane or the same regimen with another drug that was substituted for the taxane. Preliminary evidence suggests that taxanes are more effective for women with lymph node-positive disease than for those with lymph node-negative disease. Considerable heterogeneity across studies probably reflects the...
Source: Cochrane Database of Systematic Reviews - September 2, 2019 Category: General Medicine Authors: Willson ML, Burke L, Ferguson T, Ghersi D, Nowak AK, Wilcken N Tags: Cochrane Database Syst Rev Source Type: research

Co-Treatment with Sulforaphane and Nano-Metformin Molecules Accelerates Apoptosis in HER2+ Breast Cancer Cells by Inhibiting Key Molecules.
In conclusion, our data indicate that SLFN and MTFN can reduce cancer cell viability via both collaborative and differential effects and suggest that MTFN increases SLFN effectiveness by targeting common molecules/pathways downstream of HER2 and key for CSC signaling. PMID: 31474154 [PubMed - as supplied by publisher]
Source: Nutrition and Cancer - September 2, 2019 Category: Cancer & Oncology Authors: Keshandehghan A, Nikkhah S, Tahermansouri H, Heidari-Keshel S, Gardaneh M Tags: Nutr Cancer Source Type: research

Chitosan coatings incorporated with propolis extract and Zataria multiflora Boiss oil for active packaging of chicken breast meat.
Abstract The impact of dipping in combination of propolis extract (PE) and chitosan (CH) coating enriched with Zataria multiflora essential oil (ZEO) on chemical, microbial and organoleptic properties of poultry meat was determined at 4 °C. GC-MS analysis showed that the most components of PE were Dihydrochrysin (9.69%) and b- Pinostrobin (7.41%). The results of mesophilic total viable plate counts (TVC), lactic acid bacteria (LAB), Psychotropic bacteria and Pseudomonas spp. showed detectably lower (p < 0.05) microbial count in CH-PE 1%-Z 0.5% and CH-PE 1%-Z 1% samples at the last day of storage. The res...
Source: International Journal of Biological Macromolecules - September 2, 2019 Category: Biochemistry Authors: Mehdizadeh T, Langroodi AM Tags: Int J Biol Macromol Source Type: research

Cancers, Vol. 11, Pages 1288: FAK-Copy-Gain Is a Predictive Marker for Sensitivity to FAK Inhibition in Breast Cancer
Conclusion: FAK-copy-gain may be a predictive marker for FAK inhibition therapy in breast cancer.
Source: Cancers - September 2, 2019 Category: Cancer & Oncology Authors: Young-Ho Kim Hyun-Kyoung Kim Hee Yeon Kim HyeRan Gawk Seung-Hyun Bae Hye Won Sim Eun-Kyung Kang Ju-Young Seoh Hyonchol Jang Kyeong-Man Hong Tags: Article Source Type: research

Detection of early breast cancer beyond mammographic screening: a promising biomarker panel.
Conclusion: This biomarker panel may improve early detection of BC and influence the assessment of breast imaging. It might be useful for a risk-adapted cancer surveillance or primary prevention program by a more precise determination of an individualized BC risk. PMID: 31468986 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - September 1, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Debbie McGee health: 'It scared me to death' - breast cancer early warning signs
Debbie McGee has been a warm and familiar presence on people ’s TV screens since the early 80s. Fans were shocked when she revealed she had secretly battled breast cancer. What are the warning signs?
Source: Daily Express - Health - September 1, 2019 Category: Consumer Health News Source Type: news

An update on genetic risk assessment and prevention: the role of genetic testing panels in breast cancer.
Authors: Piccinin C, Panchal S, Watkins N, Kim RH Abstract INTRODUCTION: In the past five years, multi-gene panels have replaced the practice of BRCA1 and BRCA2 genetic testing in cases of suspected inherited breast cancer susceptibility. A variety of genes have been included on these panels without certainty of their clinical utility. Pertinent current and historical literature was reviewed to provide an up-to-date snapshot of the changing landscape of the use of gene panel tests in the context of breast cancer. Areas covered: Following a recent review of the evidence, ten genes have been found to have definitive ...
Source: Expert Review of Anticancer Therapy - September 1, 2019 Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research

Identification of Carpesium cernuum extract as a tumor migration inhibitor based on its biological response profiling in breast cancer cells
ConclusionsOverall, both molecular and phenotypic assays showed that CCE has potential in the treatment of breast cancer, especially for the treatment of breast cancer metastasis. CCE-derived sesquiterpene lactone substances are the foundation for the tumor inhibitory effect of CCE.Graphical abstract
Source: Phytomedicine - September 1, 2019 Category: Drugs & Pharmacology Source Type: research

Breast lesion size assessment in mastectomy specimens: Correlation of cone-beam breast-CT, digital breast tomosynthesis and full-field digital mammography with histopathology
To compare the accuracy of breast lesion size measurement of cone-beam breast-CT (CBBCT), digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM). Patients scheduled for mastectomy due to at least 1 malignant breast lesion were included. Mastectomy specimens were examined by CBBCT, DBT, FFDM, and histopathology. A total of 94 lesions (40 patients) were included. Histopathological analyses revealed 47 malignant, 6 high-risk, and 41 benign lesions. Mean histopathological lesion size was 20.8 mm (range 2–100). Mean absolute size deviation from histopathology was largest for FFDM (5.3 ± 6.7 mm...
Source: Medicine - September 1, 2019 Category: Internal Medicine Tags: Research Article: Diagnostic Accuracy Study Source Type: research

Clinical efficacy of weekly cisplatin for treatment of patients with breast cancer
Conclusion: This study will provide latest evidence of WC for the treatment of patients with BC. Systematic review registration: PROSPERO CRD42019145358.
Source: Medicine - September 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Highly durable response to capecitabine in patient with metastatic estrogen receptor positive breast cancer: A case report
We report the case of a 49-year-old woman with ER+ HER2- metastatic breast cancer who experienced an exceptionally long response to capecitabine administered as second-line therapy following a first-line anthracycline-based chemotherapy. Diagnoses: The patient was diagnosed with ER+ HER2- metastatic breast cancer with massive liver involvement and mediastinal lymph nodes metastasis. Interventions: This patient was treated with capecitabine 1000 mg/mq bid given intermittently for 14 days within a 21-day cycle as a second-line therapy following a rapid progression on letrozole treatment given as a maintenance therapy...
Source: Medicine - September 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Can we cure stage IV triple-negative breast carcinoma?: Another case report of long-term survival (7 years)
Rationale: Triple-negative breast cancer has a dismal prognosis, especially once it has spread to other organs, due to the lack of effective treatments available at this time. Finding an effective treatment for metastatic triple-negative breast cancer remains an unmet medical need. Patient concerns: A 60-year-old woman was diagnosed with stage IIIC triple-negative breast cancer after undergoing a mastectomy. Her mastectomy was followed by adjuvant chemotherapy and radiation therapy. Approximately 1 year later, the patient presented with enlarging lymph nodes in her neck. A biopsy of a left supraclavicular lymph node w...
Source: Medicine - September 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Effectiveness, safety, and economic evaluation of adjuvant moxibustion therapy for aromatase inhibitor-induced arthralgia of postmenopausal breast cancer stage I to III patients: Study protocol for a prospective, randomized, assessor-blind, usual-care controlled, parallel-group, pilot clinical trial
This study is a prospective, assessor-blinded, parallel-group, randomized controlled pilot trial to explore the effectiveness of 12-week adjuvant moxibustion therapy for arthralgia in menopausal females at stage I to III breast cancer on aromatase inhibitor (AI) administration, compared with those receiving usual care. Methods/design: Forty-six menopausal female patients with breast cancer who completed cancer therapy will be randomly allocated to either adjuvant moxibustion or usual care groups with a 1:1 allocation ratio. The intervention group will undergo 24 sessions of adjuvant moxibustion therapy with usual care f...
Source: Medicine - September 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Clinical efficacy of combination of pertuzumab, trastuzumab, and docetaxel for treatment of patients with HER2-positive breast cancer
Conclusion: This study will provide efficacy and safety of PTD for HER2-PBC.
Source: Medicine - September 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Effect of age at first use of oral contraceptives on breast cancer risk: An updated meta-analysis
Background: We evaluated the relationship between the age at first use of oral contraceptives (OC) and breast cancer (BC) risk. Methods: We searched PubMed, Embase, and related reviews published through June 28, 2018, and used summary relative risk (RR) and 95% confidence intervals (CIs) to evaluate the cancer risks, and fixed-effects dose–response meta-analysis to assess potential linear and non-linear dose–response relationships. Results: We included 10 studies, with 8585 BC cases among 686,305 participants. The pooled RR for BC was 1.24 (95% CI: 1.10–1.41), with moderate heterogeneities (I2 = 66.5%, P 
Source: Medicine - September 1, 2019 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Elevated expression of MTDH predicts better prognosis of locally advanced HER-2 positive breast cancer patients receiving neoadjuvant chemotherapy plus trastuzumab
This study aimed to investigate the expression of MTDH in locally advanced HER-2 positive breast cancer, and evaluate the clinical significance of MTDH in predicting the prognosis of patients with HER-2 positive advanced breast cancer who received the neoadjuvant chemotherapy plus trastuzumab. In 144 HER-2 positive breast cancer tissues, 79 cases showed high expression of MTDH and 65 cases showed low expression. The expression of MTDH in locally advanced HER-2 positive breast cancer tissues was correlated with TNM stage, lymph node metastasis, Miller-Payne (MP) grade, and pathologic complete response (pCR) status (P  ...
Source: Medicine - September 1, 2019 Category: Internal Medicine Tags: Research Article: Quality Improvement Study Source Type: research

Essential oil extracted from erythrina corallodendron L. leaves inhibits the proliferation, migration, and invasion of breast cancer cells
In this study, the composition of essential oil extracted from the leaves was analysed by GC-MS (gas chromatograph-mass spectrometer), with linalool identified as the main compound. Its cytotoxicity against MDA-MB-231, MCF-7 and HMLE cells was examined by MTT and cloning assays. Transwell and wound-healing assays were used to examine the inhibition of migration and invasion. Western blot, qRT-PCR and immunofluorescence staining were used to measure the mRNA and protein expression of factors related to EMT (snail, slug, E-cadherin, N-cadherin and vimentin). The essential oil of Erythrina corallodendron leaves was found to i...
Source: Medicine - September 1, 2019 Category: Internal Medicine Tags: Research Article: Quality Improvement Study Source Type: research

Improving functional outcome and quality of life for patients with metastatic lesion of acetabulum undergoing cement augmentation
There is an increased enthusiasm in treating osteolytic metastatic acetabulum via injecting polymethyl-methacrylate (PMMA) as a bone filler to provide pain relief and potential structural support. The aim of this respective study is to determine the function and quality of life improvement after cement acetabuloplasty. Thirty two patients underwent acetabular cement augmentation between May 2014 and March 2018 were respectively reviewed. Isolated percutaneous acetabuloplasty (PA) was performed in 15 patients (group A) while radiofrequency ablation with PA (RFA-PA) in 12 patients (group B). Together with PA, open reconstru...
Source: Medicine - September 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Ophthalmic artery occlusion combined with superior sagittal sinus thrombosis caused by hyaluronic acid injection for facial soft tissue augmentation: A case report
Rationale: Cosmetic hyaluronic acid injections for facial soft tissue augmentation are gaining popularity because of their convenience and favorable outcomes. Several associated complications have been described; however, ophthalmic artery occlusion (OAO) combined with superior sagittal sinus thrombosis (SSST) has been rarely reported. Patient concerns: A 21-year-old woman presented with sudden loss of vision and severe pain in the left eye, right upper limb weakness, and headache immediately after hyaluronic acid injection on the left side of her forehead. Diagnosis: Clinical manifestations and multimodal imaging,...
Source: Medicine - September 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Breast Tumor Detection and Classification Using Intravoxel Incoherent Motion Hyperspectral Imaging Techniques.
Abstract Breast cancer is a main cause of disease and death for women globally. Because of the limitations of traditional mammography and ultrasonography, magnetic resonance imaging (MRI) has gradually become an important radiological method for breast cancer assessment over the past decades. MRI is free of the problems related to radiation exposure and provides excellent image resolution and contrast. However, a disadvantage is the injection of contrast agent, which is toxic for some patients (such as patients with chronic renal disease or pregnant and lactating women). Recent findings of gadolinium deposits in t...
Source: Biomed Res - September 1, 2019 Category: Research Authors: Chan SW, Chang YC, Huang PW, Ouyang YC, Chang YT, Chang RF, Chai JW, Chen CC, Chen HM, Chang CI, Lin CY Tags: Biomed Res Int Source Type: research

Letrozole and fertility preservation in patients with breast cancer
Ovarian stimulation with exogenous gonadotropins leads to a significant rise in circulating estrogen levels which could aggravate the spread of breast cancer. The use of anti aromatase agents such as letrozole could prevent this elevation. But is it safe and effective in fertility preservation?
Source: Fertility and Sterility - September 1, 2019 Category: Reproduction Medicine Authors: Marouen Braham, Sarah Amari, Khadija Feriel Kacem Berjeb, Haithem Khalil, Manel Hamdoun, Mounir Ben Meftah, Habiba Essoussi, Olfa Bahri, Anis Fadhlaoui, Fethi Zhioua Tags: Poster session Source Type: research

Utilization of gonadotropin-releasing hormone agonists for preservation of ovarian function in women with breast cancer receiving chemotherapy
To determine the use and predictors of GnRH (gonadotropin-releasing hormone) agonists for ovarian conservation in young, reproductive age women with newly diagnosed breast cancer undergoing chemotherapy.
Source: Fertility and Sterility - September 1, 2019 Category: Reproduction Medicine Authors: Sally F. Vitez, Ling Chen, Paula C. Brady, Jason D. Wright Tags: Poster session Source Type: research

A Novel Tissue-Based liver-kidney-on-a-chip can Mimic Liver Tropism of Extracellular Vesicles Derived from Breast Cancer Cells.
CONCLUSIONS: Overall, the tropism of EVs to different organs was reconstituted on the microfluidic model. The liver-kidney-on-a-chip may expand the capabilities of traditional cell culture models and provide a faster alternative to animal models for EV studies. This article is protected by copyright. All rights reserved. PMID: 31473998 [PubMed - as supplied by publisher]
Source: Biotechnology Journal - September 1, 2019 Category: Biotechnology Authors: Tian H, Pang J, Qin K, Yuan W, Kong J, Ma H, He J, Yang X, Luo Y, Lu Y, Lin B, Liu T Tags: Biotechnol J Source Type: research

Diagnosis and Treatment of Breast Cancer in Men.
This article discusses types of MBC, risk factors, treatment options, and ethical concerns men encounter after they receive a breast cancer diagnosis. PMID: 31471487 [PubMed - in process]
Source: Radiologic Technology - September 1, 2019 Category: Radiology Authors: Zehr KR Tags: Radiol Technol Source Type: research

Novel Use of Chatbot Technology to Educate Patients Before Breast Biopsy
In this pilot study, we created and deployed a chatbot via a touch-screen tablet to our patients who were scheduled to undergo a breast biopsy procedure to provide evidence-based answers to frequently asked questions. A chatbot is a computer program designed to conduct conversation with a user through text or speech [1]. Chatbot programs are designed to aid the user in information acquisition, while providing a touch of humanlike connection and improving timely, patient-centric health care dissemination.
Source: Journal of the American College of Radiology : JACR - September 1, 2019 Category: Radiology Authors: Alison Chetlen, Rick Artrip, Brian Drury, Anthony Arbaiza, Michael Moore Tags: Data science and radiologic practice Source Type: research

Effects of dienogest on breast : MCF cell line data
Dienogest (DNG) is a widely used progestin which is safe and effective for long-term management of endometriosis. However, its association to breast cells remains to be elucidated. We perform this study to investigate whether in vitro treatment of DNG can cause any biologic changes on MCF cell line (human estrogen receptor (ER)-positive breast cancer cell line) experiments.
Source: Fertility and Sterility - September 1, 2019 Category: Reproduction Medicine Authors: Hyun Jin Kim, Sung Hoon KIM, Young Sang Oh, DoYoung Kim, Sa Ra Lee, Hee Dong Chae, Byung Moon Kang Tags: Poster session Source Type: research

How best to address breast pain in nonbreastfeeding women.
Abstract This guide-with accompanying algorithms-will help you to streamline your approach to breast pain in a patient who isn't breastfeeding. PMID: 31532814 [PubMed - in process]
Source: The Journal of Family Practice - September 1, 2019 Category: Practice Management Authors: Lochner J, Larson M, Torell E, Schrager S Tags: J Fam Pract Source Type: research

Exploring the views and experiences of women with diabetes in pregnancy in Australia who have been advised to express breast milk antenatally, and implications for clinical practice
Background: The Diabetes and Antenatal Milk Expressing (DAME) randomised controlled trial (RCT) was conducted in 2011 –2015, at six sites in Melbourne, Australia to explore the effect of advising women with diabetes in pregnancy to express breast milk from 36 weeks gestation. The DAME study found no evidence of harm, and that infants whose mothers were randomised to express in pregnancy were more likely to be exc lusively breast milk fed during the hospital stay. The total median amount of breast milk women expressed antenatally was 5mLs and mean number of times of expressing was 22.
Source: Women and Birth - September 1, 2019 Category: Midwifery Authors: Anita Moorhead, Lisa H. Amir, Sharinne Crawford, Della A. Forster Tags: O72 Source Type: research

IJERPH, Vol. 16, Pages 3199: Co-Exposure to SiO2 Nanoparticles and Arsenic Induced Augmentation of Oxidative Stress and Mitochondria-Dependent Apoptosis in Human Cells
adlaq Widespread application of silica nanoparticles (nSiO2) and ubiquitous metalloid arsenic (As) may increase their chances of co-exposure to human beings in daily life. Nonetheless, studies on combined effects of nSiO2 and As in human cells are lacking. We investigated the co-exposure effects of nSiO2 and As in human liver (HepG2) and human fibroblast (HT1080) cells. Results showed that nSiO2 did not cause cytotoxicity. However, exposure of As caused oxidative stress and apoptosis in both types of cells. Interesting results were that co-exposure of a non-cytotoxic concentration of nSiO2 significantly augmented the A...
Source: International Journal of Environmental Research and Public Health - September 1, 2019 Category: Environmental Health Authors: Maqusood Ahamed Mohd Javed Akhtar Hisham A. Alhadlaq Tags: Article Source Type: research

Cancers, Vol. 11, Pages 1285: KCa3.1 Channels Confer Radioresistance to Breast Cancer Cells
er Lukowski KCa3.1 K+ channels reportedly contribute to the proliferation of breast tumor cells and may serve pro-tumor functions in the microenvironment. The putative interaction of KCa3.1 with major anti-cancer treatment strategies, which are based on cytotoxic drugs or radiotherapy, remains largely unexplored. We employed KCa3.1-proficient and -deficient breast cancer cells derived from breast cancer-prone MMTV-PyMT mice, pharmacological KCa3.1 inhibition, and a syngeneic orthotopic mouse model to study the relevance of functional KCa3.1 for therapy response. The KCa3.1 status of MMTV-PyMT cells did not determine...
Source: Cancers - September 1, 2019 Category: Cancer & Oncology Authors: Mohr Gross Sezgin Steudel Ruth Huber Lukowski Tags: Article Source Type: research

Corrigendum to "The chemotherapeutic potential of doxorubicin-loaded PEG-b-PLGA nanopolymersomes in mouse breast cancer model." Eur. J. Pharm. Biopharm. 94 (2015) 521-531.
PMID: 31470967 [PubMed - in process]
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 1, 2019 Category: Drugs & Pharmacology Authors: Alibolandi M, Sadeghi F, Abnous K, Atyabi F, Ramezani M, Hadizadeh F Tags: Eur J Pharm Biopharm Source Type: research

Leiomyosarcoma with osteoclast ‐like (LMS‐OGC) giant cells the breast: A report of a rare case
Leiomyosarcoma with osteoclast ‐like giant cells (LMS‐OGC) has seldom been reported clinically. LMS‐OGC of the breast is extremely rare according to the literature. Here, we report a case of LMS‐OGC leiomyosarcoma with osteoclast‐like giant cells of the breast. A 51‐year‐old female patient presented with a breast ma ss which was treated surgically and the pathological examination of the tumor indicated LMS‐OGC. Microscopically, the tumor was composed of spindle cells arranged in bundles or spokes with giant tumor cells and mitosis. Eosinophilic cytoplasm and morphologically benign osteoclast‐like cells we...
Source: Thoracic Cancer - September 1, 2019 Category: Cancer & Oncology Authors: Zhonghai Xu, Junjun Gu, Shan Zhang, Zhanjiao Zhang, Wei Fang Tags: CASE REPORT Source Type: research

Stimulation of the ovaries in women with breast cancer undergoing fertility preservation: alternative versus standard stimulation protocols
to evaluate the effectiveness of ovarian stimulation with tamoxifen or letrozole compared to standard ovarian stimulation on the number of oocytes retrieved in women with breast cancer in the course of fertility preservation.
Source: Fertility and Sterility - September 1, 2019 Category: Reproduction Medicine Authors: E.M.E. Balkenende, T. Dahhan, C.C.M. Beerendonk, K. Fleischer, A.M.E. Bos, C.B. Lambalk, Roelof Schats, L. Louw é, A.E.P. Cantineau, J.M.J. Smeenk, J.P. de Bruin, F. van der Veen, S.C. Linn, M. van Wely, Mariette Goddijn Tags: Oral session Source Type: research

Pleomorphic Invasive Lobular Carcinoma of the Male Breast: Two Case Reports with Opposite Hormone Receptor Status.
Abstract Male breast cancer represents <1% of breast cancers, with invasive lobular carcinoma in male breast being extremely rare. Only four cases of male breast with pleomorphic lobular carcinoma (PLC) are reported in literature. Here, we report two additional cases. The first case was a 63-year old male presenting with a left neck mass, progressive facial numbness, bilateral cervical lymphadenopathy, and brain metastasis. Neck mass and left breast biopsies confirmed left breast PLC with metastasis. The second case was a 79-year old male with a left breast mass; biopsy and subsequent mastectomy showed PLC. Awa...
Source: Annals of Clinical and Laboratory Science - September 1, 2019 Category: Laboratory Medicine Authors: Murzabdillaeva A, Ali Y, Aakash N, Armstrong J, Ghorbani R, Zhang S Tags: Ann Clin Lab Sci Source Type: research

A novel BRCA1 germline mutation promotes triple-negative breast cancer cells progression and enhances sensitivity to DNA damage agents
In this study, we conducted whole-exome sequencing to identify the disease-associated genes in a specific pedigree, in which at least eight individuals were diagnosed with cancers, including breast cancer, urothelial cancer, uterine cancer and colorectal cancer. Furthermore, a nonsense mutation BRCA1 p.Trp372X was identified in the proband. The Sanger sequencing data has validated the same nonsense mutation in other 4 cancer patients and 3 normal family members. Additionally, functional experiments detected that this mutation was implicated in TNBC progression, manifesting as increased cell proliferation and migration. Cel...
Source: Cancer Genetics - August 31, 2019 Category: Cancer & Oncology Source Type: research

A Systematic Review and Meta-Analysis on Microsurgical Safety and Efficacy of Profunda Artery Perforator Flap in Breast Reconstruction.
Conclusion: To date, this study is the first meta-analysis of microsurgical efficacy and safety evaluation of the PAP flap in breast reconstruction. This present work confirmed that the PAP flap is safe and reliable in breast reconstruction with high success rate, but a relatively low complication rate. Moreover, it might be more than an alternative to the deep inferior epigastric perforator flap (DIEP) in microsurgical breast reconstruction in selected patients. PMID: 31467545 [PubMed]
Source: Journal of Oncology - August 31, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Polymorphisms in Survivin (BIRC5 Gene) Are Associated with Age of Onset in Breast Cancer Patients.
Authors: Sušac I, Ozretić P, Gregorić M, Levačić Cvok M, Sabol M, Levanat S, Trnski D, Eljuga D, Seiwerth S, Aralica G, Stanec M, Musani V Abstract Survivin, encoded by BIRC5 gene (baculoviral IAP repeat containing 5), belongs to the family of inhibitors of apoptosis proteins (IAPs). In mammalian cells it participates in the control of mitosis, apoptosis regulation, and cellular stress response. Its expression is increased in almost all types of cancers. The aim of this study was to investigate the role of BIRC5 polymorphisms in breast cancer (BC) and to connect survivin expression with various clinicopatholog...
Source: Journal of Oncology - August 31, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

The female adolescent breast: disorders of development
This article will provide an overview on female breast development and focus on common abnormalities of growth, the emerging role of breast self-awareness, and discuss trends in the evaluation and treatment of the breast masses and disorders most often encountered in the female adolescent population. Recent findings Although the embryology of breast development is unchanged, data are emerging on the role of environmental factors on the timing of puberty and thelarche. As breast development occurs, the role of breast self-awareness is also a new trend that allows teens to be cognizant of changes in their own breast and t...
Source: Current Opinion in Obstetrics and Gynecology - August 31, 2019 Category: OBGYN Tags: ADOLESCENT AND PEDIATRIC GYNECOLOGY: Edited by Roshi M. Zinn Source Type: research