This page shows you the latest news items in this category. This is page number 7.

Total 220191 results found since Jan 2013.

Tomographic evaluation of the influence of the placement of a collagen membrane subjacent to the sinus mucosa during maxillary sinus floor augmentation: a randomized clinical trial
To study the influence of a collagen membrane placed subjacent to the sinus mucosa on the dimensional changes of augmented maxillary sinus floor.
Source: International Journal of Implant Dentistry - August 19, 2019 Category: Dentistry Authors: Atsuya Hirota, Niklaus P. Lang, Mauro Ferri, Natalia Fortich Mesa, Karol Ali Apaza Alccayhuaman and Daniele Botticelli Tags: Research Source Type: research

Silica-coated iron oxide nanoparticles as a novel nano-radiosensitizer for electron therapy
Publication date: 1 October 2019Source: Life Sciences, Volume 234Author(s): Mohamed M. Fathy, Heba M. Fahmy, Omnia A. Saad, Wael M. ElshemeyAbstractAimsConventional radiotherapy is mainly restricted by the low radiation absorption efficiency of tumors tissues and the hypoxic tumor cells radio-resistance. In this paper, novel nano-radiosensitizers, magnetic nanoparticles core coated with silica, were successfully prepared to overcome these limitations.Main methodsThe prepared nanoparticles have been characterized by transmission electron microscope (TEM), Dynamic light scattering (DLS), atomic force microscope (AFM) and vib...
Source: Life Sciences - August 19, 2019 Category: Biology Source Type: research

Tailoring of Au-TiO2 Nanoparticles conjugated with Doxorubicin for their Synergistic Response and Photodynamic Therapy Applications
Publication date: Available online 16 August 2019Source: Journal of Photochemistry and Photobiology A: ChemistryAuthor(s): M. Waseem Akram, Fazal Raziq, Muhammad Fakhar-e-Alam, Muhammad Hammad Aziz, K.S. Alimgeer, M. Atif, M. Amir, Atif Hanif, W. Aslam FarooqAbstractAu-TiO2 nanoparticles conjugated with doxorubicin (DOX) were synthesized for new photodynamic therapy (PDT) plans and for comprehensive and reliable treatment of breast cancer-related acute diseases. The anatase/rutile phase junction effect combined with plasmonic resonance is amplified in Au- TiO2 conjugated with DOX, leading to a synergistic response of PDT. ...
Source: Journal of Photochemistry and Photobiology A: Chemistry - August 19, 2019 Category: Chemistry Source Type: research

siRNA therapeutics for breast cancer: recent efforts in targeting metastasis, drug resistance, and immune evasion
Small interfering RNA (siRNA) has an established and precise mode of action to achieve protein knockdown. With the ability to target any protein, it is very attractive as a potential therapeutic for a plethora of diseases driven by the (over)expression of certain proteins. Utilizing siRNA to understand and treat cancer, a disease largely driven by genetic aberration, is thus actively investigated. However, the main hurdle for the clinical translation of siRNA therapeutics is to achieve effective delivery of siRNA molecules to tumors and the site of action, the cytosol, within cancer cells.
Source: Translational Research - August 19, 2019 Category: Research Authors: Worapol Ngamcherdtrakul, Wassana Yantasee Tags: Review Article Source Type: research

Assessment of prenatal care for indigenous women in Brazil: findings from the First National Survey of Indigenous People's Health and Nutrition.
This study assesses prenatal care for indigenous women 14-49 years of age with children under five years of age in Brazil. The First National Survey of Indigenous People's Health and Nutrition assessed 3,967 women who met these criteria, of whom 41.3% in the North, 21.2% in the Central, 22.2% in the Northeast, and 15% in the South/Southeast. Prenatal care was offered to 3,437 (86.6%) of these women. The North of Brazil showed the highest proportion of indigenous women who did not receive prenatal care. Coverage was 90.4%, but only some 30% began prenatal care in the first trimester, and only 60% of the eligible women were ...
Source: Cadernos de Saude Publica - August 19, 2019 Category: International Medicine & Public Health Authors: Garnelo L, Horta BL, Escobar AL, Santos RV, Cardoso AM, Welch JR, Tavares FG, Coimbra CEA Tags: Cad Saude Publica Source Type: research

Identification of LCN1 as a Potential Biomarker for Breast Cancer by Bioinformatic Analysis
DNA and Cell Biology, Ahead of Print.
Source: DNA and Cell Biology - August 19, 2019 Category: Cytology Authors: Yuemei Yang Feng Li Xueying Luo Binghan Jia Xiaoling Zhao Baoer Liu Rui Gao Liping Yang Wei Wei Jinsong He Source Type: research

Cisplatin-resistant MDA-MB-231 cell-derived exosomes increase the resistance of recipient cells in an exosomal miR-423-5p-dependent manner.
CONCLUSIONS: Exosomes from DDP-resistant TNBC cells (231/DDP) altered the sensitivity of other breast cancer cells to DDP in an exosomal miR-423-5p dependent manner. Our research helps to elucidate the mechanism of DDP resistance in breast cancer. PMID: 31424364 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - August 19, 2019 Category: Drugs & Pharmacology Authors: Wang B, Zhang Y, Ye M, Wu J, Ma L, Chen H Tags: Curr Drug Metab Source Type: research

Pan-Trk immunohistochemistry reliably identifies ETV6-NTRK3 fusion in secretory carcinoma of the salivary gland
In conclusion, our data showed that pan-Trk IHC is a reasonable screening test for diagnosing secretory carcinoma of the salivary gland.
Source: Virchows Archiv - August 19, 2019 Category: Pathology Source Type: research

The time of sentinel lymph node biopsy and neoadjuvant chemotherapy in clinical negative axilla breast cancer: before or after?
Future Oncology,Volume 15, Issue 23, Page 2669-2671, August 2019.
Source: Future Oncology - August 19, 2019 Category: Cancer & Oncology Authors: Zhao Bi Jingjing Liu Peng Chen Xianrang Song Yongsheng Wang Source Type: research

Molecules, Vol. 24, Pages 3000: In Vitro Inhibitory Effects of APINACA on Human Major Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Drug Transporters
In this study, the inhibitory effects of APINACA on eight major human cytochrome P450s (CYPs) and six uridine 5′-diphospho-glucuronosyltransferases (UGTs) in human liver microsomes, as well as on the transport activities of six solute carrier transporters and two efflux transporters in transporter-overexpressed cells, were investigated. APINACA exhibited time-dependent inhibition of CYP3A4-mediated midazolam 1′-hydroxylation (Ki, 4.5 µM; kinact, 0.04686 min−1) and noncompetitive inhibition of UGT1A9-mediated mycophenolic acid glucuronidation (Ki, 5.9 µM)...
Source: Molecules - August 19, 2019 Category: Chemistry Authors: Sunjoo Kim Won-Gu Choi Mihwa Kwon Sowon Lee Yong-Yeon Cho Joo Young Lee Han Chang Kang Im-Sook Song Hye Suk Lee Tags: Article Source Type: research

Cancer incidence and associations with known risk and protective factors: the Alaska EARTH study
ConclusionsCancer incidence in the Alaska EARTH cohort was similar to incidence observed statewide. Risk and protective factors for leading cancers among AN people mirror those observed among other populations.
Source: Cancer Causes and Control - August 19, 2019 Category: Cancer & Oncology Source Type: research

Pre-surgical oncolytic virotherapy improves breast cancer outcomes
.
Source: OncoImmunology - August 19, 2019 Category: Cancer & Oncology Authors: Victor Mullins-Dansereau Gr égory Petrazzo Karen Geoffroy Delphine B éland Marie-Claude Bourgeois-Daigneault Source Type: research

Estrogen-independent molecular actions of mutant estrogen receptor 1 in endometrial cancer RESEARCH
Estrogen receptor 1 (ESR1) mutations have been identified in hormone therapy–resistant breast cancer and primary endometrial cancer. Analyses in breast cancer suggest that mutant ESR1 exhibits estrogen-independent activity. In endometrial cancer, ESR1 mutations are associated with worse outcomes and less obesity, however, experimental investigation of these mutations has not been performed. Using a unique CRISPR/Cas9 strategy, we introduced the D538G mutation, a common endometrial cancer mutation that alters the ligand binding domain of ESR1, while epitope tagging the endogenous locus. We discovered estrogen-independ...
Source: Genome Research - August 19, 2019 Category: Genetics & Stem Cells Authors: Blanchard, Z., Vahrenkamp, J. M., Berrett, K. C., Arnesen, S., Gertz, J. Tags: RESEARCH Source Type: research

Treatment of patients with fragility fractures.
CONCLUSION: There is evidence that with optimal care the treatment of patients with fragility fractures can be significantly improved. PMID: 31428807 [PubMed - as supplied by publisher]
Source: Der Unfallchirurg - August 19, 2019 Category: Orthopaedics Authors: Bücking B, Neuerburg C, Knobe M, Liener U Tags: Unfallchirurg Source Type: research

Bridging the Gap in Training and Clinical Practice in Sub-Saharan Africa
AbstractPurpose of ReviewAs medical knowledge and innovation reaches new heights, there is a growing gap in medical advancements between low- and middle-income countries (LMICs) and high-income countries (HICs). The former has lack of basic health care and preventive or diagnostic services for early cancer while the latter has access to novel diagnostic and therapeutic modalities.Recent FindingsKey to overcoming this disparity is finding ways to bridge this divide across distances and continental divides through innovative technology and sharing of knowledge by committed individuals and through public private partnerships....
Source: Current Breast Cancer Reports - August 19, 2019 Category: Cancer & Oncology Source Type: research

Interventional Techniques for the Ablation and Augmentation of Extraspinal Lytic Bone Metastases
This article presents an approach to assess extraspinal metastases, reviews available interventional techniques in use today, and offers example cases as an introductory primer to the thought process used for selecting the appropriate interventional treatment. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Seminars in Interventional Radiology - August 19, 2019 Category: Radiology Authors: Ahmed, Osman Feinberg, Nicholas Lea, William B. Tags: Review Article Source Type: research

Percutaneous Interventional Management of Spinal Metastasis
Semin intervent Radiol 2019; 36: 249-254 DOI: 10.1055/s-0039-1694698Spinal metastasis is usually associated with debilitating pain and results in deteriorating life quality. The role of percutaneous management of spinal metastasis has evolved from a diagnostic role to a significant part of therapeutic options in conjunction with conventional management techniques, including radiotherapy and open surgical options. Percutaneous vertebral augmentation (PVA) showed substantial pain reduction, vertebral stabilization, and improvement of quality of life. Minimally invasive local ablative procedures (MILAPs) demonstrated signific...
Source: Seminars in Interventional Radiology - August 19, 2019 Category: Radiology Authors: Lee, Seon-Kyu Weiss, Brandon Yanamadala, Vijay Brook, Allan Tags: Review Article Source Type: research

Pre-surgical oncolytic virotherapy improves breast cancer outcomes
.
Source: OncoImmunology - August 19, 2019 Category: Cancer & Oncology Authors: Victor Mullins-Dansereau Gr égory Petrazzo Karen Geoffroy Delphine B éland Marie-Claude Bourgeois-Daigneault Source Type: research

Practice Changing Potential of TAILORx: A Retrospective Review of the National Cancer Data Base from 2010 to 2015.
CONCLUSIONS: The most potential impact of TAILORx findings on practice change is for patients ≤ 50 years of age with RS of 16-25 who did not receive chemotherapy but may benefit. These findings may serve as a baseline for future analysis of practice patterns related to TAILORx. PMID: 31429016 [PubMed - as supplied by publisher]
Source: Ann Oncol - August 19, 2019 Category: Cancer & Oncology Authors: Reyes SA, De La Cruz LM, Ru M, Pisapati KV, Port E Tags: Ann Surg Oncol Source Type: research

Alcohol, health and cardiovascular disease
Publication date: Available online 17 August 2019Source: Revista Clínica Española (English Edition)Author(s): J. Masip, J.R. Germà LluchAbstractRecent epidemiological studies have shown that alcohol consumption can increase the risk of arterial hypertension, atrial fibrillation and gastrointestinal and breast cancer. Various sectors are therefore promoting abstinence from alcohol. However, light alcohol consumption has once again been shown to reduce the risk of myocardial infarction and diabetes but with an unclear effect on cerebrovascular disease. The decision to consume alcohol should therefore be an individual one ...
Source: Revista Clinica Espanola - August 18, 2019 Category: Internal Medicine Source Type: research

Clinicopathological and prognostic significance of TINCR in caner: a meta-analysis
ConclusionIn this study, we found that over-expression of TINCR may influence the tumor size and contribute to the poor prognosis of cancer.
Source: Pathology Research and Practice - August 18, 2019 Category: Pathology Source Type: research

Breastfeeding is best, but why do some countries struggle?
Breastfeeding provides ideal food for the healthy growth and development of infants; it is also an integral part of the reproductive process with important implications for the health of mothers. Breastfeeding has numerous health benefits for both the mother and infant. Breast milk contains all the nutrients infants need in the first six months of […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - August 18, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/melvin-sanicas" rel="tag" > Melvin Sanicas, MD < /a > < /span > Tags: Conditions Pediatrics Source Type: blogs

Fight Aging! Newsletter, August 19th 2019
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - August 18, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Factors Associated With Complications in Immediate Breast Reconstruction in 1 Stage With Completely Submuscular Implants
Conclusions Immediate breast reconstruction in 1 stage using permanent implants can be performed with acceptable complication rates and cosmetic outcomes. Our study demonstrated that high BMI is a risk factor for overall complications. With proper patient selection and surgical technique, implants could be completely covered under a submuscular pocket.
Source: Annals of Plastic Surgery - August 17, 2019 Category: Cosmetic Surgery Tags: Breast Surgery Source Type: research

Medical News Today: The power of electromagnetic energy on breast cancer cells
Electromagnetic energy could be used to halt the movement of breast cancer cells, reducing metastatic cases. New research explains how.
Source: Health News from Medical News Today - August 17, 2019 Category: Consumer Health News Tags: Breast Cancer Source Type: news

Pathology Meets Biology: the New Era of Breast Cancer Staging
AbstractPurpose of ReviewBreast cancer is now recognized to be a very heterogeneous disease. This complexity was recently reflected in the newest American Joint Committee on Cancer (AJCC) breast cancer staging, implemented in 2018. Although it seems very daunting, the new staging is based on both the anatomical extent of the disease and the prognostic factors such as hormonal and HER2 status, grade of the tumor, and genomic assays providing information regarding risk of recurrence. The purpose of this review is to illustrate the reasoning for the change in previous, solely an anatomically based breast cancer staging system...
Source: Current Breast Cancer Reports - August 16, 2019 Category: Cancer & Oncology Source Type: research

Leveraging system sciences methods in clinical trial evaluation: An example concerning African American women diagnosed with breast cancer via the Patient Navigation in Medically Underserved Areas study.
Discussion: Our study results will provide promising venues for leveraging systems science methodologies in clinical trial evaluation. PMID: 31406947 [PubMed]
Source: Clinical Breast Cancer - August 14, 2019 Category: Cancer & Oncology Authors: Molina Y, Khanna A, Watson KS, Villines D, Bergeron N, Strayhorn S, Strahan D, Skwara A, Cronin M, Mohan P, Walton S, Wang T, Schneider JA, Calhoun EA Tags: Contemp Clin Trials Commun Source Type: research

Phase II Study of Weekly Paclitaxel with Trastuzumab and Pertuzumab in Patients with Human Epidermal Growth Receptor 2 Overexpressing Metastatic Breast Cancer: 5‐Year Follow‐up
Conclusion.With a longer follow‐up of almost 5 years, combination of weekly paclitaxel, trastuzumab, and pertuzumab remains effective with a favorable median PFS and a median OS not reached.Implications for Practice.The combination of weekly paclitaxel, trastuzumab, and pertuzumab has been endorsed by the National Comprehensive Cancer Network as one of the first‐line treatment options in patients with human epidermal growth receptor 2 (HER2)‐positive metastatic breast cancer (MBC). However, the long‐term safety and efficacy are still unknown. Findings from this phase II study provide favorable preliminary data on t...
Source: The Oncologist - August 14, 2019 Category: Cancer & Oncology Authors: Rui Wang, Lillian M. Smyth, Neil Iyengar, Sarat Chandarlapaty, Shanu Modi, Maxine Jochelson, Sujata Patil, Larry Norton, Clifford A. Hudis, Chau T. Dang Tags: Breast Cancer Source Type: research

Aromatase Inhibitors and Newly Developed Nonalcoholic Fatty Liver Disease in Postmenopausal Patients with Early Breast Cancer: A Propensity Score‐Matched Cohort Study
Conclusion.Results of this study suggest that inhibition of estrogen synthesis in postmenopausal women undergoing treatment with aromatase inhibitors could increase the risk of NAFLD, which might have some influence on the prognosis of patients with breast cancer.Implications for Practice.Unlike tamoxifen, the role of aromatase inhibitor treatment use in postmenopausal patients with breast cancer in development of fatty liver is not well known. In this propensity‐matched cohort study, postmenopausal patients with breast cancer treated with aromatase inhibitors had increased risk of nonalcoholic fatty liver disease compar...
Source: The Oncologist - August 14, 2019 Category: Cancer & Oncology Authors: Jung Il Lee, Jung-Hwan Yu, Sung Gwe Anh, Hyun Woong Lee, Joon Jeong, Kwan Sik Lee Tags: Breast Cancer Source Type: research

Local Treatment of the Axilla in Early Breast Cancer: So Many Questions, Still Few Answers
Madam — Axillary management for early breast cancer with micrometastatic sentinel nodes is well established [1,2], whereas there is still no consensus in the case of macrometastatic involvement. It is crucial to make a clear distinction between different questions:
Source: Clinical Oncology - August 14, 2019 Category: Radiology Authors: I. Meattini, M.C. De Santis, F. De Rose, I. Desideri, P. Franco, O. Kaidar-Person, B. Meduri, N. Pasinetti, V. Lancellotta, Clinical Oncology Breast Cancer Group (COBCG) Investigators Tags: Letter Source Type: research

miR-638 represses the stem cell characteristics of breast cancer cells by targeting E2F2.
CONCLUSION: MiR-638 represses the characteristics and behaviors of BCSCs by targeting E2F2. MiR-638 may be a potential target for breast cancer therapy. PMID: 31410735 [PubMed - as supplied by publisher]
Source: Breast Cancer - August 13, 2019 Category: Cancer & Oncology Authors: Lin QY, Wang JQ, Wu LL, Zheng WE, Chen PR Tags: Breast Cancer Source Type: research

Usefulness of second-look ultrasonography using anatomical breast structures as indicators for magnetic resonance imaging-detected breast abnormalities.
CONCLUSIONS: Second-look US using anatomical breast structures as indicators and US-guided FNAC are useful for refining the diagnosis of suspicious breast lesions detected using MRI. PMID: 31407151 [PubMed - as supplied by publisher]
Source: Breast Cancer - August 12, 2019 Category: Cancer & Oncology Authors: Izumori A, Kokubu Y, Sato K, Gomi N, Morizono H, Sakai T, Horii R, Akiyama F, Iwase T, Ohno S Tags: Breast Cancer Source Type: research

Chemotherapy-induced nausea and vomiting in patients with breast cancer: a prospective cohort study.
CONCLUSIONS: The degree of nausea was worst in the acute phase, although delayed nausea was more in proportion in HEC. Estimation by medical staff is not accurate. PMID: 31407150 [PubMed - as supplied by publisher]
Source: Breast Cancer - August 12, 2019 Category: Cancer & Oncology Authors: Naito Y, Kai Y, Ishikawa T, Fujita T, Uehara K, Doihara H, Tokunaga S, Shimokawa M, Ito Y, Saeki T Tags: Breast Cancer Source Type: research

Assessment of significant procedures in multigene molecular detection for breast cancer in clinical laboratories: from variant detection to targeted therapy.
CONCLUSION: The variant detection capability was satisfactory, but the ability to provide accuracy and comprehensive targeted drug information should be urgently improved. Our study summarized a completed NGS-based multigene molecular detection pipeline, aiming to better inform precision treatment for breast cancer patients. PMID: 31388961 [PubMed - as supplied by publisher]
Source: Breast Cancer - August 6, 2019 Category: Cancer & Oncology Authors: Zhang R, Gao P, Ding J, Li Z, Li J Tags: Breast Cancer Source Type: research

Evolution of older patients diagnosed with early breast cancer in Spain between 1998 and 2001 included in El Alamo III project.
CONCLUSIONS: Our study suggests that older BC patients have worse outcomes what can be a consequence of receiving inadequate adjuvant treatments. Specific trials for these patients are warranted to allow us to treat them with the same scientific rigor than younger patients. PMID: 31385227 [PubMed - as supplied by publisher]
Source: Clinical Breast Cancer - August 5, 2019 Category: Cancer & Oncology Authors: Torregrosa MD, Escudero MJ, Paredero I, Carrasco E, Bermejo B, Gavila J, García-Saenz J, Santaballa A, Martínez P, Llombart A, Andrés R, Batista N, Fernández A, Antón A, Seguí M, Gonzalez S, Ruiz A, GEICAM, the Spanish Breast Cancer Group Tags: Clin Transl Oncol Source Type: research

Lymph node infiltration, parallel metastasis and treatment success in breast cancer.
CONCLUSION: The number of pLNs is an epiphenomenon of the onset and chronometer for the duration of TCs disseminating from growing BCs. METs are initiated parallel to LNs by PTs and not caused by pLNs. This LN process without cascade-like MET initiation should be generalizable to all common solid tumors. PMID: 31415842 [PubMed - as supplied by publisher]
Source: Breast - August 5, 2019 Category: Cancer & Oncology Authors: Engel J, Weichert W, Jung A, Emeny R, Hölzel D Tags: Breast Source Type: research

When to assess the DIEP flap perfusion by intraoperative indocyanine green angiography in breast reconstruction?
CONCLUSIONS: several advantages have been found in performing the ICGA on the donor site to assess the perfusion of the DIEP flap. PMID: 31404745 [PubMed - as supplied by publisher]
Source: Breast - August 5, 2019 Category: Cancer & Oncology Authors: Malagón-López P, Carrasco-López C, García-Senosiain O, Vilà J, Del-Río M, Priego D, Julian-Ibáñez JF, Higueras-Suñe C Tags: Breast Source Type: research

Developing a checksheet for breast cancer patients receiving endocrine therapy-examining reliability and validity.
CONCLUSION: This study verified that the checksheet in its initial development as a scale has high reliability and validity. PMID: 31376075 [PubMed - as supplied by publisher]
Source: Breast Cancer - August 2, 2019 Category: Cancer & Oncology Authors: Iioka Y, Iwata T, Yamauchi H Tags: Breast Cancer Source Type: research

High expression of soluble CD155 in estrogen receptor-negative breast cancer.
CONCLUSIONS: The serum level of sCD155 is correlated with high risk factors in breast cancer. PMID: 31372841 [PubMed - as supplied by publisher]
Source: Breast Cancer - August 1, 2019 Category: Cancer & Oncology Authors: Iguchi-Manaka A, Okumura G, Ichioka E, Kiyomatsu H, Ikeda T, Bando H, Shibuya A, Shibuya K Tags: Breast Cancer Source Type: research

Effects of General Anesthesia on Quality of Recovery After Transaxillary Endoscopic Breast Augmentation
Conditions:   Breast Augmentation;   Inhalation Anesthesia;   Total Intravenous Anesthesia;   Quality of Recovery Interventions:   Drug: Desflurane;   Drug: Propofol Sponsor:   Chih-Cheng Hung Completed
Source: ClinicalTrials.gov - July 29, 2019 Category: Research Source Type: clinical trials