Mutation Profile via Next-Generation Sequencing in Patients with Colorectal Adenocarcinoma and Its Clinicopathological Correlation
CONCLUSION: It is necessary to have a comprehensive database of genomic alterations of colorectal carcinomas to interpret mutations more accurately clinically. There are no studies on the frequency of mutations in colorectal carcinomas in the Turkish population; thus, follow-up and treatment protocols are organized following the European and American databases and guidelines. A comprehensive study of the colorectal carcinoma patients' mutation profile in the Turkish patient cohort by the next-generation sequencing method will help to provide significant therapeutic, prognostic, and predictive data and design more successfu...
Source: The Turkish Journal of Gastroenterology - September 22, 2023 Category: Gastroenterology Authors: Sibel Osman Nesibe Kahraman Çetin İbrahim Halil Erdoğdu İbrahim Meteoğlu Source Type: research

Elevated profiles of peripheral Th22, Th17, Th2 cells, and decreased percentage of Th1 cells in breast cancer patients
ConclusionTh22, Th17, Th1, and Th2 subsets may play an essential role in BC patients. Th22, Th17, Th1, and Th2 cells may have potential significance to be used as clinical markers in BC patients with different molecular classification. Th22 cells may have potential value in BC patients ’ outcomes prediction, providing clinical value.
Source: Thoracic Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Zhiguo Peng, Xinyue Dong, Miao He, Yajing Zhao, Yujia Liu, Mo Li, Guosheng Li, Xiuwen Wang, Li Li, Yu Hu Tags: ORIGINAL ARTICLE Source Type: research

4 ways to intervene sooner and smarter to drive cancer ’s impact down
Better prevention, detection and treatment of cancer have been the basis of initiatives large and small, from the War on Cancer and Cancer Moonshot, to fundraising walks in communities across America. But our progress has been modest. Among nearly 40 major cancer types or disease sites, only five — breast, cervical, colorectal, lung and prostate cancers — can be detected at early stages through imaging or lab tests. Even for those cancers we can detect early, we’re not seeing enough of…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - September 22, 2023 Category: Pharmaceuticals Authors: Dr. Raghu Ram Source Type: news

FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis
Cell Death & Disease, Published online: 22 September 2023; doi:10.1038/s41419-023-06127-xFBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis
Source: Cell death and disease - September 22, 2023 Category: Internal Medicine Authors: Ganesh Kumar Barik Osheen Sahay Anindya Mukhopadhyay Rajesh Kumar Manne Sehbanul Islam Anup Roy Somsubhra Nath Manas Kumar Santra Source Type: research

Sensors, Vol. 23, Pages 8017: Transcranial Magnetic Stimulation for the Treatment of Chemo Brain
Conclusions: This first patient in the phase 1 clinical trial testing of TMS for the treatment of “chemo brain” provided important lessons for feasibility and insights into mechanisms of potential benefit.
Source: Sensors - September 22, 2023 Category: Biotechnology Authors: Phillip H. Kuo Allison Yu-Chin Chen Rudolph J. Rodriguez Carol Stuehm Pavani Chalasani Nan-Kuei Chen Ying-Hui Chou Tags: Case Report Source Type: research

A simple and convenient model combining multiparametric MRI and clinical features to predict tumour-infiltrating lymphocytes in breast cancer
To develop a simple and convenient method based on multiparametric magnetic resonance imaging (MRI) and clinical features to non-invasively predict tumour-infiltrating lymphocytes (TILs) in breast cancer (BC) and to explore the relationship between TIL levels and disease-free survival (DFS).
Source: Clinical Radiology - September 22, 2023 Category: Radiology Authors: S. Chen, Y. Sui, S. Ding, C. Chen, C. Liu, Z. Zhong, Y. Liang, W. Tang, Q. Kong, Y. Guo Source Type: research

Upright patient positioning for gantry-free breast radiotherapy: feasibility tests using a robotic chair and specialised bras
In conclusion, upright body positioning for breast radiotherapy appears to be comfortable and feasible. Of the 9 patients who received conventional, supine radiotherapy (mean age 63.5 years, maximum age 90 years), 7 reported that they preferred upright positioning. Radiotherapy bras were effective in reducing/eliminating ISF for upright body positions, including for very large breasted volunteers. For upright proton radiotherapy to the breast, beam access should be straightforward, even for arms-down treatments, as en-face field directions are typically used. For photon radiotherapy, additional research is now required to ...
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research

Updates in pathobiological aspects of anaplastic large cell lymphoma
Anaplastic large cell lymphomas (ALCL) encompass several distinct subtypes of mature T-cell neoplasms that are unified by the expression of CD30 and anaplastic cytomorphology. Identification of the cytogenetic abnormality t(2;5)(p23;q35) led to the subclassification of ALCLs into ALK+ ALCL and ALK- ALCL. According to the most recent World Health Organization (WHO) Classification of Haematolymphoid Tumours as well as the International Consensus Classification (ICC) of Mature Lymphoid Neoplasms, ALCLs encompass ALK+ ALCL, ALK- ALCL, and breast implant-associated ALCL (BI-ALCL). Approximately 80% of systemic ALCLs harbor rear...
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research

Ki-67 index after neoadjuvant endocrine therapy as a prognostic biomarker in patients with ER-positive/HER2-negative early breast cancer: a systematic review and meta-analysis
Neoadjuvant treatment discriminates responders, but pathologic complete response is uncommon in ER-positive/HER2-negative early breast cancer. We aimed to assess the prognostic value of Ki-67 index after neoadjuvant endocrine therapy (NET).
Source: European Journal of Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Diogo Martins-Branco, Guilherme Nader-Marta, Chiara Molinelli, Lieveke Ameye, Marianne Paesmans, Michail Ignatiadis, Philippe Aftimos, Roberto Salgado, Evandro de Azambuja Tags: Original Research Source Type: research

Cancers, Vol. 15, Pages 4682: PD-1/PD-L1 Inhibitors Response in Triple-Negative Breast Cancer: Can Long Noncoding RNAs Be Associated?
valho de Oliveira As immune checkpoint inhibitors (ICI) emerge as a paradigm-shifting treatment option for patients with advanced or metastatic cancer, there is a growing demand for biomarkers that can distinguish which patients are likely to benefit. In the case of triple-negative breast cancer (TNBC), characterized by a lack of therapeutic targets, pembrolizumab approval for high-risk early-stage disease occurred regardless of PD-L1 status, which keeps the condition in a biomarker limbus. In this review, we highlight the participation of long non-coding RNAs (lncRNAs) in the regulation of the PD-1/PD-L1 pathway, as w...
Source: Cancers - September 22, 2023 Category: Cancer & Oncology Authors: Carolina Mathias Vanessa Nascimento Kozak Jessica Maria Magno Suelen Cristina Soares Baal Victor Henrique Apolonio dos Santos Enilze Maria de Souza Fonseca Ribeiro Daniela Fiori Gradia Mauro Antonio Alves Castro Jaqueline Carvalho de Oliveira Tags: Review Source Type: research

Sensors, Vol. 23, Pages 8031: Integrating Target and Shadow Features for SAR Target Recognition
ng Zhou Synthetic aperture radar (SAR) sensor often produces a shadow in pairs with the target due to its slant-viewing imaging. As a result, shadows in SAR images can provide critical discriminative features for classifiers, such as target contours and relative positions. However, shadows possess unique properties that differ from targets, such as low intensity and sensitivity to depression angles, making it challenging to extract depth features from shadows directly using convolutional neural networks (CNN). In this paper, we propose a new SAR image-classification framework to utilize target and shadow information co...
Source: Sensors - September 22, 2023 Category: Biotechnology Authors: Zhiyuan Zhao Xiaorong Xue Iqra Mariam Xing Zhou Tags: Article Source Type: research

Cancers, Vol. 15, Pages 4679: Glucocorticoid Receptor Activation in Lobular Breast Cancer Is Associated with Reduced Cell Proliferation and Promotion of Metastases
Suzanne D. Conzen Estrogen receptor-positive (ER+) invasive lobular breast cancer (ILC) comprises about ~15% of breast cancer. ILC’s unique genotypic (loss of wild type E-cadherin expression) and phenotypic (small individual round cancer cells that grow in discontinuous nests) are thought to contribute to a distinctive pattern of metastases to serosal membranes. Unlike invasive ductal carcinoma (IDC), ILC metastases often intercalate into the mesothelial layer of the peritoneum and other serosal surfaces. While ER activity is a known driver of ILC proliferation, very little is known about how additiona...
Source: Cancers - September 22, 2023 Category: Cancer & Oncology Authors: Baylee A. Porter Candace Frerich Muriel Lain é Abigail B. Clark Ishrat Durdana Jeon Lee Manisha Taya Sunati Sahoo Geoffrey L. Greene Lynda Bennett Suzanne D. Conzen Tags: Article Source Type: research

Cancers, Vol. 15, Pages 4678: Clinical Characteristics and Prognosis of HER2-0 and HER2-Low-Positive Breast Cancer Patients: Real-World Data from Patients Treated with Neoadjuvant Chemotherapy
Erber Paul Gass In our study, we observed the long-term survival outcomes investigated for HER2-0 and HER2-low-positive breast cancer patients who received neoadjuvant chemotherapy. Between 1998 and 2020, 10,333 patients with primary breast cancer were treated, including 1373 patients with HER2-0 or HER2-low-positive disease with neoadjuvant chemotherapy. Descriptive analyses were performed, and logistic regression models and survival analyses were calculated for disease-free survival (DFS) and overall survival (OS). Among the 1373 patients, 930 (67.73%) had HER2-low-positive and 443 (32.27%) had HER2-0 tumors. Patie...
Source: Cancers - September 22, 2023 Category: Cancer & Oncology Authors: Patrik P öschke Peter A. Fasching Werner Adler Matthias R übner Matthias W. Beckmann Carolin C. Hack Felix Heindl Arndt Hartmann Ramona Erber Paul Gass Tags: Article Source Type: research

Cancers, Vol. 15, Pages 4676: Time-Dependent ROC Curve Analysis for Assessing the Capability of Radiation-Induced CD8 T-Lymphocyte Apoptosis to Predict Late Toxicities after Adjuvant Radiotherapy of Breast Cancer Patients
This article evaluates the predictive performance of the RILA using a ROC curve analysis that takes into account the dynamic nature of fibrosis occurrence. This time-dependent ROC curve approach is also applied to evaluate the ability of the RILA combined with the other previously identified factors. Our analysis includes a Monte Carlo cross-validation procedure and the calculation of an expected cost of misclassification, which provides more importance to patients who have no risk of late fibrosis in order to be able to treat them with the maximal irradiation dose. Performance evaluation was assessed at 12, 24, 36 and 50 ...
Source: Cancers - September 22, 2023 Category: Cancer & Oncology Authors: C élia Touraine Audrey Winter Florence Castan David Azria Sophie Gourgou Tags: Article Source Type: research

A Randomised Clinical Feasibility Trial of a Breast Immobilisation Device: the SuPPORT 4 All Bra
Despite the breast being a mobile organ, there is currently no standard suitable immobilisation device to optimise radiotherapy for women with larger breasts treated after a wide local excision. The SuPPORT 4 All (S4A) bra was co-designed with patients and radiotherapy professionals. The purpose of this study was to test the feasibility of using the S4A bra in the existing breast cancer radiotherapy pathway.
Source: Clinical Oncology - September 22, 2023 Category: Radiology Authors: H. Probst, H. Reed, A. Stanton, R.M. Simpson, S.J. Walters, H. Simpson, G. Brown, S. Hielscher, K. Bryan-Jones, J. Johnson, J. Horsman, O.S. Din Source Type: research

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