Prevalence of women with breast implants in Sweden: a study based on the population-based mammography screening programme
CONCLUSION: The prevalence of breast implants in Swedish women is estimated to be around 4%. The population-based mammography screening programme in countries with a publicly funded welfare-type healthcare system and a clear documentation of mammography screening attendance, seems to be a feasible way to establish the prevalence of breast implants in the population. The large number of women with breast implants warrants further studies regarding the best diagnostic and treatment alternatives for this group. Pre-registration: ClinicalTrials.Gov identifier NCT05222100.PMID:37728392 | DOI:10.2340/jphs.v58.15298
Source: Journal of Plastic Surgery and Hand Surgery - September 20, 2023 Category: Surgery Authors: Emma Hansson Sarah Zaya Susanne Meyer Alexa Freiin von Wrangel Fredrik W ärnberg Sophia Zackrisson Source Type: research

PD-L1 testing in metastatic triple negative breast cancer: Results of an Italian survey
CONCLUSION: Our results raise some important issues concerning the evaluation of PD-L1 in the "real-life" setting, providing strategies for its implementation.PMID:37726962 | DOI:10.1177/03008916231196781
Source: Tumori - September 20, 2023 Category: Cancer & Oncology Authors: Bruna Cerbelli Alessio Cirillo Giulia Pomati Angelina Pernazza Andrea Ascione Simona Pisegna Annalinda Pisano Martina Leopizzi Maria Gemma Pignataro Leopoldo Costarelli Antonino Mul è Andrea Vecchione Piera Catalano Luigi Coppola Giuseppe Perrone Letizia Source Type: research

Ectopic breast tissue of the vulva
We present a case of a 62-year-old woman with a left vulvar mass of 30 years duration that progressively increased in size. The patient reported having pressure and discomfort, especially during movement. Surgical excision was performed, and a histopathological examination revealed a well-differentiated ectopic breast. We also review other cases of vulvar ectopic breast to further comprehend the characteristics of this rare disease. Clinicians and pathologists should always consider it as a differential diagnosis when presented with a vulvar mass.PMID:37728473 | DOI:10.5114/pjp.2023.128787
Source: Polish Journal of Pathology - September 20, 2023 Category: Pathology Authors: Lanzhi Zhang Xiao Ling Yao Xiujuan Zhu Ying Fu Shaojun Li Source Type: research

Potential impact of HercepTest ™ mAb PharmDx (Dako Omnis) (ge001) in breast cancer diagnosis
Pol J Pathol. 2023;74(2):82-88. doi: 10.5114/pjp.2023.129352.ABSTRACTThe HER2 gene is a biomarker for breast cancer prognosis and treatment. Overexpression of HER2 protein determined by immunohistochemistry (IHC) or amplification of the HER2 gene determined by fluorescence in situ hybridization (FISH) is a condition for qualifying patients for anti-HER2 therapy. Due to the high toxicity of anti-HER2 treatment, proper patient selection is essential. In our study we compared 40 cases with IHC staining of HER2 antibody determined by Ventana PATHWAY anti-HER2/neu antibody (4B5) as HER2 2+ with the new antibody (HercepTest™ m...
Source: Polish Journal of Pathology - September 20, 2023 Category: Pathology Authors: Andrzej Marsza łek Agata Kubicka Inga Jagie łło Anna Malicka-Durczak Source Type: research

Nuclear expression of Ku70/80 is associated with CHEK2 germline mutations in breast cancer
This study is the first reporting an association of Ku70/80 expression with CHEK2 germline mutations in breast cancer. The results suggest that evaluation of Ku70/80 expression in breast cancer may improve the selection of breast cancer patients for Ku70/80 inhibitor therapy, and point to CHEK2-associated breast cancer and a subset of ER-positive breast cancer as potential suitable targets for such therapy.PMID:37728466 | DOI:10.5114/pjp.2023.129518
Source: Polish Journal of Pathology - September 20, 2023 Category: Pathology Authors: Rosik Jakub Machaj Filip Bodnar Daniel Hybiak Jolanta Huzarski Tomasz Cybulski Cezary Lubi ński Jan Domaga ła Wenancjusz Pawe ł Domagała Source Type: research

Prognosis-related novel immunostaining pattern for programmed cell death ligand 1 and prognostic value of tumour-infiltrating lymphocytes in triple-negative breast cancer
This study aims to determine the prognostic significance of programmed cell death ligand 1 (PD-L1) expression and tumour-infiltrating lymphocytes (TILs) in triple- negative breast cancer (TNBC). PD-L1 expression and TIL percentage were determined in TNBCs that did not receive neoadjuvant therapy. The relationship between PD-L1 expression and the percentage of TILs with survival was investigated. The presence of intratumoural PD-L1-positive tumour-infiltrating immune cells (TIICs) in tumours with ≥ 1% PD-L1 expression was identified as a new PD-L1 evaluation parameter. The presence of intratumoural PD-L1-positive TIICs as...
Source: Polish Journal of Pathology - September 20, 2023 Category: Pathology Authors: P ınar Savaş G ürdeniz Serin P ınar Gürsoy Osman Zekio ğlu Necmettin Özdemir Source Type: research

DNA is Better at Math than You Are
By KIM BELLARD I was tempted to write about the work being done at Wharton that suggests that AI may already be better at being entrepreneurial than most of us, and of course I’m always interested to see how nanoparticles are starting to change health care (e.g., breast cancer or cancer more generally), but when I saw what researchers at China’s Shanghai Jiao Tong University have done with DNA-based computers, well, I couldn’t pass that up.  If PCs helped change the image of computers from the big mainframes, and mobile phones further redefined what a computer is, then DNA computers may cause us to one day...
Source: The Health Care Blog - September 20, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Tech DNA Future of Computing Kim Bellard Source Type: blogs

Glenohumeral osteoarthritis: what the surgeon needs from the radiologist
This article reviews the above concepts and details what a surgeon needs from a radiologist and could benefit from accurate reporting of preoperative imaging studies.
Source: Skeletal Radiology - September 20, 2023 Category: Radiology Source Type: research

Genes, Vol. 14, Pages 1820: Identification of Breast Cancer Metastasis Markers from Gene Expression Profiles Using Machine Learning Approaches
Yoo Cancer metastasis accounts for approximately 90% of cancer deaths, and elucidating markers in metastasis is the first step in its prevention. To characterize metastasis marker genes (MGs) of breast cancer, XGBoost models that classify metastasis status were trained with gene expression profiles from TCGA. Then, a metastasis score (MS) was assigned to each gene by calculating the inner product between the feature importance and the AUC performance of the models. As a result, 54, 202, and 357 genes with the highest MS were characterized as MGs by empirical p-value cutoffs of 0.001, 0.005, and 0.01, respectively. The ...
Source: Genes - September 20, 2023 Category: Genetics & Stem Cells Authors: Jinmyung Jung Sunyong Yoo Tags: Article Source Type: research

Heat-shock protein 90α protects NME1 against degradation and suppresses metastasis of breast cancer
British Journal of Cancer, Published online: 20 September 2023; doi:10.1038/s41416-023-02435-3Heat-shock protein 90α protects NME1 against degradation and suppresses metastasis of breast cancer
Source: British Journal of Cancer - September 20, 2023 Category: Cancer & Oncology Authors: Yanchao Zhang Guomeng Zhao Liting Yu Xindong Wang Yao Meng Jinlei Mao Ziyi Fu Yongmei Yin Jinyao Li Xun Wang Changying Guo Source Type: research

Self-efficacy, motivation, and habits: psychological correlates of exercise among women with breast cancer
ConclusionResults suggest that incorporating strategies that support identified motivation, habits, and coping self-efficacy in future interventions could promote increased exercise behaviour among breast cancer populations. Future longitudinal research should examine associations with exercise in a more representative, population-based sample.
Source: Supportive Care in Cancer - September 20, 2023 Category: Cancer & Oncology Source Type: research

Cost-effectiveness of granulocyte colony-stimulating factors (G-CSFs) for the prevention of febrile neutropenia (FN) in patients with cancer
ConclusionsBiosimilar filgrastim and pegfilgrastim as primary prophylaxis are cost-effective approaches to avoid FN events in patients with BC, NSCLC, or NHL at intermediate risk for FN in Austria, France, and Germany.
Source: Supportive Care in Cancer - September 20, 2023 Category: Cancer & Oncology Source Type: research

The interaction of financial toxicity and social support on social functioning in post-chemotherapy breast cancer patients: a cross-sectional study
ConclusionThere was an additive interaction of financial toxicity and social support in the social functioning of post-chemotherapy breast cancer patients. Those patients with high financial toxicity and low social support are the most likely to benefit from relevant intervention measures compared to other breast cancer populations.
Source: Supportive Care in Cancer - September 20, 2023 Category: Cancer & Oncology Source Type: research

Did the COVID-19 pandemic impact the dietary intake of individuals living with and beyond breast, prostate, and colorectal cancer and who were most likely to experience change?
ConclusionsFindings suggest decreased intake for fruit, vegetable, and alcohol consumption and increased snack intake in response to the pandemic amongst individuals LWBC. These changes appear to differ across various characteristics, suggesting the pandemic has not equally impacted everyone in this population. Findings highlight the need for targeted post-COVID strategies to support individuals LWBC most adversely affected by the pandemic, including women and socially isolated individuals. This encourages resources to be prioritised amongst these groups to prevent further negative impact of the pandemic. Whilst the findin...
Source: Supportive Care in Cancer - September 20, 2023 Category: Cancer & Oncology Source Type: research

The impact of poor metabolic health on aggressive breast cancer: adipose tissue and tumor metabolism
Obesity and type 2 diabetes are chronic metabolic diseases that impact tens to hundreds of millions of adults, especially in developed countries. Each condition is associated with an elevated risk of breast cancer and with a poor prognosis after treatment. The mechanisms connecting poor metabolic health to breast cancer are numerous and include hyperinsulinemia, inflammation, excess nutrient availability, and adipose tissue dysfunction. Here, we focus on adipose tissue, highlighting important roles for both adipocytes and fibroblasts in breast cancer progression. One potentially important mediator of adipose tissue effects...
Source: Frontiers in Endocrinology - September 20, 2023 Category: Endocrinology Source Type: research

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