Augmentation plate without bone graft in the management of distal tibial diaphyseal non-union
The objective of this study was to assess the efficacy of augmentation plating with retaining of previous implant in situ in cases of non-united oligotrophic or atrophic aseptic distal tibial diaphyseal and metaphyseal fractures without bone grafting depending on the unified bone healing and non-union theory.
Source: Injury - September 21, 2023 Category: Orthopaedics Authors: Radwan G. Metwaly, Ahmed Saeed Younis Source Type: research

Cartilage Injuries
The last several decades have brought about substantial development in our understanding of the biomolecular pathways associated with chondral disease and progression to arthritis. Within domains relevant to foot and ankle, genetic modification of stem cells, augmentation of bone marrow stimulation techniques, and improvement on existing scaffolds for delivery of orthobiologic agents hold promise in improving treatment of chondral injuries. This review summarizes novel developments in the understanding of the molecular pathways underlying chondral damage and some of the recent advancements within related therapeutics.
Source: Foot and Ankle Clinics - September 21, 2023 Category: Orthopaedics Authors: Albert T. Anastasio, Samuel B. Adams Source Type: research

Celebrity Identification and Reasoned Action: An Integrative Model of the Relationship Between Media Use and Breast Cancer Screening Intention
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Source: Health Communication - September 21, 2023 Category: Health Management Authors: Suahn Jang ChoYan TianDepartment of Communication & Media, University of Missouri-St. Louis Source Type: research

A Versatile PDA(DOX) Nanoplatform for Chemo-Photothermal Synergistic Therapy against Breast Cancer and Attenuated Doxorubicin-Induced Cardiotoxicity
Photothermal therapy (PTT) is a highly clinical application promising cancer treatment strategy with safe, convenient surgical procedures and excellent therapeutic efficacy on superficial tumors. However, a si...
Source: Journal of Nanobiotechnology - September 21, 2023 Category: Nanotechnology Authors: Siqi Geng, Qiang Feng, Chujie Wang, Ying Li, Jiaying Qin, Mingsheng Hou, Jiedong Zhou, Xiaoyu Pan, Fei Xu, Baoru Fang, Ke Wang and Zhangsen Yu Tags: Methodology Source Type: research

Use of Circulating Tumor DNA (ctDNA) for Early Molecular Detection of Breast Cancer Relapse in Patients with Triple-Negative Breast Cancer (TNBC)
AbstractPurpose of ReviewThe intent of this review is to discuss the clinical utility of circulating tumor DNA (ctDNA) analysis for molecular residual disease (MRD) detection in patients with early-stage TNBC.Recent FindingsBaseline ctDNA concentration correlates with tumor clinical features. ctDNA dynamics during neoadjuvant chemotherapy (NAC) predicts pathologic complete response (pCR), residual cancer burden (RCB), and relapse. Use of ctDNA plus imaging modalities during NAC may improve accuracy of pCR prediction. A lead-time exists from MRD detection and relapse. Tumor-informed assays tracking multiple ctDNA variants s...
Source: Current Breast Cancer Reports - September 21, 2023 Category: Cancer & Oncology Source Type: research

MetriTrack partners with Mammography Educators to Launch Custom Sonographer training with MetriTrack's Computer Assisted Breast Ultrasound solution, the BVN G-2000
MetriTrack's BVN G-2000 to expand the use of breast ultrasound by enabling standardized quality and remote expert communication for breast ultrasound HILLSIDE, Ill. , Sept. 20, 2023 /PRNewswire-PRWeb/ -- MetriTrack, Inc., a provider of automated breast ultrasound solutions is pleased to...
Source: PRWeb: Medical Pharmaceuticals - September 20, 2023 Category: Pharmaceuticals Tags: LIC Source Type: news

Effect of artificial intelligence –based computer-aided diagnosis on the screening outcomes of digital mammography: a matched cohort study
ConclusionsAI-CAD increases the specificity for radiologists without decreasing sensitivity as a supportive tool in the single reading of DM for breast cancer screening.Clinical relevance statementThis study shows that AI-CAD could improve the specificity of radiologists ’ DM interpretation in the single reading system without decreasing sensitivity, suggesting that it can benefit patients by reducing false positive and recall rates.Key Points• In this retrospective-matched cohort study (DM without AI-CAD vs DM with AI-CAD), radiologists showed higher specificity and lower AIR when AI-CAD was used to support decision-m...
Source: European Radiology - September 20, 2023 Category: Radiology Source Type: research

Spatial Variation Generation Algorithm for Motor Imagery Data Augmentation: Increasing the Density of Sample Vicinity
In this study, a Spatial Variation Generation (SVG) algorithm for MI data augmentation is proposed to alleviate the overfitting issue. In essence, SVG generates MI data using variations of electrode placement and brain spatial pattern, ultimately elevating the density of the raw sample vicinity. The proposed SVG prevents models from memorizing the training data by replacing the raw samples with the proper vicinal distribution. Moreover, SVG generates a uniform distribution and stabilizes the training process of models. In comparison studies involving five deep learning-based models across eight datasets, the proposed SVG a...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - September 20, 2023 Category: Neuroscience Source Type: research

Brain circuit behind release of breast milk at baby ’s cries uncovered
Scientists find continuous crying by mouse pups triggers release of oxytocin, which controls milk-release responseThe brain circuit that causes the sound of a newborn crying to trigger the release of breast milk in mothers has been uncovered by scientists.The study, in mice, gives fresh insights into sophisticated changes that occur in the brain during pregnancy and parenthood. It found that 30 seconds of continuous crying by mouse pups triggered the release of oxytocin, the brain chemical that controls the breast-milk release response in mothers.Continue reading...
Source: Guardian Unlimited Science - September 20, 2023 Category: Science Authors: Hannah Devlin Science correspondent Tags: Breastfeeding Science Women Research UK news Neuroscience Biology Source Type: news

Preventing Breast Cancer Overtreatment Preventing Breast Cancer Overtreatment
The risk of developing breast cancer in individuals with pathogenic cancer syndrome variants may be less elevated in those without a first-degree family history.MDedge News
Source: Medscape Hematology-Oncology Headlines - September 20, 2023 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

A Baby Cries & Mom ' s Breast Milk Releases: New Study Could Explain Why
WEDNESDAY, Sept. 20, 2023 -- Many a new mom knows that when her newborn cries, her milk releases. Now, animal research reveals a newly discovered brain circuit that may explain why that happens. This new study showed that when a mouse pup starts...
Source: Drugs.com - Daily MedNews - September 20, 2023 Category: General Medicine Source Type: news

Molecular Biology Mechanisms and Emerging Therapeutics of Triple-Negative Breast Cancer
Source: Biologics: Targets and Therapy - September 20, 2023 Category: Biochemistry Tags: Biologics: Targets and Therapy Source Type: research

Namibia: Breast Cancer, the Second-Most Common Cancer in Namibia
[Namibian] Breast cancer has affected the lives of countless Namibian women and their families, but Namibians are determined to improve breast cancer awareness, early detection, and treatment.
Source: AllAfrica News: Health and Medicine - September 20, 2023 Category: African Health Tags: Health and Medicine Namibia Noncommunicable Diseases Southern Africa Source Type: news

IceCure Medical Receives FDA Response to De Novo Classification Request for Breast Cancer
CAESAREA, Israel, Sept. 20, 2023 -- (Healthcare Sales & Marketing Network) -- IceCure Medical Ltd. (Nasdaq: ICCM), developer of the ProSense® System, a minimally-invasive cryoablation technology that destroys tumors by freezing as an alternative to su... Devices, FDA IceCure Medical, ProSense System, cryoablation
Source: HSMN NewsFeed - September 20, 2023 Category: Pharmaceuticals Source Type: news

Bilateral Breast Cancer With Contralateral Axillary Metastasis Warrants Aggressive Treatment: Let's Go for It!
This patient with a history of left breast cancer now presents with bilateral breast cancers (right: pT1N0M0, anatomic and prognostic stage IA; left: pT4bNXM1, anatomic and prognostic stage IV with contralateral axillary metastasis [CAM]).1 With limited information regarding her prior cancer, we have staged the current left-sided cancer as a new primary.
Source: International Journal of Radiation Oncology * Biology * Physics - September 20, 2023 Category: Radiology Authors: Meriem Mokhtech, Christin A. Knowlton Tags: Gray Zone Source Type: research

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