This page shows you the latest news items in this category. This is page number 12.

Total 251735 results found since Jan 2013.

Single-dose local intraosseous injection of simvastatin suppresses breast cancer with tumor vascular normalization.
In this study, we found that intraosseous injection of simvastatin improves tumor vascular structure, along with increasing the percentage of pericyte coverage on tumor vessels, and reducing vascular permeability, tumor hypoxia and tumor necrosis. Further, we demonstrate that a single-dose local intraosseous simvastatin injection suppresses tumor growth, facilitates sensitivity of chemotherapy and prolongs survival in breast cancer-bearing mice. In addition, oral application, intravenous, subcutaneous and intraperitoneal injection of simvastatin do not show these effects. Taken together, these results demonstrate that intr...
Source: Translational Oncology - September 17, 2020 Category: Cancer & Oncology Authors: Yuan W, Hai B, Ren X, Zhu J, Zhang C, Guan Z, Jia J, Wang H, Cao B, Song C Tags: Transl Oncol Source Type: research

Dose-sparing effect of deep inspiration breath hold technique on coronary artery and left ventricle segments in treatment of breast cancer.
CONCLUSIONS: Our study demonstrates the dose-sparing effects of DIBH in various cardiac structures, especially the distal LAD and apical LV segments. The large dose reductions seen in the distal LAD and apical LV segments could potentially translate into clinical benefit of reduced cardiac toxicity, as these structures have been previously shown to receive the highest doses and are associated with radiation-induced injury. PMID: 32950530 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 17, 2020 Category: Radiology Authors: Song J, Tang T, Caudrelier JM, Bélec J, Chan J, Lacasse P, Aldosary G, Nair V Tags: Radiother Oncol Source Type: research

Disparities in Breast Cancer Stage at Diagnosis between Immigrant and Native-Born Women: A Meta-Analysis.
CONCLUSIONS: This meta-analysis confirmed the presence of significant differences in breast cancer stage at diagnosis according to nativity. Across diverse immigrant groups and host countries, foreign-born women were significantly less likely to be diagnosed with localized breast cancer than native women; the magnitude of the disparity varied by region and economic condition of immigrants' birthplace. PMID: 32950654 [PubMed - as supplied by publisher]
Source: Annals of Epidemiology - September 17, 2020 Category: Epidemiology Authors: Herbach EL, Weeks KS, O'Rorke M, Novak NL, Schweizer ML Tags: Ann Epidemiol Source Type: research

Characterization of stromal tumor-infiltrating lymphocytes and genomic alterations in metastatic lobular breast cancer.
CONCLUSIONS: ILC metastases harbor genomic alterations that may potentially explain endocrine resistance in a large proportion of patients, and present genomic differences as compared to IDC metastases. PMID: 32943456 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - September 17, 2020 Category: Cancer & Oncology Authors: Richard F, Majjaj S, Venet D, Rothé F, Pingitore J, Boeckx B, Marchiò C, Clatot F, Bertucci F, Mariani O, Galant C, Van den Eynden GG, Salgado R, Biganzoli E, Lambrechts D, Vincent-Salomon A, Pruneri G, Larsimont DP, Sotiriou C, Desmedt C Tags: Clin Cancer Res Source Type: research

Anthropometric breast measurements of young women with no history of pregnancy or surgery in Turkey.
This study revealed the average breast size and measurements of women in Turkey. It can be useful to guide for both reconstructive and aesthetic procedures of the breast. PMID: 32921201 [PubMed - as supplied by publisher]
Source: Journal of Plastic Surgery and Hand Surgery - September 16, 2020 Category: Surgery Tags: J Plast Surg Hand Surg Source Type: research

OX40 genetic variations in patients with breast cancer: a case-control study.
Authors: Faghih Z, Taherifard E, Daneshmand A, Talei A, Erfani N PMID: 32921275 [PubMed - as supplied by publisher]
Source: British Journal of Biomedical Science - September 16, 2020 Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research

Spironolactone Not Tied to Breast Cancer Recurrence
Drug can be used for alopecia treatment in breast cancer survivors
Source: The Doctors Lounge - Oncology - September 16, 2020 Category: Cancer & Oncology Tags: Dermatology, Oncology, Pharmacy, Journal, Source Type: news

Evaluation of reconstruction algorithms for  a stationary digital breast tomosynthesis system using a carbon nanotube X-ray source array.
Evaluation of reconstruction algorithms for a stationary digital breast tomosynthesis system using a carbon nanotube X-ray source array. J Xray Sci Technol. 2020 Sep 10;: Authors: Hu Z, Chen Z, Zhou C, Hong X, Chen J, Zhang Q, Jiang C, Ge Y, Yang Y, Liu X, Zheng H, Li Z, Liang D Abstract Breast cancer is the most frequently diagnosed cancer in women worldwide. Digital breast tomosynthesis (DBT), which is based on limited-angle tomography, was developed to solve tissue overlapping problems associated with traditional breast mammography. However, due to the problems associated with tube movement during ...
Source: Journal of X-Ray Science and Technology - September 16, 2020 Category: Radiology Tags: J Xray Sci Technol Source Type: research

Neoadjuvant Study of Targeting ROS1 in Combination With Endocrine Therapy in Invasive Lobular Carcinoma of the Breast (ROSALINE)
Conditions:   Invasive Lobular Breast Carcinoma;   ER+ Breast Cancer;   HER2-negative Breast Cancer Interventions:   Drug: Entrectinib;   Drug: Letrozole;   Drug: Goserelin Sponsors:   Jules Bordet Institute;   Hoffmann-La Roche Not yet recruiting
Source: ClinicalTrials.gov - September 16, 2020 Category: Research Source Type: clinical trials

Evaluation of TaiHao Breast Ultrasound Diagnosis Software
Conditions:   Breast Cancer;   Breast Diseases Interventions:   Diagnostic Test: Reader Group X;   Diagnostic Test: Reader Group Y Sponsors:   TaiHao Medical Inc.;   Columbia University Irving Medical Center;   Taipei Veterans General Hospital, Taiwan;   Virginia Polytechnic Institute and State University Active, not recruiting
Source: ClinicalTrials.gov - September 16, 2020 Category: Research Source Type: clinical trials

Neoadjuvant Study of Targeting ROS1 in Combination With Endocrine Therapy in Invasive Lobular Carcinoma of the Breast (ROSALINE)
Conditions:   Invasive Lobular Breast Carcinoma;   ER+ Breast Cancer;   HER2-negative Breast Cancer Interventions:   Drug: Entrectinib;   Drug: Letrozole;   Drug: Goserelin Sponsors:   Jules Bordet Institute;   Hoffmann-La Roche Not yet recruiting
Source: ClinicalTrials.gov - September 16, 2020 Category: Research Source Type: clinical trials

Evaluation of TaiHao Breast Ultrasound Diagnosis Software
Conditions:   Breast Cancer;   Breast Diseases Interventions:   Diagnostic Test: Reader Group X;   Diagnostic Test: Reader Group Y Sponsors:   TaiHao Medical Inc.;   Columbia University Irving Medical Center;   Taipei Veterans General Hospital, Taiwan;   Virginia Polytechnic Institute and State University Active, not recruiting
Source: ClinicalTrials.gov - September 16, 2020 Category: Research Source Type: clinical trials

RCT Comparing 2 Radiotherapy HypoFractionation Schedules In Breast Cancer Patients
Conditions:   Radiotherapy Side Effect;   Locoregional Recurrence Intervention:   Radiation: Hypofractionation Schedules for Breast Cancer patients after mastecomy Sponsor:   National Cancer Institute, Egypt Recruiting
Source: ClinicalTrials.gov - September 16, 2020 Category: Research Source Type: clinical trials

Evaluation of TaiHao Breast Ultrasound Diagnosis Software
Conditions:   Breast Cancer;   Breast Diseases Interventions:   Diagnostic Test: Reader Group X;   Diagnostic Test: Reader Group Y Sponsors:   TaiHao Medical Inc.;   Columbia University Irving Medical Center;   Taipei Veterans General Hospital, Taiwan;   Virginia Polytechnic Institute and State University Active, not recruiting
Source: ClinicalTrials.gov - September 16, 2020 Category: Research Source Type: clinical trials

RCT Comparing 2 Radiotherapy HypoFractionation Schedules In Breast Cancer Patients
Conditions:   Radiotherapy Side Effect;   Locoregional Recurrence Intervention:   Radiation: Hypofractionation Schedules for Breast Cancer patients after mastecomy Sponsor:   National Cancer Institute, Egypt Recruiting
Source: ClinicalTrials.gov - September 16, 2020 Category: Research Source Type: clinical trials

Neoadjuvant Study of Targeting ROS1 in Combination With Endocrine Therapy in Invasive Lobular Carcinoma of the Breast (ROSALINE)
Conditions:   Invasive Lobular Breast Carcinoma;   ER+ Breast Cancer;   HER2-negative Breast Cancer Interventions:   Drug: Entrectinib;   Drug: Letrozole;   Drug: Goserelin Sponsors:   Jules Bordet Institute;   Hoffmann-La Roche Not yet recruiting
Source: ClinicalTrials.gov - September 16, 2020 Category: Research Source Type: clinical trials

Evaluation of TaiHao Breast Ultrasound Diagnosis Software
Conditions:   Breast Cancer;   Breast Diseases Interventions:   Diagnostic Test: Reader Group X;   Diagnostic Test: Reader Group Y Sponsors:   TaiHao Medical Inc.;   Columbia University Irving Medical Center;   Taipei Veterans General Hospital, Taiwan;   Virginia Polytechnic Institute and State University Active, not recruiting
Source: ClinicalTrials.gov - September 16, 2020 Category: Research Source Type: clinical trials

RCT Comparing 2 Radiotherapy HypoFractionation Schedules In Breast Cancer Patients
Conditions:   Radiotherapy Side Effect;   Locoregional Recurrence Intervention:   Radiation: Hypofractionation Schedules for Breast Cancer patients after mastecomy Sponsor:   National Cancer Institute, Egypt Recruiting
Source: ClinicalTrials.gov - September 16, 2020 Category: Research Source Type: clinical trials

Neoadjuvant Study of Targeting ROS1 in Combination With Endocrine Therapy in Invasive Lobular Carcinoma of the Breast (ROSALINE)
Conditions:   Invasive Lobular Breast Carcinoma;   ER+ Breast Cancer;   HER2-negative Breast Cancer Interventions:   Drug: Entrectinib;   Drug: Letrozole;   Drug: Goserelin Sponsors:   Jules Bordet Institute;   Hoffmann-La Roche Not yet recruiting
Source: ClinicalTrials.gov - September 16, 2020 Category: Research Source Type: clinical trials

Evaluation of TaiHao Breast Ultrasound Diagnosis Software
Conditions:   Breast Cancer;   Breast Diseases Interventions:   Diagnostic Test: Reader Group X;   Diagnostic Test: Reader Group Y Sponsors:   TaiHao Medical Inc.;   Columbia University Irving Medical Center;   Taipei Veterans General Hospital, Taiwan;   Virginia Polytechnic Institute and State University Active, not recruiting
Source: ClinicalTrials.gov - September 16, 2020 Category: Research Source Type: clinical trials

RCT Comparing 2 Radiotherapy HypoFractionation Schedules In Breast Cancer Patients
Conditions:   Radiotherapy Side Effect;   Locoregional Recurrence Intervention:   Radiation: Hypofractionation Schedules for Breast Cancer patients after mastecomy Sponsor:   National Cancer Institute, Egypt Recruiting
Source: ClinicalTrials.gov - September 16, 2020 Category: Research Source Type: clinical trials

Evaluation of TaiHao Breast Ultrasound Diagnosis Software
Conditions:   Breast Cancer;   Breast Diseases Interventions:   Diagnostic Test: Reader Group X;   Diagnostic Test: Reader Group Y Sponsors:   TaiHao Medical Inc.;   Columbia University Irving Medical Center;   Taipei Veterans General Hospital, Taiwan;   Virginia Polytechnic Institute and State University Active, not recruiting
Source: ClinicalTrials.gov - September 16, 2020 Category: Research Source Type: clinical trials

RCT Comparing 2 Radiotherapy HypoFractionation Schedules In Breast Cancer Patients
Conditions:   Radiotherapy Side Effect;   Locoregional Recurrence Intervention:   Radiation: Hypofractionation Schedules for Breast Cancer patients after mastecomy Sponsor:   National Cancer Institute, Egypt Recruiting
Source: ClinicalTrials.gov - September 16, 2020 Category: Research Source Type: clinical trials

Neoadjuvant Study of Targeting ROS1 in Combination With Endocrine Therapy in Invasive Lobular Carcinoma of the Breast (ROSALINE)
Conditions:   Invasive Lobular Breast Carcinoma;   ER+ Breast Cancer;   HER2-negative Breast Cancer Interventions:   Drug: Entrectinib;   Drug: Letrozole;   Drug: Goserelin Sponsors:   Jules Bordet Institute;   Hoffmann-La Roche Not yet recruiting
Source: ClinicalTrials.gov - September 16, 2020 Category: Research Source Type: clinical trials

Evaluation of TaiHao Breast Ultrasound Diagnosis Software
Conditions:   Breast Cancer;   Breast Diseases Interventions:   Diagnostic Test: Reader Group X;   Diagnostic Test: Reader Group Y Sponsors:   TaiHao Medical Inc.;   Columbia University Irving Medical Center;   Taipei Veterans General Hospital, Taiwan;   Virginia Polytechnic Institute and State University Active, not recruiting
Source: ClinicalTrials.gov - September 16, 2020 Category: Research Source Type: clinical trials

RCT Comparing 2 Radiotherapy HypoFractionation Schedules In Breast Cancer Patients
Conditions:   Radiotherapy Side Effect;   Locoregional Recurrence Intervention:   Radiation: Hypofractionation Schedules for Breast Cancer patients after mastecomy Sponsor:   National Cancer Institute, Egypt Recruiting
Source: ClinicalTrials.gov - September 16, 2020 Category: Research Source Type: clinical trials

NAD(P)H:quinone oxidoreductase 1 determines radiosensitivity of triple negative breast cancer cells and is controlled by long non-coding RNA NEAT1.
In conclusion, the NQO1 expression in triple-negative breast cancer cells determined their radiosensitivity and was controlled by NEAT1. In addition, NOQ1 bioactivatable compounds displayed potential for application in the development of radiation sensitizers in breast cancer. PMID: 32922184 [PubMed - in process]
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Spironolactone Not Tied to Breast Cancer Recurrence
WEDNESDAY, Sept. 16, 2020 -- Spironolactone is not independently associated with increased breast cancer recurrence, according to a study published in the October issue of the Journal of the American Academy of Dermatology. Chapman Wei, from the...
Source: Drugs.com - Pharma News - September 16, 2020 Category: Pharmaceuticals Source Type: news

Financial toxicity and contralateral prophylactic mastectomy: an analysis using propensity score methods
ConclusionsChoice for CPM was associated with higher minor complications, but led to improved psychosocial well-being without a higher degree of patient-reported financial toxicity. Prospective studies are needed to discern the influence of CPM on the incidence and trajectory of financial toxicity.
Source: Breast Cancer Research and Treatment - September 16, 2020 Category: Cancer & Oncology Source Type: research

Breast cancer surgery type, quality of life among younger women
(JAMA Network) Researchers investigated differences in quality of life and other outcomes (including physical functioning, body image, sexual health, anxiety and depressive symptoms) by type of breast cancer surgery (such as mastectomy or breast conserving surgery) in women 40 and younger.
Source: EurekAlert! - Cancer - September 16, 2020 Category: Cancer & Oncology Source Type: news

Breast Cancer Surgery and Quality of Life and Psychosocial Well-being in Young Breast Cancer Survivors
This study evaluates the differential associations of surgery with quality of life and psychosocial outcomes among women with breast cancer from 1 to 5 years following diagnosis.
Source: JAMA Surgery - September 16, 2020 Category: Sports Medicine Source Type: research

Buccal Sliding Palatal Pedicle Flap Technique for Wound Closure After Ridge Augmentation.
Authors: Pohl S, Salama M, Petrakakis P Abstract One standard approach for wound closure after ridge augmentation is coronal flap advancement. Coronal flap advancement results in displacement of the mucogingival junction and reduction of the vestibulum. In the maxilla, a buccal sliding palatal flap can be applied for primary wound closure after ridge augmentation. The dissected part of the palatal connective tissue is left exposed, thus eliminating or reducing the amount of the coronal flap advancement respectively and increasing the amount of keratinized gingiva. In combination with guided soft tissue augmentation...
Source: International Journal of Periodontics and Restorative Dentistry - September 16, 2020 Category: Dentistry Tags: Int J Periodontics Restorative Dent Source Type: research

Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Exerts Anti-Breast Cancer Effect via miR-200c-PDE7B/PD-L1-AKT/MAPK Axis.
Conclusions: This study implicates that EA11 prevents breast tumor development by interfering with the miR-200c-PDE7B/PD-L1-AKT/MAPK axis. EA11 may represent a potential therapeutic candidate for breast cancer. PMID: 32922506 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - September 16, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Testosterone therapy and breast histopathological features in transgender individuals
Modern Pathology, Published online: 16 September 2020; doi:10.1038/s41379-020-00675-9Testosterone therapy and breast histopathological features in transgender individuals
Source: Modern Pathology - September 16, 2020 Category: Pathology Authors: Gabrielle M. Baker Yaileen D. Guzman-Arocho Vanessa C. Bret-Mounet Vanda F. Torous Stuart J. Schnitt Adam M. Tobias Richard A. Bartlett Valerie J. Fein-Zachary Laura C. Collins Gerburg M. Wulf Yujing J. Heng Source Type: research

Identification and Validation of an Immunological Expression-Based Prognostic Signature in Breast Cancer
Conclusions: Our study revealed that a PIRDEG signature could be a candidate prognostic biomarker for predicting the overall survival (OS) of patients with BRCA.
Source: Frontiers in Genetics - September 16, 2020 Category: Genetics & Stem Cells Source Type: research

The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study
ConclusionOur findings indicate a null association between genetically determined GTs and breast cancer risk among European women. Our findings may contribute to more complete characterizing of metabolic pathways in GTs and breast cancer.
Source: Frontiers in Genetics - September 16, 2020 Category: Genetics & Stem Cells Source Type: research

Letter to the Editor Regarding; Risk of Breast Implant Associated Anaplastic Large Cell Lymphoma in a Cohort of 3546 Women Prospectively Followed Long Term After Reconstruction with Macro-Textured Breast Implants
Re: Risk of breast implant associated anaplastic large cell lymphoma (BIA-ALCL) in a cohort of 3546 women prospectively followed long term after reconstruction with textured breast implants
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - September 16, 2020 Category: Cosmetic Surgery Authors: Mark L. Jewell Tags: Correspondence and Communications Source Type: research

Cancers, Vol. 12, Pages 2638: How Different Are the Molecular Mechanisms of Nodal and Distant Metastasis in Luminal A Breast Cancer?
vel Bouchal Lymph node status is one of the best prognostic factors in breast cancer, however, its association with distant metastasis is not straightforward. Here we compare molecular mechanisms of nodal and distant metastasis in molecular subtypes of breast cancer, with major focus on luminal A patients. We analyze a new cohort of 706 patients (MMCI_706) as well as an independent cohort of 836 primary tumors with full gene expression information (SUPERTAM_HGU133A). We evaluate the risk of distant metastasis, analyze targetable molecular mechanisms in Gene Set Enrichment Analysis and identify relevant inhibitors. Lymp...
Source: Cancers - September 16, 2020 Category: Cancer & Oncology Authors: Petr Lapcik Anna Pospisilova Lucia Janacova Peter Grell Pavel Fabian Pavel Bouchal Tags: Article Source Type: research

Cancers, Vol. 12, Pages 2634: Beyond Chemotherapies: Recent Strategies in Breast Cancer Treatment
Kischel In 2018, about 2.1 million women have been diagnosed with breast cancer worldwide. Treatments include—among others—surgery, chemotherapy, radiotherapy, or endocrine therapy. The current policy of care tends rather at therapeutic de-escalation, and systemic treatment such as chemotherapies alone are not systematically considered as the best option anymore. With recent advances in the understanding of cancer biology, and as a complement to anatomic staging, some biological factors (assessed notably via gene-expression signatures) are taken into account to evaluate the benefit of a chem...
Source: Cancers - September 16, 2020 Category: Cancer & Oncology Authors: Arthur Foulon Pierrick Theret Lise Rodat-Despoix Philippe Kischel Tags: Review Source Type: research

OXPHOS-dependent metabolic reprogramming prompts metastatic potential of breast cancer cells under osteogenic differentiation
British Journal of Cancer, Published online: 16 September 2020; doi:10.1038/s41416-020-01040-yThis manuscript provides a simplified overview of the involvement of mitochondrial activity and OXPHOS in the metastasis of breast cancer with calcification. We propose that massive accumulation of calcified granules due to breast cancer necrosis or deposition of spontaneous secretions around the glands lead to reprogramming of tumour metabolism, particularly enhancement of mitochondrial metabolism. Upregulation of the OXPHOS complex and subsequent activation of TGFβ-SMAD and MAPK (e.g., JNK, ERK, P38) signalling pathways facilit...
Source: British Journal of Cancer - September 16, 2020 Category: Cancer & Oncology Authors: Yangling Hu Weimin Xu Hui Zeng Zilong He Xiao Lu Daming Zuo Genggeng Qin Weiguo Chen Source Type: research

Molecules, Vol. 25, Pages 4240: Elaeagnus angustifolia Plant Extract Inhibits Epithelial-Mesenchymal Transition and Induces Apoptosis via HER2 Inactivation and JNK Pathway in HER2-Positive Breast Cancer Cells
a F. Al Farsi Elaeagnus angustifolia (EA) is a medicinal plant used for treating several human diseases in the Middle East. Meanwhile, the outcome of EA extract on HER2-positive breast cancer remains nascent. Thus, we herein investigated the effects of the aqueous EA extract obtained from the flowers of EA on two HER2-positive breast cancer cell lines, SKBR3 and ZR75-1. Our data revealed that EA extract inhibits cell proliferation and deregulates cell-cycle progression of these two cancer cell lines. EA extract also prevents the progression of epithelial-mesenchymal transition (EMT), an important event for cancer invas...
Source: Molecules - September 16, 2020 Category: Chemistry Authors: Ayesha Jabeen Anju Sharma Ishita Gupta Hadeel Kheraldine Semir Vranic Ala-Eddin Al Moustafa Halema F. Al Farsi Tags: Article Source Type: research