This page shows you the latest news items in this category. This is page number 8.

Total 220191 results found since Jan 2013.

GSE118810 The genome-wide enhancer profiling of breast cancer in the MMTV-PyVT mice ChIP-seq
Contributors : Qing-Lan Li ; Dan-Ya Wang ; Lin-Gao Ju ; Chuan Gao ; Pin-Ji Lei ; Lian-Yun Li ; Xiao-Lu Zhao ; Min WuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism :Activation of transcription enhancers, especially super enhancers, is one of the important epigenetic features of tumorigenesis. However, only very few studies reported how the enhancer landscape evolves during tumorigensis. Here we utilized a proteomics approach and found that H3K27ac and H4K8ac are elevated in the mammary tumor of MMTV-PyVT mouse model, which was then confirmed by IHC results in human BRCA chips. ChIP-se...
Source: GEO: Gene Expression Omnibus - August 18, 2019 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Source Type: research

GSE118802 The genome-wide enhancer profiling of breast cancer in the MMTV-PyVT mice RNA-seq
Contributors : Qing-Lan Li ; Dan-Ya Wang ; Lin-Gao Ju ; Chuan Gao ; Pin-Ji Lei ; Lian-Yun Li ; Xiao-Lu Zhao ; Min WuSeries Type : Expression profiling by high throughput sequencingOrganism :Activation of transcription enhancers, especially super enhancers, is one of the important epigenetic features of tumorigenesis. However, only very few studies reported how the enhancer landscape evolves during tumorigensis. Here we utilized a proteomics approach and found that H3K27ac and H4K8ac are elevated in the mammary tumor of MMTV-PyVT mouse model, which was then confirmed by IHC results in human BRCA chips. ChIP-seq studies reve...
Source: GEO: Gene Expression Omnibus - August 18, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research

Breast tomosynthesis: What do we know and where do we stand?
Publication date: Available online 16 August 2019Source: Diagnostic and Interventional ImagingAuthor(s): C. Mandoul, C. Verheyden, I. Millet, C. Orliac, E. Pages, I. Thomassin, P. TaourelAbstractDigital breast tomosynthesis (DBT) is a new imaging technology that addresses the limitation caused by overlapping structures in conventional two-dimensional digital mammography owing to the acquisition of a series of low-dose projection images. This unique technique provides a dual benefit to patients screened for breast cancer. First, DBT increases the cancer detection rate mostly by highlighting architectural distortions and all...
Source: Diagnostic and Interventional Imaging - August 17, 2019 Category: Radiology Source Type: research

CyclinB1 Deubiquitination by USP14 Regulates Cell Cycle Progression in Breast Cancer
In conclusion, our study demonstrated that USP14 regulated the cell cycle of breast cancer cells by regulating the ubiquitination of CyclinB1, which will provide a solid theoretical basis for the development of anti-cancer drugs targeting USP14.
Source: Pathology Research and Practice - August 17, 2019 Category: Pathology Source Type: research

Hysteroscopic evaluation of endometrial changes in breast cancer women with or without hormone therapies: results from a large multicenter cohort study
ConclusionTAM treatment does not seem to be associated with a higher rate of endometrial cancer in women with breast cancer compared to women treated with AIs or no treatment.
Source: Journal of Minimally Invasive Gynecology - August 17, 2019 Category: OBGYN Source Type: research

Toxic Shock Syndrome Caused by Staphylococcal Infection After Breast Implant Surgery: A Case Report and Literature Review
We describe a 77-year-old woman who developed toxic shock syndrome caused by methicillin-resistant Staphylococcus aureus after breast implant reconstruction. Despite a high fever and markedly increased white blood cell count, suggesting severe infection, she initially had no symptoms of local findings, such as wound swelling and redness of the breast. Soon after diagnosis of toxic shock syndrome and removal of her breast implant, she was recovered from the shock state. To date, 16 cases of toxic shock syndrome have been reported, including this case, and they were related to breast implants or tissue expander surgery. The ...
Source: Annals of Plastic Surgery - August 17, 2019 Category: Cosmetic Surgery Tags: Review Papers Source Type: research

Pharmacokinetics of pertuzumab administered concurrently with trastuzumab in Chinese patients with HER2-positive early breast cancer
The objective of this analysis was to assess the pharmacokinetics of pertuzumab in combination with trastuzumab in Chinese patients with early breast cancer. Samples for pertuzumab and trastuzumab pharmacokinetic analysis were taken from Chinese patients during cycle 1 of treatment and at steady-state in cycle 10. Noncompartmental analysis was used to estimate minimum and maximum serum concentrations (Cmax and Cmin), area under the concentration-time curve, clearance, and other pharmacokinetic parameters. In 15 patients, mean steady-state Cmax and Cmin pertuzumab serum concentrations (368 ± 177 μg/ml, and 122 ± 47 μg/m...
Source: Anti-Cancer Drugs - August 17, 2019 Category: Cancer & Oncology Tags: Clinical Papers Source Type: research

Genomics applied to the treatment of breast cancer.
Authors: Hamdan D, Nguyen TT, Leboeuf C, Meles S, Janin A, Bousquet G Abstract Breast cancer remains a major health issue in the world with 1.7 million new cases in 2012 worldwide. It is the second cause of death from cancer in western countries. Genomics have started to modify the treatment of breast cancer, and the developments should become more and more significant, especially in the present era of treatment personalization and with the implementation of new technologies. With molecular signatures, genomics enabled a de-escalation of chemotherapy and personalized treatments of localized forms of estrogen-depend...
Source: Oncotarget - August 17, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

KDM2A-dependent reduction of rRNA transcription on glucose starvation requires HP1 in cells, including triple-negative breast cancer cells.
In this study, we turned our attention to the nucleolar accumulation of KDM2A. We found that KDM2A had multiple regions for its nucleolar localization, and one of the regions was directly bound by heterochromatin protein 1γ (HP1γ) using valine 801 in the LxVxL motif of KDM2A. A knockdown of HP1γ or a point mutation of valine 801 in KDM2A decreased the nucleolar accumulation of KDM2A, and suppressed the reduction of rRNA transcription on glucose starvation. These results uncovered a novel function of HP1γ: the regulation of rRNA transcription, and suggested that HP1γ stimulates the nucleolar accumulation of KDM2A to su...
Source: Oncotarget - August 17, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Evaluating the experience of rural individuals with prostate and breast cancer participating in research via telehealth.
CONCLUSIONS: For studies and assessments requiring face-to-face contact, telehealth is clearly a feasible option for improving research representativeness and access for individuals residing in rural areas. Future research should make use of telehealth services, to give a voice to rural individuals who are too often left out. PMID: 31412701 [PubMed - in process]
Source: Rural and Remote Health - August 17, 2019 Category: Rural Health Tags: Rural Remote Health Source Type: research

Development and validation of a sexual relations satisfaction scale in patients with breast cancer — “SEXSAT-Q”
Because the currently available questionnaires to evaluate sexual changes on breast cancer women only address the sexual sphere with a few questions our purpose was to develop a questionnaire that assesses cha...
Source: Health and Quality of Life Outcomes - August 17, 2019 Category: International Medicine & Public Health Authors: Rosario Gonz ález Mancha, Montserrat Muñoz, Luis de la Cruz-Merino, Lourdes Calvo, Josefina Cruz, Jose Manuel Baena-Cañada, Yolanda Fernandez, Manuel Ramos, Cesar Augusto Rodriguez, Jose Ignacio Chacón, Isabel Palomero, Julia Llinares, María Rivero a Tags: Research Source Type: research

Genetic studies suggest alcohol isn ’t linked to breast cancer afterall
Genetic studies rebut current warnings from health officials that alcohol causes breast tumours, and that even light drinking causes throat cancer
Source: New Scientist - Health - August 17, 2019 Category: Consumer Health News Source Type: research

Cancers, Vol. 11, Pages 1201: Progesterone Receptor B signaling Reduces Breast Cancer Cell Aggressiveness: Role of Cyclin-D1/Cdk4 Mediating Paxillin Phosphorylation
Francesca De Amicis Progesterone-Receptor (PR) positivity is related with an enhanced response to breast cancer therapy, conversely cyclin D1 (CD1) is a retained marker of poor outcome. Herein, we demonstrate that hydroxyprogesterone (OHPg) through progesterone receptor B (PR-B) reduces breast cancer cell aggressiveness, by targeting the cytoplasmic CD1. Specifically, OHPg diminishes CD1 expression by a transcriptional regulation due to the recruitment of PR-B at a canonical half-PRE site of the CD1 promoter, together with HDAC1, determining a chromatin conformation less prone for gene transcription. CD1, together wit...
Source: Cancers - August 17, 2019 Category: Cancer & Oncology Authors: Francesca Ida Montalto Francesca Giordano Chiara Chiodo Stefania Marsico Loredana Mauro Diego Sisci Saveria Aquila Marilena Lanzino Maria Luisa Panno Sebastiano And ò Francesca De Amicis Tags: Article Source Type: research

Genetic studies hint alcohol isn ’t linked to breast cancer after all
Genetic studies rebut current warnings from health officials that alcohol causes breast tumours, and that even light drinking causes throat cancer
Source: New Scientist - Health - August 17, 2019 Category: Consumer Health News Source Type: research

Usefulness of preoperative breast magnetic resonance imaging with a dedicated axillary sequence for the detection of axillary lymph node metastasis in patients with early ductal breast cancer
ConclusionOur findings suggest that preoperative axial  + reconstructed coronal MR images exhibit good diagnostic performance for ALN metastasis in patients with early ductal breast cancer. In addition, peritumoral high signal intensity on T2-weighted images of the primary tumor can be used as a predictor of ALN metastasis in these patients.
Source: La Radiologia Medica - August 17, 2019 Category: Radiology Source Type: research

International comparison of cosmetic outcomes of breast conserving surgery and radiation therapy for women with ductal carcinoma in situ of the breast
Breast conserving surgery (BCS) followed by radiation therapy (RT) is the primary management for many women with early-stage, invasive breast cancer and ductal carcinoma in situ (DCIS) [1 –4]. Most women achieve good to excellent cosmesis after BCS and RT but some experience cosmetic failure, defined as fair or poor cosmetic outcomes [5–17]. However, comparisons of cosmetic outcomes across international jurisdictions using contemporary surgical and RT techniques for DCIS are lack ing.
Source: Radiotherapy and Oncology - August 17, 2019 Category: Radiology Authors: Ivo A. Olivotto, Emma Link, Claire Phillips, Timothy J. Whelan, Guy Bryant, Ian H. Kunkler, A. Helen Westenberg, Kash Purohit, Verity Ahern, Peter H. Graham, Mohamed Akra, Orla McArdle, Joanna J. Ludbrook, Jennifer A. Harvey, John H. Maduro, Carine Kirkov Tags: Original Article Source Type: research

Management of complications and unsatisfactory results of aesthetic mammary augmentation by implants.
Abstract Complications of breast implants are rare in regard to the morphological and psychological benefits induced by this intervention. The main complications are; hematoma, infection, seroma with the absolute necessity to look for anaplastic large cell lymphoma associated with breast implants and capsular contracture. Apart from complications, the plastic surgeon may be faced with a bad result, from his surgery or after an intervention realised by a colleague. It is most often a malposition of the implant, primary or secondary ptosis of the breast. The rupture of the implant membrane is inevitable in the more ...
Source: Annales de Chirurgie Plastique et Esthetique - August 14, 2019 Category: Cosmetic Surgery Authors: de Mortillet S Tags: Ann Chir Plast Esthet Source Type: research

Lymphangitic spread of invasive lobular carcinoma to the contralateral breast
Breast cancer typically spreads primarily to regional lymph nodes and subsequently to distant sites via hematogenous routes. Occasionally metastasis can occur through lymphangitic spread, usually to the lungs, resulting in lymphangitic carcinomatosis. Lymphangitic spread of several malignancies have been reported at other sites in the body with varying degrees of clinical significance. In this case report, we describe a rare case of lymphangitic spread of invasive lobular carcinoma to the contralateral breast identified on imaging as significant background enhancement without a discrete suspicious mass.
Source: Clinical Imaging - August 13, 2019 Category: Radiology Authors: Zachariah Burns, Lena Omar, Lindsay Compton, Jody Hayes, Sunati Sahoo, Kanwal Merchant Tags: Breast Imaging Source Type: research

Polygenic Risk Scores in Breast Cancer
AbstractPurpose of ReviewBreast cancer is a complex disease that is fueled by genetic as well as non-genetic factors. As data risk estimates become better, stratifying a woman ’s risk for breast cancer can lead to better prevention strategies. The purpose of this review is to introduce the polygenic risk score (PRS) and shed light on its clinical applications as well as shortcomings in the field of breast cancer prevention.Recent FindingsA PRS combines relevant single-nucleotide polypeptides (SNPs) and generates an estimated risk of a specific cancer. It has the ability of questioning the whole genome and incorporating t...
Source: Current Breast Cancer Reports - August 13, 2019 Category: Cancer & Oncology Source Type: research

Eating Red Meat Tied to Increased Breast Cancer Risk
White meat like chicken was tied to a reduced risk of breast cancer.
Source: NYT Health - August 12, 2019 Category: Consumer Health News Authors: Nicholas Bakalar Tags: Meat Breast Cancer Diet and Nutrition Women and Girls Source Type: news

Evaluation OF IN vitro degradation of commercially available breast implants
This study investigated the mechanical and physicochemical properties of breast implants from five manufactures. Surface morphology, chemical composition, thermal behavior, cross-linking degree and mechanical properties were monitored on samples as received and after submitted to degradation in acidic and basic conditions. All samples demonstrated changes in chemical structure after degradation experiments, and parameters such as cross-linking degree and chemical composition seems to play important role on material performance.
Source: Polymer Testing - August 11, 2019 Category: Chemistry Source Type: research

Prognostic factors and survival according to tumor subtype in newly diagnosed breast cancer with liver metastases: A competing risk analysis.
Abstract Population-based study for predicting the prognosis for breast cancer liver metastasis (BCLM) is lacking at present. Therefore, the present study aimed to evaluate newly diagnosed BCLM patients of different tumor subtypes and assess potential prognostic factors for predicting the survival for BCLM patients. Specifically, data were collected from the Surveillance, Epidemiology and End Results program from 2010 to 2014, and were assessed, including the data of patients with BCLM. Differences in the overall survival (OS) among patients was compared via Kaplan-Meier analysis. Other prognostic factors of OS we...
Source: Clinical Breast Cancer - August 11, 2019 Category: Cancer & Oncology Authors: Chen QF, Huang T, Shen L, Wu P, Huang ZL, Li W Tags: Mol Clin Oncol Source Type: research

Medical News Today: Replacing 'beef with chicken' could reduce breast cancer risk
The role of nutrition in cancer is a hot topic. A new study concludes that red meat increases the risk of breast cancer, but poultry may reduce risk.
Source: Health News from Medical News Today - August 11, 2019 Category: Consumer Health News Tags: Breast Cancer Source Type: news

Promising Blood Test Could Help to Predict Breast Cancer Recurrence
Doctors have gotten much better at detecting and treating breast cancer early. Drug and chemotherapy regimens to control tumors have gotten so effective, in fact, that in some cases, surgery is no longer necessary. In up to 30% of cases of early-stage breast cancer treated before surgery, doctors can’t find evidence of cancer cells in postoperative biopsies. The problem, however, is that there is currently no reliable way to tell which cancers have been pushed into remission and which ones have not. That’s where an easy identifier, like a blood test, could transform the way early stage breast cancer is treated....
Source: TIME: Health - August 8, 2019 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized blood tests Breast Cancer Source Type: news

Breast Ultrasound in the Emergency Department
The important role breast ultrasound plays in the emergency department —and the improvements that need to happen.
Source: Diagnostic Imaging - August 5, 2019 Category: Radiology Authors: Whitney J. Palmer Tags: Breast Health Ultrasound Source Type: news

Patient Comfort During Whole-Breast Ultrasound
What patients think of automated whole-breast ultrasounds.
Source: Diagnostic Imaging - August 5, 2019 Category: Radiology Authors: Whitney J. Palmer Tags: Breast Health Ultrasound Source Type: news

Pregnancy-associated breast cancer: A review of 47 women
Pregnancy-associated breast cancer (PABC) is a rare disease. However, its expected incidence tends to be increased because of delayed maternal age. The purpose of this study was to describe the clinical, radiological, and histopathological characteristics of PABC cases diagnosed in our center.
Source: Clinical Imaging - August 5, 2019 Category: Radiology Authors: Fusun Taskin, Yasemin Polat, İbrahim H. Erdoğdu, Aykut Soyder Tags: Breast Imaging Source Type: research

A systematic review of the international prevalence of BRCA mutation in breast cancer.
Abstract A systematic review was conducted, summarizing international BRCA 1 or 2 (BRCA1/2) mutation prevalence in breast cancer. Databases (eg, Medline and Embase; N=7) and conferences were searched (January 2012 to December 2017). From 17,872 records, 70 studies were included. In 58 large (N>100) studies, BRCA1/2 mutation prevalence varied widely from 1.8% (Spain) in sporadic breast cancer to 36.9% (United States) in estrogen receptor/progesterone receptor low+ (1-9% on immunohistochemistry/human epidermal growth factor receptor 2-negative [HER2-]) breast cancer. In 2 large studies unselected for family histo...
Source: Clinical Breast Cancer - August 4, 2019 Category: Cancer & Oncology Authors: Armstrong N, Ryder S, Forbes C, Ross J, Quek RG Tags: Clin Epidemiol Source Type: research

Learning Health System for Breast Cancer: Pilot Project Experience.
CONCLUSION: It is possible to extract, read, and combine data from the EHR to view the patient journey. The agreement between NLP and the gold standard was high, which supports validity. PMID: 31369338 [PubMed - in process]
Source: Clinical Breast Cancer - August 1, 2019 Category: Cancer & Oncology Authors: Levine MN, Alexander G, Sathiyapalan A, Agrawal A, Pond G Tags: JCO Clin Cancer Inform Source Type: research

Adipose Tissue Distribution and Cardiovascular Disease Risk Among Breast Cancer Survivors.
CONCLUSION: Visceral and intramuscular adiposity were associated with increased CVD incidence after breast cancer diagnosis, independent of pre-existing CVD risk factors and cancer treatments. The increased CVD incidence among normal-weight patients with greater visceral adiposity would go undetected with BMI alone. Measures of adipose tissue distribution may help identify high-risk patients and tailor CVD prevention strategies. PMID: 31369302 [PubMed - as supplied by publisher]
Source: Clinical Breast Cancer - August 1, 2019 Category: Cancer & Oncology Authors: Cespedes Feliciano EM, Chen WY, Bradshaw PT, Prado CM, Alexeeff S, Albers KB, Castillo AL, Caan BJ Tags: J Clin Oncol Source Type: research

Axillary nodal involvement by primary tumor features in early breast cancer: an analysis of 2600 patients.
CONCLUSIONS: These results raise the question whether axillary node status is redundant in cases with exceptionally good features, i.e., small tumors with low Ki67, or in those candidate to adjuvant systemic treatment/radiotherapy anyway including TNBC, and support the incorporation of primary BC tumor characteristics as stratification factors in ongoing trials aiming at de-escalating axillary surgical procedures. PMID: 31372896 [PubMed - as supplied by publisher]
Source: Clinical Breast Cancer - August 1, 2019 Category: Cancer & Oncology Authors: De Santis MC, La Rocca E, Meneghini E, Bregni G, Di Lorenzo G, Galli G, Di Nicola M, Folli S, Gennaro M, Pruneri G, Paolini B, Daidone MG, De Braud F, Apolone G, Sant M, Di Cosimo S Tags: Clin Transl Oncol Source Type: research

AHR and GPER mediate the stimulatory effects induced by 3-methylcholanthrene in breast cancer cells and cancer-associated fibroblasts (CAFs).
CONCLUSIONS: In the present study we have provided novel insights regarding the molecular mechanisms by which 3MC may trigger a physical and functional interaction between AHR and GPER, leading to the stimulation of both SkBr3 breast cancer cells and CAFs. Altogether, our results indicate that 3MC may engage both GPER and AHR transduction pathways toward breast cancer progression. PMID: 31370872 [PubMed - in process]
Source: Clinical Breast Cancer - August 1, 2019 Category: Cancer & Oncology Authors: Cirillo F, Lappano R, Bruno L, Rizzuti B, Grande F, Guzzi R, Briguori S, Miglietta AM, Nakajima M, Di Martino MT, Maggiolini M Tags: J Exp Clin Cancer Res Source Type: research

Phase II study of irinotecan and temozolomide in breast cancer patients with progressing central nervous system disease
ConclusionsThe combination of irinotecan and temozolomide was well tolerated, demonstrated some clinical activity across multiple breast cancer subtypes with progressing CNS disease, and offers a reasonable option for patients who are not candidates for further radiation or clinical trials.
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research

A review of the influence of mammographic density on breast cancer clinical and pathological phenotype
AbstractPurposeIt is well established that high mammographic density (MD), when adjusted for age and body mass index, is one of the strongest known risk factors for breast cancer (BC), and also associates with higher incidence of interval cancers in screening due to the masking of early mammographic abnormalities. Increasing research is being undertaken to determine the underlying histological and biochemical determinants of MD and their consequences for BC pathogenesis, anticipating that improved mechanistic insights may lead to novel preventative or treatment interventions. At the same time, technological advances in dig...
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research

Locoregional risk assessment after neoadjuvant chemotherapy in patients with primary breast cancer: clinical utility of the CPS  + EG score
ConclusionThe CPS  + EG score, originally designed to predict distant relapse, is also valuable for assessing local recurrence risks. Our data demonstrate that distant and locoregional recurrence risks are closely related. As prognosis of patients with high risk of locoregional failure based on CPS + EG is do minated by distant recurrences, escalating local therapies may have limited impact on overall prognosis.
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research

Iniparib administered weekly or twice-weekly in combination with gemcitabine/carboplatin in patients with metastatic triple-negative breast cancer: a phase II randomized open-label study with pharmacokinetics
ConclusionsDespite a doubled maximum concentration with weekly iniparib, no detectable differences in safety or efficacy were observed between the weekly and twice-weekly administration schedules in this population.Trial registrationClinicalTrial.gov Identifier NCT01045304.
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research

Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer
ConclusionDual targeting of AURKA and PAK1 may be a promising therapeutic strategy for treatment of breast cancer, with a particular effectiveness in luminal and HER2-enriched tumor subtypes.
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research

Is core needle biopsy effective at diagnosing male breast lesions?
ConclusionSonographically guided 14-gauge CNB is an accurate, reliable and low invasive procedure for assessing breast lesions in men. Triple tests and follow-up checks of benign cases are essential for a successful breast biopsy program in men.
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research

Breast leptomeningeal disease: a review of current practices and updates on management
ConclusionsWe recognize the shortcomings in our current understanding of the disease and explore the future role of genomic/molecular disease characterization, technological innovations, and ongoing clinical trials attempting to improve the prognosis for this advanced disease state.
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research

Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype
ConclusionsThe sensitivity of BT-549 and Hs578T cells to englerin A and digoxin suggests a subset of TNBCs are highly susceptible to cation disruption and encourages investigation of TRPC1 and TRPC4 as potential new biomarkers of sensitivity to cardiac glycosides.
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research

Role of docosahexaenoic acid in enhancement of docetaxel action in patient-derived breast cancer xenografts
ConclusionsThis work is the first to confirm that DHA supplementation during chemotherapy treatment improves TXT action in two PDX models of TNBC. The results suggest that decreases in tumor size occurred via changes in apoptosis, cell proliferation, and cell cycle pathways.
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research

HER2+ breast cancer treatment and cardiotoxicity: monitoring and management
ConclusionsThe future of cardiotoxicity management in patients with HER2+  breast cancer is discussed, with a focus on novel techniques to improve cardiac outcomes, including new imaging modalities, biomarkers, interventional therapies, and ongoing trials.
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research

Adherence to anti-estrogen therapy in women with hormone receptor-positive breast cancer utilizing bubble packaging: a pilot study
ConclusionAdherence rate to bubble packaging was higher than that in historical studies. Although this is a single-arm pilot study, these data suggest bubble packaging of anti-estrogen may be a reasonable option to improve adherence in hormone receptor-positive breast cancer patients.
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research

Treatment and survival of Asian women diagnosed with breast cancer in New Zealand
ConclusionsAsian women are more likely to have high grade, larger and HER2+ breast cancers than European women. In spite of this, they had better breast cancer outcomes. Possible explanations include the differences in adherence to endocrine therapy, age, BMI and comorbidities.
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research

Indolylkojyl methane analogue IKM5 potentially inhibits invasion of breast cancer cells via attenuation of GRP78
ConclusionOur study warrants IKM5, a potential anticancer agent that can abrogate invasion and metastasis, suggesting its clinical development for the treatment of patients with advanced breast cancer.
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research

Schlafen-11 expression is associated with immune signatures and basal-like phenotype in breast cancer
ConclusionsOur findings are suggestive of a relevant role for SLFN11 in BC and its immune and molecular variability.
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research

Somatic loss of PIK3R1 may sensitize breast cancer to inhibitors of the MAPK pathway
ConclusionsOur findings suggest that breast cancers with loss of p85 α may not respond to mTOR inhibition, but may be sensitive to MEK inhibition.
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research

Associations between mammographic density and tumor characteristics in Chinese women with breast cancer
ConclusionsAmong Chinese women with normal BMI, higher breast density was associated with HER2-enriched tumors. The results may partially explain the higher proportion of HER2+  tumors previously reported in Asian women.
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research

Preliminary results of computer-aided diagnosis for magnetic resonance imaging of solid breast lesions
ConclusionCAD is feasible to differentiate breast lesions, and it can complement MRI, thereby making it easier to diagnose breast lesions and obviating the need for unnecessary biopsies.
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research

Effects of high-intensity interval training on vascular endothelial function and vascular wall thickness in breast cancer patients receiving anthracycline-based chemotherapy: a randomized pilot study
ConclusionThis study may suggest that HIIT improved vascular endothelial function and maintained wall thickness in breast cancer patients undergoing anthracycline-based chemotherapy.Trial registration: ClinicalTrials.gov: NCT02454777.
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research