Recent advances in targeted therapy of colorectal cancer: impacts of monoclonal antibodies nanoconjugates.
Authors: Akbarzadeh Khiavi M, Safary A, Somi MH Abstract Despite rapid advances in diagnostic and treatment approaches, the overall survival rate of cancer has not been improved. Colorectal cancer (CRC) is recognized as the third leading cause of neoplasm-related deaths worldwide, in large part due to its considerable metastasis and drug resistance. For developing new anticancer strategies, rapid progression of multimodal nanomedicines and nanoconjugates has provided promising treatment modalities for effective therapy of cancer. The limitations of cancer chemotherapy might be overcome through the use of such nanos...
Source: BioImpacts - September 13, 2019 Category: Research Tags: Bioimpacts Source Type: research

Academic bullies leave no trace.
Authors: Mahmoudi M Abstract Bullying in academic science is a growing concern. It may vary in severity from insults, snubs, or invasions of privacy to violations of intellectual property and unfair crediting of authors. In extreme cases it may even include coercing lab workers to sign away rights to authorship or even intellectual property. Cumbersome institutional protocols and fears of reprisal may discourage targets of bullying from reporting such incidents; lab workers in the US on visas may feel especially vulnerable. Possible strategies to combat bullying include detailed examination of relevant documentatio...
Source: BioImpacts - September 13, 2019 Category: Research Tags: Bioimpacts Source Type: research

A multi-method and structure-based in silico vaccine designing against Echinococcus granulosus through investigating enolase protein.
Conclusion: Based on the results, this step-by-step immunoinformatics approach could be considered as a rational platform for designing vaccines against such multi-stage parasites. Furthermore, it is proposed that this multi-epitope vaccine is served as a promising preventive anti-echinococcosis agent. PMID: 31508329 [PubMed] (Source: BioImpacts)
Source: BioImpacts - September 13, 2019 Category: Research Tags: Bioimpacts Source Type: research

Functional expression and impact of testis-specific gene antigen 10 in breast cancer: a combined in vitro and in silico analysis.
Conclusions: Collectively, TSGA10 functional expression alters under the hyper-/hypo-glycemia and hypoxia, which indicates its importance as a candidate bio-target for the cancer therapy. PMID: 31508330 [PubMed] (Source: BioImpacts)
Source: BioImpacts - September 13, 2019 Category: Research Tags: Bioimpacts Source Type: research

A short-term plastic adherence incubation of the stromal vascular fraction leads to a predictable GMP-compliant cell-product.
Conclusion: Addition of a short purification-step after the SVF isolation is a cheap and fast strategy to isolate a homogeneous uncultivated GMP-compliant cell fraction of ASCs. PMID: 31508331 [PubMed] (Source: BioImpacts)
Source: BioImpacts - September 13, 2019 Category: Research Tags: Bioimpacts Source Type: research

The effects of natural nano-sized clinoptilolite and Nigella sativa supplementation on serum bone markers in diabetic rats.
This study was conducted to examine the effects of separate and concurrent supplementation of natural nano-sized clinoptilolite (NCLN) and NS on serum bone markers in rats with type 2 diabetes. Methods: A total of 42 (case=36 and control=6) adult male Wistar rats were divided into 2 groups: diabetic and non-diabetic. An oral glucose tolerance test and a homeostatic model assessment of insulin resistance (HOMA-IR) test were conducted to confirm diabetes. Then, the diabetic group was divided into 4 subgroups: [1] control (n=9), [2] NS 1%/food (n=9), [3] NCLN 2%/food (n=9), [4] NS 1%/food + NCLN 2%/food (n=9). After 7 weeks, ...
Source: BioImpacts - September 13, 2019 Category: Research Tags: Bioimpacts Source Type: research

Electrosprayed polymeric nanobeads and nanofibers of modafinil: preparation, characterization, and drug release studies.
Conclusion: The results suggest that by optimization of variables such as solution concentration of MDF-ERS nanofibers and nanobeads with higher dissolution rates can be made by electrospray. Electrospray deposition as a simple, continuous, and surfactant free method is an excellent choice for preparation of drug loaded polymeric nanoparticles. PMID: 31508333 [PubMed] (Source: BioImpacts)
Source: BioImpacts - September 13, 2019 Category: Research Tags: Bioimpacts Source Type: research

Manifestation of hemispheric laterality in chewing side preference and handedness.
Conclusion: Thereupon masticatory preference is found with probable origins in the dominant hemisphere of the brain. PMID: 31508334 [PubMed] (Source: BioImpacts)
Source: BioImpacts - September 13, 2019 Category: Research Tags: Bioimpacts Source Type: research

Aptamedicine: a new treatment modality in personalized cancer therapy.
Authors: Vandghanooni S, Eskandani M, Barar J, Omidi Y Abstract Aptamers ( Aps ) are short single-strand nucleic acids exhibiting unique 3D structure which facilitate their targeting potential against various cancer molecular markers ( CMMs ). Such features of Aps not only make them as suitable homing agents in targeted drug delivery systems (DDSs) but also candidate them as macromolecules that inhibit the interaction of the target ligand with other proteins. On the other hand, the conjugation of Aps with another therapeutic molecule such as antisense oligonucleotides (ASOs), siRNAs/miRNAs, Aps , toxins, chemothera...
Source: BioImpacts - July 25, 2019 Category: Research Tags: Bioimpacts Source Type: research

SPR signals enhancement by gold nanorods for cell surface marker detection.
Authors: Fathi F, Jalili R, Amjadi M, Rashidi MR Abstract Introduction: The detection of micrometer-sized particles like cells is limited by surface plasmon resonance (SPR) biosensors because of having a depth of evanescent wave
Source: BioImpacts - July 25, 2019 Category: Research Tags: Bioimpacts Source Type: research

Therapeutic potency of substituted chromones as Alzheimer's drug: Elucidation of acetylcholinesterase inhibitory activity through spectroscopic and molecular modelling investigation.
Conclusion: This comparative study affirms the importance of meticulous substitution in the chromone scaffold to promote maximum inhibition potency, while considering their usage as AD drugs. PMID: 31334039 [PubMed] (Source: BioImpacts)
Source: BioImpacts - July 25, 2019 Category: Research Tags: Bioimpacts Source Type: research

Chondroitin sulfate degradation and eicosanoid metabolism pathways are impaired in focal segmental glomerulosclerosis: Experimental confirmation of an in silico prediction.
Conclusion: Our data supported the implication of these target genes and pathways in the pathogenesis of FSGS. In addition, these genes can be considered as non-invasive biomarkers for FSGS. PMID: 31334040 [PubMed] (Source: BioImpacts)
Source: BioImpacts - July 25, 2019 Category: Research Tags: Bioimpacts Source Type: research

Numerical investigation of hemodynamic performance of a stent in the main branch of a coronary artery bifurcation.
Conclusion: The use of a one-part stent in the main branch of a coronary artery bifurcation for the aforementioned type of stenosis is recommended. PMID: 31334041 [PubMed] (Source: BioImpacts)
Source: BioImpacts - July 25, 2019 Category: Research Tags: Bioimpacts Source Type: research

Determination of valproic acid and 3-heptanone in plasma using air-assisted liquid-liquid microextraction with the assistance of vortex: Application in the real samples.
Conclusion: The obtained results indicated that this procedure is easy, sensitive, and reliable, and can be used for the analysis of the selected analytes in the plasma samples of patients with epilepsy. PMID: 31334042 [PubMed] (Source: BioImpacts)
Source: BioImpacts - July 25, 2019 Category: Research Tags: Bioimpacts Source Type: research

Spectroscopic overview of quercetin and its Cu(II) complex interaction with serum albumins.
Conclusion: To enhance the pharmaceutical outcomes of Qu molecules, one may use Qu-Cu(II) complex for the development and delivery of the small molecules. PMID: 31334043 [PubMed] (Source: BioImpacts)
Source: BioImpacts - July 25, 2019 Category: Research Tags: Bioimpacts Source Type: research

Indoleamine 2, 3-dioxygenase inhibitors in immunochemotherapy of breast cancer: challenges and opportunities.
Authors: Hashemzadeh N, Adibkia K, Barar J Abstract Trafficking of macromolecular immunotherapy agent into the tumor microenvironment (TME) is a challenging issue. In the TME, cancer cells exploit indoleamine 2, 3-dioxygenase (IDO), as a cytosolic enzyme that catalyzes the L-tryptophan (Trp) through the kynurenine (Kyn) pathway, which could negatively regulate the activity of T cells. Thus, Trp/Kyn pathway, can be targeted with novel treatment modalities such as IDO1 inhibitor to benefit patients with aggressive solid tumors. PMID: 30788254 [PubMed] (Source: BioImpacts)
Source: BioImpacts - February 23, 2019 Category: Research Tags: Bioimpacts Source Type: research

Carboxymethylcellulose/MOF-5/Graphene oxide bio-nanocomposite as antibacterial drug nanocarrier agent.
Conclusion: Carboxymethylcellulose/MOF-5/GO bio-nanocomposite (CMC/MOF-5/GO) was successfully synthesized through the solvothermal technique. Tetracycline (TC) was encapsulated in the GO and CMC/MOF-5/GO. The drug release tests showed that the TC-loaded CMC/MOF5/GO has an effective protection against stomach pH. With controlling the TC release in the gastrointestinal tract conditions, the long-time stability of drug dosing was enhanced. Furthermore, antibacterial activity tests showed that the TC-loaded CMC/MOF-5/GO has an antibacterial activity to negatively charge E. coli bacteria in contrast to TC-loaded GO. PMID: 3...
Source: BioImpacts - February 23, 2019 Category: Research Tags: Bioimpacts Source Type: research

Highly efficient novel recombinant L-asparaginase with no glutaminase activity from a new halo-thermotolerant Bacillus strain.
Conclusion: The biochemical properties of the novel ASPase A1 derived from Bacillus sp. SL-l indicated a great potential for the identified enzyme in pharmaceutical and industrial applications. PMID: 30788256 [PubMed] (Source: BioImpacts)
Source: BioImpacts - February 23, 2019 Category: Research Tags: Bioimpacts Source Type: research

In vitro and in vivo evaluation of a dextran-graft-polybutylmethacrylate copolymer coated on CoCr metallic stent.
Conclusion: Based on our findings, Dex-PBMA exhibited vascular compatibility and can potentially be used as a coating for metallic coronary stents. PMID: 30788257 [PubMed] (Source: BioImpacts)
Source: BioImpacts - February 23, 2019 Category: Research Tags: Bioimpacts Source Type: research

Preparation and characterization of biocomposite films of carrageenan/locust bean gum/montmorrillonite for transdermal delivery of curcumin.
Conclusion: In vitro release profiles showed that increasing concentration of LBG and MMT sustained the release of the drug from the polymer composite transdermal films. Decreased percent cumulative release as the concentration of LBG and MMT increases in polymer composite transdermal film. PMID: 30788258 [PubMed] (Source: BioImpacts)
Source: BioImpacts - February 23, 2019 Category: Research Tags: Bioimpacts Source Type: research

In silico design of a triple-negative breast cancer vaccine by targeting cancer testis antigens.
Conclusion: Based on our in-silico analyses, the proposed vaccine may be considered for the immunotherapy of TNBC. PMID: 30788259 [PubMed] (Source: BioImpacts)
Source: BioImpacts - February 23, 2019 Category: Research Tags: Bioimpacts Source Type: research

In vitro study of the anticancer activity of various doxorubicin-containing dispersions.
Conclusion: The importance of Dextran-PNIPAM copolymer as a universal platform for drug delivery was established, and the huge potential of Dextran-PNIPAM+Dox NPs as novel anticancer agents was noted. Based on the in vitro study of the SWCNT+Dox and GO+Dox nanofluids, it was concluded that SWCNT and GO NPs can be effective cytoprotectors against the highly toxic drugs. PMID: 30788260 [PubMed] (Source: BioImpacts)
Source: BioImpacts - February 23, 2019 Category: Research Tags: Bioimpacts Source Type: research

Correction: A cancer vaccine with dendritic cells differentiated with GM-CSF and IFN α and pulsed with a squaric acid treated cell lysate improves T cell priming and tumor growth control in a mouse model.
Correction: A cancer vaccine with dendritic cells differentiated with GM-CSF and IFNα and pulsed with a squaric acid treated cell lysate improves T cell priming and tumor growth control in a mouse model. Bioimpacts. 2019;9(1):65 Authors: Mookerjee A, Graciotti M, Kandalaft LE Abstract [This corrects the article DOI: 10.15171/bi.2018.24.]. PMID: 30788261 [PubMed - in process] (Source: BioImpacts)
Source: BioImpacts - February 23, 2019 Category: Research Tags: Bioimpacts Source Type: research

Microfluidic paper-based analytical devices ( µPADs) for fast and ultrasensitive sensing of biomarkers and monitoring of diseases.
Microfluidic paper-based analytical devices (µPADs) for fast and ultrasensitive sensing of biomarkers and monitoring of diseases. Bioimpacts. 2018;8(4):237-240 Authors: Abdollahi-Aghdam A, Majidi MR, Omidi Y Abstract Through the development of analytical techniques, microscaled devices have displayed attractive advantages, including ultrasensitive detection and analysis, cost-effectiveness, portability, process integrity, multi-process functionality, and in-situ analysis. In the last decade, a new generation of analytical devices has emerged based on the cellulose materials - so-called microfluid...
Source: BioImpacts - November 8, 2018 Category: Research Tags: Bioimpacts Source Type: research

Effect of PEGylation on assembly morphology and cellular uptake of poly ethyleneimine-cholesterol conjugates for delivery of sorafenib tosylate in hepatocellular carcinoma.
Conclusion: The combinatory effects of enhanced cellular uptake and reduced general cytotoxicity can present PEGylated PEI-cholesterol conjugates as a potential carrier for delivery of poorly soluble chemotherapeutic agents such as SFB in HCC that certainly requires further investigations in vitro and in vivo. PMID: 30397579 [PubMed] (Source: BioImpacts)
Source: BioImpacts - November 8, 2018 Category: Research Tags: Bioimpacts Source Type: research

Characterization and partial purification of an antibacterial agent from halophilic actinomycetes Kocuria sp. strain rsk4.
Conclusion : The result suggests that a broad-spectrum antibacterial compound obtained from halophilic actinomycetes is effective against pathogenic bacteria. This compound may be a good alternative treatment against antibiotic-resistant pathogen S. aureus. PMID: 30397580 [PubMed] (Source: BioImpacts)
Source: BioImpacts - November 8, 2018 Category: Research Tags: Bioimpacts Source Type: research

Nafion-coated cadmium pentacyanonitrosylferrate-modified glassy carbon electrode for detection of dopamine in biological samples.
Conclusion : In comparison with the bare electrode, the Nafion|CdPCNF|GC electrode could determine DA in the biological samples with adequate sensitivity and selectivity. Therefore, we propose that the modified electrode is utilizable as an amperometric DA sensor for the biological sample analysis. PMID: 30397581 [PubMed] (Source: BioImpacts)
Source: BioImpacts - November 8, 2018 Category: Research Tags: Bioimpacts Source Type: research

Numerical study on the impulsive growth of a gaseous plug inside a cylindrical vein with compliant coating.
Conclusion : This numerical research showed that the compliant coating on the internal wall of the rigid cylindrical vein had the tendency of reducing the impact of the impulsive growth of the gaseous plug. Therefore, in the case of having severed arteriosclerosis, treatment of the cancerous or damaged tissues by use of the gaseous embolism must be done very carefully in order to prevent the hazardous effects of the gaseous plug's impulsive growth. PMID: 30397582 [PubMed] (Source: BioImpacts)
Source: BioImpacts - November 8, 2018 Category: Research Tags: Bioimpacts Source Type: research

Comparative in vitro/theoretical studies on the anti-angiogenic activity of date pollen hydro-alcoholic extract: Highlighting the important roles of its hot polyphenols.
Conclusion: The DPP is the new source of non-toxic anti-cancer agents to use as a dietary supplement in the pre-treatment of cancer. PMID: 30397583 [PubMed] (Source: BioImpacts)
Source: BioImpacts - November 8, 2018 Category: Research Tags: Bioimpacts Source Type: research

An fMRI investigation of the neural correlates underlying the autonomous sensory meridian response (ASMR).
Conclusion : This is the first study to measure the activation of various brain regions during ASMR and these results may help to reveal the mechanistic underpinnings of this sensation. PMID: 30397584 [PubMed] (Source: BioImpacts)
Source: BioImpacts - November 8, 2018 Category: Research Tags: Bioimpacts Source Type: research

Recent advances in improving oral drug bioavailability by cocrystals.
Conclusions : Cocrystals have found their way from the proof-of-principle stage to the clinic. Up to now, at least two cocrystal products have gained approval from regulatory bodies. However, there are remaining challenges on safety, predicting in vivo behavior and revealing real potential of cocrystals in the human. PMID: 30397585 [PubMed] (Source: BioImpacts)
Source: BioImpacts - November 8, 2018 Category: Research Tags: Bioimpacts Source Type: research

Retraction Note: Inhibition of hTERT Gene Expression by SilibininLoaded PLGA-PEG-Fe ₃O₄ in T47D Breast Cancer Cell Line.
Retraction Note: Inhibition of hTERT Gene Expression by SilibininLoaded PLGA-PEG-Fe₃O₄ in T47D Breast Cancer Cell Line. Bioimpacts. 2018;8(4):321 Authors: Ebrahimnezhad Z, Zarghami N, Keyhani M, Amirsaadat S, Akbarzadeh A, Rahmati M, Mohammad Taheri Z, Nejati-Koshki K Abstract [This retracts the article DOI: 10.5681/bi.2013.005.]. PMID: 30397586 [PubMed - in process] (Source: BioImpacts)
Source: BioImpacts - November 8, 2018 Category: Research Tags: Bioimpacts Source Type: research

Enzyme replacement therapies: what is the best option?
Authors: Safary A, Akbarzadeh Khiavi M, Mousavi R, Barar J, Rafi MA Abstract Despite many beneficial outcomes of the conventional enzyme replacement therapy (ERT), several limitations such as the high-cost of the treatment and various inadvertent side effects including the occurrence of an immunological response against the infused enzyme and development of resistance to enzymes persist. These issues may limit the desired therapeutic outcomes of a majority of the lysosomal storage diseases (LSDs). Furthermore, the biodistribution of the recombinant enzymes into the target cells within the central nervous system (CN...
Source: BioImpacts - September 15, 2018 Category: Research Tags: Bioimpacts Source Type: research

Risk association, linkage disequilibrium and haplotype analyses of FASN rs4246445, rs2229425, rs2228305 and rs2229422 polymorphisms in overweight and obesity.
Conclusion: Our findings suggest a lack of evidence to associate the FASN rs4246445, rs2229425, rs2228305, and rs2229422 SNPs with the risk of overweight and obesity in the Malaysian population. All 4 SNPs were independent of each other and not all identified haplotypes were significantly associated with overweight and obesity in this study. PMID: 30211075 [PubMed] (Source: BioImpacts)
Source: BioImpacts - September 15, 2018 Category: Research Tags: Bioimpacts Source Type: research

Expression, purification and DNA-binding properties of zinc finger domains of DOF proteins from Arabidopsis thaliana.
Conclusion: Studied DOF-ZF domains formed stable complexes with the double-motif probe. Although DOF3.4-ZF and DOF5.8-ZF do not dimerize with an appreciable affinity in the absence of DNA (judging from size-exclusion and multiangle laser light scattering data), it is possible that these ZFs form protein-protein contacts when bound to this oligonucleotide, consistent with previous reports that DOF proteins can homo- and hetero-dimerize. PMID: 30211076 [PubMed] (Source: BioImpacts)
Source: BioImpacts - September 15, 2018 Category: Research Tags: Bioimpacts Source Type: research

Altered levels of immune-regulatory microRNAs in plasma samples of patients with lupus nephritis.
In this study, 26 patients with LN and 26 healthy individuals were included. The plasma levels of the microRNAs were evaluated by a quantitative real-time PCR. Moreover, the correlation of circulating plasma microRNAs with disease activity and pathological findings along with their ability to distinguish patients with LN were assessed. Results: Plasma levels of miR-125a (P = 0.048), miR-146a (P = 0.005), and miR-155 (P
Source: BioImpacts - September 15, 2018 Category: Research Tags: Bioimpacts Source Type: research

Gallic acid and curcumin induce cytotoxicity and apoptosis in human breast cancer cell MDA-MB-231.
Conclusion: These results suggest that GA in combination with Cur could be a possible candidate for chemoprevention agent of triple negative breast cancer. PMID: 30211078 [PubMed] (Source: BioImpacts)
Source: BioImpacts - September 15, 2018 Category: Research Tags: Bioimpacts Source Type: research

Numerical investigation of the blood flow through the middle cerebral artery.
Conclusion: It can be concluded that the application of the Newtonian model for the blood flowing in the MCA is acceptable. Also, atherosclerosis has the potential to occur at the middle of a branch of the MCA which has the highest geometrical curvature. PMID: 30211079 [PubMed] (Source: BioImpacts)
Source: BioImpacts - September 15, 2018 Category: Research Tags: Bioimpacts Source Type: research

In silico identification of albendazole as a quorum sensing inhibitor and its in vitro verification using CviR and LasB receptors based assay systems.
Conclusion: It is that structure-based molecular docking guided bioassay evaluation is an efficient tool for finding the new therapeutic use of old drugs which could have more chances to come easily in clinical application for their newly identified therapeutic uses. PMID: 30211080 [PubMed] (Source: BioImpacts)
Source: BioImpacts - September 15, 2018 Category: Research Tags: Bioimpacts Source Type: research

A cancer vaccine with dendritic cells differentiated with GM-CSF and IFN α and pulsed with a squaric acid treated cell lysate improves T cell priming and tumor growth control in a mouse model.
Conclusion: We identified squaric acid as a novel immunogenic treatment of tumor cells for cancer vaccines particularly efficient in prolonging animal survival when used in combination with IFNα-differentiated DCs. These promising results support future efforts for the clinical translation of this approach. PMID: 30211081 [PubMed] (Source: BioImpacts)
Source: BioImpacts - September 15, 2018 Category: Research Tags: Bioimpacts Source Type: research

Breast cancer vaccination comes to age: impacts of bioinformatics.
Conclusion: Despite the invention of a number of vaccines for the cancer immunotherapy, more computational and clinical trials are required to design much more efficient vaccines against various malignancies, including breast cancer. PMID: 30211082 [PubMed] (Source: BioImpacts)
Source: BioImpacts - September 15, 2018 Category: Research Tags: Bioimpacts Source Type: research

Made-on-demand, complex and personalized 3D-printed drug products.
Authors: Osouli-Bostanabad K, Adibkia K Abstract Layer-by-layer fabrication of three dimensional (3D) objects from digital models is called 3D printing. This technology established just about three decades ago at the confluence of materials science, chemistry, robotics, and optics researches to ease the fabrication of UV-cured resin prototypes. The 3D technology was rapidly considered as a standard instrument in the aerospace, automotive, and consumer goods production factories. Nowadays, research interests in the 3D printed products have been raised and achieved ever-increasing traction in the pharmaceutical indus...
Source: BioImpacts - July 7, 2018 Category: Research Tags: Bioimpacts Source Type: research

Biosynthesis of TiO2 and ZnO nanoparticles by Halomonas elongata IBRC-M 10214 in different conditions of medium.
Conclusion: The ZnO NPs have the antibacterial effect that can be operative in the medicinal aspect for fighting against prominent MDR bacteria such as E. coli ATCC 25922 and S. aureus ATCC 43300. In total, this study presents a simple method in the biosynthesis of TiO2 and ZnO NPs with low the expense, eco-friendly, and high productivity properties. PMID: 29977829 [PubMed] (Source: BioImpacts)
Source: BioImpacts - July 7, 2018 Category: Research Tags: Bioimpacts Source Type: research

Design, fabrication, and implantation of tube-shaped devices for the treatment of salivary duct diseases.
Conclusion: These devices were adapted to sialendoscopic guidewires and able to be implanted in the salivary ducts of pigs. If a longer lasting tube is required, the crystallinity of the starch material should be improved. PMID: 29977830 [PubMed] (Source: BioImpacts)
Source: BioImpacts - July 7, 2018 Category: Research Tags: Bioimpacts Source Type: research

Drug nanocarrier agents based on starch-g-amino acids.
Conclusion: New amino acid derivatives of starch and their nanocarriers successfully prepared through a simple and convenient method. The size of nanocarriers evaluated using DLS and TEM experiments. The spherical shape of particles shows that nanocarriers have been formed and the size of these particles are approximately 92, 137 and 97 nm. Performing the wettability test determined that all the resulted materials are soluble in water. Nanocarriers of the obtained modified starches were prepared using dialysis method and naproxen was utilized as a model drug molecule. The drug release dynamics in buffered solution were stu...
Source: BioImpacts - July 7, 2018 Category: Research Tags: Bioimpacts Source Type: research

The assessment of metabolite alteration induced by -OH functionalized multi-walled carbon nanotubes in mice using NMR-based metabonomics.
Conclusion: These pathways can reflect perturbation of energy, amino acids, and fat metabolism, as well as oxidative stress. The data obtained by biochemistry, metabonomics, and histopathology were in good agreement, proving that MWCNTs-OH was excreted within 24 h, through the biliary pathway. PMID: 29977832 [PubMed] (Source: BioImpacts)
Source: BioImpacts - July 7, 2018 Category: Research Tags: Bioimpacts Source Type: research

Mucin-1 aptamer-armed superparamagnetic iron oxide nanoparticles for targeted delivery of doxorubicin to breast cancer cells.
Conclusion: Based on our findings, the anti-MUC-1 Ap-armed PEGylated SPIONs loaded with DOX molecules could serve as an effective multifunctional theranostics for simultaneous detection and eradication of MUC-1-positive breast cancer cells. PMID: 29977833 [PubMed] (Source: BioImpacts)
Source: BioImpacts - July 7, 2018 Category: Research Tags: Bioimpacts Source Type: research

Reprogramming of mouse fibroblasts into neural lineage cells using biomaterials.
Conclusion: Changes in the expression of Klf4, NFIa, NFIb, Ptbp1 and SOX9 indicated that fibroblasts were differentiated into an astrocytic lineage. It is possible that the well-designed biomaterials could work as powerful tools in the reprogramming process of fibroblasts into iNSCs. PMID: 29977834 [PubMed] (Source: BioImpacts)
Source: BioImpacts - July 7, 2018 Category: Research Tags: Bioimpacts Source Type: research

An update of the recombinant protein expression systems of Cyanovirin-N and challenges of preclinical development.
Conclusion: To produce pharmaceutically effective CVN, we first need to identify the best expression system, with Escherichia coli, Pichia pastoris , Lactic acid bacteria and transgenic plants being possible candidates. For this reason, heterologous production of this valuable protein is a serious challenge. Since different obstacles influence clinical trials on microbicides in the field of HIV prevention, these items should be considered for evaluating the CVN activity in pre-clinical and clinical studies. PMID: 29977835 [PubMed] (Source: BioImpacts)
Source: BioImpacts - July 7, 2018 Category: Research Tags: Bioimpacts Source Type: research

Bacterial NanoCellulose: what future?
Authors: Portela da Gama FM, Dourado F Abstract Acetic acid bacteria (AAB) have been used in various fermentation processes. Of several ABB, the bacterial nanocellulose (BNC) producers, notably Komagataeibacter xylinus, appears as an interesting species, in large part because of their ability in the secretion of cellulose as nano/microfibrils. In fact, BNC is characterized by a native nanofibrillar structure, which may outperform the currently used celluloses in the food industry as a promising novel hydrocolloid additive. During the last couple of years, a number of companies worldwide have introduced some BNC-bas...
Source: BioImpacts - May 3, 2018 Category: Research Tags: Bioimpacts Source Type: research