Essential role of CD38 in platelet aggregation through the PKC-mediated internalization and activation
CONCLUSION: PKC is involved in many signaling pathways. Specifically, PKC is involved in the internalization of CD38 via MHCIIA in CD38+/+ wild-type (WT) and CD38-/- knockout mice (KO). CD38 generates calcium-mobilizing agents that act on specific receptors of the calcium stores. Calcium triggered platelet aggregation while serving as a secondary messenger.PMID:38505670 | PMC:PMC10945299 | DOI:10.34172/bi.2023.27780 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Mazhar Mushtaq Maira Mahmood Uzma Jabbar Uh-Hyun Kim Source Type: research
Comparative molecular docking and toxicity between carbon-capped metal oxide nanoparticles and standard drugs in cancer and bacterial infections
CONCLUSION: The toxicity of MONPs is one of the major challenges in the development of drugs based on them. According to the results of these molecular docking studies, MgO and Fe2O3 NPs had the highest efficiency among the investigated MONPs.PMID:38505671 | PMC:PMC10945298 | DOI:10.34172/bi.2023.27778 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Navid Mohammadjani Sahand Karimi Musa Moetasam Zorab Morahem Ashengroph Mehran Alavi Source Type: research
Simultaneous suppression of miR-21 and restoration of miR-145 in gastric cancer cells; a promising strategy for inhibition of cell proliferation and migration
CONCLUSION: Our research revealed that utilizing miR-145-5p and anti-miR-21-5p together could be a promising therapeutic approach for treating GC.PMID:38505672 | PMC:PMC10945301 | DOI:10.34172/bi.2023.27764 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Farzaneh Bilan Mohammad Amini Mohammad Amin Doustvandi Maryam Tohidast Amir Baghbanzadeh Seyed Samad Hosseini Ahad Mokhtarzadeh Behzad Baradaran Source Type: research
A novel imidazo[1,2-a]pyridine derivative and its co-administration with curcumin exert anti-inflammatory effects by modulating the STAT3/NF- κB/iNOS/COX-2 signaling pathway in breast and ovarian cancer cell lines
CONCLUSION: This study indicated that the anti-inflammatory activity of MIA is exerted by suppressing the NF-κB and STAT3 signaling pathways in MDA-MB-231 and SKOV3 cancer cell lines.PMID:38505673 | PMC:PMC10945297 | DOI:10.34172/bi.2023.27618 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Havva Afshari Shokoofe Noori Mitra Nourbakhsh Azam Daraei Mahsa Azami Movahed Afshin Zarghi Source Type: research
Molecular properties prediction, anticancer and anti-inflammatory activities of some pyrimido[1,2-b]pyridazin-2-one derivatives
CONCLUSION: These findings showed that the pyrimidine derivative 1 displayed potent anti-inflammatory and anticancer properties in vitro, and can be selected as a lead compound for further investigation.PMID:38505674 | PMC:PMC10945296 | DOI:10.34172/bi.2023.27688 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Ali Zeiz Ranin Kawtharani Mirvat Elmasri Ghada Khawaja Eva Hamade Aida Habib Abeer J Ayoub Mohamed Abarbri Mohammad H El-Dakdouki Source Type: research
Introduction of a new recombinant vaccine based on GRP78 for breast cancer immunotherapy and evaluation in a mouse model
CONCLUSION: cGRP78 vaccines generated potent immunotherapeutic effects in a breast cancer mouse model. This novel strategy of targeting the GRP78 protein can promote the development of cancer vaccines and immunotherapies for breast cancer malignancies.PMID:38505675 | PMC:PMC10945302 | DOI:10.34172/bi.2023.27829 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Hamed Zare Hamid Bakherad Arman Nasr Esfahani Mohamad Norouzi Hossein Aghamollaei Seyed Latif Mousavi Gargari Fatemeh Mahmoodi Mahdi Aliomrani Walead Ebrahimizadeh Source Type: research
Protective effects of limb remote ischemic per-conditioning on the heart injury induced by renal ischemic-reperfusion through the interaction of the apelin with the RAS/iNOS pathway
CONCLUSION: Our results indicated that RIPerC protects the heart against renal ischemia- reperfusion injury, likely via interaction of the apelin with the RAS/iNOS pathway.PMID:38505676 | PMC:PMC10945303 | DOI:10.34172/bi.2023.27567 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Sahar Janfeshan Fatemeh Masjedi Zeinab Karimi Source Type: research
Benchmarking different docking protocols for predicting the binding poses of ligands complexed with cyclooxygenase enzymes and screening chemical libraries
CONCLUSION: The obtained results support the importance of choosing appropriate docking method for predicting ligand-receptor binding modes, and provide specific information about docking calculations on COXs ligands.PMID:38505677 | PMC:PMC10945300 | DOI:10.34172/bi.2023.29955 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Sara Shamsian Babak Sokouti Siavoush Dastmalchi Source Type: research
Essential role of CD38 in platelet aggregation through the PKC-mediated internalization and activation
CONCLUSION: PKC is involved in many signaling pathways. Specifically, PKC is involved in the internalization of CD38 via MHCIIA in CD38+/+ wild-type (WT) and CD38-/- knockout mice (KO). CD38 generates calcium-mobilizing agents that act on specific receptors of the calcium stores. Calcium triggered platelet aggregation while serving as a secondary messenger.PMID:38505670 | PMC:PMC10945299 | DOI:10.34172/bi.2023.27780 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Mazhar Mushtaq Maira Mahmood Uzma Jabbar Uh-Hyun Kim Source Type: research
Comparative molecular docking and toxicity between carbon-capped metal oxide nanoparticles and standard drugs in cancer and bacterial infections
CONCLUSION: The toxicity of MONPs is one of the major challenges in the development of drugs based on them. According to the results of these molecular docking studies, MgO and Fe2O3 NPs had the highest efficiency among the investigated MONPs.PMID:38505671 | PMC:PMC10945298 | DOI:10.34172/bi.2023.27778 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Navid Mohammadjani Sahand Karimi Musa Moetasam Zorab Morahem Ashengroph Mehran Alavi Source Type: research
Simultaneous suppression of miR-21 and restoration of miR-145 in gastric cancer cells; a promising strategy for inhibition of cell proliferation and migration
CONCLUSION: Our research revealed that utilizing miR-145-5p and anti-miR-21-5p together could be a promising therapeutic approach for treating GC.PMID:38505672 | PMC:PMC10945301 | DOI:10.34172/bi.2023.27764 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Farzaneh Bilan Mohammad Amini Mohammad Amin Doustvandi Maryam Tohidast Amir Baghbanzadeh Seyed Samad Hosseini Ahad Mokhtarzadeh Behzad Baradaran Source Type: research
A novel imidazo[1,2-a]pyridine derivative and its co-administration with curcumin exert anti-inflammatory effects by modulating the STAT3/NF- κB/iNOS/COX-2 signaling pathway in breast and ovarian cancer cell lines
CONCLUSION: This study indicated that the anti-inflammatory activity of MIA is exerted by suppressing the NF-κB and STAT3 signaling pathways in MDA-MB-231 and SKOV3 cancer cell lines.PMID:38505673 | PMC:PMC10945297 | DOI:10.34172/bi.2023.27618 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Havva Afshari Shokoofe Noori Mitra Nourbakhsh Azam Daraei Mahsa Azami Movahed Afshin Zarghi Source Type: research
Molecular properties prediction, anticancer and anti-inflammatory activities of some pyrimido[1,2-b]pyridazin-2-one derivatives
CONCLUSION: These findings showed that the pyrimidine derivative 1 displayed potent anti-inflammatory and anticancer properties in vitro, and can be selected as a lead compound for further investigation.PMID:38505674 | PMC:PMC10945296 | DOI:10.34172/bi.2023.27688 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Ali Zeiz Ranin Kawtharani Mirvat Elmasri Ghada Khawaja Eva Hamade Aida Habib Abeer J Ayoub Mohamed Abarbri Mohammad H El-Dakdouki Source Type: research
Introduction of a new recombinant vaccine based on GRP78 for breast cancer immunotherapy and evaluation in a mouse model
CONCLUSION: cGRP78 vaccines generated potent immunotherapeutic effects in a breast cancer mouse model. This novel strategy of targeting the GRP78 protein can promote the development of cancer vaccines and immunotherapies for breast cancer malignancies.PMID:38505675 | PMC:PMC10945302 | DOI:10.34172/bi.2023.27829 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Hamed Zare Hamid Bakherad Arman Nasr Esfahani Mohamad Norouzi Hossein Aghamollaei Seyed Latif Mousavi Gargari Fatemeh Mahmoodi Mahdi Aliomrani Walead Ebrahimizadeh Source Type: research
Protective effects of limb remote ischemic per-conditioning on the heart injury induced by renal ischemic-reperfusion through the interaction of the apelin with the RAS/iNOS pathway
CONCLUSION: Our results indicated that RIPerC protects the heart against renal ischemia- reperfusion injury, likely via interaction of the apelin with the RAS/iNOS pathway.PMID:38505676 | PMC:PMC10945303 | DOI:10.34172/bi.2023.27567 (Source: BioImpacts)
Source: BioImpacts - March 20, 2024 Category: Research Authors: Sahar Janfeshan Fatemeh Masjedi Zeinab Karimi Source Type: research
