The absence of legal remedies following academic bullying.
Authors: Mahmoudi M, Moss S Abstract Currently, victims of discrimination and sexual harassment have institutional reporting systems and legal remedies which support them in finding justice for these crimes. However, victims of academic bullying, who suffer similar repercussions, have no legal or institutional remedies. Because academic bullying is not a crime, targets often suffer in silence because there is no recourse. It is time for institutions to ask for governmental support to create legislation, similar to that for sexual harassment and discrimination, which will bring justice to academic bullies and relief...
Source: BioImpacts - May 6, 2020 Category: Research Tags: Bioimpacts Source Type: research

Lactobacillus plantarum induces apoptosis in gastric cancer cells via modulation of signaling pathways in Helicobacter pylori.
Conclusion: In agreement with different reports, our results proved the anti-cancer effects of the locally isolated L. plantarum through some immunological cell signaling pathways. Accordingly, it seems the probiotics could be considered as at least a complementary treatment for different types of malignancies. PMID: 32363150 [PubMed] (Source: BioImpacts)
Source: BioImpacts - May 6, 2020 Category: Research Tags: Bioimpacts Source Type: research

Freeze-dried multiscale porous nanofibrous three dimensional scaffolds for bone regenerations.
Conclusion: Novel multiscale porous nanofibrous 3D scaffolds made from PTFE/ PVA polymers with and without GO nanoparticles could be an ideal candidate for bone tissue engineering as a 3D template. PMID: 32363151 [PubMed] (Source: BioImpacts)
Source: BioImpacts - May 6, 2020 Category: Research Tags: Bioimpacts Source Type: research

Poly(ethylene glycol)-poly( ε-caprolactone)-based micelles for solubilization and tumor-targeted delivery of silibinin.
Conclusion: Our findings showed that PEG-PBCL micellar nanocarriers can be a useful vehicle for solubilization and targeted delivery of silibinin. PMID: 32363152 [PubMed] (Source: BioImpacts)
Source: BioImpacts - May 6, 2020 Category: Research Tags: Bioimpacts Source Type: research

Identification and ranking of important bio-elements in drug-drug interaction by Market Basket Analysis.
Conclusion: The discovery of the underlying mechanisms behind the DDI phenomena can help predict and prevent the inadvertent occurrence of DDIs. Ranking of the extracted rules based on their association can be a supportive tool to predict the outcome of unknown DDIs. PMID: 32363153 [PubMed] (Source: BioImpacts)
Source: BioImpacts - May 6, 2020 Category: Research Tags: Bioimpacts Source Type: research

Conditions for combining gene therapy with bone marrow transplantation in murine Krabbe disease.
Conclusion: These studies provide the conditions optimum for successfully treating the murine model of KD. There is some flexibility in dosing and timing to obtain a satisfactory outcome. These studies are critical to the planning of a human trial combining the "standard of care", HSCT, with a single iv injection of AAVrh10-GALC. PMID: 32363154 [PubMed] (Source: BioImpacts)
Source: BioImpacts - May 6, 2020 Category: Research Tags: Bioimpacts Source Type: research

Placenta mesenchymal stem cells differentiation toward neuronal-like cells on nanofibrous scaffold.
Conclusion: Taken together, these results delegated that PDMSCs differentiated on PLLA/PCL scaffolds are more likely to differentiate towards diversity lineages of neural cells. It proposed that PDMSCs have cell subpopulations that have the capability to be differentiated into neurogenic cells. PMID: 32363155 [PubMed] (Source: BioImpacts)
Source: BioImpacts - May 6, 2020 Category: Research Tags: Bioimpacts Source Type: research

Proteomic profiling of Serratia marcescens by high-resolution mass spectrometry.
Conclusion: To the best of our knowledge, this is the first high-throughput proteomics study of S. marcescens (ATCC 13880). These novel observations provide a crucial baseline molecular profile of the S. marcescens proteome which will prove to be helpful for the future research in understanding the host-pathogen interactions during infection, elucidating the mechanism of multidrug resistance, and developing novel diagnostic markers or vaccine for the disease. PMID: 32363156 [PubMed] (Source: BioImpacts)
Source: BioImpacts - May 6, 2020 Category: Research Tags: Bioimpacts Source Type: research

Therapeutic impacts of enzyme-responsive smart nanobiosystems.
Authors: Fathi M, Safary A, Barar J Abstract An important arena of the sophisticated nanosystems (NSs) is the combination of the responsive features of NSs with the biocatalytic properties of enzymes. The development of such smart drug delivery systems (DDSs) has seminal effectiveness in targeting, imaging, and monitoring of cancer. These NSs can exhibit site-specific delivery of the toxic cargo in response to the endogenous/exogenous stimuli. Enzyme responsive/targeted DDSs display enhanced accumulation of cargo molecules in the tumor microenvironment (TME) with a spatiotemporal controlled-release behavior. Based ...
Source: BioImpacts - January 30, 2020 Category: Research Tags: Bioimpacts Source Type: research

The urgent need for modification of scientific ranking indexes to facilitate scientific progress and diminish academic bullying.
Authors: Mahmoudi M, Ameli S, Moss S Abstract Academic bullying occurs when senior scientists direct abusive behavior such as verbal insults, public shaming, isolation, and threatening toward vulnerable junior colleagues such as postdocs, graduate students and lab members. We believe that one root cause of bullying behavior is the pressure felt by scientists to compete for rankings designed to measure their scientific worth. These ratings, such as the h-index, have several unintended consequences, one of which we believe is academic bullying. Under pressure to achieve higher and higher rankings, in exchange for pos...
Source: BioImpacts - January 30, 2020 Category: Research Tags: Bioimpacts Source Type: research

Incorporating ifosfamide into salvia oil-based nanoemulsion diminishes its nephrotoxicity in mice inoculated with tumor.
Conclusion: Incorporating IFO into SAL-NE has protected the kidneys from the damage induced by IFO. PMID: 31988852 [PubMed] (Source: BioImpacts)
Source: BioImpacts - January 30, 2020 Category: Research Tags: Bioimpacts Source Type: research

Kinetic and thermodynamic study of beta-Boswellic acid interaction with Tau protein investigated by surface plasmon resonance and molecular modeling methods.
Conclusion: The binding affinity increased by temperature enhancement, while it decreased significantly in the presence of glucose. Both association and dissociation of the BBA-Tau complex were accompanied with an entropic activation barrier; however, positive enthalpy and entropy changes revealed that hydrophobic bonding is the main force involved in the interaction. PMID: 31988853 [PubMed] (Source: BioImpacts)
Source: BioImpacts - January 30, 2020 Category: Research Tags: Bioimpacts Source Type: research

PEGylated gold nanoparticles-ribonuclease induced oxidative stress and apoptosis in colorectal cancer cells.
Conclusion: Based on the efficient ROS-responsiveness and the anticancer activity of RNase A of the engineered nanomedicine, this nanoscaled biologics may be considered as a potential candidate for the treatment of CRC. PMID: 31988854 [PubMed] (Source: BioImpacts)
Source: BioImpacts - January 30, 2020 Category: Research Tags: Bioimpacts Source Type: research

Comparative impact of platelet rich plasma and transforming growth factor- β on chondrogenic differentiation of human adipose derived stem cells.
Conclusion: PRP induces in vitro chondrogenesis, as well as TGF-β with lesser inflammatory and hypertrophic side effects. PMID: 31988855 [PubMed] (Source: BioImpacts)
Source: BioImpacts - January 30, 2020 Category: Research Tags: Bioimpacts Source Type: research

Propagation of limbal stem cells on polycaprolactone and polycaprolactone/gelatin fibrous scaffolds and transplantation in animal model.
Conclusion: The represented data indicated the priority of PCL to PCL/Gel for the LESC attachment, proliferation and final outcome in an animal model of alkaline injury. This finding might be promising for cell therapy of corneal diseases. PMID: 31988856 [PubMed] (Source: BioImpacts)
Source: BioImpacts - January 30, 2020 Category: Research Tags: Bioimpacts Source Type: research

Role of the K ölliker-Fuse nucleus in cardiovascular responses to hypoxia and baroreceptor activation in anesthetized rats.
Conclusion: The KF played no significant role in the baroreflex, but could account for cardiovascular chemoreflex in urethane anesthetized rats. PMID: 31988857 [PubMed] (Source: BioImpacts)
Source: BioImpacts - January 30, 2020 Category: Research Tags: Bioimpacts Source Type: research

Renewed interests in carbonic anhydrase IX in relevance to breast cancer treatment.
Authors: Dolatkhah M, Omidi Y Abstract The highly proliferating cancerous cells can form permissive accommodating milieu - the so-called tumor microenvironment (TME). During the initiation of solid tumors, hypoxia plays a key role in glycolysis, which can trigger the anomalous overexpression of several enzymes and transporters involved in the metabolism of glucose. Of these, carbonic anhydrases (CAs), especially CAIX, together with other molecular machinery involved in the production/trafficking of acidic byproducts, play key roles in the regulation of intracellular and extracellular pH. CAIX, along with other mole...
Source: BioImpacts - December 6, 2019 Category: Research Tags: Bioimpacts Source Type: research

Design, synthesis and evaluation of biological activities of some novel anti-TB agents with bio-reducible functional group.
Conclusion: It was found that the majority of POEs containing a bioreducible center showed higher inhibitory activities on Mtb growth when compared to the similar compounds without a bio-reducible functional group. PMID: 31799156 [PubMed] (Source: BioImpacts)
Source: BioImpacts - December 6, 2019 Category: Research Tags: Bioimpacts Source Type: research

Mode of photoexcited C60 fullerene involvement in potentiating cisplatin toxicity against drug-resistant L1210 cells.
Conclusion: The effect of the synergic cytotoxic activity of both agents allowed to suppose that photoexcited C60 fullerene promoted Cis-Pt accumulation in leukemic cells resistant to Cis-Pt. The data obtained could be useful for the development of new approaches to overcome drug-resistance of leukemic cells. PMID: 31799157 [PubMed] (Source: BioImpacts)
Source: BioImpacts - December 6, 2019 Category: Research Tags: Bioimpacts Source Type: research

Association of MS4A6A, CD33, and TREM2 gene polymorphisms with the late-onset Alzheimer's disease.
Conclusion: The evidence from the present study suggests that T allele of CD33 rs3865444 polymorphism is associated with LOAD in the studied Iranian population. PMID: 31799158 [PubMed] (Source: BioImpacts)
Source: BioImpacts - December 6, 2019 Category: Research Tags: Bioimpacts Source Type: research

Water-soluble pristine C60 fullerene attenuates acetaminophen-induced liver injury.
Conclusion: C60FAS could partially correct acute and chronic toxic liver injury, however, it could not normalize bilirubin metabolism after acute exposure. PMID: 31799159 [PubMed] (Source: BioImpacts)
Source: BioImpacts - December 6, 2019 Category: Research Tags: Bioimpacts Source Type: research

In silico, in vitro: antioxidant and antihepatotoxic activity of gnetol from Gnetum ula Brongn.
Conclusion: Gnetum ula stem extract and its isolated compound are safe and offered significant hepatoprotection against CCl4 induced toxicity. Isolated compound gnetol exhibited a potent antioxidant activity offering protection to liver damage. However, in vivo studies need to be carried out to validate the traditional use of G. ula . PMID: 31799160 [PubMed] (Source: BioImpacts)
Source: BioImpacts - December 6, 2019 Category: Research Tags: Bioimpacts Source Type: research

Scarcity of lab positions in high-ranked institutions creates a breeding ground for bullies.
Authors: Mahmoudi M, Moss S PMID: 31799161 [PubMed] (Source: BioImpacts)
Source: BioImpacts - December 6, 2019 Category: Research Tags: Bioimpacts Source Type: research

Recent advances in targeted therapy of colorectal cancer: impacts of monoclonal antibodies nanoconjugates.
Authors: Akbarzadeh Khiavi M, Safary A, Somi MH Abstract Despite rapid advances in diagnostic and treatment approaches, the overall survival rate of cancer has not been improved. Colorectal cancer (CRC) is recognized as the third leading cause of neoplasm-related deaths worldwide, in large part due to its considerable metastasis and drug resistance. For developing new anticancer strategies, rapid progression of multimodal nanomedicines and nanoconjugates has provided promising treatment modalities for effective therapy of cancer. The limitations of cancer chemotherapy might be overcome through the use of such nanos...
Source: BioImpacts - September 13, 2019 Category: Research Tags: Bioimpacts Source Type: research

Academic bullies leave no trace.
Authors: Mahmoudi M Abstract Bullying in academic science is a growing concern. It may vary in severity from insults, snubs, or invasions of privacy to violations of intellectual property and unfair crediting of authors. In extreme cases it may even include coercing lab workers to sign away rights to authorship or even intellectual property. Cumbersome institutional protocols and fears of reprisal may discourage targets of bullying from reporting such incidents; lab workers in the US on visas may feel especially vulnerable. Possible strategies to combat bullying include detailed examination of relevant documentatio...
Source: BioImpacts - September 13, 2019 Category: Research Tags: Bioimpacts Source Type: research

A multi-method and structure-based in silico vaccine designing against Echinococcus granulosus through investigating enolase protein.
Conclusion: Based on the results, this step-by-step immunoinformatics approach could be considered as a rational platform for designing vaccines against such multi-stage parasites. Furthermore, it is proposed that this multi-epitope vaccine is served as a promising preventive anti-echinococcosis agent. PMID: 31508329 [PubMed] (Source: BioImpacts)
Source: BioImpacts - September 13, 2019 Category: Research Tags: Bioimpacts Source Type: research

Functional expression and impact of testis-specific gene antigen 10 in breast cancer: a combined in vitro and in silico analysis.
Conclusions: Collectively, TSGA10 functional expression alters under the hyper-/hypo-glycemia and hypoxia, which indicates its importance as a candidate bio-target for the cancer therapy. PMID: 31508330 [PubMed] (Source: BioImpacts)
Source: BioImpacts - September 13, 2019 Category: Research Tags: Bioimpacts Source Type: research

A short-term plastic adherence incubation of the stromal vascular fraction leads to a predictable GMP-compliant cell-product.
Conclusion: Addition of a short purification-step after the SVF isolation is a cheap and fast strategy to isolate a homogeneous uncultivated GMP-compliant cell fraction of ASCs. PMID: 31508331 [PubMed] (Source: BioImpacts)
Source: BioImpacts - September 13, 2019 Category: Research Tags: Bioimpacts Source Type: research

The effects of natural nano-sized clinoptilolite and Nigella sativa supplementation on serum bone markers in diabetic rats.
This study was conducted to examine the effects of separate and concurrent supplementation of natural nano-sized clinoptilolite (NCLN) and NS on serum bone markers in rats with type 2 diabetes. Methods: A total of 42 (case=36 and control=6) adult male Wistar rats were divided into 2 groups: diabetic and non-diabetic. An oral glucose tolerance test and a homeostatic model assessment of insulin resistance (HOMA-IR) test were conducted to confirm diabetes. Then, the diabetic group was divided into 4 subgroups: [1] control (n=9), [2] NS 1%/food (n=9), [3] NCLN 2%/food (n=9), [4] NS 1%/food + NCLN 2%/food (n=9). After 7 weeks, ...
Source: BioImpacts - September 13, 2019 Category: Research Tags: Bioimpacts Source Type: research

Electrosprayed polymeric nanobeads and nanofibers of modafinil: preparation, characterization, and drug release studies.
Conclusion: The results suggest that by optimization of variables such as solution concentration of MDF-ERS nanofibers and nanobeads with higher dissolution rates can be made by electrospray. Electrospray deposition as a simple, continuous, and surfactant free method is an excellent choice for preparation of drug loaded polymeric nanoparticles. PMID: 31508333 [PubMed] (Source: BioImpacts)
Source: BioImpacts - September 13, 2019 Category: Research Tags: Bioimpacts Source Type: research

Manifestation of hemispheric laterality in chewing side preference and handedness.
Conclusion: Thereupon masticatory preference is found with probable origins in the dominant hemisphere of the brain. PMID: 31508334 [PubMed] (Source: BioImpacts)
Source: BioImpacts - September 13, 2019 Category: Research Tags: Bioimpacts Source Type: research

Aptamedicine: a new treatment modality in personalized cancer therapy.
Authors: Vandghanooni S, Eskandani M, Barar J, Omidi Y Abstract Aptamers ( Aps ) are short single-strand nucleic acids exhibiting unique 3D structure which facilitate their targeting potential against various cancer molecular markers ( CMMs ). Such features of Aps not only make them as suitable homing agents in targeted drug delivery systems (DDSs) but also candidate them as macromolecules that inhibit the interaction of the target ligand with other proteins. On the other hand, the conjugation of Aps with another therapeutic molecule such as antisense oligonucleotides (ASOs), siRNAs/miRNAs, Aps , toxins, chemothera...
Source: BioImpacts - July 25, 2019 Category: Research Tags: Bioimpacts Source Type: research

SPR signals enhancement by gold nanorods for cell surface marker detection.
Authors: Fathi F, Jalili R, Amjadi M, Rashidi MR Abstract Introduction: The detection of micrometer-sized particles like cells is limited by surface plasmon resonance (SPR) biosensors because of having a depth of evanescent wave
Source: BioImpacts - July 25, 2019 Category: Research Tags: Bioimpacts Source Type: research

Therapeutic potency of substituted chromones as Alzheimer's drug: Elucidation of acetylcholinesterase inhibitory activity through spectroscopic and molecular modelling investigation.
Conclusion: This comparative study affirms the importance of meticulous substitution in the chromone scaffold to promote maximum inhibition potency, while considering their usage as AD drugs. PMID: 31334039 [PubMed] (Source: BioImpacts)
Source: BioImpacts - July 25, 2019 Category: Research Tags: Bioimpacts Source Type: research

Chondroitin sulfate degradation and eicosanoid metabolism pathways are impaired in focal segmental glomerulosclerosis: Experimental confirmation of an in silico prediction.
Conclusion: Our data supported the implication of these target genes and pathways in the pathogenesis of FSGS. In addition, these genes can be considered as non-invasive biomarkers for FSGS. PMID: 31334040 [PubMed] (Source: BioImpacts)
Source: BioImpacts - July 25, 2019 Category: Research Tags: Bioimpacts Source Type: research

Numerical investigation of hemodynamic performance of a stent in the main branch of a coronary artery bifurcation.
Conclusion: The use of a one-part stent in the main branch of a coronary artery bifurcation for the aforementioned type of stenosis is recommended. PMID: 31334041 [PubMed] (Source: BioImpacts)
Source: BioImpacts - July 25, 2019 Category: Research Tags: Bioimpacts Source Type: research

Determination of valproic acid and 3-heptanone in plasma using air-assisted liquid-liquid microextraction with the assistance of vortex: Application in the real samples.
Conclusion: The obtained results indicated that this procedure is easy, sensitive, and reliable, and can be used for the analysis of the selected analytes in the plasma samples of patients with epilepsy. PMID: 31334042 [PubMed] (Source: BioImpacts)
Source: BioImpacts - July 25, 2019 Category: Research Tags: Bioimpacts Source Type: research

Spectroscopic overview of quercetin and its Cu(II) complex interaction with serum albumins.
Conclusion: To enhance the pharmaceutical outcomes of Qu molecules, one may use Qu-Cu(II) complex for the development and delivery of the small molecules. PMID: 31334043 [PubMed] (Source: BioImpacts)
Source: BioImpacts - July 25, 2019 Category: Research Tags: Bioimpacts Source Type: research

Indoleamine 2, 3-dioxygenase inhibitors in immunochemotherapy of breast cancer: challenges and opportunities.
Authors: Hashemzadeh N, Adibkia K, Barar J Abstract Trafficking of macromolecular immunotherapy agent into the tumor microenvironment (TME) is a challenging issue. In the TME, cancer cells exploit indoleamine 2, 3-dioxygenase (IDO), as a cytosolic enzyme that catalyzes the L-tryptophan (Trp) through the kynurenine (Kyn) pathway, which could negatively regulate the activity of T cells. Thus, Trp/Kyn pathway, can be targeted with novel treatment modalities such as IDO1 inhibitor to benefit patients with aggressive solid tumors. PMID: 30788254 [PubMed] (Source: BioImpacts)
Source: BioImpacts - February 23, 2019 Category: Research Tags: Bioimpacts Source Type: research

Carboxymethylcellulose/MOF-5/Graphene oxide bio-nanocomposite as antibacterial drug nanocarrier agent.
Conclusion: Carboxymethylcellulose/MOF-5/GO bio-nanocomposite (CMC/MOF-5/GO) was successfully synthesized through the solvothermal technique. Tetracycline (TC) was encapsulated in the GO and CMC/MOF-5/GO. The drug release tests showed that the TC-loaded CMC/MOF5/GO has an effective protection against stomach pH. With controlling the TC release in the gastrointestinal tract conditions, the long-time stability of drug dosing was enhanced. Furthermore, antibacterial activity tests showed that the TC-loaded CMC/MOF-5/GO has an antibacterial activity to negatively charge E. coli bacteria in contrast to TC-loaded GO. PMID: 3...
Source: BioImpacts - February 23, 2019 Category: Research Tags: Bioimpacts Source Type: research

Highly efficient novel recombinant L-asparaginase with no glutaminase activity from a new halo-thermotolerant Bacillus strain.
Conclusion: The biochemical properties of the novel ASPase A1 derived from Bacillus sp. SL-l indicated a great potential for the identified enzyme in pharmaceutical and industrial applications. PMID: 30788256 [PubMed] (Source: BioImpacts)
Source: BioImpacts - February 23, 2019 Category: Research Tags: Bioimpacts Source Type: research

In vitro and in vivo evaluation of a dextran-graft-polybutylmethacrylate copolymer coated on CoCr metallic stent.
Conclusion: Based on our findings, Dex-PBMA exhibited vascular compatibility and can potentially be used as a coating for metallic coronary stents. PMID: 30788257 [PubMed] (Source: BioImpacts)
Source: BioImpacts - February 23, 2019 Category: Research Tags: Bioimpacts Source Type: research

Preparation and characterization of biocomposite films of carrageenan/locust bean gum/montmorrillonite for transdermal delivery of curcumin.
Conclusion: In vitro release profiles showed that increasing concentration of LBG and MMT sustained the release of the drug from the polymer composite transdermal films. Decreased percent cumulative release as the concentration of LBG and MMT increases in polymer composite transdermal film. PMID: 30788258 [PubMed] (Source: BioImpacts)
Source: BioImpacts - February 23, 2019 Category: Research Tags: Bioimpacts Source Type: research

In silico design of a triple-negative breast cancer vaccine by targeting cancer testis antigens.
Conclusion: Based on our in-silico analyses, the proposed vaccine may be considered for the immunotherapy of TNBC. PMID: 30788259 [PubMed] (Source: BioImpacts)
Source: BioImpacts - February 23, 2019 Category: Research Tags: Bioimpacts Source Type: research

In vitro study of the anticancer activity of various doxorubicin-containing dispersions.
Conclusion: The importance of Dextran-PNIPAM copolymer as a universal platform for drug delivery was established, and the huge potential of Dextran-PNIPAM+Dox NPs as novel anticancer agents was noted. Based on the in vitro study of the SWCNT+Dox and GO+Dox nanofluids, it was concluded that SWCNT and GO NPs can be effective cytoprotectors against the highly toxic drugs. PMID: 30788260 [PubMed] (Source: BioImpacts)
Source: BioImpacts - February 23, 2019 Category: Research Tags: Bioimpacts Source Type: research

Correction: A cancer vaccine with dendritic cells differentiated with GM-CSF and IFN α and pulsed with a squaric acid treated cell lysate improves T cell priming and tumor growth control in a mouse model.
Correction: A cancer vaccine with dendritic cells differentiated with GM-CSF and IFNα and pulsed with a squaric acid treated cell lysate improves T cell priming and tumor growth control in a mouse model. Bioimpacts. 2019;9(1):65 Authors: Mookerjee A, Graciotti M, Kandalaft LE Abstract [This corrects the article DOI: 10.15171/bi.2018.24.]. PMID: 30788261 [PubMed - in process] (Source: BioImpacts)
Source: BioImpacts - February 23, 2019 Category: Research Tags: Bioimpacts Source Type: research

Microfluidic paper-based analytical devices ( µPADs) for fast and ultrasensitive sensing of biomarkers and monitoring of diseases.
Microfluidic paper-based analytical devices (µPADs) for fast and ultrasensitive sensing of biomarkers and monitoring of diseases. Bioimpacts. 2018;8(4):237-240 Authors: Abdollahi-Aghdam A, Majidi MR, Omidi Y Abstract Through the development of analytical techniques, microscaled devices have displayed attractive advantages, including ultrasensitive detection and analysis, cost-effectiveness, portability, process integrity, multi-process functionality, and in-situ analysis. In the last decade, a new generation of analytical devices has emerged based on the cellulose materials - so-called microfluid...
Source: BioImpacts - November 8, 2018 Category: Research Tags: Bioimpacts Source Type: research

Effect of PEGylation on assembly morphology and cellular uptake of poly ethyleneimine-cholesterol conjugates for delivery of sorafenib tosylate in hepatocellular carcinoma.
Conclusion: The combinatory effects of enhanced cellular uptake and reduced general cytotoxicity can present PEGylated PEI-cholesterol conjugates as a potential carrier for delivery of poorly soluble chemotherapeutic agents such as SFB in HCC that certainly requires further investigations in vitro and in vivo. PMID: 30397579 [PubMed] (Source: BioImpacts)
Source: BioImpacts - November 8, 2018 Category: Research Tags: Bioimpacts Source Type: research

Characterization and partial purification of an antibacterial agent from halophilic actinomycetes Kocuria sp. strain rsk4.
Conclusion : The result suggests that a broad-spectrum antibacterial compound obtained from halophilic actinomycetes is effective against pathogenic bacteria. This compound may be a good alternative treatment against antibiotic-resistant pathogen S. aureus. PMID: 30397580 [PubMed] (Source: BioImpacts)
Source: BioImpacts - November 8, 2018 Category: Research Tags: Bioimpacts Source Type: research

Nafion-coated cadmium pentacyanonitrosylferrate-modified glassy carbon electrode for detection of dopamine in biological samples.
Conclusion : In comparison with the bare electrode, the Nafion|CdPCNF|GC electrode could determine DA in the biological samples with adequate sensitivity and selectivity. Therefore, we propose that the modified electrode is utilizable as an amperometric DA sensor for the biological sample analysis. PMID: 30397581 [PubMed] (Source: BioImpacts)
Source: BioImpacts - November 8, 2018 Category: Research Tags: Bioimpacts Source Type: research