Platycodin D induces neutrophil apoptosis by downregulating PD-L1 expression to inhibit breast cancer pulmonary metastasis

In conclusion, the administration of PlaD inhibited the PI3K/Akt signaling pathway by reducing the expression of PD-L1 in neutrophils. PlaD promoted neutrophil apoptosis, thereby inhibiting the establishment of a premetastatic niche and ultimately blocking the development of pulmonary metastasis.PMID:37724959 | DOI:10.1016/j.intimp.2023.109733

Source: International Immunopharmacology - September 19, 2023 Category: Allergy & Immunology Authors: Yiyi Ye Ying Xie Lixia Pei Ziwei Jiang Chunyu Wu Sheng Liu Source Type: research