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Total 656 results found since Jan 2013.
Hispidulin exhibits neuroprotective activities against cerebral ischemia reperfusion injury through suppressing NLRP3-mediated pyroptosis
ConclusionHispidulin is a neuroprotective agent with clinical potential against IR-induced neurological injury.
Source: Life Sciences - June 25, 2019 Category: Biology Source Type: research
Study finds link between hypertension and air pollution
(Oxford University Press USA) A new study soon to appear in the Faculty of Public Health's Journal of Public Health, published by Oxford University Press, suggests that air pollution and living in apartment buildings may be associated with an increased risk for dangerous conditions like heart disease, stroke, and type 2 diabetes. This paper is embargoed until midnight EST on June 25.
Source: EurekAlert! - Biology - June 25, 2019 Category: Biology Source Type: news
New therapy promotes vascular repair following stroke
(University of Zurich) Following a stroke, antibodies that inhibit the signaling molecule Nogo-A can help repair blood vessels in the affected brain regions. This also promotes the regaining of motor functions, researchers at the University of Zurich have shown in a mouse model. The study opens up new avenues for treatment.
Source: EurekAlert! - Biology - June 24, 2019 Category: Biology Source Type: news
Scientists make a discovery that may explain some forms of stroke
(University of Sheffield) Scientists from the University of Sheffield have discovered a novel behaviour of the blood vessels of the brain in zebrafish that may explain some forms of stroke in humans.
Source: EurekAlert! - Biology - June 21, 2019 Category: Biology Source Type: news
The interleukin-4/PPAR γ signaling axis promotes oligodendrocyte differentiation and remyelination after brain injury
by Qingxiu Zhang, Wen Zhu, Fei Xu, Xuejiao Dai, Ligen Shi, Wei Cai, Hongfeng Mu, T. Kevin Hitchens, Lesley M. Foley, Xiangrong Liu, Fang Yu, Jie Chen, Yejie Shi, Rehana K. Leak, Yanqin Gao, Jun Chen, Xiaoming Hu
The repair of white matter damage is of paramount importance for functional recovery after brain injuries. Here, we report that interleukin-4 (IL-4) promotes oligodendrocyte regeneration and remyelination. IL-4 receptor expression was detected in a variety of glial cells after ischemic brain injur y, including oligodendrocyte lineage cells. IL-4 deficiency in knockout mice resulted in greater deterioration of whit...
Source: PLoS Biology: Archived Table of Contents - June 20, 2019 Category: Biology Authors: Qingxiu Zhang Source Type: research
Comprehensive metabolomic and proteomic analyses reveal candidate biomarkers and related metabolic networks in atrial fibrillation
Conclusionwe used a comprehensive multiple-omics strategy to systematically investigate the dysregulated molecules in the plasma of AF patients, thereby revealing potential biomarkers for diagnosis and providing information for pathological studies.
Source: Metabolomics - June 20, 2019 Category: Biology Source Type: research
Renin-angiotensin system activation and imbalance of matrix metalloproteinase-9/tissue inhibitor of matrix metalloproteinase-1 in cold-induced stroke
Publication date: Available online 12 June 2019Source: Life SciencesAuthor(s): Yu-ying Su, Huan-min Li, Zhen-xing Yan, Ming-chun Li, Ji-peng Wei, Wen-xia Zheng, Si-qin Liu, Yi-ting Deng, Hui-fang Xie, Chun-guang LiAbstractAimsIn the present study, we investigated the roles of renin-angiotensin system (RAS) activation and imbalance of matrix metalloproteinase-9 (MMP-9)/tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in cold-induced stroke during chronic hypertension, as well as the protective effects of captopril and recombinant human TIMP-1 (rhTIMP-1).Main methodsRats were randomly assigned to sham; 2-kidney, 2-cli...
Source: Life Sciences - June 12, 2019 Category: Biology Source Type: research
ADAMTS13 maintains cerebrovascular integrity to ameliorate Alzheimer-like pathology
by Yongliang Cao, Haochen Xu, Yuanbo Zhu, Mei-Juan Shi, Lixiang Wei, Jin Zhang, Shuo Cheng, Yiqian Shi, Haiyang Tong, Lijing Kang, Lu Lu, Haiyu Luo, Xing Yang, Xiaofei Bai, Ranran Wang, Yuanyuan Ma, Yun Wang, Zhongfeng Wang, Kai Zhong, Bing-Qiao Zhao, Wenying Fan
Blood-brain barrier (BBB) defects and cerebrovascular dysfunction contribute to amyloid-β (Aβ) brain accumulation and drive Alzheimer disease (AD) pathology. By regulating vascular functions and inflammation in the microvasculature, a disintegrin and metalloprotease with thrombospondin type I mo tif, member 13 (ADAMTS13) plays a significant protective effect in...
Source: PLoS Biology: Archived Table of Contents - June 10, 2019 Category: Biology Authors: Yongliang Cao Source Type: research
Proteomic analyses identify a potential mechanism by which extracellular vesicles aggravate ischemic stroke
Publication date: Available online 7 June 2019Source: Life SciencesAuthor(s): Xintong Wang, Jiaoqi Wang, Xiaohua Shi, Chengliang Pan, Hongyu Liu, Yue Dong, Rui Dong, Jing Mang, Zhongxin XuAbstractAimsExtracellular vesicles (EVs) are vital for information exchange between donor and recipient cells. When cells are stressed (e.g., by oxygen glucose deprivation, OGD), the complex information carried by the EVs is altered by the donor cells. Here, we aimed to analyze the proteomic differences between EVs derived from OGD-damaged cells and EVs derived from undamaged cells to explore the potential mechanisms by which EVs aggravat...
Source: Life Sciences - June 7, 2019 Category: Biology Source Type: research
NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress.
Abstract
Cellular exposure to ionizing radiation leads to oxidatively generated DNA damage, which has been implicated in neurodegenerative diseases. DNA damage is repaired by the evolutionarily conserved BER system. Exposure of mice to ionizing radiation affects neurogenesis and neuroinflammation. However, the consequences of deficient DNA repair in adult neurogenesis and neuroinflammation are poorly understood despite their potential relevance for homeostasis. We previously reported that loss of NEIL1, an important DNA glycosylase involved in BER system, is associated with deficiencies in spatial memory, olfactio...
Source: Free Radical Biology and Medicine - June 4, 2019 Category: Biology Authors: Yang B, Figueroa D, Hou Y, Babbar M, Baringer SL, Croteau DL, Bohr VA Tags: Free Radic Biol Med Source Type: research
Selenoprotein T as a new positive inotrope in the goldfish, Carassius auratus RESEARCH ARTICLE
This study aimed to evaluate the cardiac expression of SELENOT, and the effects of exogenous PSELT (a 43–52 SELENOT-derived peptide) on the heart function of C. auratus, a hypoxia tolerance fish model. We found that SELENOT was expressed in cardiac extracts of juvenile and adult fish, located in the sarcoplasmic reticulum (SR) together with calsequestrin-2. Expression increased under acute hypoxia. On ex vivo isolated and perfused goldfish heart preparations, under normoxia, PSELT dose dependently increased stroke volume (VS), cardiac output
and stroke work (SW), involving cAMP, PKA, L-type calcium channels, SERCA2...
Source: Journal of Experimental Biology - June 3, 2019 Category: Biology Authors: Mazza, R., Gattuso, A., Imbrogno, S., Boukhzar, L., Leo, S., Mallouki, B. Y., Filice, M., Rocca, C., Angelone, T., Anouar, Y., Cerra, M. C. Tags: RESEARCH ARTICLE Source Type: research
Upstroke-based acceleration and head stabilization are the norm for the wing-propelled swimming of alcid seabirds RESEARCH ARTICLE
Anthony B. Lapsansky and Bret W. Tobalske Alcids, a family of seabirds including murres, guillemots, and puffins, exhibit the greatest mass-specific dive depths and durations of any birds or mammals. These impressive diving capabilities have motivated numerous studies on the biomechanics of alcid swimming and diving, with one objective being to compare stroke-acceleration patterns of swimming alcids to those of penguins, where upstroke and downstroke are used for horizontal acceleration. Studies of free-ranging, descending alcids have found that alcids accelerate in the direction of travel during both their upstroke and do...
Source: Journal of Experimental Biology - June 2, 2019 Category: Biology Authors: Lapsansky, A. B., Tobalske, B. W. Tags: RESEARCH ARTICLE Source Type: research
Interruption of platelets and thrombin function as a new approach against liver fibrosis induced experimentally in rats
In conclusion, activation of coagulation cascade is a triggering stimulus in the initiation of CCl4-induced liver fibrosis and the anticoagulant drugs may exert promising anti-fibrotic effect.Graphical abstract
Source: Life Sciences - June 1, 2019 Category: Biology Source Type: research
MiR-145 protected the cell viability of human cerebral cortical neurons after oxygen-glucose deprivation by downregulating EPHA4
In this study, we aimed to further explore their function in a model of oxygen-glucose deprivation (OGD). The expression of miR-145 in the blood of 44 patients with ischemic stroke and 37 normal controls was detected by qRT-PCR. After transfection with either the wild- or mutant-type pGL3-promoter EPHA4 3′UTR into the miR-145 mimic and miR-145 inhibitor, a dual-luciferase reporter assay was performed to explore the interaction between miR-145 and EPHA4. qRT-PCR and Western blot were performed to further explore the effects of miR-145 on EPHA4 expression after an miR-145 mimic, an miR-145 inhibitor or LV-sh-EPHA4 was tran...
Source: Life Sciences - May 29, 2019 Category: Biology Source Type: research
Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms
This article also addresses the neuropharmacological potential of taurine analogs.Graphical abstract
Source: Redox Biology - May 22, 2019 Category: Biology Source Type: research
