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Total 656 results found since Jan 2013.
Penetrance of the V203I variant of the PRNP gene: report of a patient with stroke-like onset of Creutzfeld-Jacob Disease and review of published cases
Volume 16, Issue 1, December 2022, Page 19-22 .
Source: Prion - February 15, 2022 Category: Biology Authors: Ilaria Gandoglia Laura Strada Anna Poleggi Antonio Castaldi Massimo Del Sette Emilio Di Maria Source Type: research
Depletion of iNOS-positive inflammatory cells decelerates neuronal degeneration and alleviates cerebral ischemic damage by suppressing the inflammatory response
Free Radic Biol Med. 2022 Feb 9:S0891-5849(22)00061-2. doi: 10.1016/j.freeradbiomed.2022.02.008. Online ahead of print.ABSTRACTIschemic stroke leads to neuronal damage and severe inflammation that activate iNOS expression in different cell types, especially inflammatory cells in the brain. It is shown that NO released from iNOS contributes to the pathological development of cerebral ischemia. However, the role of these iNOS-expressing inflammatory cells in ischemic stroke has not been fully elucidated. Our purpose is to test if ischemia-induced iNOS+ inflammatory cells may exaggerate cerebral inflammation to exacerbate neu...
Source: Free Radical Biology and Medicine - February 12, 2022 Category: Biology Authors: Ting Li Ting Xu Jin Zhao Hao Gao Wenguang Xie Source Type: research
Novel mechanistic insight on the neuroprotective effect of berberine: The role of PPAR δ for antioxidant action
Free Radic Biol Med. 2022 Jan 27:S0891-5849(22)00033-8. doi: 10.1016/j.freeradbiomed.2022.01.022. Online ahead of print.ABSTRACTCerebral ischemic stroke ranks the second leading cause of death and the third leading cause of disability in lifetime all around the world, urgently necessitating effective therapeutic interventions. Reactive oxygen species (ROS) have been implicated in stroke pathogenesis and peroxisome proliferator-activated receptors (PPARs) are prominent targets for ROS management. Although recent research has shown antioxidant effect of berberine (BBR), little is known regarding its effect upon ROS-PPARs sig...
Source: Free Radical Biology and Medicine - January 30, 2022 Category: Biology Authors: Jia-Wen Shou Xiao-Xiao Li Yun-Sang Tang Bobby Lim-Ho Kong Hoi-Yan Wu Meng-Jie Xiao Chun-Kai Cheung Pang-Chui Shaw Source Type: research
The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner
by Krisztina T óth, Nikolett Lénárt, Péter Berki, Rebeka Fekete, Eszter Szabadits, Balázs Pósfai, Csaba Cserép, Ahmad Alatshan, Szilvia Benkő, Dániel Kiss, Christian A. Hübner, Attila Gulyás, Kai Kaila, Zsuzsanna Környei, Ádám Dénes
The NKCC1 ion transporter contributes to the pathophysiology of common neurological disorders, but its function in microglia, the main inflammatory cells of the brain, has remained unclear to date. Therefore, we generated a novel transgenic mouse line in which microglial NKCC1 was deleted. We show that microglial NKCC1 shapes both baseline and reactive microglia morphology, proc...
Source: PLoS Biology: Archived Table of Contents - January 27, 2022 Category: Biology Authors: Krisztina T óth Source Type: research
Circadian preference and stroke characteristics: A descriptive study
This study set out to explore this relationship by examining whether there was an association between circadian preference and stroke characteristics in a sample of stroke outpatients, considering the time of stroke onset, the topography of the stroke and the resulting disability. We also examined whether sleep complaints (snoring, insomnia, sleep apnea) were associated with circadian preferences (i.e., morning-, evening-, and intermediate-types). We also compared circadian preferences and comorbidities in this sample, matched by age and sex, with those of healthy controls who took part in an epidemiological study (EPISONO...
Source: Chronobiology International - January 5, 2022 Category: Biology Authors: Eveli Truksinas Cristina Frange Giuliano da Paz Eliana Lottenberg Vago Monica Levy Andersen Sergio Tufik Fernando Morgadinho Santos Coelho Source Type: research
Sex and age interaction in fundamental circulatory volumetric variables at peak working capacity
ConclusionsSex and age interact on the crucial circulatory relationship between total circulating BV and peak cardiac filling, with older women necessitating more BV to fill the exercising heart than age- and physical activity-matched men.
Source: Biology of Sex Differences - January 3, 2022 Category: Biology Source Type: research
Transforming a neural circuit to function without oxygen and glucose delivery
Curr Biol. 2021 Dec 20;31(24):R1564-R1565. doi: 10.1016/j.cub.2021.11.003.ABSTRACTDisruptions in the delivery of oxygen and glucose impair the function of neural circuits, with lethal consequences commonly observed in stroke and cardiac arrest. Intense focus has been placed on understanding how to overcome neuronal failure during energy stress. Important insights into neuroprotective strategies have come from studies of evolutionary adaptations for survival in hypoxic environments, such as those seen in turtles, naked mole-rats, and several other animals1. Amphibians are not usually numbered among 'champion' hypoxia-tolera...
Source: Current Biology - December 21, 2021 Category: Biology Authors: Nikolaus Bueschke Lara do Amaral-Silva Sasha Adams Joseph M Santin Source Type: research
Twist and chew: three-dimensional tongue kinematics during chewing in macaque primates
Biol Lett. 2021 Dec;17(12):20210431. doi: 10.1098/rsbl.2021.0431. Epub 2021 Dec 15.ABSTRACTThree-dimensional (3D) tongue movements are central to performance of feeding functions by mammals and other tetrapods, but 3D tongue kinematics during feeding are poorly understood. Tongue kinematics were recorded during grape chewing by macaque primates using biplanar videoradiography. Complex shape changes in the tongue during chewing are dominated by a combination of flexion in the tongue's sagittal planes and roll about its long axis. As hypothesized for humans, in macaques during tongue retraction, the middle (molar region) of ...
Source: Biology Letters - December 14, 2021 Category: Biology Authors: Kara L Feilich J D Laurence-Chasen Courtney Orsbon Nicholas J Gidmark Callum F Ross Source Type: research
