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Total 656 results found since Jan 2013.
Birth month and mortality in Japan: a population-based prospective cohort study
Chronobiol Int. 2021 Apr 1:1-9. doi: 10.1080/07420528.2021.1903482. Online ahead of print.ABSTRACTEpidemiologic studies investigating the association between birth season and risk of mortality in adulthood are limited and have yielded inconclusive results. We aimed to examine the relationship between birth month and all-cause and cause-specific mortality, after controlling for potential confounders, including lifestyle and medical factors, in a population-based cohort study in Japan. We included 28,884 subjects (13,262 men and 15,622 women) from Takayama City, aged 35 years or older without cancer, stroke, and ischemic hea...
Source: Chronobiology International - April 1, 2021 Category: Biology Authors: Takahiro Uji Keiko Wada Michiyo Yamakawa Sachi Koda Yuma Nakashima Sakiko Onuma Chisato Nagata Source Type: research
Effects of Combined Sertraline and Magnesium in Rat Atrium
The objective of this study is to determine the synergistic effects of an antioxidant ion Mg+2, combined with selective serotonin reuptake inhibitor sertraline, in treatment or prevention of major depression and regulation of inotropic effect in the early postoperative period. Adult male 40 Wistar albino rats were randomly divided into 6 groups. Three to 4-mm long atrium strips were placed in organ bath, tension was adjusted to 2 g. Isometric contractions were induced with 10-3 M adrenaline. Group 1 was the control group, cumulative sertraline was given to group 2, cumulative MgSO4 to group 3, combined cumulative sertralin...
Source: Biological Trace Element Research - March 28, 2021 Category: Biology Authors: Esra Fidan Z Isik Solak Gormus İbrahim Kilinc Mehmet Sinan İyisoy Niyazi Gormus Source Type: research
Modelling the impact of clot fragmentation on the microcirculation after thrombectomy
by Wahbi K. El-Bouri, Andrew MacGowan, Tam ás I. Józsa, Matthew J. Gounis, Stephen J. Payne
Many ischaemic stroke patients who have a mechanical removal of
their clot (thrombectomy) do not get reperfusion of tissue despite
the thrombus being removed. One hypothesis for this ‘no-reperfusion’ phenomenon is micro-emboli fragmenting off the large clot during thrombectomy and occluding sm aller blood vessels downstream of the clot location. This is impossible to observe in-vivo and so we here develop an in-silico model based on in-vitro experiments to model the effect of micro-emboli on brain tissue. Through in-vitro exp...
Source: PLoS Computational Biology - March 12, 2021 Category: Biology Authors: Wahbi K. El-Bouri Source Type: research
Repurposing metformin to treat age-related neurodegenerative disorders and ischemic stroke
Publication date: Available online 11 March 2021Source: Life SciencesAuthor(s): Sejal Sharma, Saeideh Nozohouri, Bhuvaneshwar Vaidya, Thomas Abbruscato
Source: Life Sciences - March 11, 2021 Category: Biology Source Type: research
The important role of music in neurorehabilitation: Filling in critical gaps
(IOS Press) Music-based interventions have become a core ingredient of effective neurorehabilitation in the past 20 years thanks to the growing body of knowledge. In this theme issue of Neurorehabilitation, experts in the field highlight some of the current critical gaps in clinical applications that have been less thoroughly investigated, such as post-stroke cognition, traumatic brain injury, and autism and specific learning disabilities.
Source: EurekAlert! - Biology - March 10, 2021 Category: Biology Source Type: news
Coronary blood flow influences tolerance to environmental extremes in fish RESEARCH ARTICLE
Daniel Morgenroth, Tristan McArley, Albin Gräns, Michael Axelsson, Erik Sandblom, and Andreas Ekström Approximately half of all fishes have, in addition to the luminal venous O2 supply, a coronary circulation supplying the heart with fully oxygenated blood. Yet, it is not fully understood how coronary O2 delivery affects tolerance to environmental extremes such as warming and hypoxia. Hypoxia reduces arterial oxygenation, while warming increases overall tissue O2 demand. Thus, as both stressors are associated with reduced venous O2 supply to the heart, we hypothesised that coronary flow benefits hypoxia and...
Source: Journal of Experimental Biology - March 9, 2021 Category: Biology Authors: Morgenroth, D., McArley, T., Gräns, A., Axelsson, M., Sandblom, E., Ekström, A. Tags: RESEARCH ARTICLE Source Type: research
Serum metabolomic patterns in young patients with ischemic stroke: a case study
ConclusionsSerum metabolomic patterns were significantly different between young patients with ischemic stroke and healthy controls. Our study is beneficial in providing a further view into the pathophysiology of young patients with ischemic stroke.
Source: Metabolomics - February 8, 2021 Category: Biology Source Type: research
Identification and relative quantification of 3-nitrotyrosine residues in fibrinogen nitrated in vitro and fibrinogen from ischemic stroke patient plasma using LC-MS/MS.
Abstract
Ischemic stroke is one of the leading causes of death and disability worldwide. This acute vascular event interferes with blood supply to the brain and induces a burst of free radicals such as nitric oxide and superoxide, producing peroxynitrite, a precursor of strong nitrating agents. Fibrinogen is one of the most abundant plasma proteins; it plays a role in the hemostatic system, mediating clot formation, which can be affected by nitrotyrosine formation. We hypothesized that nitration of fibrinogen by ONOOH and ONOOCO2- radical products could be one of the early events of the ischemic stroke, and protei...
Source: Free Radical Biology and Medicine - February 3, 2021 Category: Biology Authors: Medeiros R, Sousa B, Rossi S, Afonso C, Bonino L, Pitt A, López E, Spickett C, Borthagaray G Tags: Free Radic Biol Med Source Type: research
NYU Dentistry awarded $1.9M NIH grant to study mitochondrial changes behind stroke, heart attack
(New York University) The National Institute of General Medical Sciences, part of the National Institutes of Health (NIH), has awarded NYU College of Dentistry's Evgeny Pavlov a grant to study a phenomenon called mitochondrial permeability transition, one of the central causes of tissue damage during stroke and heart attack.
Source: EurekAlert! - Biology - February 1, 2021 Category: Biology Source Type: news
Peroxynitrite activates NLRP3 inflammasome and contributes to hemorrhagic transformation and poor outcome in ischemic stroke with hyperglycemia.
In conclusion, peroxynitrite could mediate activations of MMPs and NLRP3 inflammasome, aggravate the BBB damage and HT, and induce poor outcome in ischemic stroke with hyperglycemia. Therefore, targeting peroxynitrite-mediated NLRP3 inflammasome could be a promising strategy for ischemic stroke with hyperglycemia.
PMID: 33515754 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - January 27, 2021 Category: Biology Authors: Chen H, Guan B, Chen S, Yang D, Shen J Tags: Free Radic Biol Med Source Type: research
Sex differences in stroke outcome correspond to rapid and severe changes in gut permeability in adult Sprague-Dawley rats
ConclusionsThese data show that extensive leakiness of the gut barrier is associated with severe post-stroke disability and suggest that reinforcing this barrier may improve stroke outcomes.
Source: Biology of Sex Differences - January 15, 2021 Category: Biology Source Type: research
One mutation, three phenotypes: novel metabolic insights on MELAS, MIDD and myopathy caused by the m.3243A & gt; G mutation
ConclusionWe conclude by giving novel insight on the phenotypes of the m.3243A > G mutation from a metabolomics point of view. Directives are also given for future investigations that could lead to better treatment options for patients suffering from this debilitating disease.
Source: Metabolomics - January 12, 2021 Category: Biology Source Type: research
Increased P450 aromatase levels in post-menopausal women after acute ischemic stroke
ConclusionsEstradiol levels correlated with functional outcomes (change in mRS) in both men and women, at least in the acute phase (24 h) of stroke. However, no significant difference in estradiol levels is seen 24 h post-stroke in men or women. Testosterone levels decrease at 24 h after stroke in men. As seen in animal models, aromatase levels increase after acute ischemic stroke, but this was only true for women. These ind icate an active aromatization process in post-menopausal women after acute ischemic stroke.
Source: Biology of Sex Differences - January 7, 2021 Category: Biology Source Type: research
