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Total 656 results found since Jan 2013.
Properties and reactivity of the folic acid and folate photoproduct 6-formylpterin
Free Radic Biol Med. 2021 May 6:S0891-5849(21)00283-5. doi: 10.1016/j.freeradbiomed.2021.05.002. Online ahead of print.ABSTRACTFolates (vitamin B9) are essential components of our diet and our gut microbiota. They are omnipresent in our cells and blood. Folates are necessary for DNA synthesis, methylation, and other vital bioprocesses. Folic acid (FA), as the synthetic form of folates, is largely found in supplements and fortified foods. FA and folate drugs are also extensively used as therapeutics. Therefore, we are continuously exposed to the pterin derivatives, and their photo-degradation products, such as 6-formylpteri...
Source: Free Radical Biology and Medicine - May 9, 2021 Category: Biology Authors: Goossens Jean-Fran çois Xavier Thuru Christian Bailly Source Type: research
Association Between Serum Copper and Stroke Risk Factors in Adults: Evidence from the National Health and Nutrition Examination Survey, 2011-2016
This study aimed to examine the relationships between serum copper and lipid levels among 3425 participants aged 20 years and older from the 2011-2016 National Health and Nutrition Examination Survey (NHANES). Data on administered questionnaires, serum copper concentrations, and lipid levels (total cholesterol, HDL cholesterol, triglycerides, and LDL cholesterol) were used. Associations between serum copper and lipid levels were evaluated using both multivariable linear regression and logistic regression models. In the linear regression models, total cholesterol and LDL cholesterol levels increased with increasing copper c...
Source: Biological Trace Element Research - May 6, 2021 Category: Biology Authors: Jingang Xu Guofeng Xu Junkang Fang Source Type: research
Farnesyl pyrophosphate is a new danger signal inducing acute cell death
by Jing Chen, Xiaochen Zhang, Liping Li, Xianqiang Ma, Chunxiao Yang, Zhaodi Liu, Chenyang Li, Maria J. Fernandez-Cabezudo, Basel K. al-Ramadi, Chuan Wu, Weishan Huang, Yong Zhang, Yonghui Zhang, Wanli Liu
Cell death is a vital event in life. Infections and injuries cause lytic cell death, which gives rise to danger signals that can further induce cell death, inflammation, and tissue damage. The mevalonate (MVA) pathway is an essential, highly conserved and dynamic metabolic pathway. Here, we discov er that farnesyl pyrophosphate (FPP), a metabolic intermediate of the MVA pathway, functions as a newly identified danger si...
Source: PLoS Biology: Archived Table of Contents - April 26, 2021 Category: Biology Authors: Jing Chen Source Type: research
Targeting oxidative stress, a crucial challenge in renal transplantation outcome
Free Radic Biol Med. 2021 Apr 20:S0891-5849(21)00258-6. doi: 10.1016/j.freeradbiomed.2021.04.023. Online ahead of print.ABSTRACTDisorders characterized by ischemia/reperfusion (I/R) are the most common causes of debilitating diseases and death in stroke, cardiovascular ischemia, acute kidney injury or organ transplantation. In the latter example the I/R step defines both the amplitude of the damages to the graft and the functional recovery outcome. During transplantation the kidney is subjected to blood flow arrest followed by a sudden increase in oxygen supply at the time of reperfusion. This essential clinical protocol c...
Source: Free Radical Biology and Medicine - April 23, 2021 Category: Biology Authors: Carcy Romain Cougnon Marc Poet Mallorie Durandy Manon Sicard Antoine Counillon Laurent Blondeau Nicolas Hauet Thierry Tauc Michel Pisani Didier F Source Type: research
Neuroprotective Effect of Aspirin Combined with Ginkgolide Injection on Cerebral ischemic stroke Rats and Its Effect on ERK12 Signal Pathway
Publication date: Available online 15 April 2021Source: Saudi Journal of Biological SciencesAuthor(s): Yan Zhang, Qin Song, Yuanxin Wang, Bingshu Li, Jiming Pan, HaiyanYang
Source: Saudi Journal of Biological Sciences - April 17, 2021 Category: Biology Source Type: research
Therapeutic Nuclear Magnetic Resonance affects the core clock mechanism and associated Hypoxia-inducible factor-1
Chronobiol Int. 2021 Apr 13:1-15. doi: 10.1080/07420528.2021.1910288. Online ahead of print.ABSTRACTThe influence of low intensity electromagnetic fields on circadian clocks of cells and tissues has gained increasing scientific interest, either as a therapeutic tool or as a potential environmental hazard. Nuclear Magnetic Resonance (NMR) refers to the property of certain atomic nuclei to absorb the energy of radio waves under a corresponding magnetic field. NMR forms the basis for Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy and, in a low-intensity form, for NMR therapy (tNMR). Since the circadian clock is b...
Source: Chronobiology International - April 13, 2021 Category: Biology Authors: Viktoria Th öni Regina Oliva David Mauracher Margit Egg Source Type: research
Serum/Plasma Zinc Is Apparently Increased in Ischemic Stroke: a Meta-analysis
Biol Trace Elem Res. 2021 Apr 6. doi: 10.1007/s12011-021-02703-4. Online ahead of print.ABSTRACTZinc (Zn) is found in many neuronal pathways in the brain and has implications for neuromodulation and cerebrovascular disease. However, the association between Zn levels and stroke risk remains controversial. Therefore, we conducted a meta-analysis to explore these relationships. A systematic literature search using PubMed, EMBASE database, and Google Scholar was performed for relevant articles from inception to August 2020. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were considered the effect sizes...
Source: Biological Trace Element Research - April 7, 2021 Category: Biology Authors: Mengyun Huang Lijun Zhu Yan Chen Yuelong Jin Zhengmei Fang Yingshui Yao Source Type: research
A Bioinspired Nitrone Precursor to a Stabilized Nitroxide Radical
Free Radic Biol Med. 2021 Mar 30:S0891-5849(21)00190-8. doi: 10.1016/j.freeradbiomed.2021.03.030. Online ahead of print.ABSTRACTNitrones derived from natural antioxidants are emerging as highly specific therapeutics against various human diseases, including stroke, neurodegenerative pathologies, and cancer. However, the development of useful pseudo-natural nitrones requires the judicious choice of a secondary metabolite as the precursor. Betalains are nitrogen-containing natural pigments that exhibit marked antioxidant capacity and pharmacological properties and, hence, are ideal candidates for designing multifunctional ni...
Source: Free Radical Biology and Medicine - April 2, 2021 Category: Biology Authors: Amanda Capistrano Pinheiro Rodrigo Boni Fazzi Larissa Cerrato Esteves Caroline Oliveira Machado Felipe Augusto D örr Ernani Pinto Yocefu Hattori Jacinto Sa Ana Maria da Costa Ferreira Erick Leite Bastos Source Type: research
Birth month and mortality in Japan: a population-based prospective cohort study
Chronobiol Int. 2021 Apr 1:1-9. doi: 10.1080/07420528.2021.1903482. Online ahead of print.ABSTRACTEpidemiologic studies investigating the association between birth season and risk of mortality in adulthood are limited and have yielded inconclusive results. We aimed to examine the relationship between birth month and all-cause and cause-specific mortality, after controlling for potential confounders, including lifestyle and medical factors, in a population-based cohort study in Japan. We included 28,884 subjects (13,262 men and 15,622 women) from Takayama City, aged 35 years or older without cancer, stroke, and ischemic hea...
Source: Chronobiology International - April 1, 2021 Category: Biology Authors: Takahiro Uji Keiko Wada Michiyo Yamakawa Sachi Koda Yuma Nakashima Sakiko Onuma Chisato Nagata Source Type: research
