Filtered By:
Specialty: Biology
This page shows you your search results in order of date. This is page number 16.
Order by Relevance | Date
Total 656 results found since Jan 2013.
The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation
ConclusionCarvacrol provides protection for hippocampal neurons against I/R in gerbils by inhibiting ferroptosis through increasing the expression of GPx4.Graphical abstract
Source: Life Sciences - August 29, 2019 Category: Biology Source Type: research
Magnetic Resonance Imaging (MRI) reveals high cardiac ejection fractions in red-footed tortoises (Chelonoidis carbonarius) SHORT COMMUNICATION
Catherine J. A. Williams, Eva M. Greunz, Steffen Ringgaard, Kasper Hansen, Mads F. Bertelsen, and Tobias Wang The ejection fraction of the trabeculated cardiac ventricle of reptiles has not previously been measured. Here we use the gold standard clinical methodology – electrocardiogram (ECG) gated flow magnetic resonance imaging (MRI) – to validate stroke volume measurements and end diastolic ventricular blood volumes. This produces an estimate of ejection fraction in the red footed tortoise Chelonoidis carbonaria (n=5) under isoflurane anaesthesia of 88±11%. After elimination of the prevailing right-to-...
Source: Journal of Experimental Biology - August 21, 2019 Category: Biology Authors: Williams, C. J. A., Greunz, E. M., Ringgaard, S., Hansen, K., Bertelsen, M. F., Wang, T. Tags: SHORT COMMUNICATION Source Type: research
Sex-specific association of metabolic risk factors with brain ischemic lesions by severity and location
ConclusionsMetabolic syndrome was associated with brain ischemic lesions in men but not in women. Higher body mass index was related to ischemic lesions located in lobar in men and in deep brain/infratentorial areas in women. Its mechanisms remain to be further investigated.
Source: Biology of Sex Differences - August 21, 2019 Category: Biology Source Type: research
Pulse transit time estimation of aortic pulse wave velocity and blood pressure using machine learning and simulated training data
by Janne M. J. Huttunen, Leo K ärkkäinen, Harri Lindholm
Recent developments in cardiovascular modelling allow us to simulate blood flow in an entire human body. Such model can also be used to create databases of virtual subjects, with sizes limited only by computational resources. In this work, we study if it is possible to estimate cardiovascular heal th indices using machine learning approaches. In particular, we carry out theoretical assessment of estimating aortic pulse wave velocity, diastolic and systolic blood pressure and stroke volume using pulse transit/arrival timings derived from photopletyshmography signal...
Source: PLoS Computational Biology - August 14, 2019 Category: Biology Authors: Janne M. J. Huttunen Source Type: research
Envisioning the neuroprotective effect of Metformin in experimental epilepsy: A portrait of molecular crosstalk
Publication date: 15 September 2019Source: Life Sciences, Volume 233Author(s): Nandini H S, Yam Nath Paudel, Krishna K LAbstractEpilepsy is a neurological disorder characterized by an enduring predisposition to generate and aggravate epileptic seizures affecting around 1% of global population making it a serious health concern. Despite the recent advances in epilepsy research, no disease-modifying treatment able to terminate epileptogenesis have been reported yet reflecting the complexity in understanding the disease pathogenesis. To overcome the current treatment gap against epilepsy, one effective approach is to explore ...
Source: Life Sciences - August 8, 2019 Category: Biology Source Type: research
α-Tocopherol preserves cardiac function by reducing oxidative stress and inflammation in ischemia/reperfusion injury
ConclusionOverall, α-TOH inhibits ischemia/reperfusion injury-induced oxidative and inflammatory responses, and ultimately preserves cardiac function. Therefore, our study provides a strong incentive to test vitamin E as an acute therapy in patients suffering a MI.Graphical abstract
Source: Redox Biology - August 7, 2019 Category: Biology Source Type: research
A meta-analysis on relationship between paraoxonase 1 polymorphisms and atherosclerotic cardiovascular diseases
ConclusionsIn summary, this meta-analysis proved that PON1 rs854560 polymorphism could be used to identify individual with elevated susceptibility to IS, whereas rs662 polymorphism could be used to identify individual with elevated susceptibility to CAD.
Source: Life Sciences - July 26, 2019 Category: Biology Source Type: research
Combination antioxidant therapy prevents epileptogenesis and modifies chronic epilepsy
Publication date: Available online 19 July 2019Source: Redox BiologyAuthor(s): Tawfeeq Shekh-Ahmad, Andreas Lieb, Stjepana Kovac, Lukas Gola, Christian W. Wigley, Andrey Y. Abramov, Matthew C. WalkerAbstractMany epilepsies are acquired conditions following an insult to the brain such as a prolonged seizure, traumatic brain injury or stroke. The generation of reactive oxygen species (ROS) and induction of oxidative stress are common sequelae of such brain insults and have been shown to contribute to neuronal death and the development of epilepsy. Here, we show that combination therapy targeting the generation of ROS though ...
Source: Redox Biology - July 20, 2019 Category: Biology Source Type: research
Raising eyebrows on neuroinflammation: Study finds novel role for 'skin plumping' molecule
(Florida Atlantic University) Scientists have discovered a novel mechanism and role in the brain for hyaluronic acid -- a clear, gooey substance popularized by cosmetic and skin care products. Hyaluronic acid may be the key in how an immune signal moves from the blood stream to the brain, activating the brain's resident immune cells, the microglia. Findings from this study have important implications for better treatments for stroke, neurodegenerative diseases, as well as head injuries.
Source: EurekAlert! - Biology - July 11, 2019 Category: Biology Source Type: news
NIH scientists identify spasm in women with endometriosis-associated chronic pelvic pain
(NIH/National Institute of Neurological Disorders and Stroke) Pelvic pain associated with endometriosis often becomes chronic and can persist (or recur) following surgical and hormonal interventions. According to results published in Regional Anesthesia& Pain Medicine, treating pelvic floor muscle spasm with botulinum toxin may relieve pain and improve quality of life. The study was conducted by scientists at the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.
Source: EurekAlert! - Biology - July 11, 2019 Category: Biology Source Type: news
Combined local hypothermia and recanalization therapy for acute ischemic stroke: Estimation of brain and systemic temperature using an energetic numerical model
Publication date: Available online 4 July 2019Source: Journal of Thermal BiologyAuthor(s): Yannick Lutz, Axel Loewe, Stephan Meckel, Olaf Dössel, Giorgio CattaneoAbstractLocal brain hypothermia is an attractive method for providing cerebral neuroprotection for ischemic stroke patients and at the same time reducing systemic side effects of cooling. In acute ischemic stroke patients with large vessel occlusion, combination with endovascular mechanical recanalization treatment could potentially allow for an alleviation of inflammatory and apoptotic pathways in the critical phase of reperfusion. The direct cooling of arterial...
Source: Journal of Thermal Biology - July 6, 2019 Category: Biology Source Type: research
Physical training improves exercise tolerance, cardiac function and promotes changes in neurotrophins levels in chagasic mice
Publication date: Available online 3 July 2019Source: Life SciencesAuthor(s): Rafael Leite Alves, Bárbara Ramalho Ladeira Cardoso, Isalira Peroba Rezende Ramos, Bruna da Silva Oliveira, Mara Lívia dos Santos, Aline Silva de Miranda, Tatiane Cristine Silva de Almeida, Maria Aparecida Ribeiro Vieira, Fabiana Simão Machado, Anderson José Ferreira, Gleide Fernandes de AvelarAbstractAimsTo investigate the effects of moderate aerobic physical training on cardiac function and morphology as well as on the levels of glial cell-derived neurotrophic factor (GDNF), nerve growth factor (NGF) and brain derived neurotrophic factor (B...
Source: Life Sciences - July 3, 2019 Category: Biology Source Type: research
Upstroke-based acceleration and head stabilization are the norm for the wing-propelled swimming of alcid seabirds RESEARCH ARTICLE
Anthony B. Lapsansky and Bret W. Tobalske
Alcids, a family of seabirds including murres, guillemots and puffins, exhibit the greatest mass-specific dive depths and durations of any birds or mammals. These impressive diving capabilities have motivated numerous studies on the biomechanics of alcid swimming and diving, with one objective being to compare stroke–acceleration patterns of swimming alcids with those of penguins, where upstroke and downstroke are used for horizontal acceleration. Studies of free-ranging, descending alcids have found that alcids accelerate in the direction of travel during both their upstrok...
Source: Journal of Experimental Biology - July 1, 2019 Category: Biology Authors: Lapsansky, A. B., Tobalske, B. W. Tags: Comparative biomechanics of movement RESEARCH ARTICLE Source Type: research
Glowing brain cells illuminate stroke recovery research
(Emory Health Sciences) A promising strategy for helping stroke patients recover, transplanting neural progenitor cells to restore lost functions, asks a lot of those cells. To help them to integrate into the brain, the cells get help from 'optochemogenetics.'
Source: EurekAlert! - Biology - July 1, 2019 Category: Biology Source Type: news
Neurotechnology holds promise for chronic stroke patients
(Wyss Center for Bio and Neuroengineering) Personalized neurotechnology-aided rehabilitation of the arm could improve recovery in severe chronic stroke patients according to a new paper published today in the journal Brain.
Source: EurekAlert! - Biology - June 30, 2019 Category: Biology Source Type: news
