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Total 656 results found since Jan 2013.
Elabela-APJ axis attenuates cerebral ischemia/reperfusion injury by inhibiting neuronal ferroptosis
Free Radic Biol Med. 2023 Jan 18:S0891-5849(23)00009-6. doi: 10.1016/j.freeradbiomed.2023.01.008. Online ahead of print.ABSTRACTFerroptosis is a form of non-apoptotic cell death caused by iron-dependent peroxidation of lipids. It contributes to ischemic stroke-induced neuronal damage. Elabela (ELA), a novel endogenous ligand for Apelin receptor (APJ), regulates oxidative stress and exerts a protective role in cardiovascular disease. However, the effect of ELA-APJ axis on cellular ferroptosis in cerebral ischemia/reperfusion (I/R) remains elusive. The present study showed that ELA and APJ were expressed on neurons and incre...
Source: Free Radical Biology and Medicine - January 21, 2023 Category: Biology Authors: Pengfei Xu Lingqi Kong Chunrong Tao Yuyou Zhu Juan Cheng Wenyu Li Nan Shen Rui Li Chao Zhang Li Wang Yan Zhang Guoping Wang Xinfeng Liu Wen Sun Wei Hu Source Type: research
BMI Modifies the Association Between Depression Symptoms and Serum Copper Levels
Biol Trace Elem Res. 2022 Nov 27. doi: 10.1007/s12011-022-03505-y. Online ahead of print.ABSTRACTDepression is one of the most common mental disorders which dramatically threatens public health and wellness. Copper has been known to be involved in many biological processes that could help explaining the occurrence of depression. However, studies focusing on its effect have yielded mixed results. The present study aims to evaluate the association between serum copper levels and depression symptoms. It also investigates the effect of modification of BMI (body mass index) on depression symptoms. A total of 5419 US adults aged...
Source: Biological Trace Element Research - November 27, 2022 Category: Biology Authors: Wu Hongrong Li Qingqi Gao Rong Tang Shuangyang Zhang Kaifang Zhao Jianfeng Source Type: research
Taurine attenuates neuronal ferroptosis by regulating GABA < sub > B < /sub > /AKT/GSK3 β/β-catenin pathway after subarachnoid hemorrhage
Free Radic Biol Med. 2022 Nov 16:S0891-5849(22)00965-0. doi: 10.1016/j.freeradbiomed.2022.11.003. Online ahead of print.ABSTRACTFerroptosis, characterized by lipid peroxidation and intracellular iron accumulation, has been reported to be involving in the pathophysiological of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Although taurine reportedly yields neuroprotective effects in multiple central neurological diseases and can attenuated neuron damage after stroke, its role in EBI after SAH remains unclear. The present study indicated that taurine levels in cerebrospinal fluid were significantly reduced in...
Source: Free Radical Biology and Medicine - November 19, 2022 Category: Biology Authors: Chengli Liu Peibang He Yujia Guo Qi Tian Jianfeng Wang Guijun Wang Zhan Zhang Mingchang Li Source Type: research
Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's disease
Free Radic Biol Med. 2022 Nov 14:S0891-5849(22)00983-2. doi: 10.1016/j.freeradbiomed.2022.11.020. Online ahead of print.ABSTRACTOxidative stress generating DNA damage has been shown to be a key characteristic in Alzheimer's disease (AD). However, how it affects the pathogenesis of AD is not yet fully understood. Neil3 is a DNA glycosylase initiating repair of oxidative DNA base lesions and with a distinct expression pattern in proliferating cells. In brain, its function has been linked to hippocampal-dependent memory and to induction of neurogenesis after stroke and in prion disease. Here, we generated a novel AD mouse mod...
Source: Free Radical Biology and Medicine - November 17, 2022 Category: Biology Authors: Milena A Egiazarian Silje Str ømstad Teri Sakshaug Ana B Nunez-Nescolarde Nicole Bethge Magnar Bj ørås Katja Scheffler Source Type: research
Sulforaphane promotes white matter plasticity and improves long-term neurological outcomes after ischemic stroke via the Nrf2 pathway
CONCLUSION: Our results support that Nrf2 is critical for Sfn-afforded neuroprotection after ischemic stroke. Thus, targeting Nrf2 may be a promising strategy for the treatment of PSCI.PMID:36244590 | DOI:10.1016/j.freeradbiomed.2022.10.001
Source: Free Radical Biology and Medicine - October 16, 2022 Category: Biology Authors: Qianqian Li George Fadoul Milos Ikonomovic Tuo Yang Feng Zhang Source Type: research
Deep learning-based behavioral profiling of rodent stroke recovery
Stroke research heavily relies on rodent behavior when assessing underlying disease mechanisms and treatment efficacy. Although functional motor recovery is considered the primary targeted outcome, tests in ro...
Source: BMC Biology - October 15, 2022 Category: Biology Authors: Rebecca Z. Weber, Geertje Mulders, Julia Kaiser, Christian Tackenberg and Ruslan Rust Tags: Methodology article Source Type: research
Carbon dioxide and blood-feeding shift visual cue tracking during navigation in < em > Aedes aegypti < /em > mosquitoes
Biol Lett. 2022 Sep;18(9):20220270. doi: 10.1098/rsbl.2022.0270. Epub 2022 Sep 28.ABSTRACTHaematophagous mosquitoes need a blood meal to complete their reproductive cycle. To accomplish this, female mosquitoes seek vertebrate hosts, land on them and bite. As their eggs mature, they shift attention away from hosts and towards finding sites to lay eggs. We asked whether females were more tuned to visual cues when a host-related signal, carbon dioxide, was present, and further examined the effect of a blood meal, which shifts behaviour to ovipositing. Using a custom, tethered-flight arena that records wing stroke changes whil...
Source: Biology Letters - September 27, 2022 Category: Biology Authors: Elina Barredo Joshua I Raji Michael Ramon Matthew DeGennaro Jamie Theobald Source Type: research
Patterns of asymmetry and energy cost generated from predictive simulations of hemiparetic gait
by Russell T. Johnson, Nicholas A. Bianco, James M. Finley
Hemiparesis, defined as unilateral muscle weakness, often occurs in people post-stroke or people with cerebral palsy, however it is difficult to understand how this hemiparesis affects movement patterns as it often presents alongside a variety of other neuromuscular impairments. Predictive musculoskeletal modeling presents an opportunity to investigate how impairments affect gait performance assuming a particular cost function. Here, we use predictive simulation to quantify the spatiotemporal asymmetries and changes to metabolic cost that emerge when muscle streng...
Source: PLoS Computational Biology - September 9, 2022 Category: Biology Authors: Russell T. Johnson Source Type: research
Dose-Dependent Effects of Intravenous Mesenchymal Stem Cell Transplantation in Rats with Acute Focal Cerebral Ischemia
Intravenous transplantation of mesenchymal stem (stromal) cells (MSC) is a promising approach to the treatment of ischemic stroke. In the published reports of the already completed preclinical and clinical studies the dosages of transplanted MSC greatly vary. However, the optimal dosage has not been determined. The dose-dependent effect of intravenous MSC transplantation was studied, in rats with experimental cerebral infarction. To this end, 5 ×105 and 2 ×106 MSC were intravenously administered 24 h after modeling of acute focal ischemia followed by complex assessment of the therapeutic efficacy over 60 days. The rate a...
Source: Bulletin of Experimental Biology and Medicine - September 5, 2022 Category: Biology Source Type: research
Acute Ischemic Stroke Comorbid with Type 2 Diabetes: Long-Term Prognosis Determinants in a 36-Month Prospective Study for Personalized Medicine
OMICS: A Journal of Integrative Biology, Ahead of Print.
Source: OMICS: A Journal of Integrative Biology - August 2, 2022 Category: Biology Authors: Pengcheng Liu Jiheng Hao Yichun Zhang Lu Wang Chao Liu Jiyue Wang Jingjun Feng Yanbo Zhang Haifeng Hou Liyong Zhang Source Type: research
