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Total 656 results found since Jan 2013.
Sex differences in the association between cardiovascular diseases and dementia subtypes: a prospective analysis of 464,616 UK Biobank participants
ConclusionWomen with CVD were 1.5 times more likely to experience AD than men, while had 15% lower risk of having VD than men.
Source: Biology of Sex Differences - May 7, 2022 Category: Biology Source Type: research
Ultrastructural Changes in the Penumbra of the Local Cerebral Infarction in Rats
We studied changes in the ultrastructure of synapses and myelin nerve fibers that develop in the penumbra in 4 and 12 h and 2 and 4 days after modeling infarction in the frontoparietal cortex in rats. Ischemic stroke was induced by injection of a photosensitive dye into their bloodstream followed by illumination of the brain surface with a halogen lamp. Visible ultrastructural changes were observed in the penumbra zone, namely in the axodendritic and axospinous synapses; they consisted in polymorphism and disorganization of synaptic vesicles, mitochondrial swelling, swelling and vacuolization of the postsynaptic fragments ...
Source: Bulletin of Experimental Biology and Medicine - March 30, 2022 Category: Biology Source Type: research
Clinical Significance of PAC-1, CD62P, and Platelet-Leukocyte Aggregates in Acute Ischemic Stroke
We studied diagnostic and treatment values of the blood levels of platelet activation markers PNA, PMA, PLyA, PAC-1, and CD62P in 30 patients with acute ischemic stroke (median NIHSS score 4 (2; 6)) before and after treatment as well as in comparison with the control group. The levels of these markers were measured by flow cytometry. In patients with acute ischemic stroke, the levels of PLyA, PAC-1, and CD62P were significantly increased in comparison with the controls; therapy significantly reduced the levels of PAC-1, CD62P, and PMA in patients with acute ischemic stroke. The areas under the ROC curve differentiating acu...
Source: Bulletin of Experimental Biology and Medicine - March 29, 2022 Category: Biology Source Type: research
Contraceptive drug, Nestorone, enhances stem cell-mediated remodeling of the stroke brain by dampening inflammation and rescuing mitochondria
Free Radic Biol Med. 2022 Mar 24:S0891-5849(22)00123-X. doi: 10.1016/j.freeradbiomed.2022.03.020. Online ahead of print.ABSTRACTIschemic stroke remains a significant unmet need causing massive mortality and morbidity due to few treatment options with limited therapeutic window. The progestin Nestorone® (segesterone acetate) displays high affinity for the progesterone receptor in exerting its potent birth control and hormone replacement therapy. Accumulating evidence implicates a new utility of Nestorone in affording neuroprotection in a variety of central nervous system diseases, including stroke. However, the mechanism o...
Source: Free Radical Biology and Medicine - March 28, 2022 Category: Biology Authors: Jea-Young Lee Vanessa Castelli Narender Kumar Regine Sitruk-Ware Cesario V Borlongan Source Type: research
Sex differences in the association between diabetes and hypertension and the risk of stroke: cohort of the Tehran Lipid and Glucose Study
ConclusionHypertension and T2D induced higher risk of overall and ischemic stroke in men than women among Iranian population.
Source: Biology of Sex Differences - March 15, 2022 Category: Biology Source Type: research
Blood Lipids Are Not Specific for Stroke Risk
Biol Trace Elem Res. 2022 Mar 2. doi: 10.1007/s12011-022-03184-9. Online ahead of print.NO ABSTRACTPMID:35235171 | DOI:10.1007/s12011-022-03184-9
Source: Biological Trace Element Research - March 2, 2022 Category: Biology Authors: Chenchen Pan Lianping He Source Type: research
Good, bad, and neglectful: Astrocyte changes in neurodegenerative disease
Free Radic Biol Med. 2022 Feb 21:S0891-5849(22)00073-9. doi: 10.1016/j.freeradbiomed.2022.02.020. Online ahead of print.ABSTRACTAstrocytes play key roles in CNS development as well as well as neuro-supportive roles in the mature brain including ionic, bioenergetic and redox homeostasis. Astrocytes undergo rapid changes following acute CNS insults such as stroke or traumatic brain injury, but are also profoundly altered in chronic neurodegenerative conditions such as Alzheimer's disease. While disease-altered astrocytes are often referred to as reactive, this does not represent a single cellular state or group of states, bu...
Source: Free Radical Biology and Medicine - February 24, 2022 Category: Biology Authors: Zoeb Jiwaji Giles E Hardingham Source Type: research
Iron promotes neurological function recovery in mice with ischemic stroke through endogenous repair mechanisms
In this study, we first observed that changes in iron metabolism occured during neurological function recovery in the mice with distal middle cerebral artery occlusion (dMCAO). Our data showed that plasticity changes due to endogenous repair mechanisms resulted in improvements in cerebral cortex function. These changes involved gliosis, synaptic function reconstruction, remyelination, and activation of neural stem cells. In order to examine the potential role of iron, we synthesized liposomal-encapsulated deferoxamine (DFO) nanoparticles to further explore the effect and the mechanism of iron on the recovery of neurologica...
Source: Free Radical Biology and Medicine - February 24, 2022 Category: Biology Authors: Xin Guo Xiaofang Jin Kang Han Shaomeng Kang Siyu Tian Xin Lv Mudi Feng Huiwen Zheng Yong Zuo Guodong Xu Ming Hu Jing Xu Peiyuan Lv Yan-Zhong Chang Source Type: research
Good, bad, and neglectful: Astrocyte changes in neurodegenerative disease
Free Radic Biol Med. 2022 Feb 21:S0891-5849(22)00073-9. doi: 10.1016/j.freeradbiomed.2022.02.020. Online ahead of print.ABSTRACTAstrocytes play key roles in CNS development as well as well as neuro-supportive roles in the mature brain including ionic, bioenergetic and redox homeostasis. Astrocytes undergo rapid changes following acute CNS insults such as stroke or traumatic brain injury, but are also profoundly altered in chronic neurodegenerative conditions such as Alzheimer's disease. While disease-altered astrocytes are often referred to as reactive, this does not represent a single cellular state or group of states, bu...
Source: Free Radical Biology and Medicine - February 24, 2022 Category: Biology Authors: Zoeb Jiwaji Giles E Hardingham Source Type: research
Iron promotes neurological function recovery in mice with ischemic stroke through endogenous repair mechanisms
In this study, we first observed that changes in iron metabolism occured during neurological function recovery in the mice with distal middle cerebral artery occlusion (dMCAO). Our data showed that plasticity changes due to endogenous repair mechanisms resulted in improvements in cerebral cortex function. These changes involved gliosis, synaptic function reconstruction, remyelination, and activation of neural stem cells. In order to examine the potential role of iron, we synthesized liposomal-encapsulated deferoxamine (DFO) nanoparticles to further explore the effect and the mechanism of iron on the recovery of neurologica...
Source: Free Radical Biology and Medicine - February 24, 2022 Category: Biology Authors: Xin Guo Xiaofang Jin Kang Han Shaomeng Kang Siyu Tian Xin Lv Mudi Feng Huiwen Zheng Yong Zuo Guodong Xu Ming Hu Jing Xu Peiyuan Lv Yan-Zhong Chang Source Type: research
Diffusional Characteristics of Brain Matter after Stroke
We analyzed characteristics of diffusion and its kurtosis obtained using diffusion-kurtosis MRI in the hemisphere contralateral to the one affected by acute cerebrovascular accident. Diffusion characteristics in the white and gray matter were compared using analysis of covariance (ANCOVA) in healthy subjects and stroke patients with consideration for the age and sex factors. Significant differences between the groups were revealed for apparent diffusion coefficient and mean kurtosis in the white matter. Age dependence was studied using regression analysis and, according to the results of ANCOVA, this factor was found to be...
Source: Bulletin of Experimental Biology and Medicine - February 17, 2022 Category: Biology Source Type: research
Mechanisms of Arsenic Exposure-Induced Hypertension and Atherosclerosis: an Updated Overview
Biol Trace Elem Res. 2022 Feb 15. doi: 10.1007/s12011-022-03153-2. Online ahead of print.ABSTRACTArsenic is an abundant element in the earth's crust. In the environment and within the human body, this toxic element can be found in both organic and inorganic forms. Chronic exposure to arsenic can predispose humans to cardiovascular diseases including hypertension, stroke, atherosclerosis, and blackfoot disease. Oxidative damage induced by reactive oxygen species is a major player in arsenic-induced toxicity, and it can affect genes expression, inflammatory responses, and/or nitric oxide homeostasis. Exposure to arsenic in d...
Source: Biological Trace Element Research - February 15, 2022 Category: Biology Authors: Soudabeh Balarastaghi Ramin Rezaee A Wallace Hayes Fatemeh Yarmohammadi Gholamreza Karimi Source Type: research
Penetrance of the V203I variant of the PRNP gene: report of a patient with stroke-like onset of Creutzfeld-Jacob Disease and review of published cases
Volume 16, Issue 1, December 2022, Page 19-22 .
Source: Prion - February 15, 2022 Category: Biology Authors: Ilaria Gandoglia Laura Strada Anna Poleggi Antonio Castaldi Massimo Del Sette Emilio Di Maria Source Type: research
