Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms
This article also addresses the neuropharmacological potential of taurine analogs.Graphical abstract
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We report the psychiatric, behavioral, and cognitive profiles over the course of disease from a large, prospectively-enrolled, longitudinal cohort of children with CECTS. We further characterize the detailed seizure course and test the relationship between several proposed risk factors and neuropsychiatric and seizure outcomes in these children.MethodsPatients diagnosed with CECTS were enrolled as part of a community-based study and followed from diagnosis through disease resolution (16.0 ± 3.1 years, N = 60). Twenty sibling controls were also recruited. We report the natural history of premorbid neuropsyc...
In conclusion, CWE seem to benefit from interventions and behavior modification techniques first developed for children with ADHD.
ConclusionsDiffuse lesions may help to predict the poor neurological outcomes in patients with TSC.
We present the first quantitative comparison of simultaneously acquired clinical and mobile consumer-grade EEG for a clinical use-case.
This study was conducted with 210 hospital staff working at Van Regional Educational and Training Hospital in Van, Turkey. Data regarding the demographics and familiarity with epilepsy were obtained. Epilepsy knowledge scale and epilepsy attitude scale were used to evaluate the level of knowledge and attitudes regarding epilepsy, respectively.ResultsThe mean score of epilepsy knowledge scale was 11.3 ± 3.8 and the mean score of epilepsy attitude scale was 58.2 ± 6.3. The level of knowledge was positively associated with being familiar with epilepsy. Positive attitudes regarding epilepsy correlated wit...
ConclusionThis study suggests a lower search interest over time in epilepsy surgery, and various associated terms, with increased interest in vagus nerve stimulation and laser ablation procedures over time. There is no clear indication from these data regarding the apparent shift from mesial temporal cases to an increase in extratemporal case workload.
This article is part of the Special Issue “NEWroscience 2018”
ConclusionsNon-motor symptoms are independent of motor features and likely belong to the clinical spectrum of blepharospasm. The presence of non-motor symptoms possibly reflects a complex network disorder of blepharospasm.
AbstractEpilepsy self-management practices enhance a patient ’s competence and confidence in managing their chronic condition, which is assumed to lead to an improved quality of life (QoL). We analyzed the relationship between the Epilepsy Self-Management Scale (ESMS) responses and the Quality of Life in Epilepsy (QOLIE-31) scores. Baseline questionnaires f rom HOBSCOTCH, a self-management program for cognitive problems, were administered in four New England epilepsy centers on adults (n = 100) with epilepsy and subjective memory complaints. There was no correlation between overall self-management score...