Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms

This article also addresses the neuropharmacological potential of taurine analogs.Graphical abstract
Source: Redox Biology - Category: Biology Source Type: research

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Conversations and healthy debate about issues facing our industry and the health care system are critical to addressing some of today ’s challenges and opportunities. The Catalyst welcomes guest contributors, including patients, stakeholders, innovators and others, to share their perspectives and point of view. Views represented here may not be those of PhRMA, though they are no less key to a healthy dialogue on issues in health care today.
Source: The Catalyst - Category: Pharmaceuticals Authors: Tags: diabetes Out of Pocket Costs Voters for Cures Source Type: news
We report the psychiatric, behavioral, and cognitive profiles over the course of disease from a large, prospectively-enrolled, longitudinal cohort of children with CECTS. We further characterize the detailed seizure course and test the relationship between several proposed risk factors and neuropsychiatric and seizure outcomes in these children.MethodsPatients diagnosed with CECTS were enrolled as part of a community-based study and followed from diagnosis through disease resolution (16.0 ± 3.1 years, N = 60). Twenty sibling controls were also recruited. We report the natural history of premorbid neuropsyc...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
In conclusion, CWE seem to benefit from interventions and behavior modification techniques first developed for children with ADHD.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
ConclusionsDiffuse lesions may help to predict the poor neurological outcomes in patients with TSC.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
We present the first quantitative comparison of simultaneously acquired clinical and mobile consumer-grade EEG for a clinical use-case.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
This study was conducted with 210 hospital staff working at Van Regional Educational and Training Hospital in Van, Turkey. Data regarding the demographics and familiarity with epilepsy were obtained. Epilepsy knowledge scale and epilepsy attitude scale were used to evaluate the level of knowledge and attitudes regarding epilepsy, respectively.ResultsThe mean score of epilepsy knowledge scale was 11.3 ± 3.8 and the mean score of epilepsy attitude scale was 58.2 ± 6.3. The level of knowledge was positively associated with being familiar with epilepsy. Positive attitudes regarding epilepsy correlated wit...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
ConclusionThis study suggests a lower search interest over time in epilepsy surgery, and various associated terms, with increased interest in vagus nerve stimulation and laser ablation procedures over time. There is no clear indication from these data regarding the apparent shift from mesial temporal cases to an increase in extratemporal case workload.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
This article is part of the Special Issue “NEWroscience 2018”
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
ConclusionsNon-motor symptoms are independent of motor features and likely belong to the clinical spectrum of blepharospasm. The presence of non-motor symptoms possibly reflects a complex network disorder of blepharospasm.
Source: Journal of Neurology - Category: Neurology Source Type: research
AbstractEpilepsy self-management practices enhance a patient ’s competence and confidence in managing their chronic condition, which is assumed to lead to an improved quality of life (QoL). We analyzed the relationship between the Epilepsy Self-Management Scale (ESMS) responses and the Quality of Life in Epilepsy (QOLIE-31) scores. Baseline questionnaires f rom HOBSCOTCH, a self-management program for cognitive problems, were administered in four New England epilepsy centers on adults (n = 100) with epilepsy and subjective memory complaints. There was no correlation between overall self-management score...
Source: Journal of Neurology - Category: Neurology Source Type: research
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