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Specialty: Neurology
Therapy: Statin Therapy
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Total 360 results found since Jan 2013.
Statin effects on post-stroke epilepsy and mortality - Taiwan population-based study.
Conclusion: Statins have a modest but non-significant effect in preventing post-apoplectic epilepsy in Taiwan. Statins decrease post-stroke mortality only in men. Further studies are needed to depict their exact roles in these issues.
PMID: 32122287 [PubMed - as supplied by publisher]
Source: Neurological Research - March 4, 2020 Category: Neurology Tags: Neurol Res Source Type: research
The influence of statins on the risk of post-stroke epilepsy
ConclusionAdequate treatment with statins after stroke may lower the risk of PSE.
Source: Neurological Sciences - February 20, 2020 Category: Neurology Source Type: research
Statin Pretreatment Might Be Associated with Decreased Myocardial Injury After Ischemic Stroke
In this study, we aimed at investigating the association between statin pretreatment and poststroke myocardial injury. Methods: Six hundred seventy-one patients diagnosed as acute ischemic stroke were enrolled. According to the histories of statin pretreatment before stroke, patients were categorized into nonstatin (n = 474) and statin groups (n = 197), with the latter further divided into low-dosage, standard-dosage, and high-dosage subgroups according the dosages of statins.
Source: Journal of Stroke and Cerebrovascular Diseases - February 20, 2020 Category: Neurology Authors: Ke-Wu Wang, Chao Feng, Yin-Fei Wu, Jing Huang, Wen-Bo Xiao, Shu-Dong Xia Source Type: research
Apolipoproteins B and A1 in Ischemic Stroke Subtypes
Introduction: Elevated serum apolipoprotein B and the apolipoprotein B/A1 ratio have been associated with ischemic stroke and intracranial atherosclerotic disease. We sought to assess the relationship between serum levels of apolipoprotein B, apolipoprotein A1, and the apolipoprotein B/A1 ratio with ischemic stroke subtypes and large artery atherosclerosis location. Materials and Methods: We evaluated serum apolipoprotein B and apolipoprotein A1 levels in consecutive, statin-na ïve, adult ischemic stroke patients admitted to an academic medical center in southern India.
Source: Journal of Stroke and Cerebrovascular Diseases - February 9, 2020 Category: Neurology Authors: Rizwan Kalani, Soumya Krishnamoorthy, D. Deepa, Srinivas Gopala, Dorairaj Prabhakaran, David Tirschwell, P.N. Sylaja Source Type: research
Statin Therapy in Ischemic Stroke Models: A Meta-Analysis
AbstractStatins, drugs known for lipid lowering capabilities and reduction of cardiovascular disease, have demonstrated neuroprotective effects following ischemic stroke in retrospective clinical and animal studies. However, dosing (methods, time, type of statin, and quantity) varies across studies, limiting the clinical applicability of these findings. Furthermore, a comprehensive review of statins in edema and blood-brain barrier (BBB) breakdown is needed to provide insight on diverse, less explored neuroprotective effects. In the present study, we conduct a meta-analysis of publications evaluating statin administration ...
Source: Translational Stroke Research - December 1, 2019 Category: Neurology Source Type: research
Simvastatin preconditioning confers neuroprotection against hypoxia-ischemia induced brain damage in neonatal rats via autophagy and silent information regulator 1 (SIRT1) activation.
This study provides further preclinical evidence of the PC-like effect of statins in brain tissue, supporting their beneficial effects in improving stroke outcome after prophylactic treatments.
PMID: 31734315 [PubMed - as supplied by publisher]
Source: Experimental Neurology - November 13, 2019 Category: Neurology Authors: Carloni S, Balduini W Tags: Exp Neurol Source Type: research
Effect of Simvastatin on Permeability in Cerebral Cavernous Malformation Type 1 Patients: Results from a Pilot Small Randomized Controlled Clinical Trial
Source: Translational Stroke Research - October 22, 2019 Category: Neurology Source Type: research
Prestroke statins use reduces oxidized low density lipoprotein levels and improves clinical outcomes in patients with atrial fibrillation related acute ischemic stroke
Atrial fibrillation (AF) is a common cause of cerebral infarction, which could lead to endothelial dysfunction, increased reactive oxygen species (ROS) and oxidized low density lipoprotein (Ox-LDL).AF is assoc...
Source: BMC Neurology - October 18, 2019 Category: Neurology Authors: Lanying He, Ronghua Xu, Jian Wang, Lili Zhang, Lijuan Zhang, Wang Zhao and Weiwei Dong Tags: Research article Source Type: research
Characteristics and Factors for Short-Term Functional Outcome in Stroke Patients With Atrial Fibrillation, Nationwide Retrospective Cohort Study
Conclusion: Our results suggest that presence of non-relevant extracranial cerebral atherosclerosis may affect poor functional outcome and prior stroke statin therapy may be feasible in Korean stroke patients with AF.
Source: Frontiers in Neurology - October 17, 2019 Category: Neurology Source Type: research
Association Between Endothelial Cell Stabilizing Medication and Small Vessel Disease Stroke: A Case-Control Study
Increasing evidence suggests a role for endothelial cell (EC) dysfunction in pathogenesis of cerebral small vessel disease. Commonly used medications including certain antihypertensives and statins have EC-stabilizing effects. We used individual patient data from completed acute stroke trials to assess whether prior exposure to EC-stabilizing medications was associated with lacunar stroke, using lacunar stroke as a clinical proxy for cerebral small vessel disease. Across 12,002 patients with relevant data, 2,855 (24%) had a lacunar stroke presentation. Univariable analyses suggested potential confounding from vascular dise...
Source: Frontiers in Neurology - September 24, 2019 Category: Neurology Source Type: research
The Benefits and Risks of Statin Therapy in Ischemic Stroke: A Review of the Literature
Wang Zhao, Zhi-Jie Xiao, Shui-Ping ZhaoNeurology India 2019 67(4):983-992
Statins are effective cholesterol-lowering drugs for reducing the risks of mortality and morbidity of cardiovascular diseases. Increasing evidence has shown that statin use is associated with a significant beneficial effect in patients with ischemic stroke. Both pre-stroke and post-stroke statin use has been found to be beneficial in ischemic stroke. Furthermore, good adherence is associated with a better clinical outcome, and statin withdrawal is associated with a poor functional outcome in patients with ischemic stroke. High-intensity statin thera...
Source: Neurology India - September 9, 2019 Category: Neurology Authors: Wang Zhao Zhi-Jie Xiao Shui-Ping Zhao Source Type: research
Use of cardiovascular polypills for the secondary prevention of cerebrovascular disease
ConclusionsThis document is the first to establish recommendations for the use of the CV polypill in cerebrovascular disease, beyond its advantages in terms of treatment adherence.ResumenIntroducciónEl control de los factores de riesgo cardiovascular (CV) en la prevención secundaria tras un ictus isquémico es bajo, en parte debido a la falta de adherencia terapéutica. La polipíldora CV puede contribuir a la buena cumplimentación del adecuado tratamiento para la prevención cerebrovascular. El objetivo fue establecer cómo y en qué casos se debería administrar.MétodosUn grupo de 8 neurólogos redactaron recome...
Source: Neurologia - August 12, 2019 Category: Neurology Source Type: research
Efficacy of Statin Therapy in Post-Stroke Seizure Prophylaxis: Clues from an Observational Study of Routine Secondary Prevention Treatment
ConclusionsStatin treatment, especially with intensive-dose statins, can reduce the risk of PSS. In addition, the risk of developing PSE appears to be significantly lower for prolonged statin treatment. However, due to the observational nature of this study, more investigations are warranted to confirm its findings.
Source: Seizure - July 25, 2019 Category: Neurology Source Type: research
Inpatient statin use and stroke recurrence in patients with or without diabetes mellitus.
Conclusion: Inpatient statin use was associated with lower stroke recurrence in non-diabetic patients after acute ischaemic stroke, but no definite association between inpatient statin use and stroke recurrence in patients with diabetes mellitus was found.
PMID: 31328681 [PubMed - as supplied by publisher]
Source: Neurological Research - July 23, 2019 Category: Neurology Tags: Neurol Res Source Type: research
